The DOI matches its Crossref record; 202 of the 208 references it cites were found in a registry or an index, and 6 are not checked yet.
Can we ‘seize’ the gut microbiota to treat epilepsy?
Open accessAbstract
The gut-microbiota, the complex intestinal microbial ecosystem essential to health, is an emerging concept in medicine. Several studies demonstrate a microbiota-gut-brain bidirectional connection via neural, endocrine, metabolic and immune pathways. Accordingly, the gut microbiota has a crucial role in modulating intestinal permeability, to alter local/peripheral immune responses and in production of essential metabolites and neurotransmitters. Its alterations may consequently influence all these pathways that contribute to neuronal hyper-excitability and mirrored neuroinflammation in epilepsy and similarly other neurological conditions. Indeed, pre- and clinical studies support the role of the microbiome in pathogenesis, seizure modulation and responses to treatment in epilepsy. Up to now, researchers have focussed attention above all on the brain to develop antiepileptic treatments, but considering the microbiome, could extend our possibilities for developing novel therapies in the future. We provide here a comprehensive overview of the available data on the potential role of gut microbiota in the physiopathology and therapy of epilepsy and the supposed underlying mechanisms.
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“However, neurotransmitters produced in the gut may influence the brain indirectly, by acting on the ENS [30,31].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [30]
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Cited by
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The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
Mitrea, L., Nemeș, S. A., Szabo, K., Teleky, B., & Vodnar, D. C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.813204 · Cited by 251
Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics
Ding, M., Lang, Y., Shu, H., Shao, J., & Cui, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742449 · Cited by 176
Raimondi, I., Izzo, L., Tunesi, M., Comar, M., Albani, D., & Giordano, C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00435 · Cited by 149
The gut microbiome in epilepsy
Şafak, B., Altunan, B., Topçu, B., & Topkaya, A. E. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.103853 · Cited by 110
Metadata
- Authors
- De Caro, C., Iannone, L. F., Citraro, R., Striano, P., De Sarro, G., Constanti, A., Cryan, J. F., & Russo, E.
- Affiliations
- Magna Graecia University (IT)
- Istituto Giannina Gaslini (IT)
- UCL School of Pharmacy (GB)
- University College Cork (IE)
- Corresponding author
- Russo, Emilio
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 107
- Pages
- 750-764
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2981158203
- Semantic Scholar
- 7a62794dd18c936586c183f6a8b8fdb79ffab79d
- Cited by
- 110
- References
- 203
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 16 · 2023: 16 · 2022: 21 · 2021: 14 · 2020: 9 · 2019: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Funders
- Dupont, Nutrition, Cremo SA, Alkermes Inc.
- 4D Pharma PLC
- Mead Johnson Nutrition
- Nutricia Danone
- GW Pharmaceuticals
- Pfizer
- Italian Ministry of Health
- Italian Medicine Agency
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, epilepsy, microbiome, gut-brain axis, intestinal permeability, neuroinflammation, neuronal hyperexcitability, anticonvulsant therapy, microbial metabolites, neurotransmitters, immune response
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Epilepsy, Humans, Mice, Diet, Ketogenic
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