The DOI matches its Crossref record; 558 of the 563 references it cites were found in a registry or an index.
The lipid paradox in neuroprogressive disorders: Causes and consequences
Open accessAbstract
Chronic systemic inflammation is associated with an increased risk of cardiovascular disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and with the pathophysiology of neuroprogressive disorders. The causes and consequences of this lipid paradox are explored. Circulating activated neutrophils can release inflammatory molecules such as myeloperoxidase and the pro-inflammatory cytokines interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha. Since activated neutrophils are associated with atherosclerosis and cardiovascular disease and with major depressive disorder, bipolar disorder and schizophrenia, it seems reasonable to hypothesise that the inflammatory molecules released by them may act as mediators of the link between systemic inflammation and the development of atherosclerosis in neuroprogressive disorders. This hypothesis is tested by considering the association at a molecular level of systemic inflammation with increased LDL oxidation; increased small dense LDL levels; increased lipoprotein (a) concentration; secretory phospholipase A 2 activation; cytosolic phospholipase A 2 activation; increased platelet activation; decreased apolipoprotein A1 levels and function; decreased paroxonase-1 activity; hyperhomocysteinaemia; and metabolic endotoxaemia. These molecular mechanisms suggest potential therapeutic targets.
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“Over the last two decades, chronic systemic inflammation and immunity are relevant to the pathophysiology of SCZ3 and BD.4”
From Albumin and Associated Biomarkers in Severe Neuropsychiatric Disorders: Acute-Phase Schizophrenia and Bipolar Disorder (2023) · cites this paper as [3]
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Metadata
- Authors
- Morris, G., Berk, M., Walder, K., O’Neil, A., Maes, M., & Puri, B. K.
- Affiliations
- Barwon Health (AU)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 128
- Pages
- 35-57
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W3170312532
- Cited by
- 17
- References
- 563
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 2
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council (1059660)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- lipid paradox, neurodegenerative diseases, platelet activation, apolipoprotein A-I, hyperhomocysteinemia, endotoxemia, lipid metabolism, therapeutic target
- MeSH terms
- Humans, Inflammation, Lipids, Lipoproteins, LDL, Peroxidase, Neutrophils, Cytokines, Neurodegenerative Diseases, Atherosclerosis, Phospholipases A2
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