Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice
Abstract
Gangliosides have been shown to be necessary for beta-amyloid (Abeta) binding and aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, including two of the four major brain gangliosides. We examined Abeta-ganglioside interactions in neural tissue from mice lacking the gene coding for GD3S (St8sia1), and in a double-transgenic (APP/PSEN1) mouse model of Alzheimer's disease cross-bred with GD3S-/- mice. In primary neurons and astrocytes lacking GD3S, Abeta-induced cell death and Abeta aggregation were inhibited. Like GD3S-/- and APP/PSEN1 double-transgenic mice, APP/PSEN1/GD3S-/- "triple-mutant" mice are indistinguishable from wild-type mice on casual examination. APP/PSEN1 double-transgenics exhibit robust impairments on a number of reference-memory tasks. In contrast, APP/PSEN1/GD3S-/- triple-mutant mice performed as well as wild-type control and GD3S-/- mice. Consistent with the behavioral improvements, both aggregated and unaggregated Abeta and associated neuropathology were almost completely eliminated in triple-mutant mice. These results suggest that GD3 synthase may be a novel therapeutic target to combat the cognitive deficits, amyloid plaque formation, and neurodegeneration that afflict Alzheimer's patients.
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In APP/PS1, impairments in reference memory develop by 6 months and persist through the rest of the life.
“Impairments in reference memory develop by 6 months and persist through the rest of the life of this model (Reiserer et al., 2007; Bernardo et al., 2009; O'leary and Brown, 2009).”
From Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014) · cites this paper as Bernardo et al., 2009
Cites
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088 · see citing works
Activation of microglial cells by β-amyloid protein and interferon-γ
Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314 · see citing works
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940 · see citing works
Haass, C., Koo, E. H., Mellon, A., Hung, A. Y., & Selkoe, D. J. (1992) · Nature · doi:10.1038/357500a0 · Cited by 899 · see citing works
GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease
Yanagisawa, K., Odaka, A., Suzuki, N., & Ihara, Y. (1995) · Nature Medicine · doi:10.1038/nm1095-1062 · Cited by 544 · see citing works
The Use of Sep‐Pak™ C 18 Cartridges During the Isolation of Gangliosides
Williams, M. A., & McCluer, R. H. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb12515.x · Cited by 475 · see citing works
Primary culture of identified neurons from the visual cortex of postnatal rats
Huettner, J., & Baughman, R. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-03044.1986 · Cited by 444 · see citing works
Formation of Isoprostane-like Compounds (Neuroprostanes) in Vivo from Docosahexaenoic Acid*
Roberts, L., Montine, T., Markesbery, W., Tapper, A. R., Hardy, P., Chemtob, S., Dettbarn, W., & Morrow, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13605 · Cited by 430 · see citing works
Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat
Barnes, C. A. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90143-9 · Cited by 421 · see citing works
Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis
Maria, R. D., Lenti, L., Malisan, F., D’Agostino, F., Tomassini, B., Zeuner, A., Rippo, M. R., & Testi, R. (1997) · Science · doi:10.1126/science.277.5332.1652 · Cited by 421 · see citing works
Kakio, A., Nishimoto, S., Yanagisawa, K., Kozutsumi, Y., & Matsuzaki, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100252200 · Cited by 406 · see citing works
Kakio, A., Nishimoto, S., Yanagisawa, K., Kozutsumi, Y., & Matsuzaki, K. (2002) · Biochemistry · doi:10.1021/bi0255874 · Cited by 387 · see citing works
Miyakawa, T., Yamada, M., Duttaroy, A., & Wess, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05239.2001 · Cited by 366 · see citing works
Gangliosides of human, bovine, and rabbit plasma
Yu, R. K., & Ledeen, R. W. (1972) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39374-3 · Cited by 353 · see citing works
Self-citationMcLaurin, J., & Chakrabartty, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.43.26482 · Cited by 333 · see citing works
Matsuoka, Y., Saito, M., LaFrancois, J. J., Saito, M., Gaynor, K., Olm, V., Wang, L., Casey, E., Lu, Y., Shiratori, C., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00029.2003 · Cited by 324 · see citing works
Self-citationReiserer, R. S., Harrison, F. E., Syverud, D. C., & McDonald, M. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00221.x · Cited by 324 · see citing works
Self-citationChoo, L.-P., Garzon-Rodriguez, W., Glabe, C. G., & Surewicz, W. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.22987 · Cited by 312 · see citing works
Mitochondrial dysfunction, apoptotic cell death, and Alzheimer’s disease
Eckert, A., Keil, U., Marques, C. A., Bonert, A., Frey, C., Schüssel, K., & Müller, W. E. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00534-3 · Cited by 309 · see citing works
Comparative cytoarchitectonic atlas of the C57BL/6 and 129/Sv mouse brains
Hof, P. R. (2000) · Elsevier eBooks · Cited by 289 · see citing works
Holmes, A., Wrenn, C. C., Harris, A. P., Thayer, K. E., & Crawley, J. N. (2002) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2001.00005.x · Cited by 275 · see citing works
Spatial and nonspatial escape strategies in the Barnes mazePreprint
Harrison, F. E., Reiserer, R. S., Tomarken, A. J., & McDonald, M. P. (2006) · Learning & Memory · doi:10.1101/lm.334306 · Cited by 245 · see citing works
Self-citationA Seed for Alzheimer Amyloid in the Brain
Hayashi, H., Kimura, N., Yamaguchi, H., Hasegawa, K., Yokoseki, T., Shibata, M. S., Yamamoto, N., Michikawa, M., Yoshikawa, Y., Terao, K., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0861-04.2004 · Cited by 239 · see citing works
Mice Expressing Only Monosialoganglioside GM3 Exhibit Lethal Audiogenic Seizures
Kawai, H., Allende, M. L., Wada, R., Kono, M., Sango, K., Deng, C., Miyakawa, T., Crawley, J. N., Werth, N., Bierfreund, U., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000847200 · Cited by 228 · see citing works
Interactions of Amyloid β-Peptide (1−40) with Ganglioside-Containing Membranes
Matsuzaki, K., & Horikiri, C. (1999) · Biochemistry · doi:10.1021/bi982345o · Cited by 217 · see citing works
Raft lipids as common components of human extracellular amyloid fibrils
Gellermann, G. P., Appel, T. R., Tannert, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407035102 · Cited by 207 · see citing works
Aβ-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice
Bornemann, K. D., Wiederhold, K., Pauli, C., Ermini, F., Stalder, M., Schnell, L., Sommer, B., Jucker, M., & Staufenbiel, M. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63945-4 · Cited by 204 · see citing works
Sango, K., McDonald, M. P., Crawley, J. N., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-348 · Cited by 202 · see citing works
Self-citationGarcía‐Ruiz, C., Colell, A., Parı́s, R., & Fernández-Checa, J. C. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.847 · Cited by 197 · see citing works
McLaurin, J., Franklin, T., Fraser, P. E., & Chakrabartty, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4506 · Cited by 188 · see citing works
The interaction between Alzheimer amyloid β(1–40) peptide and ganglioside GM1‐containing membranes
Choo, L.-P., & Surewicz, W. K. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01504-9 · Cited by 178 · see citing works
Miyakawa, T., Yared, E., Pak, J. H., Huang, F. L., Huang, K., & Crawley, J. N. (2001) · Hippocampus · doi:10.1002/hipo.1092 · Cited by 178 · see citing works
Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease
Masliah, E., Hansen, L. A., Albright, T., Mallory, M. E., & Terry, R. D. (1991) · Acta Neuropathologica · doi:10.1007/bf00293464 · Cited by 174 · see citing works
Lalonde, R., Kim, H. D., Maxwell, J. A., & Fukuchi, K. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.028 · Cited by 170 · see citing works
Scorrano, L., Petronilli, V., Lisa, F. D., & Bernardi, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22581 · Cited by 161 · see citing works
Characterization of High-Affinity Binding between Gangliosides and Amyloid β-Protein
Ariga, T., Kobayashi, K., Hasegawa, A., Kiso, M., Ishida, H., & Miyatake, T. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2304 · Cited by 158 · see citing works
Self-citationPompl, P. N., MULLAN, M. J., Bjugstad, K. B., & Arendash, G. W. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00169-1 · Cited by 149 · see citing works
Melnikova, T., Savonenko, A. V., Wang, Q., Liang, X., Hand, T. A., Wu, L., Kaufmann, W. E., Vehmas, A. K., & Andreasson, K. I. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.001 · Cited by 134 · see citing works
Apoptogenic Ganglioside GD3 Directly Induces the Mitochondrial Permeability Transition
Kristal, B. S., & Brown, A. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23169 · Cited by 129 · see citing works
Svennerholm, L., Bråne, G., Karlsson, I., Lekman, A., Ramström, I., & Wikkelsö, C. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000063604 · Cited by 126 · see citing works
GM1 ganglioside-mediated accumulation of amyloid β-protein on cell membranes
Wakabayashi, M., Okada, T., Kozutsumi, Y., & Matsuzaki, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.060 · Cited by 125 · see citing works
Cortical distribution of gangliosides in Alzheimer's disease
Kraĉun, I., Bognar, S. K., Talan-Hranilović, J., & Ćosović, Č. (1992) · Neurochemistry International · doi:10.1016/0197-0186(92)90058-y · Cited by 125 · see citing works
Tamboli, I. Y., Prager, K., Barth, E., Heneka, M. T., Sandhoff, K., & Walter, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414525200 · Cited by 122 · see citing works
Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice
Lalonde, R., Kim, H. D., & Fukuchi, K. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.07.069 · Cited by 121 · see citing works
Amyloid β oligomerization is induced by brain lipid rafts
Kim, S., Yi, J.-S., & Ko, Y. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20978 · Cited by 118 · see citing works
Guillain-Barré syndrome associated with high titers of anti-GM1 antibodies
Nobile‐Orazio, E., Carpo, M., Meucci, N., et al. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90169-l · Cited by 104 · see citing works
Mouse model of G M2 activator deficiency manifests cerebellar pathology and motor impairment
Liu, Y., Hoffmann, A., Grinberg, A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8138 · Cited by 104 · see citing works
Fighera, M. R., Royes, L. F. F., Furian, A. F., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.002 · Cited by 100 · see citing works
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice2
Nishitomi, K., Sakaguchi, G., Horikoshi, Y., Gray, A. J., Maeda, M., Hirata‐Fukae, C., Becker, A. G., Hosono, M., Sakaguchi, I., Minami, S., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04178.x · Cited by 97 · see citing works
Self-citationEffects of ganglioside treatment in rats with a lesion of the cholinergic forebrain nuclei
Casamenti, F., Bracco, L., Bartolini, L., & Pepeu, G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90246-x · Cited by 91 · see citing works
Copani, A., Melchiorri, D., Caricasole, A., Martini, F., Sale, P., Carnevale, R., Gradini, R., Sortino, M. A., Lenti, L., Maria, R. D., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-03963.2002 · Cited by 90 · see citing works
Liao, M. Q., Tzeng, Y., Chang, L. Y. X., Huang, H., Lin, T.-C., Chyan, C. L., & Chen, Y. C. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.02.026 · Cited by 90 · see citing works
Development of A$beta; terminal end-specific antibodies and sensitive ELISA for A$beta; variant
Horikoshi, Y., Sakaguchi, G., Becker, A. G., Gray, A. J., Duff, K., Aisen, P. S. S., Yamaguchi, H., Maeda, M., Kinoshita, N., & Matsuoka, Y. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.051 · Cited by 89 · see citing works
Self-citationBrain gangliosides and memory formation
Rahmann, H. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00131-x · Cited by 86 · see citing works
McDonald, M. P., & Overmier, J. B. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00024-9 · Cited by 85 · see citing works
Self-citationEffects of an exogenous β-amyloid peptide on retention for spatial learning
McDonald, M. P., Dahl, E. E., Overmier, J. B., Mantyh, P. W., & Cleary, J. P. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80059-7 · Cited by 80 · see citing works
Self-citationSchneider, J. S., Roeltgen, D. P., Mancall, E. L., et al. (1998) · Neurology · doi:10.1212/wnl.50.6.1630 · Cited by 78 · see citing works
Gangliosides prevent excitotoxicity through activation of TrkB receptor
Bachis, A., Rabin, S. J., Fiacco, M. D., & Mocchetti, I. (2002) · Neurotoxicity Research · doi:10.1080/10298420290015836 · Cited by 71 · see citing works
Sasaki, A., Shoji, M., Harigaya, Y., Kawarabayashi, T., Ikeda, M., Naito, M., Matsubara, E., Abe, K., & Nakazato, Y. (2002) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-002-0643-8 · Cited by 61 · see citing works
Emerich, D. F., & Walsh, T. J. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90170-4 · Cited by 60 · see citing works
Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet
Bernardo, A., McCord, M. C., Troen, A. M., Allison, J. D., & McDonald, M. P. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.035 · Cited by 60 · see citing works
Self-citationMcDonald, M. P., Willard, L. B., Wenk, G. L., & Crawley, J. N. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-05078.1998 · Cited by 60 · see citing works
Self-citationKurganov, B. I., Doh, M., & Arispe, N. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.01.001 · Cited by 59 · see citing works
Growth Factors and Gangliosides as Neuroprotective Agents in Excitotoxicity and Ischemia*
Hicks, D., Heidinger, V., Mohand‐Saïd, S., et al. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)00356-x · Cited by 54 · see citing works
Sweeney, W. A., Luedtke, J., McDonald, M. P., & Overmier, J. B. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3770 · Cited by 53 · see citing works
Self-citationTashima, Y., Oe, R., Lee, S., Sugihara, G., Chambers, E. J., Takahashi, M., & Yamada, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308622200 · Cited by 52 · see citing works
Intracerebroventricular Administration of GM1 Ganglioside to Presenile Alzheimer Patients
Augustinsson, L.-E., Blennow, K., Blomstrand, C., et al. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106597 · Cited by 51 · see citing works
Ganglioside GM1 attenuates scopolamine-induced amnesia in rats and mice
Silva, R. H., Felício, L. F., & Frussa‐Filho, R. (1999) · Psychopharmacology · doi:10.1007/s002130050814 · Cited by 50 · see citing works
Regional distribution of brain gangliosides in Alzheimer's disease.
Bognar, S. K., Kraĉun, I., Rösner, H., & Ćosović, Č. (1991) · PubMed · Cited by 49 · see citing works
GM1 Inhibits Amyloid β-Protein-Induced Cytokine Release
Ariga, T., & Yu, R. K. (1999) · Neurochemical Research · doi:10.1023/a:1022557920150 · Cited by 44 · see citing works
Self-citationMahadik, S. P., Vilim, F. S., Korenovsky, A., et al. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490200411 · Cited by 42 · see citing works
GM1 ganglioside improves spatial learning and memory of aged rats
Fong, T. G., Neff, N. H., & Hadjiconstantinou, M. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)87584-5 · Cited by 40 · see citing works
Motoneuron-disease-like disorder after ganglioside therapy
Scarlato, G., Nobile‐Orazio, E., Yuki, N., et al. (1991) · The Lancet · doi:10.1016/0140-6736(91)90453-v · Cited by 40 · see citing works
Motoneuron-disease-like disorder after ganglioside therapy
Yuki, N., Sato, S., Miyatake, T., et al. (1991) · The Lancet · doi:10.1016/0140-6736(91)91767-o · Cited by 40 · see citing works
Amyloid precursor protein truncated at any of the ?-secretase sites is not cleaved to ?-amyloid
Paganetti, P., Lis, M., Klafki, H.-W., & Staufenbiel, M. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19961101)46:3 · Cited by 39 · see citing works
McDonald, M. P., Wenk, G. L., & Crawley, J. N. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.3.552 · Cited by 37 · see citing works
Self-citationCharacterization of tumor-associated fucogangliosides from PC 12 pheochromocytoma cells.
Ariga, T., Kobayashi, K., Kuroda, Y., et al. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47916-1 · Cited by 36 · see citing works
Self-citationKnapp, P. E. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490300209 · Cited by 36 · see citing works
Ferrari, G. V. D., & La, G. (1996) · PubMed · Cited by 36 · see citing works
The Ganglioside GD3 as the Greek Goddess Hecate: Several Faces Turned Towards as Many Directions
Malisan, F., & Testi, R. (2005) · IUBMB Life · doi:10.1080/15216540500167179 · Cited by 31 · see citing works
Effect of Ganglioside (GM1) on Memory in Senescent Rats
Silva, R. H., Felício, L. F., Nasello, A. G., Vital, M. A. B. F., & Frussa‐Filho, R. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00065-6 · Cited by 30 · see citing works
Systemic treatments with GM1 ganglioside reduce quinolinic acid-induced striatal lesions in the rat
Lombardi, G., Zanoni, R., & Moroni, F. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90883-2 · Cited by 29 · see citing works
Flicker, C., Ferris, S. H., Kalkstein, D., et al. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.1.126 · Cited by 27 · see citing works
Reversal of β-Amyloid-Induced Retention Deficit after Exposure to Training and State Cues
McDonald, M. P., Overmier, J. B., Bandyopadhyay, S., et al. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0004 · Cited by 26 · see citing works
Self-citationWalsh, T. J., Emerich, D. F., & Schmechel, D. E. (1989) · Brain Research · doi:10.1016/0006-8993(89)91473-x · Cited by 25 · see citing works
Skaper, S. D., Leon, A., & Facci, L. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20463-3 · Cited by 25 · see citing works
Glasier, M. M., SUTTON, R. L., & Stein, D. G. (1995) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1995.0003 · Cited by 23 · see citing works
Induction of the ganglioside marker A2B5 on cultured cerebellar neural cells by growth factors
Drago, J., Reid, K., & Bartlett, P. F. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90825-2 · Cited by 22 · see citing works
Antibodies to GM1(NeuGc) in Guillain–Barré syndrome after ganglioside therapy
Odaka, M., Yuki, N., Nobile‐Orazio, E., et al. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00287-2 · Cited by 18 · see citing works
Mahadik, S. P., Hungund, B. L., Gokhale, V. S., et al. (1993) · Neurochemistry International · doi:10.1016/0197-0186(93)90094-l · Cited by 18 · see citing works
Glasier, M. M., Janis, L. S., GONCALVES, M., & Stein, D. G. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00304-7 · Cited by 12 · see citing works
Magoski, N. S., Walz, W., & Juurlink, B. H. J. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490330112 · Cited by 12 · see citing works
Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes
Zhu, M.-Y., Hasty, A. H., Harris, C. M., Linton, M. F., Fazio, S., & Swift, L. L. (2005) · Metabolism · doi:10.1016/j.metabol.2005.04.019 · Cited by 12 · see citing works
Santucci, A. C., Gluck, R., Kanof, P. D., et al. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107333 · Cited by 5 · see citing works
Roeser, C., Cassel, J., & Kelche, C. R. (1997) · Experimental Brain Research · doi:10.1007/pl00005722 · Cited by 3 · see citing works
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Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755 · see citing works
“Impairments in reference memory develop by 6 months and persist through the rest of the life of this model (Reiserer et al., 2007; Bernardo et al., 2009; O’leary and Brown, 2009).”
BackgroundEndogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks
Harrison, F. E., Hosseini, A. H., & McDonald, M. P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.015 · Cited by 399 · see citing works
Self-citationThe multi-tasked life of GM1 ganglioside, a true factotum of nature
Ledeen, R. W., & Wu, G. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.04.005 · Cited by 212 · see citing works
Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?
Whyte, L. S., Lau, A. A., Hemsley, K. M., Hopwood, J. J., & Sargeant, T. J. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13935 · Cited by 150 · see citing works
Li, W., Yu, J., Liu, Y., Huang, X., Abumaria, N., Zhu, Y., Huang, X., Xiong, W., Ren, C., Liu, X.-G., et al. (2014) · Molecular Brain · doi:10.1186/s13041-014-0065-y · Cited by 146 · see citing works
Implications of Glycosylation in Alzheimer’s Disease
Haukedal, H., & Freude, K. K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.625348 · Cited by 114 · see citing works
Yang, D.-S., Stavrides, P., Saito, M., Kumar, A., Rodriguez-Navarro, J. A., Pawlik, M., Huo, C., Walkley, S. U., Saito, M., Cuervo, A. M., et al. (2014) · Brain · doi:10.1093/brain/awu278 · Cited by 114 · see citing works
APP Function and Lipids: A Bidirectional Link
Grimm, M. O. W., Mett, J., Grimm, H. S., & Hartmann, T. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00063 · Cited by 104 · see citing works
Flanigan, T. J., Xue, Y., Kishan Rao, S., Dhanushkodi, A., & McDonald, M. P. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12133 · Cited by 104 · see citing works
Self-citationSiglec receptors and hiding plaques in Alzheimer's disease
Salminen, A., & Kaarniranta, K. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0472-1 · Cited by 73 · see citing works
Herzer, S., Hagan, C., von Gerichten, J., Dieterle, V., Munteanu, B., Sandhoff, R., Hopf, C., & Nordström, V. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00206 · Cited by 27 · see citing works
- Authors
- Bernardo, A., Harrison, F. E., McCord, M., Zhao, J., Bruchey, A., Davies, S. S., Jackson Roberts, L., Mathews, P. M., Matsuoka, Y., Ariga, T., Yu, R. K., Thompson, R., & McDonald, M. P.
- Affiliations
- Vanderbilt University (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Georgetown University (US)
- Augusta University (US)
- University of Tennessee Health Science Center (US)
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 30
- Issue
- 11
- Pages
- 1777-1791
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1974394119
- Cited by
- 127
- References
- 95
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 13 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 9
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG023597, R01AG022439, AG022455, AG023597, K01AG022455, AG-022439)
- National Institute of General Medical Sciences (GM 42056)
- National Institute of Neurological Disorders and Stroke (NS04520, R21NS043581)
- H2020 European Research Council
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Keywords
- GD3 synthase, ST8SIA1, gangliosides, amyloid-beta, amyloid plaques, Alzheimer's disease, memory impairment, amyloid fibril formation, neurodegeneration, astrocytes, neurons, therapeutic target
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Cells, Cultured, Cerebral Cortex, Disease Models, Animal, Humans, Gas Chromatography-Mass Spectrometry, Memory, Memory Disorders, Mice, Transgenic, Mutation, Neurons, Protein Binding, Sialyltransferases, Lipid Peroxidation, Amyloid beta-Protein Precursor, Maze Learning, CD11b Antigen, Mice, Presenilin-1, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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