Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats.
Abstract
Previously, it was shown that milk fermented with lactic acid bacteria lowers blood pressure, suggesting that metabolites or components of the bacteria have hypotensive action. To examine whether one of lactobacilli, Lactobacillus johnsonii La1 (LJLa1), a probiotic strain adhesive onto intestinal epithelial cells, or its metabolite has hypotensive action, and if so the mechanism of action, we determined the effects of intraduodenal injection of LJLa1 on blood pressure (BP) and the activity of autonomic nerves in urethane-anesthetized rats. Intraduodenal injection of LJLa1 reduced renal sympathetic nerve activity (RSNA) and BP and enhanced gastric vagal nerve activity (GVNA). Pre-treatment with thioperamide, a histaminergic H3-receptor antagonist, eliminated the effects of LJLa1 on RSNA, GVNA, and BP. Furthermore, bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN), the master circadian oscillator, abolished the suppression of RSNA and BP and the elevation of GVNA caused by LJLa1. These findings suggest that LJLa1 or its metabolites might lower BP by changing autonomic neurotransmission via the central histaminergic nerves and the suprachiasmatic nucleus in rats.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Commensal bacteria can signal to local sensory neurons to alter their excitability state, which can last long after the bacteria have been removed.
“It has become apparent that commensal bacteria can signal to local sensory neurons to alter their excitability state, which itself can last long after the bacteria have been removed (Tanida et al., 2005)”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Tanida et al., 2005
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor
Arrang, J., Garbarg, M., & Schwartz, J. (1983) · Nature · doi:10.1038/302832a0 · Cited by 1,584 · see citing works
Seppo, L., Jauhiainen, T., Poussa, T. A., & Korpela, R. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.326 · Cited by 666 · see citing works
A detailed mapping of the histamine H3 receptor and its gene transcripts in rat brain
Pillot, C., Héron, A., Cochois, V., Tardivel‐Lacombe, J., Ligneau, X., Schwartz, J. C., & Arrang, J. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00135-5 · Cited by 340 · see citing works
Probiotics, infection and immunity
Macfarlane, G. T., & Cummings, J. H. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200210000-00008 · Cited by 185 · see citing works
Sipola, M., Finckenberg, P., Santisteban, J., Korpela, R., Vapaatalo, H., & Nurminen, M. L. (2001) · PubMed · Cited by 162 · see citing works
Chapter 8 Role of medulla oblongata in generation of sympathetic and vagal outflows
Guyenet, P. G., Koshiya, N., Huangfu, D., Baraban, S. C., Stornetta, R. L., & Li, Y. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61862-2 · Cited by 147 · see citing works
Nagai, K., Nagai, N., Shimizu, K., Chun, S.-J., Nakagawa, H., & Niijima, A. (1996) · Progress in Brain Research · doi:10.1016/s0079-6123(08)60413-6 · Cited by 135 · see citing works
Self-citationSubstance P in the nucleus of the solitary tract augments bronchopulmonary C fiber reflex output
Mutoh, T., Bonham, A. C., & Joad, J. P. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1215 · Cited by 102 · see citing works
Yamano, T., Iino, H., Takada, M., Blum, S., Rochat, F., & Fukushima, Y. (2006) · British Journal of Nutrition · doi:10.1079/bjn20051507 · Cited by 98 · see citing works
Self-citationIdentification of neural projections from the forebrain to the kidney, using the virus pseudorabies
Sly, D. J., Colvill, L., McKinley, M. J., & Oldfield, B. J. (1999) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(99)00031-4 · Cited by 97 · see citing works
Tanida, M., Niijima, A., Fukuda, Y., Sawai, H., Tsuruoka, N., Shen, J., Yamada, S., Kiso, Y., & Nagai, K. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00275.2004 · Cited by 70 · see citing works
Self-citationYamano, T., Niijima, A., Iimori, S., Tsuruoka, N., Kiso, Y., & Nagai, K. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02231-5 · Cited by 64 · see citing works
Self-citationEffects of l-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats
Niijima, A., Okui, T., Matsumura, Y., Yamano, T., Tsuruoka, N., Kiso, Y., & Nagai, K. (2002) · Autonomic Neuroscience · doi:10.1016/s1566-0702(02)00048-6 · Cited by 53 · see citing works
Self-citationJochem, J. (2000) · PubMed · Cited by 40 · see citing works
Effect of umami taste stimulations on vagal efferent activity in the rat
Niijima, A. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90131-3 · Cited by 30 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Gut microbiota in cardiovascular health and disease
Tang, W. H. W., Kitai, T., & Hazen, S. L. (2017) · Circulation Research · doi:10.1161/circresaha.117.309715 · Cited by 1,670 · see citing works
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503 · see citing works
The vagus nerve at the interface of the microbiota-gut-brain axis
Bonaz, B., Bazin, T., & Pellissier, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00049 · Cited by 1,397 · see citing works
Martin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.04.003 · Cited by 1,284 · see citing works
Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01796.x · Cited by 1,018 · see citing works
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works
Vagal pathways for microbiome-brain-gut axis communication
Forsythe, P., Bienenstock, J., & Kunze, W. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_5 · Cited by 576 · see citing works
Microbiome–microglia connections via the gut–brain axis
Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471 · see citing works
“Oral inoculation with the pathogen Campylobacter jejuni or intraduodenal injection of the probiotic strain Lactobacillus johnsonii are sufficient to induce activation of vagal sensory neurons innervating the GI tract, as well as neurons in the brainstem (Goehler et al., 2005; Tanida et al., 2005).”
BackgroundDysbiosis of gut microbiota and microbial metabolites in Parkinson's disease
Sun, M.-F., & Shen, Y.-Q. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.004 · Cited by 445 · see citing works
Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.058 · Cited by 429 · see citing works
Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12427 · Cited by 418 · see citing works
Gut Microbiota in Hypertension and Atherosclerosis: A Review
Verhaar, B. J. H., Prodan, A., Nieuwdorp, M., & Muller, M. (2020) · Nutrients · doi:10.3390/nu12102982 · Cited by 411 · see citing works
Beyond gut feelings: how the gut microbiota regulates blood pressure
Marques, F. Z., Mackay, C. R., & Kaye, D. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.120 · Cited by 400 · see citing works
Voices from within: gut microbes and the CNS
Forsythe, P., & Kunze, W. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1028-z · Cited by 336 · see citing works
The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works
Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling
Hamamah, S., Aghazarian, A., Nazaryan, A., Hajnal, A. S., & Covașă, M. (2022) · Biomedicines · doi:10.3390/biomedicines10020436 · Cited by 316 · see citing works
The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation
Rahman, M. M., Islam, F., Harun-Or-Rashid, M., Mamun, A. A., Rahaman, M. S., Islam, M. M., Meem, A. F. K., Sutradhar, P. R., Mitra, S., Mimi, A. A., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.903570 · Cited by 267 · see citing works
Communication of gut microbiota and brain via immune and neuroendocrine signaling
Kasarełło, K., Cudnoch‐Jędrzejewska, A., & Czarzasta, K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1118529 · Cited by 270 · see citing works
The role of the gut microbiota in dietary interventions for depression and anxiety
Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa016 · Cited by 229 · see citing works
Liang, D., Leung, R. K., Guan, W., & Au, W. W. (2018) · Gut Pathogens · doi:10.1186/s13099-018-0230-4 · Cited by 198 · see citing works
Longo, S., Rizza, S., & Federici, M. (2023) · Acta Diabetologica · doi:10.1007/s00592-023-02088-x · Cited by 202 · see citing works
The role of gut microbiota in pathogenesis of Alzheimer's disease
Bostancıklıoğlu, M. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14264 · Cited by 200 · see citing works
The Gut-Brain Axis, the Human Gut Microbiota and Their Integration in the Development of Obesity
Bliss, E., & Whiteside, E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00900 · Cited by 188 · see citing works
The Role of the Gut Microbiome in Diabetes and Obesity-Related Kidney Disease
Zaky, A. A., Glastras, S. J., Wong, M. Y. W., Pollock, C. A., & Saad, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179641 · Cited by 174 · see citing works
Choi, C. H., Jo, S. Y., Park, H. J., Chang, S. K., Byeon, J.-S., & Myung, S.-J. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318204593e · Cited by 144 · see citing works
“Probiotics also inhibit the release of adrenocorticotropic hormone and corticosterone,(40) and provoke behavioral alterations by releasing soluble factors.(41,42) Finally, dosing could have been sufficient to improve patient QOL, but inadequate to improve individual symptoms.”
BackgroundSuda, K., & Matsuda, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031172 · Cited by 147 · see citing works
On communication between gut microbes and the brain
Forsythe, P., Kunze, W. A., & Bienenstock, J. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283572ffa · Cited by 137 · see citing works
Antihypertensive Effects of Probiotics
Robles‐Vera, I., Toral, M., Romero, M., Jiménez, R., Sánchez, M., Pérez‐Vizcaíno, F., & Duarte, J. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0723-4 · Cited by 137 · see citing works
Impact of Gut Microbiota Composition on Onset and Progression of Chronic Non-Communicable Diseases
Noce, A., Marrone, G., Daniele, F. D., Ottaviani, E., Jones, G. W., Bernini, R., Romani, A., & Rovella, V. (2019) · Nutrients · doi:10.3390/nu11051073 · Cited by 158 · see citing works
Muralitharan, R. R., Jama, H. A., Xie, L., Peh, A., Snelson, M., & Marques, F. Z. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14473 · Cited by 131 · see citing works
How functional foods play critical roles in human health
Pang, G., Xie, J., Chen, Q., & Zhi-he, H. (2012) · Food Science and Human Wellness · doi:10.1016/j.fshw.2012.10.001 · Cited by 129 · see citing works
The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress
Bear, T., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2021) · Microorganisms · doi:10.3390/microorganisms9040723 · Cited by 132 · see citing works
Santisteban, M. M., Kim, S., Pepine, C. J., & Raizada, M. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.307709 · Cited by 126 · see citing works
Lai, K.-K., Lorca, G. L., & González, C. F. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02837-08 · Cited by 121 · see citing works
Fukushima, Y., Miyaguchi, S., Yamano, T., Kaburagi, T., Iino, H., Ushida, K., & Sato, K. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507764723 · Cited by 114 · see citing works
Self-citationKunugi, H. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13551 · Cited by 112 · see citing works
Microbiota associated with type 2 diabetes and its related complications
Zhang, Y., & Zhang, H. (2013) · Food Science and Human Wellness · doi:10.1016/j.fshw.2013.09.002 · Cited by 110 · see citing works
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
Winek, K., Dirnagl, U., & Meisel, A. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0475-x · Cited by 108 · see citing works
Tanida, M., Niijima, A., Shen, J., Nakamura, T., & Nagai, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.076 · Cited by 108 · see citing works
Self-citationWang, B., Mao, Y., Diorio, C. J., Wang, L., Huizinga, J. D., Bienenstock, J., & Kunze, W. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01384.x · Cited by 106 · see citing works
Onal, E. M., Afşar, B., Covic, A. C., Vaziri, N. D., & Kanbay, M. (2018) · Hypertension Research · doi:10.1038/s41440-018-0144-z · Cited by 106 · see citing works
Gut Microbiota Interaction with the Central Nervous System throughout Life
Ojeda, J., Ávila, A., & Vidal, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061299 · Cited by 107 · see citing works
Cole‐Jeffrey, C. T., Liu, M., Katovich, M. J., Raizada, M. K., & Shenoy, V. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000307 · Cited by 103 · see citing works
Wang, B., Mao, Y., Diorio, C. J., Pasyk, M., Wu, R., Bienenstock, J., & Kunze, W. (2010) · The FASEB Journal · doi:10.1096/fj.09-153841 · Cited by 98 · see citing works
Impact of Probiotics on Risk Factors for Cardiovascular Diseases. A Review
Ebel, B., Lemetais, G., Beney, L., Cachon, R., Sokol, H., Langella, P., & Gervais, P. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.579361 · Cited by 97 · see citing works
Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats.
Tanida, M., Shen, J., Horii, Y., Matsuda, M., Kihara, S., Funahashi, T., Shimomura, I., Sawai, H., Fukuda, Y., Matsuzawa, Y., et al. (2007) · PubMed · Cited by 96 · see citing works
Self-citationMa, X., Mao, Y., Wang, B., Huizinga, J. D., Bienenstock, J., & Kunze, W. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90511.2008 · Cited by 93 · see citing works
Tanida, M., Shen, J., Maeda, K., Horii, Y., Yamano, T., Fukushima, Y., & Nagai, K. (2008) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2008.04.003 · Cited by 93 · see citing works
Self-citationYamano, T., Tanida, M., Niijima, A., Maeda, K., Okumura, N., Fukushima, Y., & Nagai, K. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.038 · Cited by 92 · see citing works
Self-citationHord, N. G. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155402 · Cited by 89 · see citing works
Martin, C. R., & Mayer, E. A. (2017) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000461732 · Cited by 84 · see citing works
Wu, R., Pasyk, M., Wang, B., Forsythe, P., Bienenstock, J., Mao, Y., Sharma, P., Stanisz, A. M., & Kunze, W. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12072 · Cited by 84 · see citing works
Probiotics and blood pressure: current insights
Sudha, R., & Upadrasta, A. (2016) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s73246 · Cited by 83 · see citing works
Defensive responses: behaviour, the brain and the body
Tseng, Y.-T., Schaefke, B., Wei, P., & Wang, L. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00736-3 · Cited by 79 · see citing works
Zhang, Y., Guo, X. Q., Guo, J., He, Q., Li, H., Song, Y., & Zhang, H. (2014) · Scientific Reports · doi:10.1038/srep05654 · Cited by 68 · see citing works
Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.736814 · Cited by 61 · see citing works
Targeting DNA Methylation in the Adult Brain through Diet
Allison, J., Kaliszewska, A., Uceda, S., Reiriz, M., & Arias, N. (2021) · Nutrients · doi:10.3390/nu13113979 · Cited by 63 · see citing works
Pharmacomicrobiomics: Exploiting the Drug-Microbiota Interactions in Antihypertensive Treatment
Chen, H., Gong, J.-Y., Xing, K., Liu, M.-Z., Ren, H., & Luo, J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.742394 · Cited by 56 · see citing works
Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake
Hamamah, S., Amin, A., Al-Kassir, A. L., Chuang, J., & Covașă, M. (2023) · Nutrients · doi:10.3390/nu15153365 · Cited by 55 · see citing works
Disruptive physiology: olfaction and the microbiome–gut–brain axis
Bienenstock, J., Kunze, W., & Forsythe, P. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12348 · Cited by 52 · see citing works
Willing, B. P., & Kessel, A. G. V. (2010) · Livestock Science · doi:10.1016/j.livsci.2010.06.031 · Cited by 50 · see citing works
The microbiome and cognitive aging: a review of mechanisms
Komanduri, M., Gondalia, S. V., Scholey, A. B., & Stough, C. K. K. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05231-1 · Cited by 48 · see citing works
The Role and Mechanism of Intestinal Flora in Blood Pressure Regulation and Hypertension Development
Li, J., Yang, X., Zhou, X., & Cai, J. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8104 · Cited by 50 · see citing works
Gut Microbiota and Pathophysiology of Depressive Disorder
Kunugi, H. (2021) · Annals of Nutrition and Metabolism · doi:10.1159/000518274 · Cited by 48 · see citing works
Kong, C., Li, Z., Mao, Y., Chen, H., Hu, W., Han, B., & Wang, L. (2021) · Food & Function · doi:10.1039/d1fo01836a · Cited by 47 · see citing works
Sashihara, T., Nagata, M., Mori, T., Ikegami, S., Gotoh, M., Okubo, K., Uchida, M., & Itoh, H. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0490 · Cited by 46 · see citing works
Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases
Schiattarella, G. G., Sannino, A., Esposito, G., & Perrino, C. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.08.003 · Cited by 47 · see citing works
Bartley, A., Yang, T., Arocha, R., Malphurs, W. L., Larkin, R., Magee, K. L., Vickroy, T. W., & Zubcevic, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01593 · Cited by 44 · see citing works
Inflammatory Stress Effects on Health and Function After Spinal Cord Injury
Noller, C. M., Groah, S. L., & Nash, M. S. (2017) · Topics in Spinal Cord Injury Rehabilitation · doi:10.1310/sci2303-207 · Cited by 42 · see citing works
Munir, M. U., Ali, S. A., Chung, K. H. K., Käkinen, A., Javed, I., & Davis, T. P. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2422468 · Cited by 44 · see citing works
Mörkl, S., Narrath, M., Schlotmann, D., Sallmutter, M.-T., Putz, J., Lang, J., Brandstätter, A., Pilz, R., Lackner, H. K., Goswami, N., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2492377 · Cited by 40 · see citing works
Hesampour, F., Bernstein, C. N., & Ghia, J. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad211 · Cited by 37 · see citing works
Hua, H., Huang, C., Liu, H., Xu, X., Xu, X., Wu, Z., Liu, C., Wang, Y. Y., & Yang, C. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109272 · Cited by 35 · see citing works
Inflammatory Bowel Disease: Role of Vagus Nerve Stimulation
Fornaro, R., Actis, G. C., Caviglia, G. P., Pitoni, D., & Ribaldone, D. G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195690 · Cited by 38 · see citing works
Ohara, K., Fukuda, T., Ishida, Y., Takahashi, C., Ohya, R., Katayama, M., Uchida, K., Tominaga, M., & Nagai, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-16150-6 · Cited by 34 · see citing works
Self-citationPathophysiological Links Between Obesity and Dementia
Zhang, D. E. W., Tran, V., Vinh, A., Dinh, Q. N., Drummond, G. R., Sobey, C. G., Jelinic, M., & Silva, T. M. D. (2023) · NeuroMolecular Medicine · doi:10.1007/s12017-023-08746-1 · Cited by 33 · see citing works
Matsutomo, T. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8375 · Cited by 33 · see citing works
The gut-brain axis in Parkinson's disease
Bonaz, B. L. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2023.11.004 · Cited by 32 · see citing works
Swann, J. R., García‐Pérez, I., Braniste, V., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., Pettersson, S., & Holmes, E. C. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.05.040 · Cited by 31 · see citing works
Parekh, P. J., Nayi, V., Johnson, D. A., & Vinik, A. I. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00055 · Cited by 31 · see citing works
Acupuncture influences multiple diseases by regulating gut microbiota
Xu, H., Luo, Y., Li, Q., & Zhu, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1371543 · Cited by 31 · see citing works
Tanida, M., Niijima, A., Shen, J., Yamada, S., Sawai, H., Fukuda, Y., & Nagai, K. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623101006 · Cited by 30 · see citing works
Self-citationHorii, Y., Kaneda, H., Fujisaki, Y., Fuyuki, R., Nakakita, Y., Shigyo, T., & Nagai, K. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12435 · Cited by 29 · see citing works
Self-citationHorii, Y., Nakakita, Y., Fujisaki, Y., Yamamoto, S., Itoh, N., Miyazaki, K., Kaneda, H., Oishi, K., Shigyo, T., & Nagai, K. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.01.037 · Cited by 28 · see citing works
Self-citationThe Potential Effects of Radiation on the Gut-Brain Axis
Jones, C. B., Davis, C. M., & Sfanos, K. S. (2020) · Radiation Research · doi:10.1667/rr15493.1 · Cited by 27 · see citing works
Shen, J., Nakamura, H., Fujisaki, Y., Tanida, M., Horii, Y., Fuyuki, R., Takumi, H., Shiraishi, K., Kometani, T., & Nagai, K. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.05.067 · Cited by 28 · see citing works
Self-citationThe Role of Gut Microbiome in Irritable Bowel Syndrome: Implications for Clinical Therapeutics
Zhao, Y., Zhu, S., Dong, Y., Xie, T., Chai, Z., Gao, X., Dai, Y., & Wang, X. (2024) · Biomolecules · doi:10.3390/biom14121643 · Cited by 30 · see citing works
Tanida, M., Imanishi, K., Akashi, H., Kurata, Y., Chonan, O., Naito, E., Kunihiro, S., Kawai, M., Kato-Kataoka, A., & Shibamoto, T. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12141 · Cited by 27 · see citing works
Self-citationEffect of Lactic Acid Bacteria on Lipid Metabolism and Fat Synthesis in Mice Fed a High-fat Diet
Yonejima, Y., Ushida, K., & Yoshiro, M. O. R. I. (2013) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.32.51 · Cited by 27 · see citing works
Mörkl, S., Butler, M., & Wagner‐Skacel, J. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100607 · Cited by 26 · see citing works
Lactobacillus rhamnosus strain JB ‐1 reverses restraint stress‐induced gut dysmotility
West, C. L., Wu, R., Wong, A., Stanisz, A. M., Yan, R., Min, K. K. H., Pasyk, M., Neufeld, K. M., Karamat, M. I., Foster, J. A., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12903 · Cited by 26 · see citing works
Changes of gut microbiota in patients at different phases of stroke
Cui, W., Xu, L., Huang, L., Tian, Y., Yang, Y., Li, Y., & Yu, Q. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14271 · Cited by 25 · see citing works
The Gut Microbiota–Brain Axis Expands Neurologic Function: A Nervous Rapport
Bauer, K. C., Rees, T., & Finlay, B. B. (2019) · BioEssays · doi:10.1002/bies.201800268 · Cited by 25 · see citing works
Vagal Sensory Gut–Brain Pathways That Control Eating—Satiety and Beyond
Méndez‐Hernández, R., Braga, I., Bali, A. P., Yang, M., & de Lartigue, G. (2025) · Comprehensive physiology · doi:10.1002/cph4.70010 · Cited by 21 · see citing works
Ушакова, Г. А., Fedkiv, O., Prykhodko, O., Pierzynowski, S. G., & Kruszewska, D. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.06.010 · Cited by 24 · see citing works
Altered physiology of gastrointestinal vagal afferents following neurotrauma
Blanke, E. N., Holmes, G. M., & Besecker, E. M. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.290883 · Cited by 23 · see citing works
Potential Therapeutic Effects of Short-Chain Fatty Acids on Chronic Pain
Tang, Y., Du, J., Wu, H., Wang, M., Liu, S., & Tao, F. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220927092016 · Cited by 26 · see citing works
Ejtahed, H., Ardeshirlarijani, E., Tabatabaei‐Malazy, O., Tavassol, Z. H., Hasani‐Ranjbar, S., Soroush, A., & Larijani, B. A. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00525-0 · Cited by 23 · see citing works
- Authors
- Tanida, M., Yamano, T., Maeda, K., Okumura, N., Fukushima, Y., & Nagai, K.
- Affiliations
- Institute for Protein Research, The University of Osaka (JP)
- Corresponding author
- Nagai, Katsuya
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 389
- Issue
- 2
- Pages
- 109-114
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2002714430
- Cited by
- 159
- References
- 18
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 12 · 2017: 11 · 2016: 7 · 2015: 3 · 2014: 8 · 2013: 10 · 2012: 7
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- probiotics, renal sympathetic nerve activity, blood pressure, histamine H3 receptor, thioperamide, suprachiasmatic nucleus, circadian rhythm, autonomic neurotransmission, gut-brain axis, antihypertensive effect
- MeSH terms
- Adrenergic Fibers, Animals, Blood Pressure, Denervation, Duodenum, Histamine, Histamine Antagonists, Kidney, Lactobacillus, Male, Neural Pathways, Reaction Time, Suprachiasmatic Nucleus, Urethane, Vagus Nerve, Yogurt, Rats, Wistar, Receptors, Histamine H3, Anesthetics, Intravenous, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
