Effects of intraduodenal injection of Lactobacillus brevis SBC8803 on autonomic neurotransmission and appetite in rodents
Abstract
Lactobacilli provide several health benefits to mammals, including humans. We previously observed that in rats, intraduodenal injection of Lactobacillus johnsonii La1 elevated efferent gastric vagal nerve activity (efferent-GVNA), while Lactobacillus paracasei ST11 suppressed efferent-GVNA, and thereby increased or decreased food intake. To determine the function of Lactobacillus brevis (SBC8803), its effect on food intake was examined by providing food containing heat-killed SBC8803 to mice. We observed that administration of SBC8803 elevated food intake. Because the afferent intestinal vagal nerve (IVN) is hypothesized to be involved in efferent-GVNA changes, we examined the effect of intraduodenal administration of heat-killed SBC8803 on efferent-GVNA and afferent-IVN activity (IVNA) in rats. In this study, we found that intraduodenal administration of heat-killed SBC8803 increased both efferent-GVNA and afferent-IVNA in rats. Moreover, IV administration of the serotonin 3 receptor antagonist granisetron eliminated the effects of SBC8803 on efferent-GVNA and afferent-IVNA. These findings suggest that heat-killed SBC8803 enhances appetite by elevating digestion and absorption abilities via changes in autonomic neurotransmission that might be mediated by the serotonin 3 receptor.
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Non-live Lactobacillus brevis SBC8803 in mice stimulated serotoninergic receptors in intestinal cells.
“Subsequent study has shown that the non-live Lactobacillus brevis SBC8803 in mice stimulated serotoninergic receptors located in the intestinal cells [127]”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [127]
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- Authors
- Horii, Y., Nakakita, Y., Fujisaki, Y., Yamamoto, S., Itoh, N., Miyazaki, K., Kaneda, H., Oishi, K., Shigyo, T., & Nagai, K.
- Affiliations
- ANBAS Corp. (Japan) (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- Sapporo Holdings (Japan) (JP)
- Corresponding author
- Horii, Yuko
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 539
- Pages
- 32-37
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2146135984
- Cited by
- 28
- References
- 11
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23617040)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- probiotics, intraduodenal administration, autonomic neurotransmission, appetite, dietary intake, granisetron, heat-killed bacteria, digestion and absorption
- MeSH terms
- Afferent Pathways, Animals, Appetite, Duodenum, Eating, Efferent Pathways, Intestines, Male, Mice, Inbred C3H, Synaptic Transmission, Serotonin Antagonists, Stomach, Vagus Nerve, Rats, Wistar, Granisetron, Mice, Rats, Levilactobacillus brevis
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