A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei
Open accessAbstract
The serotonin system is proposed to regulate physiology and behavior and to underlie mood disorders; nevertheless, the circuitry controlling serotonergic neurons remains uncharacterized. We therefore generated a comprehensive whole-brain atlas defining the monosynaptic inputs onto forebrain-projecting serotonergic neurons of dorsal versus median raphe based on a genetically restricted transsynaptic retrograde tracing strategy. We identified discrete inputs onto serotonergic neurons from forebrain and brainstem neurons, with specific inputs from hypothalamus, cortex, basal ganglia, and midbrain, displaying a greater than anticipated complexity and diversity in cell-type-specific connectivity. We identified and functionally confirmed monosynaptic glutamatergic inputs from prefrontal cortex and lateral habenula onto serotonergic neurons as well as a direct GABAergic input from striatal projection neurons. In summary, our findings emphasize the role of hyperdirect inputs to serotonergic neurons. Cell-type-specific classification of connectivity patterns will allow for further functional analysis of the diverse but specific inputs that control serotonergic neurons during behavior.
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Serotonergic and dopaminergic markers are jointly present in their developmental origins, guidepost areas, as well as within the subdomains of the PFC, which is important for their intricate interaction later in life to establish higher cognitive functions.
“Serotonergic and dopaminergic markers are jointly present in their developmental origins, guidepost areas, as well as within the subdomains of the PFC, which is important for their intricate interaction later in life to establish higher cognitive functions [209, 232–234].”
From Development of prefrontal cortex (2022) · cites this paper as [209]
DRN serotonergic neurons are controlled by glutamatergic projections from the PFC.
“In addition, DRN serotonergic neurons are controlled by glutamatergic projections from the PFC [152, 207–209].”
From Development of prefrontal cortex (2022) · cites this paper as [209]
The raphe nuclei play a critical role in regulating serotoninergic tone.
“which are critically involved in regulating serotoninergic tone (40,41)”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [41]
DR serotonin neurons as a whole receive monosynaptic inputs from diverse brain regions.
“DR serotonin neurons as a whole receive monosynaptic inputs from diverse brain regions (Ogawa et al., 2014; Pollak Dorocic et al., 2014; Weissbourd et al., 2014).”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Pollak Dorocic et al., 2014
Cites
Nonrigid registration using free-form deformations: application to breast mr images
Rueckert, D., Sonoda, L. I., Hayes, C., Hill, D. L. G., Leach, M. O., & Hawkes, D. J. (1999) · IEEE Transactions on Medical Imaging · doi:10.1109/42.796284 · Cited by 5,265 · see citing works
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,143 · see citing works
Wickersham, I. R., Sullivan, H., & Seung, H. (2010) · Nature Protocols · doi:10.1038/nprot.2009.248 · Cited by 4,905 · see citing works
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · see citing works
A mesoscale connectome of the mouse brain
Oh, S. W., Harris, J. A., Ng, L., Winslow, B., Cain, N., Mihalas, S., Wang, Q., Lau, C., Kuan, L., Henry, A. M., et al. (2014) · Nature · doi:10.1038/nature13186 · Cited by 2,612 · see citing works
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works
Self-citationStructure and function of the brain serotonin system
Jacobs, B. L., & Azmitia, E. C. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.1.165 · Cited by 2,574 · see citing works
Structural and molecular interrogation of intact biological systems
Chung, K., Wallace, J., Kim, S.-Y., Kalyanasundaram, S., Andalman, A. S., Davidson, T. J., Mirzabekov, J. J., Zalocusky, K. A., Mattis, J., Denisin, A. K., et al. (2013) · Nature · doi:10.1038/nature12107 · Cited by 2,008 · see citing works
Azmitia, E. C., & Segal, M. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901790311 · Cited by 1,908 · see citing works
Evidence for the existence of monoamine neurons in the central nervous system
Fuxé, K. (1965) · Cell and Tissue Research · doi:10.1007/bf00337069 · Cited by 1,567 · see citing works
Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550 · see citing works
Fuxé, K. (1965) · PubMed · Cited by 1,544 · see citing works
Efferent connections of the substantia nigra and ventral tegmental area in the rat
Beckstead, R. M., Domesick, V. B., & Nauta, W. J. H. (1979) · Brain Research · doi:10.1016/0006-8993(79)91001-1 · Cited by 1,293 · see citing works
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227 · see citing works
Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
Watabe‐Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A., & Uchida, N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.017 · Cited by 1,221 · see citing works
Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons
Wickersham, I. R., Lyon, D. C., Barnard, R. J. O., Mori, T., Finke, S., Conzelmann, K., Young, J. A. T., & Callaway, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.033 · Cited by 1,176 · see citing works
The spectrum of behaviors influenced by serotonin
Lucki, I. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00139-5 · Cited by 1,154 · see citing works
Gong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., & Gerfen, C. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2707-07.2007 · Cited by 977 · see citing works
A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat
Vertes, R. P. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130409 · Cited by 842 · see citing works
Raphe unit activity in freely moving cats: correlation with level of behavioral arousal.
Trulson, M., & Jacobs, B. (1979) · Brain Research · doi:10.1016/0006-8993(79)90157-4 · Cited by 815 · see citing works
Neural Networks of the Mouse Neocortex
Zingg, B., Hintiryan, H., Gou, L., Song, M. Y., Bay, M., Bienkowski, M. S., Foster, N. N., Yamashita, S., Bowman, I., Toga, A. W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.02.023 · Cited by 797 · see citing works
Distinct extended amygdala circuits for divergent motivational states
Jennings, J. H., Sparta, D. R., Stamatakis, A. M., Ung, R. L., Pleil, K. E., Kash, T. L., & Stuber, G. D. (2013) · Nature · doi:10.1038/nature12041 · Cited by 704 · cited 1× · see citing works
“The extended amygdala circuit also includes the bed nuclei of stria terminalis (BST), which controls anxiety-related behaviors (Jennings et al., 2013; Kim et al., 2013).”
Diverging neural pathways assemble a behavioural state from separable features in anxiety
Kim, S.-Y., Adhikari, A., Lee, S. Y., Marshel, J. H., Kim, C. K., Mallory, C. S., Lo, M., Pak, S., Mattis, J., Lim, B. K., et al. (2013) · Nature · doi:10.1038/nature12018 · Cited by 666 · see citing works
Serotoninergic regulation of emotional and behavioural control processes
Cools, R., Roberts, A. C., & Robbins, T. W. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.10.011 · Cited by 656 · see citing works
A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge
Warden, M. R., Selimbeyoglu, A., Mirzabekov, J. J., Lo, M., Thompson, K. R., Kim, S.-Y., Adhikari, A., Tye, K. M., Frank, L. M., & Deisseroth, K. (2012) · Nature · doi:10.1038/nature11617 · Cited by 645 · see citing works
Cognitive Inflexibility After Prefrontal Serotonin Depletion
Clarke, H. F., Dalley, J. W., Crofts, H. S., Robbins, T. W., & Roberts, A. C. (2004) · Science · doi:10.1126/science.1094987 · Cited by 632 · see citing works
Multilevel (Hierarchical) Modeling: What It Can and Cannot Do
Gelman, A. (2006) · Technometrics · doi:10.1198/004017005000000661 · Cited by 558 · see citing works
Peyron, C., Petit, J.-M., Rampon, C., Jouvet, M., & Luppi, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00268-6 · Cited by 509 · see citing works
Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons
Wall, N. R., De La Parra, M., Callaway, E. M., & Kreitzer, A. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.014 · Cited by 489 · see citing works
The principled control of false positives in neuroimaging
Bennett, C. M., Wolford, G. L., & Miller, M. B. (2009) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsp053 · Cited by 486 · see citing works
Current concepts in neuroanatomical tracing
Köbbert, C., Apps, R., Bechmann, I., Lanciego, J. L., Mey, J., & Thanos, S. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00019-8 · Cited by 419 · see citing works
Liu, R.-J., van den Pol, A. N., & Aghajanian, G. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09453.2002 · Cited by 392 · see citing works
Serotonin in Affective Control
Dayan, P., & Huys, Q. J. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135607 · Cited by 381 · see citing works
Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique
Aghajanian, G. K., & Wang, R. Y. (1977) · Brain Research · doi:10.1016/0006-8993(77)90291-8 · Cited by 380 · see citing works
Descarries, L., Watkins, K. C., Garcia, S., & Beaudet, A. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902070305 · Cited by 380 · see citing works
The organization of divergent axonal projections from the midbrain raphe nuclei in the rat
Imai, H., Steindler, D. A., & Kitai, S. T. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902430307 · Cited by 369 · see citing works
Wall, N. R., Wickersham, I. R., Cetin, A. H., Parra, M. D. L., & Callaway, E. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011756107 · Cited by 369 · see citing works
The globus pallidus sends reward-related signals to the lateral habenula
Hong, S., & Hikosaka, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.035 · Cited by 346 · see citing works
Targeted gene expression in dopamine and serotonin neurons of the mouse brain
Zhuang, X., Masson, J., Gingrich, J. A., Rayport, S., & Hen, R. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.09.020 · Cited by 316 · see citing works
Miyamichi, K., Shlomai, Y., Shu, M., Weissbourd, B., Luo, L., & Mizrahi, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.027 · Cited by 310 · see citing works
Hajós, M., Richards, C. D., Székely, A. D., & Sharp, T. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00157-2 · Cited by 299 · see citing works
Optimized large-scale production of high titer lentivirus vector pseudotypes
Sena‐Esteves, M., Tebbets, J. C., Steffens, S., Crombleholme, T. M., & Flake, A. W. (2004) · Journal of Virological Methods · doi:10.1016/j.jviromet.2004.08.017 · Cited by 287 · see citing works
Anatomic and functional topography of the dorsal raphe nucleus
ABRAMS, J. K., JOHNSON, P. L., HOLLIS, J. H., & LOWRY, C. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.005 · Cited by 284 · see citing works
Lo, L., & Anderson, D. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.12.002 · Cited by 251 · see citing works
Mapping brain circuitry with a light microscope
Osten, P., & Margrie, T. W. (2013) · Nature Methods · doi:10.1038/nmeth.2477 · Cited by 244 · see citing works
Hale, M. W., & Lowry, C. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2089-z · Cited by 243 · see citing works
The role of serotonin in the pathophysiology and treatment of schizophrenia
Abi‐Dargham, A., Laruelle, M. A., Aghajanian, G. K., Charney, D. S., & Krystal, J. H. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.1.1 · Cited by 210 · see citing works
Kirby, L. G., Pernar, L. I. M., Valentino, R. J., & Beck, S. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00584-5 · Cited by 205 · see citing works
Beier, K. T., Saunders, A. B., Oldenburg, I. A., Miyamichi, K., Akhtar, N., Luo, L., Whelan, S. P. J., Sabatini, B. L., & Cepko, C. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110854108 · Cited by 199 · see citing works
The serotonergic system in Parkinson's disease
Huot, P., Fox, S. H., & Brotchie, J. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.004 · Cited by 195 · see citing works
Structural neurobiology: missing link to a mechanistic understanding of neural computation
Denk, W. T., Briggman, K. L., & Helmstaedter, M. N. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3169 · Cited by 192 · see citing works
Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain
Fu, W.-Y., Maître, E. L., Fabre, V., Bernard, J., Xu, Q., & Hökfelt, T. G. M. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22407 · Cited by 186 · see citing works
Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms
Saper, C. B. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53014-6 · Cited by 178 · see citing works
Ranade, S., & Mainen, Z. F. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00507.2009 · Cited by 174 · see citing works
Serotonin and decision making processes
Homberg, J. R. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.001 · Cited by 167 · see citing works
Glutamatergic afferent projections to the dorsal raphe nucleus of the rat
Lee, H. S., Kim, M., Valentino, R. J., & Waterhouse, B. D. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03841-6 · Cited by 149 · see citing works
Curran, E. J., & Watson, S. J. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903610106 · Cited by 148 · see citing works
Varga, V., Székely, A. D., Csillag, A., Sharp, T., & Hajós, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00294-9 · Cited by 147 · see citing works
Behzadi, G., Kalén, P., Parvopassu, F., & Wiklund, L. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90194-9 · Cited by 140 · see citing works
Paul, E. D., & Lowry, C. A. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113490328 · Cited by 137 · see citing works
Marcinkiewicz, M., Morcos, R., & Chrétien, M. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902890103 · Cited by 134 · see citing works
Varga, V., Kocsis, B., & Sharp, T. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02465.x · Cited by 134 · see citing works
Veasey, S. C., Fornal, C. A., Metzler, C. W., & Jacobs, B. L. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00673-2 · Cited by 132 · see citing works
Ascending dopaminergic projections from the dorsal raphe nucleus in the rat
Stratford, T. R., & Wirtshafter, D. (1990) · Brain Research · doi:10.1016/0006-8993(90)90239-8 · Cited by 129 · see citing works
Occurrence of dopamine-containing neurons in the midbrain raphe nuclei of the rat
Ochi, J., & Shimizu, K. (1978) · Neuroscience Letters · doi:10.1016/0304-3940(78)90142-8 · Cited by 127 · see citing works
Steinbusch, H. W. M., van der Kooy, D., Verhofstad, A. A. J., & Pellegrino, A. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90184-6 · Cited by 126 · see citing works
Efferent connections of the caudal part of the globus pallidus in the rat
Shammah‐Lagnado, S. J., Alheid, G. F., & Heimer, L. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961216)376:3 · Cited by 123 · see citing works
Kirouac, G. J., Li, S., & Mabrouk, G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.11005 · Cited by 121 · see citing works
Serotonin and Sleep: Molecular, Functional and Clinical Aspects
Monti, J. M., Pandi-Perumal, S. R., Jacobs, B. L., & Nutt, D. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8561-3 · Cited by 107 · see citing works
The role of the dorsal raphé nucleus in reward-seeking behavior
Nakamura, K. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00060 · Cited by 104 · see citing works
Foxp1 gene expression in projection neurons of the mouse striatum
Tamura, S., Morikawa, Y., Iwanishi, H., Hisaoka, T., & Senba, E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.036 · Cited by 92 · see citing works
Kal�n, P., Skagerberg, G., & Lindvall, O. (1988) · Experimental Brain Research · doi:10.1007/bf00279662 · Cited by 81 · see citing works
Cebrián, C., Parent, A., & Prensa, L. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20741 · Cited by 80 · see citing works
Distribution of dopamine-immunoreactive fibers in the rat brainstem
Kitahama, K., Nagatsu, I., Geffard, M., & Maeda, T. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(99)00047-2 · Cited by 79 · see citing works
Prefrontal afferents to the dorsal raphe nucleus in the rat
Gonçalves, L., Nogueira, M. I., Shammah‐Lagnado, S. J., & Metzger, M. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.11.012 · Cited by 66 · see citing works
Pattern of distribution of serotonergic fibers to the thalamus of the rat
Vertes, R. P., Linley, S. B., & Hoover, W. B. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0249-x · Cited by 66 · see citing works
Efferent and afferent connections of the dorsal and median raphe nuclei in the rat
Vertes, R. P., & Linley, S. B. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8561-3_3 · Cited by 63 · see citing works
Lee, H. S., Park, S. H., Song, W., & Waterhouse, B. D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.08.016 · Cited by 57 · see citing works
Roberts, V. J., Barth, S., Meunier, H., & Vale, W. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960115)364:3 · Cited by 45 · see citing works
Park, M. R. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90075-x · Cited by 40 · see citing works
Computational studies of the role of serotonin in the basal ganglia
Reed, M. C., Nijhout, H. F., & Best, J. A. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00041 · Cited by 27 · see citing works
Coordinate regulation of noradrenergic and serotonergic brain regions by amygdalar neurons
Retson, T., & Bockstaele, E. J. V. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2013.04.003 · Cited by 26 · see citing works
Control of serotonergic neurons in the dorsal raphe nucleus by the lateral hypothalamus
Celada, P., Casanovas, J. M., Páez, X., et al. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02284-9 · Cited by 24 · see citing works
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Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov, R. A., Zeisel, A., Bakker, J., Girach, F., Hellysaz, A., Tomer, R., Alpár, A., Mulder, J., Clotman, F., Keimpema, E., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4462 · Cited by 502 · see citing works
Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems
Ren, J., Friedmann, D., Xiong, J., Liu, C. D., Ferguson, B. R., Weerakkody, T., DeLoach, K. E., Ran, C., Pun, A., Sun, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.043 · Cited by 498 · see citing works
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
Rossi, M. A., & Stuber, G. D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.021 · Cited by 415 · see citing works
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
Serotonergic neurons signal reward and punishment on multiple timescales
Cohen, J. Y., Amoroso, M. W., & Uchida, N. (2015) · eLife · doi:10.7554/elife.06346 · Cited by 388 · see citing works
A High-Resolution<i>In Vivo</i>Atlas of the Human Brain's Serotonin System
Beliveau, V., Ganz, M., Feng, L., Ozenne, B., Højgaard, L., Fisher, P. M., Svarer, C., Greve, D. N., & Knudsen, G. M. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2830-16.2016 · Cited by 368 · see citing works
Embracing diversity in the 5-HT neuronal system
Okaty, B. W., Commons, K. G., & Dymecki, S. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0151-3 · Cited by 319 · see citing works
Ren, J., Isakova, A., Friedmann, D., Zeng, J., Grutzner, S. M., Pun, A., Zhao, G. Q., Kolluru, S. S., Wang, R., Lin, R., et al. (2019) · eLife · doi:10.7554/elife.49424 · Cited by 304 · see citing works
Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons
Wang, D., He, X., Zhao, Z., Feng, Q., Lin, R., Sun, Y., Ding, T., Xu, F., Luo, M., & Zhan, C. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00040 · Cited by 298 · see citing works
Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253 · see citing works
Activity of Raphé serotonergic neurons controls emotional behaviors
Teissier, A., Chemiakine, A., Inbar, B., Bagchi, S., Ray, R. S., Palmiter, R. D., Dymecki, S. M., Moore, H., & Ansorge, M. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.061 · Cited by 197 · see citing works
Pham, T. H., & Gardier, A. M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.017 · Cited by 186 · see citing works
Neuroanatomic differences associated with stress susceptibility and resilience
Anacker, C., Scholz, J., O’Donnell, K. J., Allemang-Grand, R., Diorio, J., Bagot, R. C., Nestler, E. J., Hen, R., Lerch, J. P., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.009 · Cited by 167 · see citing works
Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior
Lecca, S., Meye, F. J., Trusel, M., Tchenio, A., Harris, J., Schwarz, M. K., Burdakov, D., Georges, F., & Mameli, M. (2017) · eLife · doi:10.7554/elife.30697 · Cited by 166 · see citing works
Fukumoto, K., Iijima, M., & Chaki, S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.233 · Cited by 174 · see citing works
Stable representations of decision variables for flexible behavior
Bari, B. A., Grossman, C. D., Lubin, E. E., Rajagopalan, A. E., Cressy, J. I., & Cohen, J. Y. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.001 · Cited by 173 · see citing works
Communication in Neural Circuits: Tools, Opportunities, and Challenges
Lerner, T. N., Ye, L., & Deisseroth, K. (2016) · Cell · doi:10.1016/j.cell.2016.02.027 · Cited by 159 · see citing works
Nucleus Accumbens Modulation in Reward and Aversion
Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163 · see citing works
Ruggiero, R. N., Rossignoli, M. T., Marques, D. B., de Sousa, B. M., Romcy-Pereira, R. N., Lopes-Aguiar, C., & Leite, J. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.732360 · Cited by 111 · see citing works
Fernandez, S. P., Cauli, B., Cabezas, C., Muzerelle, A., Poncer, J.-C., & Gaspar, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1142-4 · Cited by 100 · see citing works
Geddes, S. D., Assadzada, S., Lemelin, D., Sokolovski, A., Bergeron, R., Haj-Dahmane, S., & Béïque, J.-C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522754113 · Cited by 90 · see citing works
Valentinova, K., Tchenio, A., Trusel, M., Clerke, J. A., Lalive, A. L., Tzanoulinou, S., Matera, A., Moutkine, I., Maroteaux, L., Paolicelli, R. C., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0421-4 · Cited by 93 · see citing works
Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation
Etiévant, A., Oosterhof, C., Bétry, C., Abrial, E., Novo-Perez, M., Rovera, R., Scarna, H., Devader, C., Mazella, J., Wegener, G., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.06.023 · Cited by 65 · see citing works
Two major network domains in the dorsal raphe nucleus
Commons, K. G. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23748 · Cited by 46 · see citing works
Fuxe, K., & Borroto-Escuela, D. O. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.1074175 · Cited by 43 · see citing works
Wei, H.-H., Yuan, X.-S., Chen, Z.-K., Chen, P.-P., Xiang, Z., Qu, W.-M., Li, R.-X., Zhou, G.-M., & Huang, Z.-L. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113784 · Cited by 29 · see citing works
Garcia, L. P., Witteveen, J. S., Middelman, A., van Hulten, J. A., Martens, G. J. M., Homberg, J. R., & Kolk, S. M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1105-x · Cited by 28 · see citing works
A subcortical switchboard for perseverative, exploratory and disengaged states
Ahmadlou, M., Shirazi, M. Y., Zhang, P., Rogers, I. L. M., Dziubek, J., Young, M., & Hofer, S. B. (2025) · Nature · doi:10.1038/s41586-025-08672-1 · Cited by 25 · see citing works
Ren, L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110910 · Cited by 23 · see citing works
Serotonergic reinforcement of a complete swallowing circuit
Schoofs, A., Miroschnikow, A., Schlegel, P., Zinke, I., Schneider-Mizell, C. M., Cardona, A., & Pankratz, M. J. (2023) · doi:10.1101/2023.05.26.542464 · Cited by 7 · see citing works
- Authors
- Pollak Dorocic, I., Fürth, D., Xuan, Y., Johansson, Y., Pozzi, L., Silberberg, G., Carlén, M., & Meletis, K.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Meletis, Konstantinos
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 83
- Issue
- 3
- Pages
- 663-678
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2010915373
- Cited by
- 451
- References
- 84
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 44 · 2023: 40 · 2022: 20 · 2021: 44 · 2020: 40 · 2019: 43 · 2018: 42 · 2017: 41 · 2016: 38 · 2015: 44 · 2014: 4
- FWCI
- 19.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stiftelsen för Strategisk Forskning
- Karolinska Institutet
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- serotonergic neurons, dorsal raphe nucleus, median raphe nucleus, serotonergic system, monosynaptic input, glutamatergic input, GABAergic input, prefrontal cortex, lateral habenula, striatal projection neurons, hypothalamus, basal ganglia, midbrain, hyperdirect pathway
- MeSH terms
- Animals, Brain Mapping, Nerve Tissue, Neural Pathways, Serotonin, Chromosome Pairing, Mice, Serotonergic Neurons, Dorsal Raphe Nucleus
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