Cited by 347Pain Mechanisms and TreatmentsSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 231 of the 233 references it cites were found in a registry or an index.

Alcohol dependence as a chronic pain disorder

Open access

Egli, Mark, Koob, George F., Edwards, Scott·2012·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2012.07.010PMC PMC3612891

Open this paper in CoChat — free account

Abstract

Dysregulation of pain neurocircuitry and neurochemistry has been increasingly recognized as playing a critical role in a diverse spectrum of diseases including migraine, fibromyalgia, depression, and PTSD. Evidence presented here supports the hypothesis that alcohol dependence is among the pathologies arising from aberrant neurobiological substrates of pain. In this review, we explore the possible influence of alcohol analgesia and hyperalgesia in promoting alcohol misuse and dependence. We examine evidence that neuroanatomical sites involved in the negative emotional states of alcohol dependence also play an important role in pain transmission and may be functionally altered under chronic pain conditions. We also consider possible genetic links between pain transmission and alcohol dependence. We propose an allostatic load model in which episodes of alcohol intoxication and withdrawal, traumatic stressors, and injury are each capable of dysregulating an overlapping set of neural substrates to engender sensory and affective pain states that are integral to alcohol dependence and comorbid conditions such as anxiety, depression, and chronic pain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2012.07.010

Cites

231 of 231 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Self-citation
Prevalence and Co-occurrence of Substance Use Disorders and IndependentMood and Anxiety Disorders: Results From the National Epidemiologic Survey on Alcohol and RelatedConditions
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889
RELIEVING PAIN IN AMERICA: A BLUEPRINT FOR TRANSFORMING PREVENTION, CARE, EDUCATION, AND RESEARCH
Simon, L. S. (2012) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2012.678473 · Cited by 2,200
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Self-citation

Flagged first, then by citations

Show all 233 references

2 of the 233 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 346

Converging Effects of Chronic Pain and Binge Alcohol Consumption on Anterior Insular Cortex Neurons Projecting to the Dorsolateral Striatum in Male Mice
Yin, Y., Haggerty, D. L., Zhou, S., Atwood, B. K., & Sheets, P. L. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1287-23.2024 · Cited by 7
Readmission rates and causes in alcohol addiction patients within the first six months after discharge
Geniş, B., Çoşar, B., & Arıkan, Z. (2020) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.25077 · Cited by 7
Pain severity and anxiety sensitivity interact to predict drinking severity among hazardous drinking college students
Paulus, D. J., Rogers, A. H., Asmundson, G. J. G., & Zvolensky, M. J. (2020) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2020.1804921 · Cited by 7
Medication overuse headache and substance use disorder: A comparison based on basic research and neuroimaging
Li, C., Dai, W., Miao, S., Xie, W., & Yu, S. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1118929 · Cited by 7
Physical pain and impulsivity in alcohol-dependent patients
Jakubczyk, A., Brower, K. J., Kopera, M., Krasowska, A., Michalska, A., Łoczewska, A., Majewska, A., Ilgen, M. A., Fudalej, S., & Wojnar, M. (2016) · Addiction Research & Theory · doi:10.3109/16066359.2016.1164844 · Cited by 7
Alcohol and cannabis use for pain management: Translational findings of relative risks, benefits, and interactions
Lee, S., & Edwards, S. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114867 · Cited by 6
Self-citation
Alcohol use disorder-associated pain: clinical and preclinical evidence
Dong, Y., Buczynski, M. W., & Gregus, A. M. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.08.005 · Cited by 7
Physical Pain and History of Suicidal Behaviors in Alcohol-Dependent Patients Entering Treatment in Poland
Jakubczyk, A., Ashrafioun, L., Ilgen, M. A., Kopera, M., Klimkiewicz, A., Krasowska, A., Sołowiej, M., Brower, K. J., & Wojnar, M. (2016) · Substance Use & Misuse · doi:10.3109/10826084.2016.1168444 · Cited by 6
Repurposing Tigecycline for the Treatment of Alcohol Use Disorder
Oliveros, A., & Choi, D. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13312 · Cited by 6
Introduction to the special section on alcohol: Review of cognitive, emotional, and neural deficits and recovery with sustained abstinence and treatment.
Fama, R. (2019) · Neuropsychology · doi:10.1037/neu0000588 · Cited by 6
Beliefs About Perioperative Opioid and Alcohol Use among Elective Surgical Patients Who Report Unhealthy Drinking: A Qualitative Study
Fernandez, A. C., Lin, L. A., Bazzi, A. R., Boissoneault, J., Borsari, B. E., & Blow, F. C. (2021) · Pain Medicine · doi:10.1093/pm/pnab104 · Cited by 6
Pain Catastrophizing Is Associated With Increased Alcohol Cue-Elicited Neural Activity Among Individuals With Alcohol Use Disorder
Nieto, S. J., Grodin, E. N., Burnette, E. M., Cahill, C. M., & Ray, L. A. (2022) · Alcohol and Alcoholism · doi:10.1093/alcalc/agac029 · Cited by 6
Inflammatory pain affects alcohol intake in a dose-dependent manner in male rats in the intermittent access model
Campos‐Jurado, Y., & Morón, J. A. (2023) · PAIN Reports · doi:10.1097/pr9.0000000000001082 · Cited by 6
Increased Incidence of Depression and Chronic Pain in Traumatic Spinal Cord Injury Patients With Pre-Injury Alcohol Use Disorder: Longitudinal Analysis of Insurance Claim Database
Ugiliweneza, B., Wang, D., Rood, B. R., Boakye, M., Castillo, C., & Hetman, M. (2024) · Neurotrauma Reports · doi:10.1089/neur.2023.0096 · Cited by 6
Trauma-related guilt and pain among veterans with PTSD
Herbert, M. S., Malaktaris, A. L., Lyons, R. C., & Norman, S. B. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112820 · Cited by 6
Withdrawal interference scale: a novel measure of withdrawal-related life disruption in opioid use disorder and alcohol use disorder
Hall, O. T., Gunawan, T., Teater, J. E., Bryan, C. J., Gorka, S. M., & Ramchandani, V. A. (2024) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2024.2350057 · Cited by 5
Bidirectional Two-Sample Mendelian Randomization Analysis Reveals Causal Associations Between Modifiable Risk Factors and Fibromyalgia
Zu, W., Zhou, S., Du, T., Zhu, C., Nie, S., & Zhu, H. (2024) · Journal of Pain Research · doi:10.2147/jpr.s473101 · Cited by 5
Pain, Anxiety- and Depression-Like Behaviors in Alcohol-Preferring and -NonPreferring Rats
Ye, J.-H., Bian, E. J., Ye, J.-H., Li, J., Gajewski, M., Shiwalkar, N., Fan, Q., Mei, Q., Fu, R., Zuo, W., et al. (2020) · Neurology and Neurobiology · doi:10.31487/j.nnb.2020.02.05 · Cited by 4
Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to reduce pain among people with HIV with alcohol problems
Tsui, J. I., Rossi, S. L., Cheng, D. M., Bendiks, S., Vetrova, M., Blokhina, E. A., Winter, M. R., Gnatienko, N., Bačkonja, M., BRYANT, K. J., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0297948 · Cited by 5
Analgesic effect of oxytocin in alcohol-dependent male and female rats
Marendes, J., Muench, M. A., Young, C. L., Ghaly, A. A., & Tunstall, B. J. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.12.002 · Cited by 5
Sleep Health and Alcohol Use
Miller, M. B., Freeman, L. K., Curtis, A. F., Boissoneault, J., & McCrae, C. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816658-1.00027-2 · Cited by 5
Association between Spinal Cord Injury and Alcohol Dependence: A Population-Based Retrospective Cohort Study
Chuang, C., Chen, P., Bai, C., Wu, Y., Tsai, M., & Li, C.-Y. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12030473 · Cited by 5
Intersection of alcohol use, pain symptoms, and negative affect in total knee arthroplasty patients and people with HIV
Fitzpatrick‐Schmidt, T., Dasa, V., Leonardi, C., Ferguson, T. F., Welsh, D. A., Molina, P. E., Ronis, M. J. J., & Edwards, S. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105446 · Cited by 4
Self-citation
Alcohol use disorder is a chronic disease
Gilpin, N. W., & Molina, P. E. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70230 · Cited by 4
A role for circuitry of the cortical amygdala in excessive alcohol drinking, withdrawal, and alcohol use disorder
Xiao, T., Roland, A. V., Chen, Y., Guffey, S., Kash, T. L., & Kimbrough, A. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.02.008 · Cited by 3
A cohort of patients in New York State with an alcohol use disorder and subsequent treatment information – A merging of two administrative data sources
Lu, C., Jette, G., Falls, Z., Jacobs, D. M., Gibson, W., Bednarczyk, E. M., Kuo, T., Lape-Newman, B., Leonard, K. E., & Elkin, P. L. (2023) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2023.104443 · Cited by 4
Does treating pain with alcohol affect drinking reduction among women with HIV enrolled in a clinical trial of naltrexone?
Parisi, C. E., Gracy, H. R., Bush, N. J., Cook, R. L., Wang, Y., & Chichetto, N. E. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15165 · Cited by 4
Pain and Hazardous Alcohol Use in Veterans in Primary Care: The Role of Affective Pain Interference and Alcohol Pain-Coping Perceptions
Moskal, D., Loughran, T., Funderburk, J. S., Scharer, J. L., Buckheit, K. A., & Beehler, G. P. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.09.020 · Cited by 4
Fibromyalgia is associated with increased odds of prior pain-precipitated relapse among non-treatment-seeking individuals with opioid use disorder
Hall, O. T., Lagisetty, P., Rausch, J., Entrup, P., Deaner, M., Harte, S. E., Williams, D. A., Hassett, A. L., & Clauw, D. J. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2422050 · Cited by 4
Dose-dependent effects of alcohol consumption on pressure pain threshold
Boissoneault, J., Cushnie, A. K., Sinclair, M., Hebert, S., Schorn, R. E., Burt, J., & Dougherty, R. (2024) · Addictive Behaviors · doi:10.1016/j.addbeh.2024.108226 · Cited by 4
Genetic Association and Expression Analyses of the Phosphatidylinositol‐4‐Phosphate 5‐Kinase ( PIP 5K1C) Gene in Alcohol Use Disorder—Relevance for Pain Signaling and Alcohol Use
Lee, J. S., Sorcher, J. L., Rosen, A. D., Damadzic, R., Sun, H., Schwandt, M. L., Heilig, M. A., Kelly, J., Mauro, K. L., Luo, A. C., et al. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13751 · Cited by 4
The moderating role of fatigue sensitivity in the relation between depression and alcohol and opioid misuse among adults with chronic low back pain
Manning, K. F., Rogers, A. H., Garey, L., & Zvolensky, M. J. (2020) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2020.1818933 · Cited by 4
Determinants of long‐term opioid prescribing in an urban population: A cross‐sectional study
Naughton, M., Redmond, P., Durbaba, S., Ashworth, M. J., & Molokhia, M. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15231 · Cited by 4
Experiential Avoidance, Pain, and Suicide Risk in a National Sample of Gulf War Veterans
Grove, J. L., Young, J. R., Chen, Z., Blakey, S. M., Beckham, J. C., Calhoun, P. S., Dedert, E. A., Goldston, D. B., Pugh, M. J., & Kimbrel, N. A. (2022) · Archives of Suicide Research · doi:10.1080/13811118.2022.2160681 · Cited by 5
Neuroticism and Fibromyalgia Syndrome: A Systematic Review and Meta-analysis
Vesal, M., Asgari, K., Roohafza, H., & Adibi, P. (2023) · Middle East Journal of Rehabilitation and Health Studies · doi:10.5812/mejrh-139068 · Cited by 4
Mental nerve injury induces novelty seeking behaviour leading to increasing ethanol intake in Wistar rats
Pérez-Martínez, I. O., Acevedo-Roque, C. R., Montes-Ángeles, C. D., Martínez, M., & Miranda, F. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.01.004 · Cited by 4
Electroacupuncture Relieves Pain During Alcohol Withdrawal
Ye, J.-H., Zuo, W., Li, J., Fu, R., Eloy, J. D., & Bekker, A. (2020) · Medical Acupuncture · doi:10.1089/acu.2020.1478 · Cited by 4
Differences in the association between kappa opioid receptors and pain among Black and White adults with alcohol use disorders
de Laat, B., Nabulsi, N., Huang, Y. H., O’Malley, S. S., Morris, E. D., & Krishnan‐Sarin, S. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14879 · Cited by 4
Pleasure Gone Awry? A New Conceptualization of Chronic Pain and Addiction
Hardcastle, V. G. (2013) · Review of Philosophy and Psychology · doi:10.1007/s13164-013-0170-3 · Cited by 4
Mouse parasubthalamic Crh neurons drive alcohol drinking escalation and behavioral disinhibitionPreprint
Kreifeldt, M., Okhuarobo, A., Dunning, J. L., Lopez, C., Macedo, G. C., Sidhu, H., & Contet, C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.602357 · Cited by 4
Noninvasive Vagus Nerve Stimulation Reduces Withdrawal-Related Affective Distress and Improves Functional Outcomes in Alcohol Use Disorder: A Feasibility and Acceptability Pilot Study
Klaming, R., Harlé, K. M., Lerman, I. R., Norman, S. B., Strigo, I. A., Simmons, A. N., & Spadoni, A. D. (2025) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2025.08.413 · Cited by 3
Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain
Ma, Y., Zhang, X., Li, C., Liu, S., Xing, Y., & Tao, F. (2020) · Journal of Pain Research · doi:10.2147/jpr.s267778 · Cited by 3
The Role of Melanocortin Plasticity in Pain-Related Outcomes After Alcohol Exposure
Sharfman, N. M., & Gilpin, N. W. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.764720 · Cited by 4
Pain in alcohol use disorder: Evaluating effects of childhood trauma, perceived stress, and psychological comorbidity
Schwandt, M. L., Ramchandani, V. A., Upadhyay, J., Ramsden, C. E., Diazgranados, N., & Goldman, D. A. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.03.013 · Cited by 3
Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder
Radoman, M., McGowan, C. R., HEILNER, E. A., Lacadie, C., & Sinha, R. (2024) · Addiction Biology · doi:10.1111/adb.70010 · Cited by 3
Chronic intermittent ethanol produces nociception through endocannabinoid-independent mechanisms in mice
Miliano, C., Dong, Y., Proffit, M., Cabanas, N. C., Natividad, L. A., Buczynski, M. W., & Gregus, A. M. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110502 · Cited by 4
Polygenic risk for alcohol consumption and multisite chronic pain: Associations with ad lib drinking behavior.
White, K. M., Hess, J., Glatt, S. J., Maisto, S. A., Zvolensky, M. J., & Ditre, J. W. (2022) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000630 · Cited by 3
Surgical incision pain induced an increase in alcohol consumption in mice
Ghani, S., Alkhlaif, Y., Mann, J., Moncayo, L. V., Ulker, E., Caillaud, M., Barik, M., Ditre, J. W., Miles, M. F., & Damaj, M. I. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.03.005 · Cited by 4
Managing Pain in Patients With Comorbid Alcohol Use Disorder and Chronic Pain
Maleki, N., Thompson, B., Janiuk, K., Dhingra, L. K., & Chen, L. L. (2024) · Current Addiction Reports · doi:10.1007/s40429-024-00563-1 · Cited by 3
Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice
Nothem, M. A., Side, C. M., Tran, S. C., Brar, A., Buck, L. A., & Barker, J. M. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.09.003 · Cited by 3
What is addiction?
Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816863-9.00001-7 · Cited by 3
Self-citation
Neurobiological theories of addiction
Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816863-9.00003-0 · Cited by 3
Self-citation
Measuring Chronic Pain Intensity Among Veterans in a Residential Rehabilitation Treatment Program
Randleman, M. L., Douglas, M. E., DeLane, A. M., & Palmer, G. A. (2014) · Journal of Addictions Nursing · doi:10.1097/jan.0000000000000027 · Cited by 3
Withdrawal-associated injury site pain prevalence and correlates among opioid-using people who inject drugs in Vancouver, Canada
Rieb, L. M., DeBeck, K., Hayashi, K., Wood, E., Nosova, E., & Milloy, M. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108242 · Cited by 4
Chronic Pain Management in the Homeless Population
Pangarkar, S., & Chang, L. (2021) · Springer eBooks · doi:10.1007/978-3-030-70135-2_4 · Cited by 3
Association between risk propensity and substance use: A multilevel meta-analysis
Wang, C., Yeo, J. E., & Shou, Y. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112640 · Cited by 3
Recent Alcohol Use Influences Associations between Cortisol Levels and Negative Affect: The New Orleans Alcohol Use in HIV Study
Fitzpatrick‐Schmidt, T., Oral, E., Welsh, D. A., Molina, P. E., Ferguson, T. F., & Edwards, S. (2025) · AIDS and Behavior · doi:10.1007/s10461-025-04815-7 · Cited by 2
Self-citation
Expectancies for alcohol analgesia and drinking behavior among veterans with chronic pain: The moderating role of discrimination in medical settings
Carlin, V. E., White, K. M., Nam, J. K., Ripley, G. H., Deyo, A. G., LaRowe, L. R., & Ditre, J. W. (2025) · American Journal on Addictions · doi:10.1111/ajad.70067 · Cited by 2
Neurobiological convergence of pain and substance use disorders: A focus on opioidergic and mesolimbic circuitry
Arif, S., Madadi, S., & Haidary, M. (2025) · Addiction Neuroscience · doi:10.1016/j.addicn.2025.100220 · Cited by 2
The balance of pain treatment and pain facilitation by opioids: Relevance for opioid use disorder risk
Brouillette, A. E., & Edwards, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26504-4.00018-1 · Cited by 1
Self-citation
FAAH and MAGL inhibition: Evolving approaches to treating substance use disorders
Maddox, C., Lee, F. S., Rajadhyaksha, A. M., & Martínez-Rivera, A. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00814 · Cited by 3
Frameworks of Alcohol Addiction
Koob, G. F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00001-8 · Cited by 2
Self-citation
Volumetric brain correlates of approach-avoidance behavior and their relation to chronic back pain
Nees, F., Ruttorf, M., Fuchs, X., Rance, M., & Beyer, N. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00110-x · Cited by 2
The relationship between sociodemographic, behavioral, and clinical variables and pain in the Native Hawaiian and Pacific Islander population.
Bollinger, M., Hudson, T. J., Hu, B., Han, X., Long, C. R., & McElfish, P. A. (2020) · Asian American Journal of Psychology · doi:10.1037/aap0000173 · Cited by 2
Chondroitin sulfate role in the complex rehabilitation of elderly people with chronic pain syndrome
Shavlovskaya, O. A., Разумов, А. Н., Бокова, И. А., Shavlovskiy, N. I., & Yukhnovskaya, Y. D. (2021) · Problems of Balneology Physiotherapy and Exercise Therapy · doi:10.17116/kurort20219801171 · Cited by 2
Post-Combat-Injury Opioid Prescription and Alcohol Use Disorder in the Military
Alcover, K. C., Poltavskiy, E. A., Howard, J. T., Watrous, J. R., Janak, J. C., Walker, L. E., & Stewart, I. J. (2022) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2022.07.010 · Cited by 2
Temporal associations between use of psychoactive substances and somatic symptoms in the daily lives of people with fibromyalgia
Kuzu, D., Valentine, T. R., & Kratz, A. L. (2023) · Pain Medicine · doi:10.1093/pm/pnad069 · Cited by 2
Determinants of perceived pain relief from acute alcohol intake in a laboratory setting
Aghabeigi, S., Bush, N. J., & Boissoneault, J. (2024) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2024.100267 · Cited by 2
High-risk use of prescription opioids among patients treated for alcohol problems in New York State. A repeated cross-sectional study, 2005–2018
Kuo, T., Lu, C., Falls, Z., Jette, G., Gibson, W., Elkin, P. L., Leonard, K. E., Bednarczyk, E. M., & Jacobs, D. M. (2024) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2024.100278 · Cited by 2
Pain Severity and Experiences with Pain Management Predict Alcohol Use Among Men Who Have Sex with Men Living with HIV
Ferguson, E. G., Pantalone, D. W., Monti, P. M., Mayer, K. H., & Kahler, C. W. (2025) · AIDS and Behavior · doi:10.1007/s10461-025-04652-8 · Cited by 2
Pain in comorbid alcohol use disorder and HIV: A network meta-analysis study
Bishir, M., Azeeze, M. S. T. A., & Chang, S. L. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.05.003 · Cited by 2
Associations of physical pain, alcohol use, and related factors in the daily lives of patients with chronic low back pain
McNamara, I. A., Boissoneault, J., Ellingson, J. M., Sauer, J., & Carpenter, R. W. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.06.002 · Cited by 2
Persistent inflammation does not promote aversion-resistant binge-like alcohol drinking in rats
Cucinello‐Ragland, J. A., Campos‐Jurado, Y., Hershfelt, L., Pujol, M., Saad, Y. M., Zahoor, B., Neptune, A., & Morón, J. A. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.07.003 · Cited by 2
Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner
Quadir, S. G., Zaidi, S. D., Cone, M. G., & Patel, S. (2025) · Addiction Neuroscience · doi:10.1016/j.addicn.2025.100237 · Cited by 4
Chronic alcohol drinking delays recovery from capsaicin- and nerve injury-induced hypersensitivity in mice
Schorn, R. E., Riedl, M. S., Stone, L. S., Lee, A. M., & Vulchanova, L. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.10.001 · Cited by 2
Involvement of metabotropic glutamate receptor 5 in ethanol regulation of NMDA receptor activity in rat substantia gelatinosa neurons
Lai, C., Hsu, J.-W., Cheng, Y., & Lin, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116729 · Cited by 3
Risk of pain disorders in offspring of parents with substance use disorders
Li, D., Chen, M., Bai, Y., Tsai, S., Cheng, C., Su, T., Chen, T., Yeh, T., & Liang, C. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13357 · Cited by 2
Alcohol, Opioids, and Pain - From the Editors
Egli, M. (2021) · Alcohol research · doi:10.35946/arcr.v41.1.15 · Cited by 2
Self-citation
Analysis of Various Factors Associated With Opioid Dose Escalation in Patients With Cancer Pain
Sakamoto, R., & Koyama, A. (2022) · Cureus · doi:10.7759/cureus.25266 · Cited by 1
Ibudilast attenuates the association between pain intensity and heavy drinking in alcohol use disorder: A secondary analysis of a randomized clinical trial
Nieto, S. J., Grodin, E. N., & Ray, L. A. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.10.004 · Cited by 1
Mitochondrial dysfunction at the intersection of alcohol use disorder and chronic pain
Chapa‐Dubocq, X. R., & Edwards, S. (2026) · Function · doi:10.1152/function.091.2025 · Cited by 1
Self-citation
Chronic alcohol exposure parametric effects on anxiety- and pain-related behaviors in adult rats
Secci, M. E., Johnson, L., Lobell, T. D., Long, S., Shepherd, L., Gilpin, N. W., & Avegno, E. M. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.01.157 · Cited by 1
The analgesic effect of neuropeptide S (NPS) in alcohol-dependent male and female rats
Marendes, J., Young, C. L., & Tunstall, B. J. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.01.159 · Cited by 1
Addressing Chronic Pain Among Rural Residents Engaging in Hazardous Drinking: A Mobile Health Intervention Pilot Study
Murray, G. E., Bernier, L., Kratzer, M. P. L., & Palfai, T. P. (2026) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-026-10129-0 · Cited by 1
Multimodal profiling of gray matter differences in alcohol use disorder: An integrated SDM-PSI meta-analysis with neuroimaging fusion study
Long, S., Wang, J., Li, Y. X., Zhang, L., Cui, W., Zhang, Y., & Li, B. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113119 · Cited by 1
The Neurocircuitry of Attachment and Recovery in Alcoholics Anonymous
Fricchione, G. L. (2014) · Alcoholism Treatment Quarterly · doi:10.1080/07347324.2014.907019 · Cited by 1
Impact of Alcohol Use on Pain
Nicholas, C. R. N. (2019) · Springer eBooks · doi:10.1007/978-3-319-99124-5_251 · Cited by 1
Prevalence of Musculoskeletal Disorders Among Bank Employees of Maharashtra: A Case Study
Dhengre, N., Rajput, N. S., Katarne, R., & Kulshreshtha, S. (2021) · Lecture notes in mechanical engineering · doi:10.1007/978-981-16-0942-8_54 · Cited by 1
Alkoholkonsum und chronische Schmerzen - ein Update
Krämer, J., Koller, G., & Pogarell, O. M. (2023) · Schmerzmedizin · doi:10.1007/s00940-023-4296-9 · Cited by 1
Bridging Neuroscience and Clinical Assessment in a Patient with Alcohol Use Disorder, Anxiety, and Trauma
Gopaldas, M., Flook, E. A., & Blackford, J. U. (2024) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000763 · Cited by 1
Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le, T. M., Oba, T., Couch, L., McInerney, L., & Li, C. R. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03039-y · Cited by 2
Proteomic Analysis of Chronic Binge Alcohol-Induced Hippocampal and Anterior Cingulate Cortex Neuroadaptations in Simian Immunodeficiency Virus (SIV)-Infected Female Rhesus Macaques
Fitzpatrick‐Schmidt, T., Mansouri, A., Adamec, J., Klein, J., Coleman, L., Edwards, K. N., Simon, L., Molina, P. E., Salling, M. C., & Edwards, S. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10179-5 · Cited by 1
Self-citation
Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers
Le, T. M., Hughes, F. A., Oba, T., & Li, C. R. (2025) · Addiction Biology · doi:10.1111/adb.70020 · Cited by 1
Identification of ethanol analgesia quantitative trait loci and candidate genes in BXD recombinant inbred mouse lines
Rogers, W. D., Presley, A., Damaj, M. I., & Miles, M. F. (2025) · Addiction Biology · doi:10.1111/adb.70013 · Cited by 1
Examining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder
Radoman, M., HEILNER, E. A., McGowan, C. R., Neree-Thompson, B., Sakmar, E., & Sinha, R. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.01.095 · Cited by 1
Cannabinoids
Katz, P. S., Edwards, S., & Molina, P. E. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1071-7_23 · Cited by 1
Self-citation
2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in micePreprint
Morgan, A., Adank, D. N., Johnson, K., Blunt, E., & Patel, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.15.480609 · Cited by 1
Connecting Pain Intensity to Work Goal and Lifestyle Goal Progress:Examining Mediation and Moderation Using Multi-Level Modeling
Mun, C. J. (2014)
Corticotropin-Releasing Factor Signaling at the Intersection of Pain and Opioid Addiction
McGinn, M. A., & Edwards, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00083-3
Self-citation
Alcohol and Pain Interactions
Blanton, H. L., Bergeson, S. E., Morgan, D. J., & Guindon, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813125-1.00023-4

Authors: Egli, M., Koob, G. F., & Edwards, S.
Affiliations: National Institutes of Health (US)
Scripps Research Institute (US)
Corresponding author: Egli, Mark
ORCID: Egli, Mark
Koob, George F.
Edwards, Scott
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2012-11
Volume: 36
Issue: 10
Pages: 2179-2192
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2012.07.010
PMC: PMC3612891
OpenAlex: W1996880759
Cited by: 347
References: 233
Citations by year: 2026: 19 · 2025: 32 · 2024: 34 · 2023: 27 · 2022: 26 · 2021: 39 · 2020: 45 · 2019: 27 · 2018: 16 · 2017: 18 · 2016: 24 · 2015: 17 · 2014: 16 · 2013: 7
FWCI: 1.38
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (AA008459, AA012602, AA006420, AA007456, AA020608)
National Research Service Award (AA018250)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: alcoholism, chronic pain, hyperalgesia, neurochemistry, alcohol withdrawal, traumatic stress, anxiety comorbidity, comorbid depression, affective pain
MeSH terms: Alcoholism, Amygdala, Catechol O-Methyltransferase, Chronic Disease, Humans, Neural Pathways, Prefrontal Cortex, Receptors, Opioid, mu, Chronic Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alcohol dependence as a chronic pain disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks