The Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior
Open accessAbstract
In this review, we propose a broader view of the role of the fibroblast growth factor (FGF) family in modulating brain function. We suggest that some of the FGF ligands together with the FGF receptors are altered in individuals with affective disorder and modulate emotionality in animal models. Thus, we propose that members of the FGF family may be genetic predisposing factors for anxiety, depression, or substance abuse; that they play a key organizing role during early development but continue to play a central role in neuroplasticity in adulthood; and that they work not only over extended time frames, but also via rapid signaling mechanisms, allowing them to exert an "on-line" influence on behavior. Therefore, the FGF family appears to be a prototype of "switch genes" that are endowed with organizational and modulatory properties across the lifespan, and that may represent molecular candidates as biomarkers and treatment targets for affective and addictive disorders.
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FGF1 and FGF2 bind all four receptor subtypes to activate PLC-γ1 MAPK and AKT pathways.
“They can bind all four receptor subtypes in order to activate the phospholipase C-γ (PLC-γ1 MAPK and AKT pathways (Turner et al. 2006; Turner et al. 2012).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Turner et al. 2012
The Overview of the FGF Family (page unavailable) says FGF receptors signal primarily through PLCγ, MAPK, and AKT. The FGF Receptors section says many ligands activate one or more of four receptors, but does not say that FGF1 and FGF2 each bind all four. (LLM, conf=0.88)
Experimental — accuracy not yet measuredFGF1 and FGF2 are dysregulated in mood disorders.
“FGF1 and FGF2 are the most studied ligands of this family and have been shown to be dysregulated in mood disorders (Turner et al. 2006; Turner et al. 2012).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Turner et al. 2012
The review’s “Why Link the FGF System to Mood and Affect?” section reports that FGF1 and FGF2 were downregulated in brain regions of patients with major depressive disorder (page unavailable). Its “FGF System in Human Studies” section says the FGF family was not altered in the bipolar-disorder subjects studied, so the broader wording “mood disorders” needs qualification. (LLM, conf=0.84)
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Fgfr3 regulates development of the caudal telencephalon
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Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the rat
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Self-citationThe Genetics of Major Depression
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“, 1997]) and impaired corticosteroid receptor signaling (Holsboer, 2000), more recent hypotheses include the involvement of neurotrophins (Samuels and Hen, 2011), fibroblast growth factors (both ligands and receptors) (Turner et al., 2012), GABAergic deficits (Luscher et al.”
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Fibroblast Growth Factors in Depression
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- Authors
- Turner, C. A., Watson, S. J., & Akil, H.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Turner, Cortney A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 76
- Issue
- 1
- Pages
- 160-174
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3476848
- OpenAlex
- W2063710526
- Cited by
- 160
- References
- 159
- Citations by year
- 2026: 10 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 12 · 2017: 17 · 2016: 12 · 2015: 11 · 2014: 18 · 2013: 13 · 2012: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Hope for Depression Research Foundation
- University of Michigan
- National Institute of Mental Health (P50MH60398, P50MH060398, P01MH042251)
- National Institute on Drug Abuse (P01DA021633, T32DA007268, R01DA013386)
- National Center for Research Resources (UL1RR024986)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- fibroblast growth factor family, fibroblast growth factor receptor, mood disorders, anxiety, depression, substance abuse, emotionality, neuroplasticity, brain development, switch genes, biomarkers, treatment goals
- MeSH terms
- Animals, Brain, Fibroblast Growth Factors, Humans, Neurotransmitter Agents, Mood Disorders, Genetic Predisposition to Disease
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