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Cited by 237Stress Responses and CortisolAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

The relationship between stress and Alzheimer's disease

Open access
Justice, Nicholas J.·2018·Neurobiology of Stress
DOI 10.1016/j.ynstr.2018.04.002PMC PMC5991350
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Abstract

Stress is critically involved in the development and progression of disease. From the stress of undergoing treatments to facing your own mortality, the physiological processes that stress drives have a serious detrimental effect on the ability to heal, cope and maintain a positive quality of life. This is becoming increasingly clear in the case of neurodegenerative diseases. Neurodegenerative diseases involve the devastating loss of cognitive and motor function which is stressful in itself, but can also disrupt neural circuits that mediate stress responses. Disrupting these circuits produces aberrant emotional and aggressive behavior that causes long-term care to be especially difficult. In addition, added stress drives progression of the disease and can exacerbate symptoms. In this review, I describe how neural and endocrine pathways activated by stress interact with ongoing neurodegenerative disease from both a clinical and experimental perspective.

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  • Symptoms of depression, anxiety, stress, and chronic psychological distress have been associated with an increased risk of mild cognitive impairment and Alzheimer's disease.

    “Symptoms of depression, anxiety, stress, and chronic psychological distress have also been associated with an increased risk of MCI and AD [114,115].”

    From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [114]

    The clinical-relationship section (page unavailable) reports associations of late-life depression, anxiety and distress proneness with later dementia, including AD, and links depressive symptoms in people already diagnosed with MCI to progression to dementia. It does not establish an increased risk of developing MCI from those symptoms, and says the effect of stress on AD risk in humans has been difficult to demonstrate. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Justice, N. J.
Affiliations
The University of Texas Health Science Center at Houston (US)
Corresponding author
Justice, Nicholas J.
ORCID
Justice, Nicholas J.
Venue
Neurobiology of Stress
Publisher
Elsevier BV
Published
2018-02
Volume
8
Pages
127-133
ISSN
2352-2895 (ISSN-L)
DOI
10.1016/j.ynstr.2018.04.002
PMC
PMC5991350
OpenAlex
W2799823550
Cited by
237
References
16
Citations by year
2026: 26 · 2025: 29 · 2024: 34 · 2023: 31 · 2022: 33 · 2021: 42 · 2020: 21 · 2019: 18 · 2018: 3
FWCI
2.36
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurobiology of Stress (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University of Texas Health Science Center at Houston
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
stress, Alzheimer's disease, neurodegenerative diseases, stress response, neuroendocrine pathways, neural circuits, disease progression, long-term care, quality of life

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