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Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study

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Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression

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Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity

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Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

McGillicuddy, F. C., Chiquoine, E. H., Hinkle, C. C., Kim, R. J., Shah, R. D., Roche, H. M., Smyth, E. M., & Reilly, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061655 · Cited by 258

Depressive symptoms and occurrence of type 2 diabetes among Japanese men.

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Symptoms of depression as a risk factor for incident diabetes: findings from the National Health and Nutrition Examination Epidemiologic Follow-up Study, 1971-1992

Carnethon, M. R. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg172 · Cited by 244

Depression and Increased Mortality in Diabetes: Unexpected Causes of Death

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A psychoneuroimmunological review on cytokines involved in antidepressant treatment response

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Depressive Symptoms and the Risk of Type 2 Diabetes

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Depressive Symptoms, Insulin Resistance, and Risk of Diabetes in Women at Midlife

Everson‐Rose, S. A., Meyer, P., Powell, L. H., Pandey, D. K., Torréns, J. I., Kravitz, H. M., Bromberger, J. T., & Matthews, K. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2856 · Cited by 237

The psychoneuroimmunology of depression

Leonard, B. E., & Myint, A.-M. (2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1011 · Cited by 236

Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia

Grippo, A. J., Francis, J., Beltz, T. G., Felder, R. B., & Johnson, A. K. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.02.011 · Cited by 233

Permeability of the blood–brain and blood–spinal cord barriers to interferons

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Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

Varma, V., Yao-Borengasser, A., Rasouli, N., Nolen, G. T., Phanavanh, B., Starks, T., Gurley, C., Simpson, P., McGehee, R. E., Kern, P. A., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90885.2008 · Cited by 229

Psychiatric morbidity in psoriasis: A review

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The Signal Transducer and Activator of Transcription 1α and Interferon Regulatory Factor 1 Are Not Essential for the Induction of Indoleamine 2,3-Dioxygenase by Lipopolysaccharide: Involvement of p38 Mitogen-Activated Protein Kinase and Nuclear Factor-κB Pathways, and Synergistic Effect of Several Proinflammatory Cytokines

Fujigaki, H., Saito, K., Fujigaki, S., Takemura, M., Sudo, K., Ishiguro, H., & Seishima, M. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj072 · Cited by 222

Psychological distress and risk of pre‐diabetes and Type 2 diabetes in a prospective study of Swedish middle‐aged men and women

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Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age

van den Biggelaar, A. H. J., Gussekloo, J., de Craen, A. J. M., Frölich, M., Stek, M. L., van der Mast, R. C., & Westendorp, R. G. J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.011 · Cited by 209

Inflammation and the Incidence of Type 2 Diabetes

Bertoni, A. G., Burke, G. L., Owusu, J. A., Carnethon, M. R., Vaidya, D. M., Barr, R. G., Jenny, N. S., Ouyang, P., & Rotter, J. I. (2010) · Diabetes Care · doi:10.2337/dc09-1679 · Cited by 207

A Prospective Study of Inflammatory Cytokines and Diabetes Mellitus in a Multiethnic Cohort of Postmenopausal Women

Liu, S. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.15.1676 · Cited by 198

Adipokines and Risk of Type 2 Diabetes in Older Men

Wannamethee, S. G., Lowe, G. D. O., Rumley, A., Cherry, L., Whincup, P. H., & Sattar, N. A. (2007) · Diabetes Care · doi:10.2337/dc06-2416 · Cited by 194

Treadmill exercise counteracts the suppressive effects of peripheral lipopolysaccharide on hippocampal neurogenesis and learning and memory

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Neurobehavioral deficits in db/db diabetic mice

Sharma, A. N., Elased, K. M., Garrett, T. L., & Lucot, J. B. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.07.002 · Cited by 182

Role of Tumor Necrosis Factor-α in Methamphetamine-Induced Drug Dependence and Neurotoxicity

Nakajima, A., Yamada, K., Nagai, T., Uchiyama, T., Miyamoto, Y., Mamiya, T., He, J., Nitta, A., Mizuno, M., Tran, M. H., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4847-03.2004 · Cited by 176

Insulin as an Anti-Inflammatory and Antiatherogenic Modulator

Dandona, P., Chaudhuri, A., Ghanim, H., & Mohanty, P. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.038 · Cited by 173

The effects of chronic glucocorticoid exposure on dendritic length, synapse numbers and glial volume in animal models: Implications for hippocampal volume reductions in depression

Tata, D. A., & Anderson, B. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.09.008 · Cited by 173

Sex Differences in the Prediction of Type 2 Diabetes by Inflammatory Markers

Thorand, B., Baumert, J., Kolb, H., Meisinger, C., Chambless, L. E., Köenig, W., & Herder, C. (2007) · Diabetes Care · doi:10.2337/dc06-1693 · Cited by 173

Depressive Symptoms and Risk of Type 2 Diabetes in Women

Arroyo, C., Hu, F. B., RYAN, L. M., Kawachi, I. I., Colditz, G. A., Speizer, F. E., & Manson, J. E. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.129 · Cited by 172

Longitudinal Association Between Depressive Symptoms and Incident Type 2 Diabetes Mellitus in Older Adults

Carnethon, M. R. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.8.802 · Cited by 167

Depression and Diabetes: Factors Associated With Major Depression at Five-Year Follow-Up

Katon, W. J., Russo, J. E., Lin, E. H. B., Heckbert, S. R., Ciechanowski, P. S., Ludman, E. J., & Korff, M. V. (2009) · Psychosomatics · doi:10.1016/s0033-3182(09)70858-8 · Cited by 167

Diabetes Mellitus, Glycemic Control, and Incident Depressive Symptoms Among 70- to 79-Year-Old Persons

Maraldi, C., Volpato, S., Penninx, B. W. J. H., Yaffe, K. S., Simonsick, E. M., Strotmeyer, E. S., Cesari, M., Kritchevsky, S. B., Perry, S., Ayonayon, H. N., et al. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.11.1137 · Cited by 164

The Association Between C-Reactive Protein Levels and Depression: Results from the Northern Finland 1966 Birth Cohort Study

Liukkonen, T., Silvennoinen-Kassinen, S., Jokelainen, J., Räsänen, P., Leinonen, M., Meyer-Rochow, V. B., & Timonen, M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.016 · Cited by 163

Dual effect of CD4 + CD25 + regulatory T cells in neurodegeneration: A dialogue with microglia

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Longitudinal effects of depression on glycemic control in veterans with Type 2 diabetes

Richardson, L. K., Egede, L. E., Mueller, M., Echols, C. L., & Gebregziabher, M. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2008.07.001 · Cited by 162

Prevalence and Correlates of Depression in Individuals With and Without Type 1 Diabetes

Gendelman, N., Snell‐Bergeon, J. K., McFann, K., Kinney, G. L., Wadwa, R. P., Bishop, F. K., Rewers, M., & Maahs, D. M. (2009) · Diabetes Care · doi:10.2337/dc08-1835 · Cited by 161

Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men

von Känel, R., Kudielka, B. M., Preckel, D., Hanebuth, D., & Fischer, J. E. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.03.013 · Cited by 158

Toll-like receptors regulate B cell cytokine production in patients with diabetes

Jagannathan, M., McDonnell, M., Liang, Y., Hasturk, H., Hetzel, J., Rubin, D., Kantarci, A., Van Dyke, T. E., Ganley-Leal, L. M., & Nikolajczyk, B. S. (2010) · Diabetologia · doi:10.1007/s00125-010-1730-z · Cited by 156

Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984–2002

Herder, C., Baumert, J., Thorand, B., Köenig, W., de Jager, W., Meisinger, C., Illig, T., Martin, S., & Kolb, H. (2006) · Diabetologia · doi:10.1007/s00125-006-0190-y · Cited by 153

Quinolinic acid induces oxidative stress in rat brain synaptosomes

Santamarı́a, A., Galván‐Arzate, S., Lisý, V., Ali, S. F., Duhart, H. M., Osorio‐Rico, L., Rı́os, C., & Sut'astný, F. (2001) · Neuroreport · doi:10.1097/00001756-200103260-00049 · Cited by 152

Interleukin‐1‐induced neurotoxicity is mediated by glia and requires caspase activation and free radical release

Thornton, P., Pinteaux, E., Gibson, R. M., Allan, S. M., & Rothwell, N. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03872.x · Cited by 152

Leisure time physical activity, risk of depressive symptoms, and inflammatory mediators: The English Longitudinal Study of Ageing

Hamer, M., Molloy, G. J., de Oliveira, C. M., & Demakakos, P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.02.004 · Cited by 151

Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood–brain barrier

Kitagami, T., Yamada, K., Miura, H., Hashimoto, R., Nabeshima, T., & Ohta, T. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02776-8 · Cited by 147

Progression of Plasminogen Activator Inhibitor-1 and Fibrinogen Levels in Relation to Incident Type 2 Diabetes

Festa, A., Williams, K., Tracy, R. P., Wagenknecht, L. E., & Haffner, S. M. (2006) · Circulation · doi:10.1161/circulationaha.106.616177 · Cited by 147

Interleukin-1 Receptor Antagonist and Incident Depressive Symptoms Over 6 Years in Older Persons: The InCHIANTI Study

Milaneschi, Y., Corsi, A. M., Penninx, B. W. J. H., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.011 · Cited by 147

Peptides crossing the blood–brain barrier: some unusual observations

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Circulating Levels of Resistin and Risk of Type 2 Diabetes in Men and Women: Results From Two Prospective Cohorts

Chen, B. H., Song, Y., Ding, E. L., Roberts, C. K., Manson, J. E., Rifai, N., Buring, J. E., Gaziano, J. M., & Liu, S. (2008) · Diabetes Care · doi:10.2337/dc08-1625 · Cited by 143

Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes

Shin, J. H., Shin, D. W., & Noh, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.008 · Cited by 140

Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes

Carstensen, M., Herder, C., Kivimäki, M., Jokela, M., Roden, M., Shipley, M. J., Witte, D. R., Brunner, E. J., & Tabák, A. G. (2010) · Diabetes · doi:10.2337/db09-1199 · Cited by 137

Biological significance of soluble IL‐2 receptor

Caruso, C., Candore, G., Cigna, D., Colucci, A. T., & Modica, M. A. (1993) · Mediators of Inflammation · doi:10.1155/s0962935193000018 · Cited by 130

Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

Schwartz, M., & Shechter, R. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.31 · Cited by 129

Reducing post-traumatic anxiety by immunization

Lewitus, G. M., Cohen, H., & Schwartz, M. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.05.002 · Cited by 123

Systemic Immune Mediators and Lifestyle Changes in the Prevention of Type 2 Diabetes

Herder, C., Peltonen, M., Köenig, W., Kräft, I., Müller-Scholze, S., Martin, S., Lakka, T. A., Ilanne‐Parikka, P., Eriksson, J. G., Hämäläinen, H., et al. (2006) · Diabetes · doi:10.2337/db05-1320 · Cited by 120

Adipokines and the blood-brain barrier

Pan, W., & Kastin, A. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.04.023 · Cited by 118

Regulatory T cells increased while IL-1β decreased during antidepressant therapy

Himmerich, H., Milenović, S., Fulda, S., Plümäkers, B., Sheldrick, A. J., Michel, T. M., Kircher, T., & Rink, L. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.03.005 · Cited by 116

The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity

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Association of Depression and Rheumatoid Arthritis

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Prevalent and incident depression in community-dwelling elderly persons with diabetes mellitus: results from the ZARADEMP project

ZARADEMP investigators, de Jonge, P., Delgado, J. F. R., Saz, P., Rojo-Marcos, G., & Lobo, A. (2006) · Diabetologia · doi:10.1007/s00125-006-0442-x · Cited by 113

Granulocyte-macrophage colony-stimulating factor crosses the blood-- brain and blood--spinal cord barriers

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Expression of Human Chemerin Induces Insulin Resistance in the Skeletal Muscle but Does Not Affect Weight, Lipid Levels, and Atherosclerosis in LDL Receptor Knockout Mice on High-Fat Diet

Becker, M., Rabe, K., Lebherz, C., Zugwurst, J., Göke, B., Parhofer, K. G., Lehrke, M., & Broedl, U. C. (2010) · Diabetes · doi:10.2337/db10-0362 · Cited by 108

Inflammatory Mediators of Hepatic Steatosis

Hijona, E., Hijona, L., Arenas, J. I., & Bujanda, L. (2010) · Mediators of Inflammation · doi:10.1155/2010/837419 · Cited by 105

Depressive Symptoms, Race, and Circulating C-Reactive Protein: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Deverts, D. J., Cohen, S., DiLillo, V. G., Lewis, C. E., Kiefe, C. I., Whooley, M. A., & Matthews, K. A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181ec4b98 · Cited by 104

A prospective study of Type 2 diabetes and depressive symptoms in the elderly: The Rancho Bernardo Study

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Glucocorticoid Receptor Polymorphisms in Major Depression

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Tryptophan Catabolism and T Cell Responses

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The Epidemiology of Low-Grade Chronic Systemic Inflammation and Type 2 Diabetes

Duncan, B. B., & Schmidt, M. I. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.7 · Cited by 98

The Association between Conventional Antidepressants and the Metabolic Syndrome

McIntyre, R. S., Park, K. Y., Law, C. W. Y., Sultan, F., Adams, A., Lourenço, M. T. C., Lo, A., Soczynska, J. K., Woldeyohannes, H. O., Alsuwaidan, M. T., et al. (2010) · CNS Drugs · doi:10.2165/11533280-000000000-00000 · Cited by 98

Endothelial Dysfunction and C-Reactive Protein Are Risk Factors for Diabetes in Essential Hypertension

Perticone, F., Maio, R., Sciacqua, A., Andreozzi, F., Iemma, G., Perticone, M., Zoccali, C., & Sesti, G. (2007) · Diabetes · doi:10.2337/db07-1189 · Cited by 95

Association of Systemic Concentrations of Macrophage Migration Inhibitory Factor With Impaired Glucose Tolerance and Type 2 Diabetes

Herder, C., Kolb, H., Köenig, W., Haastert, B., Müller-Scholze, S., Rathmann, W., Holle, R., Thorand, B., & Wichmann, H. ‐. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1474 · Cited by 95

Reduced Glucocorticoid Receptor α Expression in Mood Disorder Patients and First-Degree Relatives

Matsubara, T., Funato, H., Kobayashi, A., Nobumoto, M., & Watanabe, Y. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.026 · Cited by 94

Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case–Cohort Study, 1984–2002

Herder, C., Klopp, N., Baumert, J., Müller‐Nurasyid, M., Khuseyinova, N., Meisinger, C., Martin, S., Illig, T., Köenig, W., & Thorand, B. (2007) · Diabetologia · doi:10.1007/s00125-007-0800-3 · Cited by 93

What does tumour necrosis factor excess do to the immune system long term?

Clark, J., Vagenas, P., Panesar, M., & Cope, A. P. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.042523 · Cited by 93

The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort Study

Holt, R. I. G., Phillips, D. I. W., Jameson, K. A., Cooper, C. C., Dennison, E. M., Peveler, R., & The Hertfordshire Cohort Study Group (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02742.x · Cited by 92

Brain-specific endothelial induction of prostaglandin E2 synthesis enzymes and its temporal relation to fever

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β-cell apoptosis in type 2 diabetes: quantitative and functional consequences

Lupi, R., & Prato, S. D. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)73396-2 · Cited by 90

Vascular risk factors and incident late-life depression in a Korean population

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Type 2 diabetes does not increase risk of depression

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Determinants of the NF-κB response to acute psychosocial stress in humans

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Associations Between Depressive Symptoms and Inflammatory/Hemostatic Markers in Women During the Menopausal Transition

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Does Diabetes Double the Risk of Depression?

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Adipocytokines and Incident Diabetes Mellitus in Older Adults

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IL-1β-Mediated Innate Immunity Is Amplified in the db/db Mouse Model of Type 2 Diabetes

O’Connor, J. C., Satpathy, A., Hartman, M. E., Horvath, E. M., Kelley, K. W., Dantzer, R., Johnson, R. W., & Freund, G. G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4991 · Cited by 86

Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorder

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Brain volume abnormalities and neurocognitive deficits in diabetes mellitus: Points of pathophysiological commonality with mood disorders?

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In VitroHyperresponsiveness to Tumor Necrosis Factor-α Contributes to Adipokine Dysregulation in Omental Adipocytes of Obese Subjects

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Transforming Growth Factor-β1 and Incident Type 2 Diabetes

Herder, C., Zierer, A., Köenig, W., Roden, M., Meisinger, C., & Thorand, B. (2009) · Diabetes Care · doi:10.2337/dc09-0476 · Cited by 81

Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA)

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Proinflammatory cytokines inhibit human placental 11β-hydroxysteroid dehydrogenase type 2 activity through Ca 2+ and cAMP pathways

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IL-1 resets glucose homeostasis at central levels

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Activated astrocytes: a therapeutic target in Alzheimer’s disease?

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Elevated Macrophage Migration Inhibitory Factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol

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Is depression related to subsequent diabetes mellitus?

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Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats

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Association of IL-6, Hypothalamus-Pituitary-Adrenal Axis Function, and Depression in Patients With Cancer

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Circulating IL-18 and the risk of type 2 diabetes in women

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Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat

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p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms

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On the role of plasminogen activator inhibitor‐1 in adipose tissue development and insulin resistance in mice

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N‐methyl‐D‐aspartate autoreceptors respond to low and high agonist concentrations by facilitating, respectively, exocytosis and carrier‐mediated release of glutamate in rat hippocampus

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Mucosal Tolerance to E-Selectin Promotes the Survival of Newly Generated Neuroblasts via Regulatory T-Cell Induction after Stroke in Spontaneously Hypertensive Rats

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Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanisms

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Resource use among patients with diabetes, diabetic neuropathy, or diabetes with depression

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Hostility, anger, and depression predict increases in C3 over a 10-year period

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So depression is an inflammatory disease, but where does the inflammation come from?

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Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder

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Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

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Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

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Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

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