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The basolateral amygdala in reward learning and addiction

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Wassum, Kate M., Izquierdo, Alicia·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2015.08.017PMC PMC4681295

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Abstract

Sophisticated behavioral paradigms partnered with the emergence of increasingly selective techniques to target the basolateral amygdala (BLA) have resulted in an enhanced understanding of the role of this nucleus in learning and using reward information. Due to the wide variety of behavioral approaches many questions remain on the circumscribed role of BLA in appetitive behavior. In this review, we integrate conclusions of BLA function in reward-related behavior using traditional interference techniques (lesion, pharmacological inactivation) with those using newer methodological approaches in experimental animals that allow in vivo manipulation of cell type-specific populations and neural recordings. Secondly, from a review of appetitive behavioral tasks in rodents and monkeys and recent computational models of reward procurement, we derive evidence for BLA as a neural integrator of reward value, history, and cost parameters. Taken together, BLA codes specific and temporally dynamic outcome representations in a distributed network to orchestrate adaptive responses. We provide evidence that experiences with opiates and psychostimulants alter these outcome representations in BLA, resulting in long-term modified action.

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Authors: Wassum, K. M., & Izquierdo, A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Izquierdo, Alicia
ORCID: Wassum, Kate M.
Izquierdo, Alicia
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-10
Volume: 57
Pages: 271-283
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2015.08.017
PMC: PMC4681295
OpenAlex: W1489713305
Cited by: 306
References: 182
Citations by year: 2026: 31 · 2025: 24 · 2024: 26 · 2023: 28 · 2022: 36 · 2021: 44 · 2020: 22 · 2019: 25 · 2018: 17 · 2017: 35 · 2016: 15 · 2015: 3
FWCI: 2.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
eScholarship (California Digital Library) (submittedVersion)
Funders: NIH (DA035443)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: basolateral amygdala, reward learning, addiction, appetitive behavior, opioid use disorder, stimulant use disorder
MeSH terms: Animals, Appetitive Behavior, Humans, Learning, Reward, Behavior, Addictive, Basolateral Nuclear Complex

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The basolateral amygdala in reward learning and addiction

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