Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice
Abstract
Bigenic APPswe + PS1/DeltaE9 mice with Abeta plaque formation in neocortex and hippocampus were evaluated in three tests measuring exploratory activity. By comparison to a non-transgenic group controlled for age and gender, 7-month-old APPswe + PS1/DeltaE9 mice spent more time in the open arms and had higher open/total entries and duration in the elevated plus-maze, indicative of disinhibitory tendencies. On the contrary, the groups did not differ in T-maze and open-field tests. Moreover, the motor coordination of the bigenic group was equivalent to that of controls in stationary beam, coat-hanger, rotorod, and grip strength tests. No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PS1-APP, PS1-APP-CX3CR1+/−, and WT littermate mice showed no difference in exploratory behavior in the open field test.
“As expected (27), PS1-APP, PS1-APP-CX3CR1+/−, and WT littermate mice showed no difference in exploratory behavior (data not shown).”
From Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice (2019) · cites this paper as [27]
Cites
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023 · see citing works
Campion, D., Dumanchin, C., Hannequin, D., Dubois, B., Belliard, S., Puel, M., Thomas-Anterion, C., Michon, A., Martin, C., Charbonnier, F., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302553 · Cited by 785 · see citing works
β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
Zheng, H., Jiang, M., Trumbauer, M. E., SIRINATHSINGHJI, D. J. S., Hopkins, R., Smith, D. W., HEAVENS, R. P., Dawson, G. R., Boyce, S., Conner, M. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90073-x · Cited by 699 · see citing works
Holcomb, L. A., Gordon, M. N., Jantzen, P., Hsiao, K., Duff, K., & Morgan, D. (1999) · Behavior Genetics · doi:10.1023/a:1021691918517 · Cited by 353 · see citing works
Arendash, G. W., King, D. L., Gordon, M. N., Morgan, D., Hatcher, J. M., Hope, C. E., & Diamond, D. M. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03186-3 · Cited by 349 · see citing works
Moran, P. M., Higgins, L. S., Cordell, B., & Moser, P. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5341 · Cited by 338 · see citing works
Rogers, D. C., Jones, D. N. C., Nelson, P. R., Jones, C. M., Quilter, C. A., Robinson, T. L., & Hagan, J. J. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00072-8 · Cited by 294 · see citing works
Preserved motor learning in Alzheimer's disease: implications for anatomy and behavior
Eslinger, P., & Damasio, A. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-03006.1986 · Cited by 264 · see citing works
Behavioral Syndromes in Alzheimer’s Disease: Description and Correlates
Frisoni, G. B., Rozzini, L., Gozzetti, A., Binetti, G. G., Zanetti, O. O., Bianchetti, A., Trabucchi, M., & Cummings, J. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017113 · Cited by 262 · see citing works
Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months
King, D. L., & Arendash, G. W. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00639-x · Cited by 240 · see citing works
King, D. L., Arendash, G. W., Crawford, F., Sterk, T., Menendez, J., & MULLAN, M. J. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00037-6 · Cited by 227 · see citing works
NEUROBEHAVIORAL AND NEUROPSYCHIATRIC SYMPTOMS IN ALZHEIMER'S DISEASE
Chung, J. A., & Cummings, J. L. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70228-0 · Cited by 174 · see citing works
The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APPSW mice
Wegiel, J. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00181-0 · Cited by 159 · see citing works
Activity Level and Balance in Subjects with Mild Alzheimer’s Disease
Pettersson, A. F., Engardt, M., & Wahlund, L. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000057699 · Cited by 156 · see citing works
Lalonde, R., Dumont, M., Staufenbiel, M., Sturchler, C., & Strazielle, C. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03476-5 · Cited by 130 · see citing works
Self-citationArendash, G. W., Gordon, M. N., Diamond, D. M., Austin, L. A., Hatcher-Martin, J. M., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., & Morgan, D. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717604 · Cited by 130 · see citing works
Hippocampal Aβ42 Levels Correlate with Spatial Memory Deficit in APP and PS1 Double Transgenic Mice
Puoliväli, J. T., Wang, J., Heikkinen, T., Heikkilä, M., Tapiola, T., van Groen, T., & Tanila, H. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0481 · Cited by 118 · see citing works
Holmes, A., & Rodgers, R. J. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00030-5 · Cited by 118 · see citing works
Lalonde, R., Lewis, T. L., Strazielle, C., Kim, H., & Fukuchi, K.-I. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02694-5 · Cited by 113 · see citing works
Self-citationSavonenko, A. V., Xu, G. M., Price, D. L., Borchelt, D., & Markowska, A. L. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00012-8 · Cited by 82 · see citing works
Lalonde, R., Qian, S., & Strazielle, C. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00230-9 · Cited by 54 · see citing works
Self-citationLiu, L., Ikonen, S., Heikkinen, T., Tapiola, T., Groen, T. V., & Tanila, H. (2002) · Experimental Neurology · doi:10.1006/exnr.2001.7819 · Cited by 51 · see citing works
Bertholet, J.-Y., & Crusio, W. E. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80071-3 · Cited by 43 · see citing works
Chapter 4.3 Motor performance of spontaneous murine mutations with cerebellar atrophy
(1999) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(99)80049-2 · Cited by 34 · see citing works
Huang, X. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00242-5 · Cited by 31 · see citing works
Marutle, A., Unger, C., Hellström‐Lindahl, E., Wang, J., Puoliväli, J. T., Tanila, H., Nordberg, A. K., & Zhang, X. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00546-3 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755 · see citing works
“No deficits were seen in alternation tasks of working memory for this model (Lalonde et al., 2004; Cao et al., 2007).”
BackgroundInfluentialLuo, R., Su, L.-Y., Li, G., Yang, J., Liu, Q., Yang, L.-X., Zhang, D.-F., Zhou, H., Xu, M., Fan, Y., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1596488 · Cited by 364 · see citing works
Reiserer, R. S., Harrison, F. E., Syverud, D. C., & McDonald, M. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00221.x · Cited by 324 · see citing works
Hippocampal neurogenesis: Learning to remember
Lazarov, O., & Hollands, C. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.006 · Cited by 281 · see citing works
Song, M., Jin, J., Lim, J.-E., Kou, J., Pattanayak, A., Rehman, J. A., Kim, H.-D., Tahara, K., Lalonde, R., & Fukuchi, K.-I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-92 · Cited by 273 · see citing works
Self-citationThe relationship between stress and Alzheimer's disease
Justice, N. J. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.04.002 · Cited by 237 · see citing works
Identifying behavioral structure from deep variational embeddings of animal motion
Luxem, K., Mocellin, P., Fuhrmann, F., Kürsch, J., Miller, S. R., Palop, J. J., Remy, S., & Bauer, P. (2022) · Communications Biology · doi:10.1038/s42003-022-04080-7 · Cited by 218 · see citing works
Pentkowski, N. S., Rogge-Obando, K., Donaldson, T. N., Bouquin, S. J., & Clark, B. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.005 · Cited by 169 · see citing works
Cheng, D., Low, J. K., Logge, W., Garner, B., & Karl, T. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3478-5 · Cited by 172 · see citing works
Hooijmans, C. R., van der Zee, C. E. E. M., Dederen, P. J. W. C., Brouwer, K. M., Reijmer, Y. D., Groen, T. V., Broersen, L. M., Lütjohann, D., Heerschap, A., & Kiliaan, A. J. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.002 · Cited by 171 · see citing works
Lalonde, R., Kim, H. D., Maxwell, J. A., & Fukuchi, K. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.028 · Cited by 170 · see citing works
Self-citationVolianskis, A., Køstner, R., Mølgaard, M., Hass, S., & Jensen, M. S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.005 · Cited by 167 · see citing works
Brain regions and genes affecting limb-clasping responses
Lalonde, R., & Strazielle, C. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.02.005 · Cited by 141 · see citing works
Self-citationWebster, S. J., Bachstetter, A. D., & Eldik, L. J. V. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt182 · Cited by 140 · see citing works
Jardanhazi‐Kurutz, D., Kummer, M. P., Terwel, D., Vogel, K., Dyrks, T., Thiele, A., & Heneka, M. T. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.001 · Cited by 133 · see citing works
Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice
Bernardo, A., Harrison, F. E., McCord, M., Zhao, J., Bruchey, A., Davies, S. S., Jackson Roberts, L., Mathews, P. M., Matsuoka, Y., Ariga, T., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.022 · Cited by 127 · see citing works
Spuch, C., Antequera, D., Portero, A., Orive, G., Hernández, R. M., Molina, J. A., Bermejo‐Pareja, F., Pedraz, J. L., & Carro, E. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.042 · Cited by 123 · see citing works
Mao, Y., Guo, Z., Zheng, T., Jiang, Y., Yan, Y., Yin, X., Chen, Y., & Zhang, B. (2016) · Aging Cell · doi:10.1111/acel.12498 · Cited by 110 · see citing works
Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer’s disease
O’Leary, T. P., Robertson, A., Chipman, P., Rafuse, V. F., & Brown, R. E. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.009 · Cited by 111 · see citing works
Wirths, O., Breyhan, H., Schäfer, S., Roth, C., & Bayer, T. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.004 · Cited by 97 · see citing works
Age‐related deterioration of motor function in male and female 5xFAD mice from 3 to 16 months of age
O’Leary, T. P., Mantolino, H. M., Stover, K. R., & Brown, R. E. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12538 · Cited by 88 · see citing works
Sierksma, A. S. R., Prickaerts, J., Chouliaras, L., Rostamian, S., Delbroek, L., Rutten, B. P. F., Steinbusch, H. W. M., & van den Hove, D. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.012 · Cited by 87 · see citing works
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
Prior, M., Dargusch, R., Ehren, J. L., Chiruta, C., & Schubert, D. A. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt179 · Cited by 87 · see citing works
Motor impairment in Alzheimer’s disease and transgenic Alzheimer’s disease mouse models
Wirths, O., & Bayer, T. A. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00373.x · Cited by 86 · see citing works
Hickman, S. E., Allison, E. K., Coleman, U., Kingery-Gallagher, N. D., & El Khoury, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02780 · Cited by 80 · see citing works
Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice
Huang, H., Nie, S., Cao, M., Marshall, C., Gao, J., Xiao, N., Hu, G., & Xiao, M. (2016) · AGE · doi:10.1007/s11357-016-9929-7 · Cited by 75 · see citing works
Timmer, N., van Dijk, L., der Zee, C. E. E. M. V., Kiliaan, A. J., de Waal, R. M. W., & Verbeek, M. M. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.06.008 · Cited by 76 · see citing works
Frye, C. A., & Walf, A. A. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.09.008 · Cited by 74 · see citing works
Analysis of Motor Function in the Tg4-42 Mouse Model of Alzheimer’s Disease
Wagner, J. M., Sichler, M. E., Schleicher, E. M., Franke, T. N., Irwin, C., Löw, M. J., Beindorff, N., Bouter, C., Bayer, T. A., & Bouter, Y. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00107 · Cited by 74 · see citing works
Tabuchi, M., Yamaguchi, T., Iizuka, S., Imamura, S., Ikarashi, Y., & Kase, Y. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.12.010 · Cited by 68 · see citing works
Parameshwaran, K., Buabeid, M. A., Karuppagounder, S. S., Uthayathas, S., Thiruchelvam, K., Shonesy, B. C., Dityatev, A. E., Escobar, M. E., Dhanasekaran, M., & Suppiramaniam, V. D. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0805-4 · Cited by 67 · see citing works
Bennett, L. E., Kersaitis, C., Macaulay, S., Münch, G. W., Niedermayer, G., Nigro, J., Payne, M. S., Sheean, P., Vallotton, P., Zabaras, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076362 · Cited by 65 · see citing works
Zou, C., Shi, Y., Ohli, J., Schüller, U., Dorostkar, M., & Herms, J. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1527-8 · Cited by 65 · see citing works
Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease
Cheng, D., Logge, W., Low, J. K., Garner, B., & Karl, T. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.008 · Cited by 64 · see citing works
Herrán, E., Pérez‐González, R., Igartúa, M., Pedraz, J. L., Carro, E., & Hernández, R. M. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.04.028 · Cited by 61 · see citing works
APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD)
Lalonde, R., Fukuchi, K., & Strazielle, C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.011 · Cited by 62 · see citing works
Self-citationSpuch, C., Antequera, D., Fernández‐Bachiller, M. I., Rodrı́guez-Franco, M. I., & Carro, E. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9121-2 · Cited by 62 · see citing works
Bayer, T. A., & Wirths, O. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00372.x · Cited by 60 · see citing works
Sato, H., Tsukamoto‐Yasui, M., Takado, Y., Kawasaki, N., Matsunaga, K., Ueno, S., Kanda, M. N., Nishimura, M., Karakawa, S., Isokawa, M., et al. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00023 · Cited by 59 · see citing works
Zou, C., Montagna, E., Shi, Y., Peters, F., Blázquez‐Llorca, L., Shi, S., Filser, S., Dorostkar, M. M., & Herms, J. W. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1421-4 · Cited by 59 · see citing works
Neurologic and motor dysfunctions in APP transgenic mice
Lalonde, R., Fukuchi, K.-I., & Strazielle, C. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0041 · Cited by 57 · see citing works
Self-citationNovel behavioural characteristics of female APPSwe/PS1ΔE9 double transgenic mice
Cheng, D., Low, J. K., Logge, W., Garner, B., & Karl, T. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.046 · Cited by 55 · see citing works
Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's Disease model
Ferguson, S. A., Sarkar, S., & Schmued, L. C. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.12.055 · Cited by 55 · see citing works
Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice
Wiesmann, M., Zerbi, V., Jansen, D., Lütjohann, D., Veltien, A. A., Heerschap, A., & Kiliaan, A. J. (2017) · Theranostics · doi:10.7150/thno.18509 · Cited by 52 · see citing works
Coles, M., Watt, G., Kreilaus, F., & Karl, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.587604 · Cited by 53 · see citing works
Jansen, D., Zerbi, V., Arnoldussen, I. A. C., Wiesmann, M., Rijpma, A., Fang, X. T., Dederen, P. J. W. C., Mutsaers, M. P. C., Broersen, L. M., Lütjohann, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075393 · Cited by 47 · see citing works
Kalueff, A. V., Keisala, T., Minasyan, A., Kumar, S. R., LaPorte, J. L., Murphy, D. L., & Tuohimaa, P. (2008) · Nature Protocols · doi:10.1038/nprot.2007.516 · Cited by 47 · see citing works
Wirianto, M., Wang, C., Kim, E., Koike, N., Gomez‐Gutierrez, R., Nohara, K., Escobedo, G., Choi, J. M., Han, C., Yagita, K., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101633r · Cited by 45 · see citing works
Song, L., Qu, Y. Q., Tang, Y. P., Chen, X., Lo, H. H., Li, Q., Yun, Y. X., Wong, V. K. W., Zhang, R. L., Wang, H. M., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102637 · Cited by 45 · see citing works
Shepherd, A. L., Tyebji, S., Hannan, A. J., & Burrows, E. L. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0837-1 · Cited by 42 · see citing works
Lok, K., Hong, Z., Zhang, C. M., He, N., Shen, H., Wang, Z., Zhao, W., & Yin, M. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.09.018 · Cited by 40 · see citing works
Wiesmann, M., Jansen, D., Zerbi, V., Broersen, L. M., Garthe, A., & Kiliaan, A. J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130179 · Cited by 38 · see citing works
Effects of Diphenyl Diselenide on Methylmercury Toxicity in Rats
Corte, C. L. D., Wagner, C., Sudati, J. H., Comparsi, B., Leite, G. O., Busanello, A., Soares, F. A. A., Aschner, M., & da Rocha, J. B. T. (2013) · BioMed Research International · doi:10.1155/2013/983821 · Cited by 38 · see citing works
The role of galectin-3 in modulation of anxiety state level in mice
Stajić, D., Selaković, D., Jovicic, N. U., Joksimović, J., Arsenijević, N., Lukić, M. L., & Rosic, G. L. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.01.019 · Cited by 38 · see citing works
Olesen, L. Ø., Bouzinova, E. V., Severino, M., Sivasaravanaparan, M., Hasselstrøm, J. B., Finsen, B. R., & Wiborg, O. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165144 · Cited by 37 · see citing works
Yang, Y. J., Cudaback, E., Jorstad, N. L., Hemingway, J. F., Hagan, C. E., Melief, E. J., Li, X., Yoo, T., Khademi, S. B., Montine, K. S., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.05.009 · Cited by 36 · see citing works
Hulshof, L. A., Frajmund, L. A., van Nuijs, D., van der Heijden, D. C. N., Middeldorp, J., & Hol, E. M. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.12.009 · Cited by 35 · see citing works
Lim, J. E., Song, M., Jin, J., Kou, J., Pattanayak, A., Lalonde, R., & Fukuchi, K. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.027 · Cited by 34 · see citing works
Self-citationHarrison, F. E., May, J. M., & McDonald, M. P. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.11.009 · Cited by 34 · see citing works
Lo, A. C., Iscru, E., Blum, D. L., Tesseur, I. C., Callaerts‐Vegh, Z., Buée, L., Strooper, B. D., Balschun, D., & D’Hooge, R. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122296 · Cited by 34 · see citing works
Barron, A. M., Verdile, G., Taddei, K., Bates, K. A., & Martins, R. N. (2010) · Endocrinology · doi:10.1210/en.2009-1168 · Cited by 34 · see citing works
One‐year longitudinal evaluation of sensorimotor functions in APP751SL transgenic mice
Cudennec, C. L., Faure, A., Ly, M., & Delatour, B. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00374.x · Cited by 31 · see citing works
Heiss, J. K., Barrett, J., Yu, Z., Haas, L. T., Kostylev, M. A., & Strittmatter, S. M. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw188 · Cited by 29 · see citing works
Stangherlin, E. C., Favero, A. M., Zeni, G. R., da Rocha, J. B. T., & Nogueira, C. W. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.01.004 · Cited by 28 · see citing works
Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice
Kennard, J. A., & Harrison, F. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.044 · Cited by 26 · see citing works
Tong, Y., Sun, Y., Tian, X., Zhou, T., Wang, H., Zhang, T., Zhan, R., Zhao, L., Kuerban, B., Li, Z., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv262 · Cited by 26 · see citing works
Lesuis, S. L., van Hoek, B. A. C. E., Lucassen, P. J., & Krugers, H. J. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.05.016 · Cited by 27 · see citing works
Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer’s disease
Chaudhari, K., Wang, L., Kruse, J. J., Winters, A., Sumien, N., Shetty, R. A., Prah, J., Liu, R., Shi, J., Forster, M. J., et al. (2021) · Neurological Research · doi:10.1080/01616412.2021.1893566 · Cited by 25 · see citing works
Progesterone reduces depression-like behavior in a murine model of Alzheimer’s Disease
Frye, C. A., & Walf, A. A. (2009) · AGE · doi:10.1007/s11357-009-9091-6 · Cited by 24 · see citing works
O’Connell, K. M. S., Ouellette, A. R., Neuner, S. M., Dunn, A. R., & Kaczorowski, C. C. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12603 · Cited by 23 · see citing works
Tag, S. H., Kim, B., Bae, J., Chang, K., & Im, H. (2022) · Molecular Brain · doi:10.1186/s13041-022-00933-8 · Cited by 22 · see citing works
Evaluation of attention in APP/PS1 mice shows impulsive and compulsive behaviours
Shepherd, A. L., May, C., Churilov, L. P., Adlard, P. A., Hannan, A. J., & Burrows, E. L. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12594 · Cited by 22 · see citing works
Matsuda, T., & Hisatsune, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160761 · Cited by 22 · see citing works
Genome-wide analysis of DNA methylation in an APP/PS1 mouse model of Alzheimer’s disease
Lin, C., Jia, J., Qin, W., Ren, Y., & Sun, Y. (2013) · Acta Neurologica Belgica · doi:10.1007/s13760-013-0267-6 · Cited by 20 · see citing works
Animal Models of Psychosis in Alzheimer Disease
Krivinko, J. M., Koppel, J. L., Savonenko, A. V., & Sweet, R. A. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.05.009 · Cited by 19 · see citing works
Sola-Sevilla, N., Mesa-Lombardo, A., Aleixo, M., Expósito, S., Diaz-Perdigón, T., Azqueta, A., Zamani, F., Suzuki, T., Maioli, S., Eroli, F., et al. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10084-9 · Cited by 19 · see citing works
O’Leary, T. P., Hussin, A. T., Gunn, R. K., & Brown, R. E. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.05.021 · Cited by 18 · see citing works
Castillo-Mariqueo, L., & Giménez‐Llort, L. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114054 · Cited by 19 · see citing works
Jansen, D., Zerbi, V., Janssen, C. I. F., Dederen, P. J. W. C., Mutsaers, M. P. C., Hafkemeijer, A., Janssen, A.-L., Nobelen, C. L. M., Veltien, A. A., van Asten, J. J. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063643 · Cited by 19 · see citing works
López‐Noguerola, J. S., Gießen, N. M.-E., Ueberück, M., Meißner, J. N., Pelgrim, C. E., Adams, J., Wirths, O., Bouter, Y., & Bayer, T. A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00064 · Cited by 18 · see citing works
Ahuja, M., Buabeid, M. A., Abdel‐Rahman, E. A., Majrashi, M., Parameshwaran, K., Amin, R., Ramesh, S., Kariharan, T., Pondugula, S. R., Suppiramaniam, V. D., et al. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.03.004 · Cited by 18 · see citing works
Olesen, L. Ø., Sivasaravanaparan, M., Severino, M., Babcock, A. A., Bouzinova, E. V., West, M. J., Wiborg, O., & Finsen, B. R. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.04.021 · Cited by 17 · see citing works
Meißner, J. N., Bouter, Y., & Bayer, T. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142868 · Cited by 16 · see citing works
Effects of Qi-Fu-Yin on aging of APP/PS1 transgenic mice by regulating the intestinal microbiome
Xiao, Q., Ye, T., Wang, X., Qi, D., & Cheng, X. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1048513 · Cited by 16 · see citing works
Diphenyl diselenide changes behavior in female pups
Favero, A. M., Weis, S. N., Zeni, G. R., da Rocha, J. B. T., & Nogueira, C. W. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.08.003 · Cited by 15 · see citing works
Unraveling Early Signs of Navigational Impairment in APPswe/PS1dE9 Mice Using Morris Water Maze
Karunakaran, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.568200 · Cited by 14 · see citing works
Brain regions and genes affecting myoclonus in animals
Lalonde, R., & Strazielle, C. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.07.004 · Cited by 13 · see citing works
Self-citationWolkmer, P., Paim, F. C., da Silva, C. B., Gai, B. M., Carvalho, F. B., SOUZA, A. C. G. D., da Rosa, M. M., Silva, A. S. D., Pereira, P. R., Lopes, S. T. A., et al. (2013) · Parasitology · doi:10.1017/s003118201300108x · Cited by 13 · see citing works
Aβ dimers induce behavioral and neurochemical deficits of relevance to early Alzheimer's disease
Abdel‐Hafiz, L., Müller‐Schiffmann, A., Korth, C., Fazari, B., Chao, O. Y.-H., Nikolaus, S., Schäble, S., Herring, A., Keyvani, K., Lamounier‐Zepter, V., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.04.005 · Cited by 13 · see citing works
Lesuis, S. L., Lucassen, P. J., & Krugers, H. J. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.012 · Cited by 13 · see citing works
den Broeck, L. V., Sierksma, A. S. R., Hansquine, P., Thonnard, D., Callaerts‐Vegh, Z., & D’Hooge, R. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12695 · Cited by 13 · see citing works
Cheng, X., Zhou, Y., Gu, W., Wu, J., Nie, A., Cheng, J., Zhou, J.-W., Zhou, W., & Zhang, Y. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130836 · Cited by 12 · see citing works
Sex-Dependent Behavioral Functions of the Purkinje Cell-Specific Gαi/o Binding Protein, Pcp2(L7)
Walton, J. C., Schilling, K., Nelson, R. J., & Oberdick, J. (2012) · The Cerebellum · doi:10.1007/s12311-012-0368-4 · Cited by 12 · see citing works
Oroszi, T., Geerts, E., Rajadhyaksha, R., Nyakas, C. J., van Heuvelen, M. J. G., & van der Zee, E. A. (2023) · Behavioral and Brain Functions · doi:10.1186/s12993-023-00208-9 · Cited by 10 · see citing works
Montgomery, K. S., Edwards, G. A., Levites, Y., Kumar, A., Myers, C. E., Gluck, M. A., Setlow, B., & Bizon, J. L. (2015) · Hippocampus · doi:10.1002/hipo.22535 · Cited by 10 · see citing works
Pareja-Galeano, H., Brioche, T., Sanchis‐Gomar, F., Escrivá, C., Dromant, M., Gómez‐Cabrera, M. C., & Viña, J. (2012) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2012.05.004 · Cited by 9 · see citing works
van Heusden, F. C., Bonsón, S. P. I., Stiedl, O., Smit, A. B., & van Kesteren, R. E. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.655449 · Cited by 4 · see citing works
Klausner, A. P., Sharma, S., Fletcher, S., Neff, P., Yang, S., Son, H., Tuttle, J. B., & Steers, W. D. (2008) · The Journal of Urology · doi:10.1016/j.juro.2007.10.034 · Cited by 6 · see citing works
Experimental Granulomatous Amebic Encephalitis Caused by Acanthamoeba castellanii
Borges, S. D. L., de Macedo, E. D. S., da Silva, F. A. V., Ataíde, B. J. D. A., Mendes, N. D. S. F., Passos, A. D. C. F., de Moraes, S. A. S., Herculano, A. M., Oliveira, K. R. H. M., Bahia, C. P., et al. (2024) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed9070145 · Cited by 5 · see citing works
Martínez-Drudis, L., Bérard, M., Musiol, D., Rivest, S., & Oueslati, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39571 · Cited by 6 · see citing works
- Authors
- Lalonde, R., Kim, H. D., & Fukuchi, K.
- Affiliations
- Inserm (FR)
- University of Alabama at Birmingham (US)
- Corresponding author
- Lalonde, R.
- ORCID
- Lalonde, R.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 369
- Issue
- 2
- Pages
- 156-161
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1969424555
- Cited by
- 121
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 18 · 2012: 7
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- APPswe, Alzheimer's disease, exploratory activity, anxiety, motor coordination, elevated plus maze, disinhibition, amyloid plaques, open field behavior, T-maze, beam walking, grip strength
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Chromosomal Proteins, Non-Histone, Exploratory Behavior, Female, Male, Mice, Transgenic, Psychomotor Performance, Amyloid beta-Protein Precursor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review