The DOI matches its Crossref record; 180 of the 182 references it cites were found in a registry or an index.
The basolateral amygdala in reward learning and addiction
Open accessAbstract
Sophisticated behavioral paradigms partnered with the emergence of increasingly selective techniques to target the basolateral amygdala (BLA) have resulted in an enhanced understanding of the role of this nucleus in learning and using reward information. Due to the wide variety of behavioral approaches many questions remain on the circumscribed role of BLA in appetitive behavior. In this review, we integrate conclusions of BLA function in reward-related behavior using traditional interference techniques (lesion, pharmacological inactivation) with those using newer methodological approaches in experimental animals that allow in vivo manipulation of cell type-specific populations and neural recordings. Secondly, from a review of appetitive behavioral tasks in rodents and monkeys and recent computational models of reward procurement, we derive evidence for BLA as a neural integrator of reward value, history, and cost parameters. Taken together, BLA codes specific and temporally dynamic outcome representations in a distributed network to orchestrate adaptive responses. We provide evidence that experiences with opiates and psychostimulants alter these outcome representations in BLA, resulting in long-term modified action.
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“Recent evidence points to the amygdala as playing a crucial role in effort-based decision making in rodents, with neurophysiological data showing that the amygdala plays an important role in valuing effort [40, 41].”
From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [41]
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“Recent evidence points to the amygdala as playing a crucial role in effort-based decision making in rodents, with neurophysiological data showing that the amygdala plays an important role in valuing effort [40, 41].”
From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [41]
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Cites
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
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Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
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Integrative activity of the brain
Konorski, J. (1967) · University of Chicago Press eBooks · Cited by 2,043
From circuits to behaviour in the amygdala
Janak, P. H., & Tye, K. M. (2015) · Nature · doi:10.1038/nature14188 · Cited by 2,011 · cited 3×
“BLA microcircuitry The circuitry of the amygdala has been extensively reviewed elsewhere (see Duvarci and Pare, 2014; Ehrlich et al., 2009; Janak and Tye, 2015).”
BackgroundMethodNeural systems responding to degrees of uncertainty in human decision-making
Hsu, M., Bhatt, M., Adolphs, R., Tranel, D., & Camerer, C. F. (2005) · Science · doi:10.1126/science.1115327 · Cited by 1,411
Cortical pathways to the mammalian amygdala
McDonald, A. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00003-3 · Cited by 1,303
The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction
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A triple dissociation of memory systems: Hippocampus, amygdala, and dorsal striatum.
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Neurocomputational mechanisms underlying subjective valuation of effort costs
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Metadata
- Authors
- Wassum, K. M., & Izquierdo, A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Izquierdo, Alicia
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 57
- Pages
- 271-283
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC4681295
- OpenAlex
- W1489713305
- Cited by
- 306
- References
- 182
- Citations by year
- 2026: 31 · 2025: 24 · 2024: 26 · 2023: 28 · 2022: 36 · 2021: 44 · 2020: 22 · 2019: 25 · 2018: 17 · 2017: 35 · 2016: 15 · 2015: 3
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (DA035443)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- basolateral amygdala, reward learning, addiction, appetitive behavior, opioid use disorder, stimulant use disorder
- MeSH terms
- Animals, Appetitive Behavior, Humans, Learning, Reward, Behavior, Addictive, Basolateral Nuclear Complex
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