Cited by 347Pain Mechanisms and TreatmentsSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 231 of the 233 references it cites were found in a registry or an index.

Alcohol dependence as a chronic pain disorder

Open access

Egli, Mark, Koob, George F., Edwards, Scott·2012·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2012.07.010PMC PMC3612891

Open this paper in CoChat — free account

Abstract

Dysregulation of pain neurocircuitry and neurochemistry has been increasingly recognized as playing a critical role in a diverse spectrum of diseases including migraine, fibromyalgia, depression, and PTSD. Evidence presented here supports the hypothesis that alcohol dependence is among the pathologies arising from aberrant neurobiological substrates of pain. In this review, we explore the possible influence of alcohol analgesia and hyperalgesia in promoting alcohol misuse and dependence. We examine evidence that neuroanatomical sites involved in the negative emotional states of alcohol dependence also play an important role in pain transmission and may be functionally altered under chronic pain conditions. We also consider possible genetic links between pain transmission and alcohol dependence. We propose an allostatic load model in which episodes of alcohol intoxication and withdrawal, traumatic stressors, and injury are each capable of dysregulating an overlapping set of neural substrates to engender sensory and affective pain states that are integral to alcohol dependence and comorbid conditions such as anxiety, depression, and chronic pain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2012.07.010

Cites

231 of 231 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Self-citation
Prevalence and Co-occurrence of Substance Use Disorders and IndependentMood and Anxiety Disorders: Results From the National Epidemiologic Survey on Alcohol and RelatedConditions
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889
RELIEVING PAIN IN AMERICA: A BLUEPRINT FOR TRANSFORMING PREVENTION, CARE, EDUCATION, AND RESEARCH
Simon, L. S. (2012) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2012.678473 · Cited by 2,200
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Self-citation

Flagged first, then by citations

Show all 233 references

2 of the 233 references couldn’t be matched to a known paper.

Sorted by citations

Items 301–346 of 346

Effect Of Inflammatory Pain On Alcohol-Induced Dopamine Release In The Nucleus Accumbens: Behavioural Implications In Rat ModelsPreprint
Campos‐Jurado, Y., Lorente, J. D., González-Romero, J. L., Granero, L. M., Polache, A., & Hipólito, L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/862318
The strategy of coping with stress and selected health-related behavioural patterns of demobilized battle participants
Wąsik, J., Ortenburger, D. E., & Andriychuk, O. (2020) · Medical Studies · doi:10.5114/ms.2020.96791
Adenosine modulates extracellular glutamate levels via adenosine A2A receptors in the delayed-ethanol induced headachePreprint
Fried, N. T., Maxwell, C. R., Hoek, J. B., Elliott, M. B., & Oshinsky, M. L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.02.324517
Mast Cell-Specific Receptor/Corticotropin-Releasing Factor Axis Regulates Alcohol Withdrawal-Associated HeadachePreprint
Son, H., Zhang, Y., Shannonhouse, J. L., Ishida, H., Gómez, R. S., Akopian, A. N., & Kim, Y. S. (2021) · SSRN Electronic Journal · doi:10.1101/2021.05.21.445199
A VIVÊNCIA DA SEXUALIDADE NOS IDOSOS: UMA LEITURA HOLÍSTICA ATRAVÉS DA ENFERMAGEM
Júnior, R. D. M. F., Brandão, T. P., & dos Santos, A. J. (2021) · Editora Omnis Scietia eBooks · doi:10.47094/978-65-88958-33-9/216-226
Fatale Menage à trois: Schmerz, Depression und Sucht
Bär, K. (2021) · Der Schmerzpatient · doi:10.1055/a-1551-6754
Parent substance use and child and adolescent health outcomes
Chassin, L., Blake, A. J., Sternberg, A., Bui, L., Ruof, A. K., Waddell, J. T., Elam, K. K., & Paxton, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818872-9.00064-9 · Cited by 1
CAPACITAÇÕES DOS PROFISSIONAIS DE SAÚDE SOBRE NOTIFICAÇÃO DAS ARBOVIROSES NA PANDEMIA POR COVID-19 EM RECIFE
Santiago, A. C. D. S., da Silva, M. L. F. I., Magalhães, L. M. V., Júnior, J. A. D. A., & Pereira, M. C. (2021) · Editora Omnis Scietia eBooks · doi:10.47094/978-65-88958-71-1/39-48
ORGANIZAÇÃO DOS SISTEMAS E SERVIÇOS DE SAÚDE DO SUDOESTE BAIANO: UM OLHAR SOBRE GESTÃO EM SAÚDE NO CONTEXTO DA PANDEMIA COVID-19
Brito, A. C. C. C., Muniz, L. S., Moreira, R. D. S., Costa, N. S. P., Santana, N., & de Barros, R. D. (2021) · Editora Omnis Scietia eBooks · doi:10.47094/978-65-88958-71-1/15-32
DORES CRÔNICAS E USO DE ÁLCOOL, CANNABIS, ALUCINÓGENOS E OPIOIDES: PERSPECTIVAS NEUROBIOLÓGICAS E PSICOSSOCIAIS
Reichert, R. A., Sales, D. A., Wisnieski, S. K. D. R., Frizzo, R. D. S., Stump, T. H., de MICHELI, D., de Oliveira, W. A., Pereira, F. A., Ramos, R. F. S., Preuhs, S. A., et al. (2021) · Editora Omnis Scietia eBooks · doi:10.47094/978-65-88958-71-1/177-198
Alcohol
(2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816793-9.00001-3
The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders
Shor, C., Zuo, W., Eloy, J. D., & Ye, J.-H. (2021) · Vide Leaf, Hyderabad eBooks · doi:10.37247/pamol2ed.2.2021.1
The strategy of coping with stress and selected health related behavioural patterns of demobilized battle participantsPreprint
Ortenburger, D. E., Wąsik, J., & Andriejczuk, O. (2019) · Research Square · doi:10.21203/rs.2.12944/v1
Chronic Pain: Third Wave Case Conceptualizations
Vowles, K. E. (2022) · Springer eBooks · doi:10.1007/978-3-031-11677-3_30
ESTILO DE VIDA E QUALIDADE DE VIDA DE PACIENTES COM DOR CRONICA NEUROPATICA
Barbosa, W. A. D. S., Magro, R. R., & Martins, M. R. I. (2023) · Revista Foco · doi:10.54751/revistafoco.v16n6-106
Pain, Addiction, and Suicidality Among Veterans
Banou, E., Angeli, N., Sandusky, S., & Miller, S. N. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780197646588.003.0013
Symptoms of Posttraumatic Stress Disorder in Middle School Students After the Covid-19 Outbreak
Rusmana, N., Hafina, A., Ruyadi, Y., Nur, L., & Riduwan, M. (2023) · Jurnal Kajian Bimbingan dan Konseling · doi:10.17977/um001v8i22023p137-146
Development of a Personalized Feedback Intervention Targeting Pain-Related Anxiety for Adults Reporting Hazardous Drinking and Chronic Pain: A Randomized Controlled Trial
Rogers, A. H., Neighbors, C., Derrick, J. L., & Zvolensky, M. J. (2024) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.23-00359
Imagery, self-efficacy and chronic pain
Ross-Stewart, L., & Miles, L. (2024) · Journal of Imagery Research in Sport and Physical Activity · doi:10.1515/jirspa-2024-0014 · Cited by 1
Sensitivity, specificity, and discordance with self-report of nail sample testing for alcohol and cannabis
Morie, K. P., Gilstad‐Hayden, K., Martino, S., Lazar, C. M., & Rosen, M. I. (2024) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2024.111358
Awareness of the potential consequences of alcohol consumption in the context of chronic pain and prescription opioid use
Lape, E. C., Paladino, M. B., Powers, J. M., LaRowe, L. R., & Ditre, J. W. (2024) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2024.2375515
Evaluating a 30-day alcohol abstinence challenge in heavy-drinking individuals with and without chronic pain: Feasibility, safety, and perceived benefits
You, D. S., Ziadni, M. S., Vest, N. A., Megerdichian, N., Maronesy, T., Castro, R. J., Darnall, B. D., Mackey, S., & Humphreys, K. N. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.10.046
Alcohol Consumption Modulates the Development of Chronic Pain in COVID-19 Patients: A Network Meta-Analysis
Bishir, M., Vigorito, M., Chan, M.-H., Khan, M. R., & Chang, S. L. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00479
Substance use disorders in outpatients with bipolar disorder and pain complaints
Chabert, J., Icick, R., Cabé, J., Moisset, X., Godin, O., Gard, S., Aouizerate, B., Loftus, J., Aubin, V., Antoine Lefrere, A., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119693
Proteomic analysis of central amygdala systems regulated by mifepristone in the context of alcohol dependence
Lee, S., Romero, L. M., Lammons, J. W., Klein, J. M., Edwards, K. N., Guidry, J. J., & Edwards, S. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110728
Self-citation
Chronic Pain and Posttraumatic Stress Among Patients in Substance Use Treatment: Protocol for NOR-APT, a Longitudinal Cohort Study
Skjærvø, I., Marciuch, A., Digranes, L. C. W., Follerås, L. M. G., Mordal, J., Solli, K. K., Abel, E. K. F., Amundsen, K., Egeland, K. M., Haugen, B. K., et al. (2025) · JMIR Research Protocols · doi:10.2196/67663
Integration of pathophysiological effects of alcohol: A convergence factor for comorbid conditions
Molina, P. E., Edwards, S., & Simon, L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-34258-5.00003-7
Self-citation
Alcohol and neurophysiology
Lee, S., Fitzpatrick‐Schmidt, T., Bookman, D., & Edwards, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-34258-5.00008-6
Self-citation
Alcohol use and pain: Novel insights and emerging questions
Boissoneault, J. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.12.001
The Relationship Between Alcohol Consumption and Persistent Posttraumatic Headache After Mild Traumatic Brain Injury: A Single‐Center Study
Zhu, Y., Chen, G., Huang, J., He, P., Wu, Z., & Jiang, C. (2025) · Acta Neurologica Scandinavica · doi:10.1155/ane/8359474
Association between quality of life before an acute pain event and the development of chronic pain-related disability
Beaudin, A., Daoust, R., Paquet, J., Yan, J. W., Williamson, D. R., Perry, J. J., Huard, V., Lang, E., Bossard, C., Cournoyer, A., et al. (2025) · Quality of Life Research · doi:10.1007/s11136-025-04143-2
Discrimination, depressive symptoms, and prescription opioid misuse among adults with chronic pain who engage in hazardous drinking
Carlin, V. E., Lape, E. C., Deyo, A. G., Ripley, G. H., Polhill, S. E., Zale, E. L., Nam, J. K., Zvolensky, M. J., Maisto, S. A., & Ditre, J. W. (2026) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2025.2576709
Glucocorticoid receptor blockade reverses heroin and alcohol withdrawal-induced hyperalgesia in rats
Skandan, N., Acosta, V., Vendruscolo, J. C. M., McGinn, M. A., & Vendruscolo, L. F. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110896
Sex and pain modality differentially modulate alcohol consumption in mice
Hunt, J., Rakholia, Y., Alshammari, T., & Damaj, M. I. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178778
Évaluation pharmacoépidémiologique des Troubles de l’usage du sulfate de morphine
Bertin, C. (2020) · theses.fr (ABES) · doi:10.70675/4ab18eaczeaefz4417z9d4ez78aac5847854
Behavioral and molecular adaptations following sucrose bingeing : insight into neuroinflammatory markers
Awad, G. (2022) · theses.fr (ABES) · doi:10.70675/9224805cz0c14z4606za1aczb2b4e532135b
Associations between daily pain severity and concurrent alcohol craving among women in early recovery following alcohol treatment
Ferguson, E. G., Min, J., Battle, C. L., Stein, M. D., & Abrantes, A. M. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113191
Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependencePreprint
Dunning, J. L., Kreifeldt, M., Okhuarobo, A., Lopez, C., Varodayan, F. P., Bajo, M., SMITH, R. M., Moreau, C., Krull, C., Shu, L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.722112
Effects of acute alcohol on pain-related activity of the anterior and posterior insular cortices
Cushnie, A. K., Sevel, L. S., Bush, N. J., Nixon, S. J., Robinson, M. E., & Boissoneault, J. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.05.003
Chronic Pain Acceptance Moderates the Association Between Pain Intensity and Alcohol Use Severity Among Veterans With Chronic Musculoskeletal Pain
White, K. M., Carlin, V. E., Nam, J. K., & Ditre, J. W. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70305
Peri-adolescent ethanol exposure differentially affects mechanical and thermal sensitivity in rats
Heitkamp, M. C., Marsland, P., Katz, H. S., Zhuo, A., Terrence Deak, B., & Karkhanis, A. N. (2026) · Journal of Pain · doi:10.1016/j.jpain.2026.106391
Chronic pain and hazardous drinking among black adults through a minority stress lens: The role of daily microaggressions
Smit, T., Rogers, A. H., Derrick, J. L., Businelle, M. S., Viana, A. G., Obasi, E. M., & Zvolensky, M. J. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113312
Pain profiles in pancreatic cancer and chronic pancreatitis: a multicenter cross-sectional analysis
Kassik, M.-T., Faghih, M., Bandhauer, C., Jäger, J., Rauschenberg, S., Olesen, S. S., Laheru, D. A., Zheng, L., Phillips, A. E., Yadav, D., et al. (2026) · Frontiers in Pain Research · doi:10.3389/fpain.2026.1903789
Alcohol-Derived Changes in Pain-Related Pathways in Crohn’s Disease
Amodeo, G., Franchi, S., Galimberti, G., Riboldi, B., Braganti, C., Ceruti, S., & Sacerdote, P. (2026) · Springer eBooks · doi:10.1007/978-3-031-35658-2_34-1
Adolescent alcohol exposure leads to persistent mechanical allodynia and enhanced inflammatory pain responses in adult female rats
Kyllo, T. R., Wills, T. A., & Gilpin, N. W. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.107465
Chronic intermittent voluntary alcohol drinking induces hyperalgesia in Sprague-Dawley rats.
(2015) · PubMed Central · Cited by 57

Authors: Egli, M., Koob, G. F., & Edwards, S.
Affiliations: National Institutes of Health (US)
Scripps Research Institute (US)
Corresponding author: Egli, Mark
ORCID: Egli, Mark
Koob, George F.
Edwards, Scott
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2012-11
Volume: 36
Issue: 10
Pages: 2179-2192
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2012.07.010
PMC: PMC3612891
OpenAlex: W1996880759
Cited by: 347
References: 233
Citations by year: 2026: 19 · 2025: 32 · 2024: 34 · 2023: 27 · 2022: 26 · 2021: 39 · 2020: 45 · 2019: 27 · 2018: 16 · 2017: 18 · 2016: 24 · 2015: 17 · 2014: 16 · 2013: 7
FWCI: 1.38
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (AA008459, AA012602, AA006420, AA007456, AA020608)
National Research Service Award (AA018250)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: alcoholism, chronic pain, hyperalgesia, neurochemistry, alcohol withdrawal, traumatic stress, anxiety comorbidity, comorbid depression, affective pain
MeSH terms: Alcoholism, Amygdala, Catechol O-Methyltransferase, Chronic Disease, Humans, Neural Pathways, Prefrontal Cortex, Receptors, Opioid, mu, Chronic Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alcohol dependence as a chronic pain disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks