The DOI matches its Crossref record; 238 of the 242 references it cites were found in a registry or an index.
Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity
Abstract
Unipolar depression and diabetes mellitus each account for a significant proportion of the global burden of disease. Epidemiological literature suggests a bi-directional relationship between these two common disorders, and evidence from the molecular sciences supports a role for inflammation in the pathogenesis and pathophysiology of each disorder individually. Recent advances in understanding the neurobiology of depression have implicated dysfunction of the hypothalamus-pituitary-adrenal axis, neurotrophins, and inflammatory mediators in the development of this disorder. Similarly, dysregulated facets of both the innate and adaptive immune system have been implicated in the onset of insulin resistance and type 2 diabetes. This review draws upon an emerging body of epidemiological and mechanistic evidence to support the hypothesis that shared inflammatory mechanisms may represent a key biological link in this co-morbidity. Given the shared mechanisms of this co-morbidity, these patients may be excellent candidates for novel immune targeted pharmacotherapy.
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“Comorbid metabolic disturbances aggravate the burden of depressive illness, in part by sharing common risk factors and pathophysiological pathways, since impaired insulin signaling and insulin resistance have been documented to play an important role in the pathogenesis of MDD [109].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [109]
Citations
Cites
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01858.x · Cited by 6,597
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322
The Prevalence of Comorbid Depression in Adults With Diabetes
Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1069 · Cited by 3,926
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
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Burns, R. J., Ford, K. J., Forget, G. C., Fardfini, K., & Ward, R. (2025) · PLoS ONE · doi:10.1371/journal.pone.0321712 · Cited by 2
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Ryan, J. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.03.003 · Cited by 2
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Górska-Ciebiada, M., & Ciebiada, M. (2017) · Psychogeriatrics · doi:10.1111/psyg.12259 · Cited by 2
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Mind-Body Practices and the Neuro-psychology of Wellbeing
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Yusha’u, Y., Adam, U. M., Wahab, A. A., Saleh, M. I. A., & Ya’u, J. (2021) · Neuroscience Research Notes · doi:10.31117/neuroscirn.v4i3.75 · Cited by 2
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Muyisa, R. M., Wahangire, J. K., & Malu, C. K. (2025) · Diabetes Epidemiology and Management · doi:10.1016/j.deman.2025.100289 · Cited by 1
Le, Z., Lou, Y., & Zou, Y. (2025) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2025.112469 · Cited by 1
Wu, X., Wang, P., Lang, X., Guo, Q., Jiang, Y., Xu, J., Wang, Q., Kang, Y., Liu, F., Ding, H., et al. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07895-4 · Cited by 1
Yuan, Q., He, S., Elhassan, M. A. M., Yu, C., Lu, J., Fang, L., Zhu, X., Wu, Z., He, J., & Gu, W. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121830 · Cited by 1
Jellesma, F. C. (2013) · Cited by 1
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Oh, H. (2014) · University of Southern California Digital Library · doi:10.25549/usctheses-c3-460345 · Cited by 1
Hackett, R. A. (2016) · UCL Discovery (University College London) · Cited by 1
Namazi, N., Irandoost, P., Firouzjaei, A., Heshmati, J., Sadeghi, E., & Ayati, M. H. (2024) · Research Square · doi:10.21203/rs.3.rs-4367363/v1 · Cited by 1
Kulzer, B., Krichbaum, M., & Hermanns, N. (2014) · Der Diabetologe · doi:10.1007/s11428-014-1263-z
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Psychoneuroimmunological factors in type 1 diabetes: characteristics and consequences
Sinnamon, G. (2015) · ResearchOnline - JCU (James Cook University) · doi:10.25903/adz6-jf17
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Baune, B. T. (2015) · Springer eBooks · doi:10.1007/978-981-4560-53-5_39-1
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Diabetes and related psychological distress
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Wm, V.-R. (2019) · Springer eBooks · doi:10.1007/978-3-030-11815-0_62
López-Montoyo, A. (2020) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) · doi:10.6035/14109.2020.261277
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Baune, B. T. (2016) · Springer eBooks · doi:10.1007/978-981-287-206-7_39
Self-citation(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811351-6.00026-7
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Choe, C. (2022) · Research Publications (Maastricht University) · doi:10.26481/dis.20220906cc
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Chen, M., Xia, H., Yu, Y., Wang, Y., Chen, W., Lou, E., Tang, Z., Yang, L., Ge, S., Yang, B. K., et al. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70139
Abate, B. B., Dachew, B. A., Ayano, G., Betts, K. S., & Alati, R. (2025) · Annals of Epidemiology · doi:10.1016/j.annepidem.2025.10.002
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Butt, M. (2013) · Otago University Research Archive (University of Otago)
Beck’s cognitive theory and the role of schemata in depression
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Lačković, M., & Grujičić, S. Š. (2025) · Medicinski podmladak · doi:10.5937/mp76-49211
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Nguyen, T. B. N. (2019) · theses.fr (ABES) · doi:10.70675/32552994z8036z4d42z8666zb7c155b59fcf
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Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_22
Abbas, U., Laghari, R. N., Tanveer, M., Musawwir, U. A., Zafar, A. A., Khalid, M. U., Hadif, M., Baloch, I. A., Fatima, K., & Abid, F. (2026) · Discover Mental Health · doi:10.1007/s44192-026-00518-0
Li, H., Liu, X., Lei, C., Xiao, X., Hu, X., Chen, X., Zhong, D., Xue, P., Fan, J., Li, Y., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06152-9
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Wáng, Y., Wang, S., Zhao, S., Lei, Y., Fan, Y., Zheng, X., Yang, L., & Ma, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1891812
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Kikuchi, Y. (2016) · Institutional Repositories DataBase (IRDB) · doi:10.15017/1654721
Silva, R. R., da Costa, M. S., Almeida, L. A. L., Cruz, P. P., Silva, R. R., Alves, A. C., de Sousa, R. D., & Cassilhas, R. C. (2026) · Journal of Diabetes and Metabolic Disorders · doi:10.1007/s40200-026-02079-z
Wu, J., & Zhou, X. (2026) · Technology and Health Care · doi:10.1177/09287329261490665
Cruz-Trujillo, R., Tejas-Juárez, J. G., Espinosa‐Juárez, J. V., Pliego, R. G., & Briones-Aranda, A. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1017781
Metadata
- Authors
- Stuart, M. J., & Baune, B. T.
- Affiliations
- James Cook University (AU)
- The University of Adelaide (AU)
- Corresponding author
- Baune, Bernhard T.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 36
- Issue
- 1
- Pages
- 658-676
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2067054442
- Cited by
- 257
- References
- 242
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 11 · 2023: 12 · 2022: 13 · 2021: 18 · 2020: 18 · 2019: 19 · 2018: 23 · 2017: 14 · 2016: 23 · 2015: 26 · 2014: 22 · 2013: 21 · 2012: 7
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, type 2 diabetes, inflammatory mechanisms, hypothalamic-pituitary-adrenal axis, neurotrophins, insulin resistance, bidirectional comorbidity
- MeSH terms
- Depression, Diabetes Mellitus, Type 2, Humans, Immune System, Inflammation, Comorbidity
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