The DOI matches its Crossref record; 293 of the 293 references it cites were found in a registry or an index.
N-3 (Omega-3) Fatty Acids: Effects on Brain Dopamine Systems and Potential Role in the Etiology and Treatment of Neuropsychiatric Disorders
Open accessAbstract
BACKGROUND & OBJECTIVE: A number of neuropsychiatric disorders, including Parkinson's disease, schizophrenia, attention deficit hyperactivity disorder, and, to some extent, depression, involve dysregulation of the brain dopamine systems. The etiology of these diseases is multifactorial, involving genetic and environmental factors. Evidence suggests that inadequate levels of n-3 (omega- 3) polyunsaturated fatty acids (PUFA) in the brain may represent a risk factor for these disorders. These fatty acids, which are derived from the diet, are a major component of neuronal membranes and are of particular importance in brain development and function. Low levels of n-3 PUFAs in the brain affect the brain dopamine systems and, when combined with appropriate genetic and other factors, increase the risk of developing these disorders and/or the severity of the disease. This article reviews the neurobiology of n-3 PUFAs and their effects on dopaminergic function. CONCLUSION: Clinical studies supporting their role in the etiologies of diseases involving the brain dopamine systems and the potential of n-3 PUFAs in the treatment of these disorders are discussed.
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“In addition to their neuroprotective effects, ω3 (especially DHA) may modulate the brain’s dopamine systems through different mechanisms [461].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [461]
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Metadata
- Authors
- Healy-Stoffel, M., & Levant, B.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Kansas Medical Center (US)
- Corresponding author
- Levant, Beth
- ORCID
- Levant, Beth
- Venue
- CNS & Neurological Disorders - Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2018-06-19
- Volume
- 17
- Issue
- 3
- Pages
- 216-232
- ISSN
- 1568-007X (ISSN-L)
- 1871-5273
- PMC
- PMC6563911
- OpenAlex
- W2797781833
- Cited by
- 133
- References
- 293
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 21 · 2023: 11 · 2022: 18 · 2021: 20 · 2020: 19 · 2019: 10
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- CNS & Neurological Disorders - Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (P20GM103418)
- National Institute of Neurological Disorders and Stroke (R21NS067422)
- National Center for Research Resources (P20RR016475)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD002528)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- omega-3 fatty acids, omega-3 polyunsaturated fatty acids, neuropsychiatric disorders, Parkinson's disease, schizophrenia, attention deficit hyperactivity disorder, depression, dopaminergic activity, dietary fatty acids, etiology
- MeSH terms
- Animals, Mental Disorders, Brain, Dopamine, Humans, Fatty Acids, Omega-3
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