Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease
Open accessAbstract
Administering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The combination of these phospholipid precursors has also been shown to partially restore dopaminergic neurotransmission in the 6-OHDA model of Parkinson's disease in rats.
“The combination of these phospholipid precursors has also shown to partially restore dopaminergic neurotransmission in the 6-OHDA model of PD in rats (Cansev et al., 2008).”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Cansev et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. A., & SEITELBERGER, F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90175-5 · Cited by 2,650 · see citing works
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb11000.x · Cited by 1,926 · see citing works
THE FUNCTION OF CYTIDINE COENZYMES IN THE BIOSYNTHESIS OF PHOSPHOLIPIDES
Kennedy, E. P., & Weiss, S. B. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50785-2 · Cited by 1,825 · see citing works
Kirik, D., Rosenblad, C., & Björklund, A. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6848 · Cited by 663 · see citing works
Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization
Hefti, F. F., Melamed, E., & Wurtman, R. J. (1980) · Brain Research · doi:10.1016/0006-8993(80)90871-9 · Cited by 502 · see citing works
Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3
Darios, F. D., & Davletov, B. A. (2006) · Nature · doi:10.1038/nature04598 · Cited by 352 · see citing works
Bousquet, M., Saint‐Pierre, M., Julien, C., Salem, N., Cicchetti, F., & Calon, F. (2007) · The FASEB Journal · doi:10.1096/fj.07-9677com · Cited by 232 · see citing works
Sakamoto, T., Cansev, M., & Wurtman, R. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.089 · Cited by 188 · see citing works
Wurtman, R. J., Ulus, I. H., Cansev, M., Watkins, C. J., Wang, L., & Marzloff, G. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.019 · Cited by 169 · see citing works
The synapsins: beyond the regulation of neurotransmitter release
Ferreira, A., & Rapoport, M. I. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8451-5 · Cited by 153 · see citing works
Choline Administration: Activation of Tyrosine Hydroxylase in Dopaminergic Neurons of Rat Brain
Ulus, İ. H., & Wurtman, R. J. (1976) · Science · doi:10.1126/science.10629 · Cited by 135 · see citing works
DeGeorge, J. J., Nariai, T., Yamazaki, S., Williams, W. M., & Rapoport, S. I. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02603.x · Cited by 116 · see citing works
Uridine enhances neurite outgrowth in nerve growth factor-differentiated pheochromocytoma cells
Pooler, A. M., Guez, D. H., Benedictus, R., & Wurtman, R. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.050 · Cited by 110 · see citing works
Cansev, M., & Wurtman, R. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.016 · Cited by 95 · see citing works
Choline Administration Elevates Brain Phosphorylcholine Concentrations
Millington, W. R., & Wurtman, R. J. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb06658.x · Cited by 89 · see citing works
Oral uridine-5′-monophosphate (UMP) increases brain CDP-choline levels in gerbils
Cansev, M., Watkins, C. J., van der Beek, E. M., & Wurtman, R. J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.054 · Cited by 65 · see citing works
Phospholipid biosynthetic enzymes in human brain
Ross, B. M., Moszczyńska, A., Blusztajn, J. K., Sherwin, A. L., Lozano, A. M., & Kish, S. J. (1997) · Lipids · doi:10.1007/s11745-997-0044-x · Cited by 64 · see citing works
Wang, L., Pooler, A. M., Albrecht, M. A., & Wurtman, R. J. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:27:1:137 · Cited by 57 · see citing works
Choline and Its Products Acetylcholine and Phosphatidylcholine
Wurtman, R., Cansev, M., & Ulus, I. (2009) · Springer eBooks · doi:10.1007/978-0-387-30378-9_18 · Cited by 53 · see citing works
OLDS, M. E., Jacques, D., & Kopyov, O. V. (2006) · Synapse · doi:10.1002/syn.20270 · Cited by 26 · see citing works
Involvement of Uridine-Nucleotide-Stimulated P2Y Receptors in Neuronal Growth and Function
Cansev, M. (2007) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152407783220814 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bazan, N. G., Molina, M. F., & Gordon, W. C. (2011) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104635 · Cited by 441 · see citing works
Gubert, C., Kong, G., Renoir, T., & Hannan, A. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104621 · Cited by 372 · see citing works
The emerging role of nutrition in Parkinson's disease
Seidl, S. E., Santiago, J. A., Bilyk, H. T., & Potashkin, J. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00036 · Cited by 209 · see citing works
The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies
Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.042 · Cited by 203 · see citing works
“The combination of these phospholipid precursors has also shown to partially restore dopaminergic neurotransmission in the 6-OHDA model of PD in rats (Cansev et al., 2008).”
BackgroundDiet in Parkinson’s Disease: Critical Role for the Microbiome
Jackson, A., Forsyth, C. B., Shaikh, M., Voigt, R. M., Engen, P. A., Ramirez, V., & Keshavarzian, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01245 · Cited by 145 · see citing works
The Promise of Neuroprotective Agents in Parkinson?s Disease
Seidl, S. E., & Potashkin, J. A. (2011) · Frontiers in Neurology · doi:10.3389/fneur.2011.00068 · Cited by 141 · see citing works
Healy-Stoffel, M., & Levant, B. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666180412153612 · Cited by 133 · see citing works
Use of Phosphatide Precursors to Promote Synaptogenesis
Wurtman, R. J., Cansev, M., Sakamoto, T., & Ulus, İ. H. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141059 · Cited by 130 · see citing works
Gut-brain and brain-gut axis in Parkinson’s disease models: effects of a uridine and fish oil diet
Perez-Pardo, P., Dodiya, H. B., Broersen, L. M., Douna, H., van Wijk, N., Lopes da Silva, S., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1294555 · Cited by 111 · see citing works
van Wijk, N., Broersen, L. M., de Wilde, M. C., Hageman, R. J. J., Groenendijk, M., Sijben, J. W. C., & Kamphuis, P. J. G. H. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130998 · Cited by 128 · see citing works
Impact of omega-3 fatty acids in Parkinson's disease
Bousquet, M., Calon, F., & Cicchetti, F. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.03.001 · Cited by 120 · see citing works
Omega-3 fatty acids in neurodegenerative diseases: Focus on mitochondria
Eckert, G. P., Lipka, U., & Muller, W. E. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.05.006 · Cited by 109 · see citing works
Uridine Function in the Central Nervous System
Dobolyi, Á., Juhász, G. D., Kovács, Z., & Kardos, J. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611795347618 · Cited by 102 · see citing works
Metabolic Network of Nucleosides in the Brain
Ipata, P. L., Camici, M., Micheli, V., & Tozzi, M. G. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611795347555 · Cited by 87 · see citing works
Perez-Pardo, P., de Jong, E. M., Broersen, L. M., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00057 · Cited by 74 · see citing works
Potential Treatment of Parkinson’s Disease with Omega-3 Polyunsaturated Fatty Acids
Li, P., & Song, C. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1735143 · Cited by 74 · see citing works
Akt as a Victim, Villain and Potential Hero in Parkinson’s Disease Pathophysiology and Treatment
Greene, L. A., Levy, O., & Malagelada, C. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9671-8 · Cited by 68 · see citing works
Wurtman, R. J., Cansev, M., Sakamoto, T., & Ulus, I. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00344.x · Cited by 66 · see citing works
Delattre, A. M., Kiss, Á., Szawka, R. E., Anselmo-Franci, J. A., Bagatini, P. B., Xavier, L. L., Rigon, P., Achaval, M., Iagher, F., de David, C., et al. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.11.006 · Cited by 63 · see citing works
Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease
Alfonsetti, M., Castelli, V., & d’Angelo, M. (2022) · Nutrients · doi:10.3390/nu14020380 · Cited by 60 · see citing works
Cardoso, H. D., Santos Junior, E. F. D., de Santana, D. F., Gonçalves-Pimentel, C., Angelim, M. K., Isaac, A. R., Lagranha, C. J., Guedes, R. C. A., Beltrão, E. I., Morya, E., et al. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.12.023 · Cited by 55 · see citing works
The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson’s disease
Özsoy, Ö., Seval, Y., Hacıoğlu, G., Yargıçoğlu, P., Demir, R., Ağar, A., & Aslan, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.06.012 · Cited by 53 · see citing works
Rationale and clinical data supporting nutritional intervention in Alzheimer’s disease
Engelborghs, S., Gilles, C., Ivanoiu, A., & Vandewoude, M. F. J. (2014) · Acta Clinica Belgica · doi:10.1179/0001551213z.0000000006 · Cited by 52 · see citing works
McCarty, M. F., & Lerner, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103624 · Cited by 51 · see citing works
Hacıoğlu, G., Seval, Y., Tanrιöver, G., Özsoy, Ö., Saka, E., Balkan, S., & Ağar, A. (2012) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.2012.0032 · Cited by 48 · see citing works
Chitre, N. M., Wood, B. J., Ray, A., Moniri, N. H., & Murnane, K. S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107976 · Cited by 45 · see citing works
A specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats
Cansev, M., van Wijk, N., Türkyılmaz, M., Orhan, F., Sijben, J., & Broersen, L. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.021 · Cited by 40 · see citing works
Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease
Perez‐Pardo, P., Broersen, L. M., Kliest, T., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00237 · Cited by 40 · see citing works
Aslan, E., Kocaelı, H., Bekâr, A., Tolunay, Ş., & Ulus, İ. H. (2011) · Neurological Research · doi:10.1179/1743132811y.0000000004 · Cited by 38 · see citing works
Barros, A. S., Crispim, R. Y. G., Cavalcanti, J. U., Souza, R. B., Lemos, J. C., Filho, G. C., Bezerra, M. M., Pinheiro, T. F. M., Vasconcelos, S. M. M., Macêdo, D. S., et al. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12713 · Cited by 34 · see citing works
Omega‐3 polyunsaturated fatty acids and Parkinson's disease: A systematic review of animal studies
Alves, B. D. S., Schimith, L. E., da Cunha, A. B., Dora, C. L., & Hort, M. A. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16154 · Cited by 33 · see citing works
Kovács, Z., Dobolyi, Á., Kékesi, K. A., & Juhász, G. D. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320340003 · Cited by 32 · see citing works
Lee, H. J., Han, J., Jang, Y., Kim, S., Park, J. H., Seo, K. S., Jeong, S., Shin, S., Lim, K., Heo, J. Y., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.12.085 · Cited by 31 · see citing works
Neuroprotective effects of uridine in a rat model of neonatal hypoxic–ischemic encephalopathy
Cansev, M., Minbay, Z., Gören, B., Yaylagül, E. Ö., Çetınkaya, M., Köksal, N., & ALKAN, T. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.02.035 · Cited by 29 · see citing works
Cardoso, H. D., Passos, P. P., Lagranha, C. J., Ferraz, A. C., dos Santos, E. F., Oliveira, R. F. S., Oliveira, P. E. L., Santos, R. D. C. F., de Santana, D. F., Borba, J. M. C., et al. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00249 · Cited by 29 · see citing works
Liu, Y., Deng, Z., Geng, L., Wang, J., & Zhang, Q. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-018-1713-x · Cited by 28 · see citing works
A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity
Roosild, T. P., Castronovo, S., Villoso, A., Ziemba, A. J., & Pizzorno, G. (2011) · Journal of Structural Biology · doi:10.1016/j.jsb.2011.08.002 · Cited by 27 · see citing works
Kundu, D., & Dubey, V. K. (2020) · Current Protein and Peptide Science · doi:10.2174/1389203721999201208200605 · Cited by 23 · see citing works
Serrano‐García, N., Fernández‐Valverde, F., Luis‐García, E. R., Granados-Rojas, L., Juárez-Zepeda, T. E., Orozco-Suárez, S. A., Pedraza‐Chaverrí, J., Orozco‐Ibarra, M., & Jiménez‐Anguiano, A. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.10.015 · Cited by 23 · see citing works
Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease
Yoo, D., Lim, Y., Son, Y., Rho, H., Shin, C., & Ahn, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-92029-x · Cited by 22 · see citing works
Özsoy, Ö., Tanrιöver, G., Derin, N., Uysal, N., Demır, N., Gemici, B., Kencebay, C., Yargıçoğlu, P., Ağar, A., & Aslan, M. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9238-y · Cited by 22 · see citing works
Regenerative effects of peptide nanofibers in an experimental model of Parkinson’s disease
Sever, M., Türkyılmaz, M., Koç, C., Çakır, A., Öcalan, B., Cansev, M., Guler, M. O., & Tekinay, A. B. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.09.011 · Cited by 22 · see citing works
Lipid Classes and Fatty Acid Patterns are Altered in the Brain of γ‐Synuclein Null Mutant Mice
Guschina, I. A., Millership, S. J., O’Donnell, V. B., Ninkina, N. N., Harwood, J. L., & Buchman, V. L. (2010) · Lipids · doi:10.1007/s11745-010-3486-0 · Cited by 21 · see citing works
Active Site Conformational Dynamics in Human Uridine Phosphorylase 1
Roosild, T. P., & Castronovo, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012741 · Cited by 20 · see citing works
Fari, R. E., Abbaoui, A., Bourziq, A., Zroudi, M., Draoui, A., Khiat, A. E., Belkouch, M., Elgot, A., & Gamrani, H. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.101686 · Cited by 19 · see citing works
Lu, Y., Gao, X., Mohammed, S. A. D., Wang, T., Fu, J., Yang, N., Yang, N., Liu, S., & Liu, S. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117182 · Cited by 19 · see citing works
Synaptogenesis: Modulation by Availability of Membrane Phospholipid Precursors
Cansev, M. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8414-x · Cited by 17 · see citing works
Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice
Amante, D. J., Kim, J.-H., Carreiro, S. T., Cooper, A. C., Jones, S. W., Li, T., Moody, J. P., Edgerly, C. K., Bordiuk, O. L., Cormier, K., et al. (2010) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482968.2010.491867 · Cited by 17 · see citing works
Passos, P. P., Borba, J. M. C., Rocha-de-Melo, A. P., Guedes, R. C. A., da Silva, R. P., Filho, W. T. M., Gouveia, K. M. M., Navarro, D. M. D. A. F., Santos, G. K. N., Borner, R., et al. (2012) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.05.003 · Cited by 16 · see citing works
Parkinson’s Disease: Is there a Role for Dietary and Herbal Supplements?
Onaolapo, O. J., Odeniyi, A. O., & Onaolapo, A. Y. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210218082954 · Cited by 15 · see citing works
Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice
Wu, R. T., Zhong, S., Ni, M., Zhu, X., Chen, Y., Chen, X., Zhang, L., & Chen, J. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/8617143 · Cited by 12 · see citing works
A Diet for Dopaminergic Neurons?
Giovanni, G. D. (2009) · Springer eBooks · doi:10.1007/978-3-211-92660-4_27 · Cited by 12 · see citing works
Exercise and Nutritional Benefits in PD: Rodent Models and Clinical Settings
Archer, T., & Kostrzewa, R. M. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_409 · Cited by 11 · see citing works
Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview
Yenisetti, S. V., & Yenisetti, S. C. (2017) · Journal of Aging Science · doi:10.4172/2329-8847.1000177 · Cited by 8 · see citing works
Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy
Kovács, Z., & Dobolyi, Á. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3903-5_29 · Cited by 9 · see citing works
Uridine Prevents Negative Effects of OXPHOS Xenobiotics on Dopaminergic Neuronal Differentiation
Iglesias, E., Bayona‐Bafaluy, M. P., Pesini, A., Garrido-Pérez, N., Meade, P., Gaudó, P., Jiménez-Salvador, I., Montoya, J., & Ruiz‐Pesini, E. (2019) · Cells · doi:10.3390/cells8111407 · Cited by 9 · see citing works
Cifelli, J. L., Berg, K. R., & Yang, J. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12788 · Cited by 8 · see citing works
Chang, E. H., Carreiro, S. T., Frattini, S. A., & Huerta, P. T. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0022-2 · Cited by 7 · see citing works
Zhu, G., Xu, C., Jiang, S., Zhang, Z., & Wang, W. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101671 · Cited by 6 · see citing works
Sijben, J., de Wilde, M. C., Wieggers, R. L., Groenendijk, M., & Kamphuis, P. J. G. H. (2011) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2011.0410 · Cited by 5 · see citing works
Ovarian Hormone-Dependent Effects of Dietary Lipids on APP/PS1 Mouse Brain
Herrera, J. L., Ordóñez‐Gutiérrez, L., Fabriàs, G., Casas, J., Morales, A., Hernández, G., Acosta, N. G., Rodríguez, C., Prieto, L., García‐Segura, L. M., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00346 · Cited by 5 · see citing works
Gut Microbes in Parkinson's Disease
Markidi, A., Elford, J. D., Berkers, C. R., Kraneveld, A. D., & Perez‐Pardo, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00002-3 · Cited by 4 · see citing works
Singh, H., Thakur, S., Sahajpal, N., Singh, H., Singh, A., Sohal, H. S., & Jain, S. K. (2020) · Current Drug Delivery · doi:10.2174/1567201817666200512103402 · Cited by 4 · see citing works
Aydin, B., & Cansev, M. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00788-5 · Cited by 3 · see citing works
Hudson, B. T., Dubrof, S. T., Settles, S. E., Park, H. J., & Filipov, N. M. (2024) · Nutritional Neuroscience · doi:10.1080/1028415x.2024.2344138 · Cited by 3 · see citing works
Cansev, M., & Ulus, İ. H. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_32 · Cited by 3 · see citing works
Effects of citicoline administration on synaptic proteins in rapid eye movement sleep-deprived rats.
Çakır, A., Öcalan, B., Koç, C., Süyen, G. G., Cansev, M., & Kahveci, N. (2022) · PubMed Central · doi:10.22038/ijbms.2022.60756 · Cited by 2 · see citing works
Omega-3 polyunsaturated fatty acids and its use in Parkinson's disease
Ramírez-Higuera, A., Peña-Montes, C., Barroso-Hernández, A., López‐Franco, Ó., & Oliart‐Ros, R. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90052-2.00016-0 · Cited by 2 · see citing works
Functional foods and Parkinson's disease: A focus on omega-3 fatty acids
Li, P., & Song, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91747-6.00007-x · Cited by 2 · see citing works
Yaylagül, E. Ö., Cansev, M., & Kasimogullari, S. C. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.05.002 · Cited by 2 · see citing works
Status and Potential Therapeutic Importance of n–3 Fatty Acids in Neurodegenerative Disease
Farooqui, A. A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0543-7_7 · Cited by 1 · see citing works
Omega-3 fatty acids and brain function
Smollich, M. (2015) · Cited by 1 · see citing works
Gül, Z., Duyu, G., Altınbaş, B., & Buyukuysal, R. L. (2020) · Experimental Brain Research · doi:10.1007/s00221-020-05912-w · Cited by 1 · see citing works
Omega‐3, 6 and 9 Fatty Acids, Inflammation and Neurodegenerative Diseases
Song, C. (2010) · doi:10.1002/9781444323351.ch19 · Cited by 1 · see citing works
Cipollina, C., & Schopfer, F. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411462-3.00034-5
Substantia Nigra Modulation by Essential Fatty Acids
Andrade‐da‐Costa, B. L. D. S., Passos, P. P., Cardoso, H. D., Gonçalves‐Pimentel, C., dos Santos, E. F., Borba, J. M. C., & Guedes, R. C. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410527-0.00020-x
Influence of Dietary Constituents on Motor and Non-motor Symptoms in Parkinson’s Disease
Löhle, M., & Reichmann, H. (2014) · Neuropsychiatric symptoms of neurological disease · doi:10.1007/978-3-319-09537-0_5
Metagenomic analysis of gut microbiota in Parkinson's disease patients from Central ChinaPreprint
Zhang, F., Zhao, Q., Fang, X., Xu, M., Tang, J., Zhang, Y., Gao, P. T., Sun, X., Sang, M., & Wang, P. (2020) · doi:10.21203/rs.2.21271/v2
Koçancı, F. G. (2021) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.202000341
Metagenomic analysis of gut microbiota in Parkinson's disease patients from Central ChinaPreprint
Zhang, F., Zhao, Q., Fang, X., Xu, M.-L., Tang, J., Zhang, Y., Gao, P., Sun, X., Sang, M., & Wang, P. (2020) · doi:10.21203/rs.2.21271/v1
- Authors
- Cansev, M., Ulus, I. H., Wang, L., Maher, T. J., & Wurtman, R. J.
- Affiliations
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Massachusetts Institute of Technology (US)
- Massachusetts College of Pharmacy and Health Sciences (US)
- Corresponding author
- Wurtman, Richard J.
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 62
- Issue
- 3
- Pages
- 206-209
- ISSN
- 0168-0102 (ISSN-L)
- PMC
- PMC2592845
- OpenAlex
- W2102907388
- Cited by
- 81
- References
- 21
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 10 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 5
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Bursa Uludag University - AVESIS (submittedVersion)
- Funders
- Türkiye Bilimler Akademisi
- National Institutes of Health
- National Institute of Mental Health (R37MH028783, MH 28783, R01MH028783)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- uridine 5'-monophosphate, docosahexaenoic acid, Parkinson's disease, 6-hydroxydopamine lesion, striatal dopaminergic neurons, rotational behavior, tyrosine hydroxylase, synapsin-1, dopamine signaling, synaptic proteins, dendritic spines, neuroprotection
- MeSH terms
- Central Nervous System Stimulants, Animals, Corpus Striatum, Dextroamphetamine, Docosahexaenoic Acids, Dopamine, Injections, Functional Laterality, Male, Parkinson Disease, Secondary, Stereotyped Behavior, Sympatholytics, Tyrosine 3-Monooxygenase, Uridine, Oxidopamine, Neostriatum, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
