Cited by 257Tryptophan and brain disordersAdipokines, Inflammation, and Metabolic DiseasesStress Responses and Cortisol

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Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity

Stuart, Michael J., Baune, Bernhard T.·2012·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2011.10.001

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Abstract

Unipolar depression and diabetes mellitus each account for a significant proportion of the global burden of disease. Epidemiological literature suggests a bi-directional relationship between these two common disorders, and evidence from the molecular sciences supports a role for inflammation in the pathogenesis and pathophysiology of each disorder individually. Recent advances in understanding the neurobiology of depression have implicated dysfunction of the hypothalamus-pituitary-adrenal axis, neurotrophins, and inflammatory mediators in the development of this disorder. Similarly, dysregulated facets of both the innate and adaptive immune system have been implicated in the onset of insulin resistance and type 2 diabetes. This review draws upon an emerging body of epidemiological and mechanistic evidence to support the hypothesis that shared inflammatory mechanisms may represent a key biological link in this co-morbidity. Given the shared mechanisms of this co-morbidity, these patients may be excellent candidates for novel immune targeted pharmacotherapy.

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Authors: Stuart, M. J., & Baune, B. T.
Affiliations: James Cook University (AU)
The University of Adelaide (AU)
Corresponding author: Baune, Bernhard T.
ORCID: Stuart, Michael J.
Baune, Bernhard T.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2012-01
Volume: 36
Issue: 1
Pages: 658-676
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2011.10.001
OpenAlex: W2067054442
Cited by: 257
References: 242
Citations by year: 2026: 10 · 2025: 17 · 2024: 11 · 2023: 12 · 2022: 13 · 2021: 18 · 2020: 18 · 2019: 19 · 2018: 23 · 2017: 14 · 2016: 23 · 2015: 26 · 2014: 22 · 2013: 21 · 2012: 7
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
ResearchOnline - JCU (James Cook University) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression, type 2 diabetes, inflammatory mechanisms, hypothalamic-pituitary-adrenal axis, neurotrophins, insulin resistance, bidirectional comorbidity
MeSH terms: Depression, Diabetes Mellitus, Type 2, Humans, Immune System, Inflammation, Comorbidity

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Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity

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