Cited by 167Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Serotonin and decision making processes

Homberg, Judith R.·2012·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2011.06.001

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Abstract

Serotonin (5-HT) is an important player in decision making. Serotonergic antidepressant, anxiolytic and antipsychotic drugs are extensively used in the treatment of neuropsychiatric disorders characterized by impaired decision making, and exert both beneficial and harmful effects in patients. Detailed insight into the serotonergic mechanisms underlying decision making is needed to strengthen the first and weaken the latter. Although much remains to be done to achieve this, accumulating studies begin to deliver a coherent view. Thus, high central 5-HT levels are generally associated with improved reversal learning, improved attentional set shifting, decreased delay discounting, and increased response inhibition, but a failure to use outcome representations. Based on 5-HT's evolutionary role, I hypothesize that 5-HT integrates expected, or changes in, relevant sensory and emotional internal/external information, leading to vigilance behaviour affecting various decision making processes. 5-HT receptor subtypes play distinctive roles in decision making. 5-HT(2A) agonists and 5-HT2c antagonists decrease compulsivity, whereas 5-HT(2A) antagonists and 5-HT(2C) agonists decrease impulsivity. 5-HT(6) antagonists univocally affect decision making processes.

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Authors: Homberg, J. R.
Affiliations: Donders Institute for Brain, Cognition and Behaviour (NL)
Corresponding author: Homberg, Judith R.
ORCID: Homberg, Judith R.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2012-01
Volume: 36
Issue: 1
Pages: 218-236
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2011.06.001
OpenAlex: W2015724371
Cited by: 167
References: 273
Citations by year: 2026: 2 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 4 · 2019: 7 · 2018: 27 · 2017: 12 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 23 · 2012: 8
FWCI: 1.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: The Netherlands Organisation for Scientific Research (NWO) (86410003)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: serotonin, decision-making, reversal learning, set-shifting, delay discounting, response inhibition, serotonergic receptors, 5-HT2A receptor, 5-HT2C receptor, 5-HT6 receptor, impulsivity, compulsivity, antidepressants, anxiolytics, antipsychotic drugs, vigilance behavior
MeSH terms: Animals, Decision Making, Humans, Receptors, Serotonin, Reversal Learning, Serotonin, Serotonin Agents

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Serotonin and decision making processes

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