Can we ‘seize’ the gut microbiota to treat epilepsy?

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638

ILAE official report: a practical clinical definition of epilepsy

Fisher, R. S., Acevedo, C., Arzimanoglou, A., Bogacz, A., Cross, J. H., Elger, C. E., Engel, J., Forsgren, L., French, J. A., Glynn, M., et al. (2014) · Epilepsia · doi:10.1111/epi.12550 · Cited by 6,108

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413

Role of the microbiota in immunity and inflammation.

Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888

Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)

Fisher, R. S., Boas, W. V. E., Blume, W. T., Elger, C. E., Genton, P., Lee, P., & Engel, J. (2005) · Epilepsia · doi:10.1111/j.0013-9580.2005.66104.x · Cited by 3,678

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622

Introduction to the human gut microbiota

Thursby, E., & Juge, N. (2017) · Biochemical Journal · doi:10.1042/bcj20160510 · Cited by 3,600

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

Gut microbiota, metabolites and host immunity

Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283

Normal gut microbiota modulates brain development and behavior

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228

Role of the normal gut microbiota

Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735

Influence of diet on the gut microbiome and implications for human health

Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530

Gut–brain axis: How the microbiome influences anxiety and depression

Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460

Neocortical excitation/inhibition balance in information processing and social dysfunction

Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454

Development, maintenance and disruption of the blood-brain barrier

Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452

Comment on Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)

Beghi, E., Berg, A. T., Carpio, A., Forsgren, L., Hesdorffer, D. C., Hauser, W. A., Malmgren, K., Shinnar, S., Temkin, N. R., Thurman, D. J., et al. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00273_1.x · Cited by 2,301

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell · doi:10.1016/j.cell.2013.12.016 · Cited by 2,200

The neuroactive potential of the human gut microbiota in quality of life and depression

Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963

Extensive impact of non-antibiotic drugs on human gut bacteria

Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., et al. (2018) · Nature · doi:10.1038/nature25979 · Cited by 1,905

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893

Regional specialization within the intestinal immune system

Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,882

You are what you eat: Diet, health and the gut microbiota

Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792

Gut feelings: the emerging biology of gut-brain communication

Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota

Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs

Chen, Z. Z., Brodie, M. J., Liew, D., & Kwan, P. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.3949 · Cited by 1,522

The central nervous system and the gut microbiome

Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513

Gut/brain axis and the microbiota

Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503

The role of gut microbiota in immune homeostasis and autoimmunity

Wu, H.-J., & Wu, E. (2012) · Gut Microbes · doi:10.4161/gmic.19320 · Cited by 1,426

The composition of the gut microbiota throughout life, with an emphasis on early life

Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,411

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity

Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323

Diet, gut microbiota and immune responses

Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6668 · Cited by 1,246

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

Unger, M. M., Spiegel, J., Dillmann, K.-U., Grundmann, D., Philippeit, H., Bürmann, J., Faßbender, K., Schwiertz, A., & Schäfer, K.-H. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.08.019 · Cited by 1,159

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

Benakis, C., Brea, D., Caballero, S., Faraco, G., Moore, J., Murphy, M., Sita, G., Racchumi, G., Ling, L., Pamer, E. G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4068 · Cited by 1,114

The microbiome-gut-brain axis in health and disease

Dinan, T. G., & Cryan, J. F. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.007 · Cited by 1,111

Microbiota and neurodevelopmental windows: implications for brain disorders

Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089

Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses

O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

Olson, C. A., Vuong, H. E., Yano, J. M., Liang, Q. Y., Nusbaum, D. J., & Hsiao, E. Y. (2018) · Cell · doi:10.1016/j.cell.2018.04.027 · Cited by 1,057

Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

Sohal, V. S., & Rubenstein, J. L. R. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0426-0 · Cited by 988

Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice

Burokas, A., Arboleya, S., Moloney, R. D., Peterson, V. L., Murphy, K., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.031 · Cited by 952

The infant microbiome development: Mom matters

Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z., & Dominguez-Bello, M. G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.002 · Cited by 943

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Berer, K., Gerdes, L. A., Cekanaviciute, E., Jia, X., Xiao, L., Xia, Z., Liu, C., Klotz, L., Stauffer, U., Baranzini, S. E., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711233114 · Cited by 933

Diet and feeding pattern affect the diurnal dynamics of the gut microbiome

Zarrinpar, A., Chaix, A., Yooseph, S., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.008 · Cited by 926

The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis

Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891

Glia and epilepsy: excitability and inflammation

Devinsky, O., Vezzani, A., Najjar, S., de Lanerolle, N. C., & Rogawski, M. A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.008 · Cited by 887

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840

Probiotic bacteria and intestinal epithelial barrier function

Ohland, C., & MacNaughton, W. K. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00243.2009 · Cited by 832

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793

Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota

Smith, K., McCoy, K. D., & Macpherson, A. J. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.10.002 · Cited by 789

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain–gut axis alterations

van de Wouw, M., Boehme, M., Lyte, J. M., Wiley, N., Strain, C., O'Sullivan, O., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2018) · The Journal of Physiology · doi:10.1113/jp276431 · Cited by 789

High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health

Russell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

Ma, Q., Xing, C., Long, W., Wang, H. Y., Liu, Q., & Wang, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1434-3 · Cited by 763

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

Zheng, P., Zeng, B., Liu, M., Chen, J., Pan, J., Han, Y., Liu, Y., Cheng, K., Zhou, C., Wang, H., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau8317 · Cited by 704

The endocannabinoid system links gut microbiota to adipogenesis

Muccioli, G. G., Naslain, D., Bäckhed, F., Reigstad, C. S., Lambert, D. M., Delzenne, N. M., & Cani, P. D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.46 · Cited by 691

Activation of the peripheral endocannabinoid system in human obesity

Engeli, S., Böhnke, J., Feldpausch, M., Gorzelniak, K., Janke, J., Bátkai, S., Pacher, P., Harvey-White, J., Luft, F. C., Sharma, A. M., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2838 · Cited by 686

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation

D'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675

The neurobiology of stress and gastrointestinal disease

MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666

Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis

Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Patel, K. V., O’Connor, G., Grati, M., Mittal, J., Yan, D. L. S., Eshraghi, A. A., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25518 · Cited by 661

Regulation of inflammation by microbiota interactions with the host

Blander, J. M., Longman, R., Iliev, I. D., Sonnenberg, G. F., & Artis, D. (2017) · Nature Immunology · doi:10.1038/ni.3780 · Cited by 655

Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naive Parkinson's disease patients

Bedarf, J. R., Hildebrand, F., Coelho, L. P., Sunagawa, S., Bahram, M., Goeser, F., Bork, P., & Wüllner, U. (2017) · Genome Medicine · doi:10.1186/s13073-017-0428-y · Cited by 642

Regulation of prefrontal cortex myelination by the microbiota

Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., Clarke, G., & Cryan, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.42 · Cited by 635

The bowel and beyond: The enteric nervous system in neurological disorders

Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612

Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease

Albenberg, L. G., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.058 · Cited by 606

Systematic Review of Gut Microbiota and Major Depression

Cheung, S. G., Goldenthal, A. R., Uhlemann, A.-C., Mann, J. J., Miller, J. M., & Sublette, M. E. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00034 · Cited by 597

Nutritional medicine as mainstream in psychiatry

Sarris, J., Logan, A. C., Akbaraly, T. N., Amminger, G. P., Balanzá-Martínez, V., Freeman, M. P., Hibbeln, J., Matsuoka, Y., Mischoulon, D., Mizoue, T., et al. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00051-0 · Cited by 592

The pharmacology of cannabinoid receptors and their ligands: an overview

Pertwee, R. G. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803272 · Cited by 586

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock

Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578

The role of cytokines in the pathophysiology of epilepsy

Vezzani, A., Balosso, S., & Ravizza, T. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.03.009 · Cited by 564

History of the ketogenic diet

Wheless, J. W. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01821.x · Cited by 535

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2012 · Cited by 530

Seizure‐Promoting Effect of Blood–Brain Barrier Disruption

Marchi, N., Angelov, L., Masaryk, T., Fazio, V. J., Granata, T., Hernandez, N., Hallene, K. L., Diglaw, T., Franic, L. A., Najm, I., et al. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.00988.x · Cited by 508

Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry

Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491

Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders

Lee, E., Lee, J., & Kim, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.011 · Cited by 468

Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders

Augustin, K., Khabbush, A., Williams, S., Eaton, S. D., Orford, M., Cross, J. H., Heales, S., Walker, M. C., & Williams, R. S. B. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30408-8 · Cited by 448

The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases

Richard, M. L., & Sokol, H. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0121-2 · Cited by 428

A comprehensive repertoire of prokaryotic species identified in human beings

Hugon, P., Dufour, J.-C., Colson, P., Fournier, P., Sallah, K., & Raoult, D. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00293-5 · Cited by 424

Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation

Riazi, K., Galic, M. A., Kuzmiski, J. B., Ho, W., Sharkey, K. A., & Pittman, Q. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806682105 · Cited by 400

The Blood–Brain Barrier and Epilepsy

Oby, E. R., & Janigro, D. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00817.x · Cited by 399

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms

Ho, L., Ono, K., Tsuji, M., Mazzola, P., Singh, R., & Pasinetti, G. M. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1400909 · Cited by 376

Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

Wouters, M. M., Balemans, D., Van Wanrooy, S., Dooley, J., Cibert-Goton, V., Alpizar, Y. A., Valdez-Morales, E. E., Nasser, Y., Van Veldhoven, P. P., Vanbrabant, W., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.034 · Cited by 372

EpileptogenesisPreprint

Pitkänen, A., Łukasiuk, K., Dudek, F. E., & Staley, K. J. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022822 · Cited by 369

Recent developments in understanding the role of the gut microbiota in brain health and disease

Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13416 · Cited by 338

Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review

Liu, F., Li, J., Wu, F., Zheng, H., Peng, Q., & Zhou, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0389-6 · Cited by 336

The ketogenic diet: metabolic influences on brain excitability and epilepsy

Lutas, A., & Yellen, G. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.005 · Cited by 327

Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders

Foss‐Feig, J. H., Adkinson, B. D., Ji, J. L., Yang, G., Srihari, V. H., McPartland, J. C., Krystal, J. H., Murray, J. D., & Anticevic, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.005 · Cited by 327

Gut reactions: Breaking down xenobiotic–microbiome interactions

Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319

Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models

Horder, J., Petrinovic, M. M., Méndez, M. A., Bruns, A., Takumi, T., Spooren, W. P. J. M., Barker, G. J., Künnecke, B., & Murphy, D. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0155-1 · Cited by 317

Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability

Riazi, K., Galic, M. A., & Pittman, Q. J. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.09.004 · Cited by 310

The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy

Lindefeldt, M., Eng, A., Darban, H., Bjerkner, A., Zetterström, C. K., Allander, T., Andersson, B., Borenstein, E., Dahlin, M., & Prast-Nielsen, S. (2019) · npj Biofilms and Microbiomes · doi:10.1038/s41522-018-0073-2 · Cited by 310

The Infant Microbiome

Yang, I. H., Corwin, E. J., Brennan, P. A., Jordan, S., Murphy, J. R., & Dunlop, A. L. (2015) · Nursing Research · doi:10.1097/nnr.0000000000000133 · Cited by 309

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Tang, A. T., Choi, J. P., Kotzin, J. J., Yang, Y., Hong, C. C., Hobson, N., Girard, R., Zeineddine, H. A., Lightle, R., Moore, T., et al. (2017) · Nature · doi:10.1038/nature22075 · Cited by 306

Interindividual variability in gut microbiota and host response to dietary interventions

Healey, G. R., Murphy, R., Brough, L., Butts, C. A., & Coad, J. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux062 · Cited by 306

Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB/c mouse

Bangsgaard Bendtsen, K. M., Krych, L., Sørensen, D. B., Pang, W., Nielsen, D. S., Josefsen, K., Hansen, L. H., Sørensen, S. J., & Hansen, A. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046231 · Cited by 299

Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy

Xie, G., Zhou, Q., Qiu, C.-Z., Dai, W.-K., Wang, H.-P., Li, Y.-H., Liao, J.-X., Lu, X.-G., Lin, S.-F., Ye, J.-H., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i33.6164 · Cited by 291

E/I balance and GABAA receptor plasticity

Fritschy, J. (2008) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.005.2008 · Cited by 289

Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate

Janik, R., Thomason, L. A. M., Stanisz, A. M., Forsythe, P., Bienenstock, J., & Stanisz, G. J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.018 · Cited by 283

Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder

Newell, C., Bomhof, M. R., Reimer, R. A., Hittel, D. S., Rho, J. M., & Shearer, J. (2016) · Molecular Autism · doi:10.1186/s13229-016-0099-3 · Cited by 272

Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet

Zhang, Y., Zhou, S., Zhou, Y., Yu, L., Zhang, L., & Wang, Y. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.06.015 · Cited by 269

The Pharmacology and Function of Receptors for Short-Chain Fatty Acids

Bolognini, D., Tobin, A. B., Milligan, G., & Hodge, D. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.102301 · Cited by 267

Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function

Cussotto, S., Strain, C. R., Fouhy, F., Strain, R. G., Peterson, V. L., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5006-5 · Cited by 266

New insights into the mechanisms of the ketogenic diet

Boison, D. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000432 · Cited by 258

Corticosteroid-related central nervous system side effects

Ciriaco, M., Ventrice, P., Russo, G., Scicchitano, M., Mazzitello, G., Scicchitano, F., & Russo, E. (2013) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.120975 · Cited by 252

Altered composition of the gut microbiome in patients with drug-resistant epilepsy

Peng, A., Qiu, X., Lai, W., Li, W., Zhang, L., Zhu, X., He, S., Duan, J., & Chen, L. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.09.013 · Cited by 247

Inflammatory pathways of seizure disorders

Marchi, N., Granata, T., & Janigro, D. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.11.002 · Cited by 247

The Enteric Nervous System

(2007) · Wiley eBooks · doi:10.1002/9780470988756 · Cited by 241

Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: The first report

He, Z., Cui, B., Zhang, T., Li, P., Long, C., Ji, G., & Zhang, F. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i19.3565 · Cited by 225

Impaired Gut-Liver-Brain Axis in Patients with Cirrhosis

Ahluwalia, V., Betrapally, N. S., Hylemon, P. B., White, M. B., Gillevet, P. M., Unser, A. B., Fagan, A., Daita, K., Heuman, D. M., Zhou, H., et al. (2016) · Scientific Reports · doi:10.1038/srep26800 · Cited by 213

Seizures as adverse events of antibiotic drugs

Sutter, R., Rüegg, S. J., & Tschudin‐Sutter, S. (2015) · Neurology · doi:10.1212/wnl.0000000000002023 · Cited by 210

Cellular and molecular mechanisms of epilepsy in the human brain

Avoli, M., Louvel, J., Pumain, R., & Köhling, R. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.09.006 · Cited by 209

Mediterranean Diet and Health: Food Effects on Gut Microbiota and Disease Control

CHIERICO, F. D., Vernocchi, P., Dallapiccola, B., & Putignani, L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150711678 · Cited by 207

Effect of probiotic supplementation on seizure activity and cognitive performance in PTZ-induced chemical kindling

Bagheri, S., Heydari, A., Alinaghipour, A., & Salami, M. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.03.038 · Cited by 201

The gut microbiome and epilepsy

Dahlin, M. G., & Prast‐Nielsen, S. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.05.024 · Cited by 200

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis

Fischer, A., Zalvide, J., Faurobert, E., Albiges-Rizo, C., & Tournier-Lasserve, E. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.02.004 · Cited by 199

Butyrate and glucose metabolism by colonocytes in experimental colitis in mice

Ahmad, M. S., Krishnan, S., Ramakrishna, B., Mathan, M. M., Pulimood, A. B., & Murthy, S. N. (2000) · Gut · doi:10.1136/gut.46.4.493 · Cited by 186

Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis

Zhang, J.-C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.112 · Cited by 182

The role of microbiota in hepatic encephalopathy

Bajaj, J. S. (2014) · Gut Microbes · doi:10.4161/gmic.28684 · Cited by 181

GAT2/BGT-1 as a System Responsible for the Transport of γ-Aminobutyric Acid at the Mouse Blood–Brain Barrier

Takanaga, H., Ohtsuki, S., Hosoya, K., & Terasaki, T. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00012 · Cited by 179

The beneficial effect of probiotics as a supplementary treatment in drug-resistant epilepsy: a pilot study

Gómez-Eguílaz, M., Ramón-Trapero, J. L., Pérez-Martínez, L., & Blanco, J. R. (2018) · Beneficial Microbes · doi:10.3920/bm2018.0018 · Cited by 177

Microbiota-gut brain axis involvement in neuropsychiatric disorders

Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., et al. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1638763 · Cited by 177

Stress, seizures, and hypothalamic–pituitary–adrenal axis targets for the treatment of epilepsy

Maguire, J. L., & Salpekar, J. A. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.09.040 · Cited by 173

A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder

Lee, R. W. Y., Corley, M. J., Pang, A. P. S., Arakaki, G., Abbott, L., Nishimoto, M., Miyamoto, R. H., Lee, E., Yamamoto, S., Maunakea, A. K., et al. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.006 · Cited by 171

Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus

Ho, Y.-H., Lin, Y., Wu, C.-W. J., Chao, Y., Chang, A. Y., & Chan, J. Y. H. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0157-8 · Cited by 168

Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity

Mehrpouya‐Bahrami, P., Chitrala, K. N., Ganewatta, M. S., Tang, C., Murphy, E. A., Enos, R. T., Velázquez, K. T., McCellan, J., Nagarkatti, M., & Nagarkatti, P. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-15154-6 · Cited by 168

Endocannabinoid system acts as a regulator of immune homeostasis in the gut

Acharya, N., Penukonda, S., Shcheglova, T. V., Hagymasi, A. T., Basu, S., & Srivastava, P. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612177114 · Cited by 167

Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re‐feeding

Izzo, A. A., Piscitelli, F., Capasso, R., Aviello, G., Romano, B., Borrelli, F., Petrosino, S., & Marzo, V. D. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00183.x · Cited by 164

Mediterranean diet and depression

Sánchez‐Villegas, A., Henríquez, P., Bes‐Rastrollo, M., & Doreste‐Alonso, J. (2006) · Public Health Nutrition · doi:10.1017/s1368980007668578 · Cited by 163

Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery

Nutsch, K., Chai, J. N., Ai, T. L., Russler-Germain, E. V., Feehley, T., Nagler‐Anderson, C., & Hsieh, C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.092 · Cited by 151

GABAergic Control of Depression-Related Brain States

Luscher, B., & Fuchs, T. (2015) · Advances in Pharmacology · doi:10.1016/bs.apha.2014.11.003 · Cited by 149

Mast Cells in Neuroimmune Interactions

Forsythe, P. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.09.006 · Cited by 146

Adding fuel to the fire: the impact of stress on the ageing brain

Prenderville, J. A., Kennedy, P. J., Dinan, T. G., & Cryan, J. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.001 · Cited by 136

An orally administered butyrate‐releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium‐induced murine colitis

Simeoli, R., Raso, G. M., Pirozzi, C., Lama, A., Santoro, A. N., Russo, R., Montero‐Melendez, T., Canani, R. B., Calignano, A., Perretti, M., et al. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13637 · Cited by 134

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation

Cerri, C., Genovesi, S., Allegra, M., Pistillo, F., Püntener, U., Guglielmotti, A., Perry, V. H., Bozzi, Y., & Caleo, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0451-15.2016 · Cited by 132

HPA axis genetic variation, cortisol and psychosis in major depression

Schatzberg, A. F., Keller, J., Tennakoon, L., Lembke, A., Williams, G., Kraemer, F. B., Sarginson, J. E., Lazzeroni, L. C., & Murphy, G. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.129 · Cited by 131

Short-term impact of a classical ketogenic diet on gut microbiota in GLUT1 Deficiency Syndrome: A 3-month prospective observational study

Tagliabue, A., Ferraris, C., Uggeri, F., Trentani, C., Bertoli, S., de Giorgis, V., Veggiotti, P., & Elli, M. (2017) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2016.11.003 · Cited by 126

Emerging roles for the intestinal microbiome in epilepsy

Lum, G. R., Olson, C. A., & Hsiao, E. Y. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104576 · Cited by 126

Epigenetics and EpilepsyPreprint

Henshall, D. C., & Kobow, K. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022731 · Cited by 121

Endocannabinoids and the Immune System in Health and Disease

Cabral, G. A., Ferreira, G. A., & Jamerson, M. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_6 · Cited by 114

Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions

Shifrin, D. A., McConnell, R. E., Nambiar, R., Higginbotham, J. N., Coffey, R. J., & Tyska, M. J. (2012) · Current Biology · doi:10.1016/j.cub.2012.02.022 · Cited by 113

Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis

Qureshi, I. A., & Mehler, M. F. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.02.005 · Cited by 112

Intracellular Cannabinoid Type 1 (CB1) Receptors Are Activated by Anandamide

Brailoiu, G. C., Oprea, T. I., Zhao, P., Abood, M. E., & Brailoiu, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217463 · Cited by 99

Benzodiazepine Biosynthesis in Streptomyces refuineus

Hu, Y., Phelan, V. V., Ntai, I., Farnet, C. M., Zazopoulos, E., & Bachmann, B. O. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.05.009 · Cited by 97

Immune-To-Brain Signaling: How Important are the Blood–Brain Barrier-independent Pathways?

Quan, N. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8026-z · Cited by 97

Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long‐term changes in hippocampal CA1 cells, in the fully kindled state

Karst, H., de Kloet, E. R., & Joëls, M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00495.x · Cited by 95

Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS®) ingestion

Gronier, B., Savignac, H. M., Di Miceli, M., Idriss, S. M., Tzortzis, G., Anthony, D., & Burnet, P. W. J. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.11.001 · Cited by 91

Discovery of a small molecule that inhibits bacterial ribosome biogenesis

Stokes, J. M., Davis, J. H., Mangat, C. S., Williamson, J. R., & Brown, E. D. (2014) · eLife · doi:10.7554/elife.03574 · Cited by 90

The Role of Mammalian Intestinal Bacteria in the Reductive Metabolism of Zonisamide

Kitamura, S., Sugihara, K., Kuwasako, M., & Tatsumi, K. (1997) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1997.tb06790.x · Cited by 86

Serum prolactin and cortisol levels in evaluation of pseudoepileptic seizures

Pritchard, P. B., Wannamaker, B. B., Sagel, J., & Daniel, C. M. (1985) · Annals of Neurology · doi:10.1002/ana.410180115 · Cited by 85

Gut bacteria provide precursors of benzodiazepine receptor ligands in a rat model of hepatic encephalopathy

Yurdaydın, C., Walsh, T. J., Engler, H. D., Ha, J., Li, Y., Jones, E. A., & Basile, A. S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00241-h · Cited by 82

Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy

DiNuzzo, M., Mangia, S., Maraviglia, B., & Giove, F. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.04.001 · Cited by 81

Effects of Histone Deacetylase Inhibitors on the Development of Epilepsy and Psychiatric Comorbidity in WAG/Rij Rats

Citraro, R., Leo, A., Caro, C. D., Nesci, V., Cantafio, M. E. G., Amodio, N., Raso, G. M., Lama, A., Russo, R., Calignano, A., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01712-8 · Cited by 78

The role of dietary fibre in inflammatory bowel disease

Pituch, A., Banaszkiewicz, A., & Albrecht, P. (2015) · Gastroenterology Review · doi:10.5114/pg.2015.52753 · Cited by 76

Modulation of Multiple Sclerosis and Its Animal Model Experimental Autoimmune Encephalomyelitis by Food and Gut Microbiota

van den Hoogen, W., Laman, J. D., & Hart, B. A. ‘. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01081 · Cited by 76

Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice

Russo, R., Caro, C. D., Avagliano, C., Cristiano, C., Rana, G. L., Raso, G. M., Canani, R. B., Meli, R., & Calignano, A. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.026 · Cited by 74

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

Bolognini, D., Barki, N., Butcher, A. J., Hudson, B. D., Sergeev, E., Molloy, C., Hodge, D., Bradley, S. J., Gouill, C. L., Bouvier, M., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0270-1 · Cited by 72

Can epilepsy be treated by antibiotics?

Braakman, H. M. H., & van Ingen, J. (2018) · Journal of Neurology · doi:10.1007/s00415-018-8943-3 · Cited by 70

Peripheral leukocyte profile in people with temporal lobe epilepsy reflects the associated proinflammatory state

Vieira, É. L. M., de Oliveira, G. N. M., Lessa, J. M. K., Gonçalves, A. P., de Oliveira, A. C. P., Bauer, M. E., Sander, J. W. A. S., Cendes, F., & Teixeira, A. L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.11.016 · Cited by 68

Evaluation and Management of Hepatic Encephalopathy: Current Status and Future Directions

Suraweera, D., Sundaram, V., & Saab, S. (2016) · Gut and Liver · doi:10.5009/gnl15419 · Cited by 67

Roles of Glutamine Synthetase Inhibition in Epilepsy

Eid, T., Behar, K. L., Dhaher, R., Bumanglag, A. V., & Lee, T.-S. W. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0766-5 · Cited by 66

Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy

Schwarzer, M., Hermanová, P. P., Šrůtková, D., Goliáš, J., Hudcovic, T., Šinkora, M., Akgün, J., Zwicker, C., Wiedermann, U., Tučková, L., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00205 · Cited by 65

Chronic Low-Dose Corticosterone Supplementation Enhances Acquired Epileptogenesis in the Rat Amygdala Kindling Model of TLE

Taher, T. R., Salzberg, M. R., Morris, M. J., Rees, S. M., & O'Brien, T. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300709 · Cited by 64

Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

Naia, L., Cunha‐Oliveira, T., Rodrigues, J., Rosenstock, T. R., Oliveira, A. M., Ribeiro, M., Carmo, C., Oliveira-Sousa, S. I., Duarte, A. I., Hayden, M. R., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2006-14.2016 · Cited by 64

Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis

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Roberts, A. J., & KEITH, L. D. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22410-7 · Cited by 36

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Fu, S., Liu, B., Wang, J. ‐., Xue, W., Liu, H. ‐., Zeng, Y., Huang, B., Li, S. ‐., Lv, Q.-K., Wang, W., et al. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12256 · Cited by 35

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den Heijer, J. M., Otte, W. M., Diessen, E. G. A. L. V., van Campen, J. S., Hompe, E. L., Jansen, F. E., Joëls, M., Braun, K. P. J., Sander, J. W. A. S., & Zijlmans, M. (2017) · Epilepsia · doi:10.1111/epi.13947 · Cited by 32

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Zhang, W., He, J.-X., Du, Y., Gao, X.-H., Liu, Y., Liu, Q.-Z., Chang, W., Cao, G.-W., & Fu, C. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8836 · Cited by 31

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Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857

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