Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer’s, and other neurodegenerative diseases

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works

The importance of the ratio of omega-6/omega-3 essential fatty acids

Simopoulos, A. P. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00253-6 · Cited by 4,166 · see citing works

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

Simopoulos, A. P. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-311 · Cited by 2,934 · see citing works

Complement factor H polymorphism and age-related macular degeneration

Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449 · see citing works

Complement factor H variant increases the risk of age-related macular degeneration

Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works

Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases

Simopoulos, A. P. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719248 · Cited by 2,014 · see citing works

A common haplotype in the complement regulatory gene factor H ( <i>HF1/CFH</i> ) predisposes individuals to age-related macular degeneration

Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961 · see citing works

Aβ Oligomers – a decade of discovery

Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938 · see citing works

Resolvins

Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works

Inflammation in neurodegenerative diseases

Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355 · see citing works

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Nicklas, W. J., Vyas, I. L., & Heikkila, R. E. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90146-8 · Cited by 1,266 · see citing works

Corneal nerves: structure, contents and function

Müller, L., Marfurt, C. F., Kruse, F. E., & Tervo, T. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00050-2 · Cited by 1,227 · see citing works

Resolvin E1 and protectin D1 activate inflammation-resolution programmes

Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works

Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: Nutritional implications for chronic diseases

Simopoulos, A. P. (2006) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2006.07.080 · Cited by 1,143 · see citing works

Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

The AMD Genetics Clinical Study Group, Gold, B., Merriam, J. E., Zernant, J., Hancox, L. S., Taiber, A. J., Gehrs, K., Cramer, K., Neel, J., Bergeron, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1750 · Cited by 1,075 · see citing works

Chemistry and metabolism of lipids in the vertebrate retina

Fliesler, A. J., & Anderson, R. E. (1983) · Progress in Lipid Research · doi:10.1016/0163-7827(83)90004-8 · Cited by 1,052 · see citing works

Resolution Phase of Inflammation: Novel Endogenous Anti-Inflammatory and Proresolving Lipid Mediators and Pathways

Serhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 997 · see citing works

Mechanisms of action of docosahexaenoic acid in the nervous system

Salem, N., Litman, B., Kim, H., & Gawrisch, K. (2001) · Lipids · doi:10.1007/s11745-001-0805-6 · Cited by 919 · see citing works

Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease11Reprint requests to: Linda Lewis, 575 Anton Blvd, Suite 900, Costa Mesa, CA 92626.

Sall, K. N., Stevenson, D., Mundorf, T. K., & Reis, B. L. (2000) · Ophthalmology · doi:10.1016/s0161-6420(99)00176-1 · Cited by 911 · see citing works

The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina

SanGiovanni, J. P., & Chew, E. Y. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.06.002 · Cited by 882 · see citing works

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

Lukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 873 · see citing works

The Genetics of Alzheimer Disease: Back to the Future

Bertram, L., Lill, C. M., & Tanzi, R. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.013 · Cited by 834 · see citing works

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression

Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802 · see citing works

Age-related macular degeneration

de Jong, P. T. V. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062326 · Cited by 787 · see citing works

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial

Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764 · see citing works

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753 · see citing works

ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial

Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751 · see citing works

Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain

de Urquiza, A. M., Liu, S., Sjöberg, M., Zetterström, R. H., Griffiths, W. J., Sjövall, J., & Perlmann, T. (2000) · Science · doi:10.1126/science.290.5499.2140 · Cited by 745 · see citing works

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4225-04.2005 · Cited by 687 · see citing works

Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis

Connor, K. M., SanGiovanni, J. P., Löfqvist, C., Aderman, C. M., Chen, J., Higuchi, A., Hong, S., Pravda, E. A., Majchrzak, S. F., Carper, D. A., et al. (2007) · Nature Medicine · doi:10.1038/nm1591 · Cited by 687 · see citing works

The Effects of Dietary α-Linolenic Acid on the Composition of Nerve Membranes, Enzymatic Activity, Amplitude of Electrophysiological Parameters, Resistance to Poisons and Performance of Learning Tasks in Rats

Bourre, J. M., Francois, M., Youyou, A., Dumont, O., Piciotti, M., Pascal, G., & Durand, G. (1989) · Journal of Nutrition · doi:10.1093/jn/119.12.1880 · Cited by 674 · see citing works

Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice

Chang, G.-Q., Hao, Y., & Wong, F. (1993) · Neuron · doi:10.1016/0896-6273(93)90072-y · Cited by 650 · see citing works

Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.

Portera‐Cailliau, C., Sung, C.-H., Nathans, J., & Adler, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.974 · Cited by 624 · see citing works

Beneficial effects of docosahexaenoic acid on cognition in age‐related cognitive decline

Yurko‐Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A. D., Salem, N., Stedman, M., & MIDAS Investigators (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.01.013 · Cited by 583 · see citing works

Obesity‐induced insulin resistance and hepatic steatosis are alleviated by ω‐3 fatty acids: a role for resolvins and protectins

González‐Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán‐Salvador, E., Titos, E., Martínez‐Clemente, M., López‐Parra, M., Arroyo, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125674 · Cited by 556 · see citing works

The Role of Apoptosis in Age-Related Macular Degeneration

Dunaief, J. L. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.11.1435 · Cited by 527 · see citing works

Fatty Acid Regulation of Hepatic Gene Transcription

Jump, D. Β., Botolin, D., Wang, Y., Xu, J., Christian, B., & Demeure, O. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2503 · Cited by 477 · see citing works

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

Ou, J., Tu, H., Shan, B., Luk, A. Y., DeBose‐Boyd, R. A., Bashmakov, Y. K., Goldstein, J. L., & Brown, M. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111138698 · Cited by 474 · see citing works

Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival

Akbar, M. D., Calderón, F. H., Wen, Z., & Kim, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502903102 · Cited by 466 · see citing works

Structural basis for the activation of PPARγ by oxidized fatty acids

Itoh, T., Fairall, L., Amin, K., Inaba, Y., Szántó, A., Bálint, B. L., Nagy, L., Yamamoto, K., & Schwabe, J. W. R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1474 · Cited by 465 · see citing works

Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes

Serhan, C. N., Gotlinger, K. H., Hong, S., Lu, Y., Siegelman, J. N., Baer, T. E., Yang, R., Colgan, S. P., & Petasis, N. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1848 · Cited by 457 · see citing works

A family of fatty acid transporters conserved from mycobacterium to man

Hirsch, D., Stahl, A., & Lodish, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8625 · Cited by 454 · see citing works

The propagation of prion-like protein inclusions in neurodegenerative diseases

Goedert, M., Clavaguera, F., & Tolnay, M. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.04.003 · Cited by 451 · see citing works

Membrane docosahexaenoate is supplied to the developing brain and retina by the liver.

Scott, B. L., & Bazan, N. (1989) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.86.8.2903 · Cited by 445 · see citing works

Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease

Ghosh, A., Roy, A., Liu, X., Kordower, J. H., Mufson, E. J., Hartley, D. M., Ghosh, S., Mosley, R. L., Gendelman, H. E., & Pahan, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704908104 · Cited by 438 · see citing works

Identification of the Major Intestinal Fatty Acid Transport Protein

Stahl, A., Hirsch, D. J., Gimeno, R. E., Punreddy, S., Ge, P., Watson, N., Patel, S., Kotler, M., Raimondi, A., Tartaglia, L. A., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80332-9 · Cited by 424 · see citing works

Corneal structure and sensitivity in type 1 diabetes mellitus.

Rosenberg, M. E., Tervo, T., Immonen, I. J. R., Müller, L., Grönhagen‐Riska, C., & Vesaluoma, M. H. (2000) · PubMed · Cited by 405 · see citing works

Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration

Feher, J., Kovacs, I., Artico, M., Cavallotti, C., Papale, A., & Balacco Gabrieli, C. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.012 · Cited by 388 · see citing works

Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases.

Sun, G. Y., Xu, J.-F., Jensen, M. D., & Simonyi, Á. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300016-jlr200 · Cited by 378 · see citing works

Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503839103 · Cited by 373 · see citing works

Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy

Mendes, H. F., van der Spuy, J., Chapple, J. P., & Cheetham, M. E. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.02.007 · Cited by 372 · see citing works

Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors

Bazan, N. G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.005 · Cited by 353 · see citing works

Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association

Fotuhi, M., Mohassel, P., & Yaffe, K. (2009) · Nature Reviews Neurology · doi:10.1038/ncpneuro1044 · Cited by 344 · see citing works

Astrocytes, Not Neurons, Produce Docosahexaenoic Acid (22:6ω‐3) and Arachidonic Acid (20:4ω‐6)

Moore, S. A., Yoder, E. J., Murphy, S., Dutton, G. R., & Spector, A. A. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08180.x · Cited by 331 · see citing works

Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels

Green, K. N., Martínez‐Coria, H., Khashwji, H., Hall, E. B., Yurko‐Mauro, K., Ellis, L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0055-07.2007 · Cited by 326 · see citing works

VEGF and endothelial guidance in angiogenic sprouting

Gerhardt, H. (2008) · Organogenesis · doi:10.4161/org.4.4.7414 · Cited by 321 · see citing works

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

Wisely, G. B., Miller, A. B., Davis, R. G., Thornquest, A. D., Johnson, R., Spitzer, T., Sefler, A., Shearer, B., Moore, J. T., Miller, A. B., et al. (2002) · Structure · doi:10.1016/s0969-2126(02)00829-8 · Cited by 311 · see citing works

Inhibition of Neuronal Apoptosis by Docosahexaenoic Acid (22:6n-3)

Kim, H., Akbar, M. D., Lau, A. O. T., & Edsall, L. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004446200 · Cited by 308 · see citing works

Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver

Rapoport, S. I., Rao, J. S., & Igarashi, M. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.023 · Cited by 295 · see citing works

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

Oksman, M., Iivonen, H., Hőgyes, E., Amtul, Z., Penke, B., Leenders, I., Broersen, L. M., Lütjohann, D., Hartmann, T., & Tanila, H. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.013 · Cited by 287 · see citing works

Anti-vascular endothelial growth factor therapy for ocular neovascular disease

Andreoli, C. M., & Miller, J. W. (2007) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e3282f0ca54 · Cited by 274 · see citing works

Essential fatty acids, DHA and human brain

Singh, M. (2005) · The Indian Journal of Pediatrics · doi:10.1007/bf02859265 · Cited by 268 · see citing works

Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease

Bazan, N. G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800068-jlr200 · Cited by 256 · see citing works

Polyunsaturated fatty acids and inflammatory diseases

Gil, Á. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00256-1 · Cited by 256 · see citing works

n−3 fatty acids and human health: Defining strategies for public policy

Simopoulos, A. P. (2001) · Lipids · doi:10.1007/s11745-001-0687-7 · Cited by 254 · see citing works

Recovery of Corneal Subbasal Nerve Density After PRK and LASIK

Erie, J. C., McLaren, J. W., Hodge, D. O., et al. (2005) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2005.07.027 · Cited by 252 · see citing works

Synaptic lipid signaling

Bazan, N. G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300013-jlr200 · Cited by 247 · see citing works

Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: A review of randomized controlled trials

Hoffman, D. R., Boettcher, J. A., & Diersen-Schade, D. A. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.003 · Cited by 246 · see citing works

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

Zhao, Y., Calon, F., Julien, C., Winkler, J. W., Petasis, N. A., Lukiw, W. J., & Bazan, N. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015816 · Cited by 243 · see citing works

One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats

DeMar, J. C., Ma, K., Bell, J. M., Igarashi, M., GREENSTEIN, D. K., & Rapoport, S. I. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500362-jlr200 · Cited by 243 · see citing works

Regulation of the α‐secretase ADAM10 by its prodomain and proprotein convertases

Anders, A., Gilbert, S., Garten, W., Postina, R., & Fahrenholz, F. (2001) · The FASEB Journal · doi:10.1096/fj.01-0007fje · Cited by 241 · see citing works

Fatty acid transport proteins: a current view of a growing family

Stahl, A., Gimeno, R. E., Tartaglia, L. A., & Lodish, H. F. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00427-1 · Cited by 239 · see citing works

The metabolism and availability of essential fatty acids in animal and human tissues

Bezard, J. A., Blond, J., Bernard, A., & Clouet, P. (1994) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19940603 · Cited by 237 · see citing works

Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease

Vijitruth, R., Liu, M., Choi, D., Nguyen, X. V., Hunter, R. L., & Bing, G. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-6 · Cited by 236 · see citing works

Macular degeneration: recent advances and therapeutic opportunities

Rattner, A., & Nathans, J. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2007 · Cited by 230 · see citing works

Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S‐hydroxy‐DHA

González‐Périz, A., Planagumà, A., Gronert, K., Miquel, R., López‐Parra, M., Titos, E., Horrillo, R., Ferré, N., Deulofeu, R., Arroyo, V., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-6250fje · Cited by 226 · see citing works

Biomarkers of Oxidative Damage and Inflammation in Alzheimer's Disease

Galasko, D. R., & Montine, T. J. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.89 · Cited by 221 · see citing works

PPAR-γ Agonists as Regulators of Microglial Activation and Brain Inflammation

Bernardo, A., & Minghetti, L. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206780574579 · Cited by 220 · see citing works

Novel Metabolism of Docosahexaenoic Acid in Neural Cells

Kim, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700015200 · Cited by 219 · see citing works

Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

Astarita, G., Jung, K.-M., Berchtold, N. C., Nguyen, V. Q., Gillen, D. L., Head, E., Cotman, C. W., & Piomelli, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012538 · Cited by 218 · see citing works

Summary of the NATO Advanced Research Workshop on Dietary ω3 and ω6 Fatty Acids: Biological Effects and Nutritional Essentiality

Simopoulos, A. P. (1989) · Journal of Nutrition · doi:10.1093/jn/119.4.521 · Cited by 214 · see citing works

Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus

Kaushik, M., Mozaffarian, D., Spiegelman, D. L., Manson, J. E., Willett, W. C., & Hu, F. B. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27424 · Cited by 208 · see citing works

Control of polyunsaturated acids in tissue lipids.

Holman, R. T. (1986) · Journal of the American College of Nutrition · doi:10.1080/07315724.1986.10720125 · Cited by 208 · see citing works

Transcriptional and translational regulation of BACE1 expression—Implications for Alzheimer's disease

Roßner, S., Sastre, M., Bourne, K. Z., & Lichtenthaler, S. F. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.001 · Cited by 196 · see citing works

Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration

Spencer, K. L., Hauser, M. A., Olson, L. M., Schmidt, S., Scott, W. K., Gallins, P. J., Agarwal, A., Postel, E. A., Pericak‐Vance, M. A., & Haines, J. L. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm146 · Cited by 189 · see citing works

Activation of cerebral peroxisome proliferator‐activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase‐2 overexpression after focal cerebral ischemia in rats

Zhao, Y., Patzer, A., Herdegen, T., Gohlke, P., & Čulman, J. (2006) · The FASEB Journal · doi:10.1096/fj.05-5007com · Cited by 188 · see citing works

Confocal microscopy in vivo in corneas of long-term contact lens wearers.

Patel, S. V., McLaren, J. W., Hodge, D. O., et al. (2002) · PubMed · Cited by 184 · see citing works

Polyunsaturated Fatty Acid Synthesis and Release

Moore, S. A. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:195 · Cited by 174 · see citing works

Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling

Mukherjee, P. K., Marcheselli, V. L., Barreiro, S., Hu, J., Bok, D., & Bazan, N. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705949104 · Cited by 170 · see citing works

Peroxisome Proliferator-Activated Receptor γ Induces a Clearance Mechanism for the Amyloid-β Peptide

Espuny-Camacho, I., Serneels, L., Spittaels, K., Merchiers, P., Dominguez, D. I., & Strooper, B. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3987-04.2004 · Cited by 169 · see citing works

Reinnervation in the cornea after LASIK.

Lee, B. H., McLaren, J. W., Erie, J. C., et al. (2002) · PubMed · Cited by 168 · see citing works

Polyunsaturated fatty acids, neuroinflammation and well being

Layé, S. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.006 · Cited by 167 · see citing works

A cell culture medium that supports the differentiation of human retinal pigment epithelium into functionally polarized monolayers.

Hu, J. G., & Bok, D. (2001) · PubMed · Cited by 165 · see citing works

The role of vascular endothelial growth factor and other endogenous interplayers in age-related macular degeneration

Grisanti, S., & Tatar, O. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.05.002 · Cited by 163 · see citing works

Oxidative damage in age-related macular degeneration.

Shen, J., Dong, A., Hackett, S. F., Bell, W. R., Green, W. R., & Campochiaro, P. A. (2007) · PubMed · doi:10.14670/hh-22.1301 · Cited by 152 · see citing works

Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes

Aveldano, M. I. (1988) · Biochemistry · doi:10.1021/bi00404a024 · Cited by 149 · see citing works

Docosahexaenoic acid (DHA) and hepatic gene transcription

Jump, D. Β., Botolin, D., Wang, Y., Xu, J., Demeure, O., & Christian, B. (2008) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2008.02.007 · Cited by 149 · see citing works

Electrophilic Cyclopentenone Neuroprostanes Are Anti-inflammatory Mediators Formed from the Peroxidation of the ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid

Musiek, E. S., Brooks, J. D., Joo, M., Brunoldi, E. M., Porta, A., Zanoni, G., Vidari, G., Blackwell, T. S., Montine, T. J., Milne, G. L., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803625200 · Cited by 139 · see citing works

The Biochemistry of the Isoprostane, Neuroprostane, and Isofuran Pathways of Lipid Peroxidation

Roberts, L. J., Fessel, J. P., & Davies, S. S. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00511.x · Cited by 131 · see citing works

Endogenous fatty acids are covalently and noncovalently bound to interphotoreceptor retinoid-binding protein in the monkey retina.

Bazan, N. G., Reddy, T. S., Redmond, T. M., Wiggert, B. O., & Chader, G. J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38777-x · Cited by 130 · see citing works

Aging and the intestine

Drozdowski, L. A. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i47.7578 · Cited by 128 · see citing works

Antiangiogenic Approaches to Age-Related Macular Degeneration Today

Bressler, N. M. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.06.048 · Cited by 128 · see citing works

n−3 Fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues

Hamilton, J., Greiner, R. S., Salem, N., et al. (2000) · Lipids · doi:10.1007/s11745-000-0595-x · Cited by 128 · see citing works

High dietary ω-6 fatty acids contribute to reduced docosahexaenoic acid in the developing brain and inhibit secondary neurite growth

Novak, E. M., Dyer, R., & Innis, S. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.107 · Cited by 125 · see citing works

Omega-3 Fatty acids and pregnancy.

Coletta, J. M., Bell, S. J., & Roman, A. S. (2010) · PubMed Central · Cited by 125 · see citing works

Coordinate Activation of HIF-1 and NF-κB DNA Binding and COX-2 and VEGF Expression in Retinal Cells by Hypoxia

Lukiw, W. J., Ottlecz, A., Lambrou, G. Ι., Grueninger, M., Finley, J., Thompson, H. W., & Bazan, N. G. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0655 · Cited by 123 · see citing works

Modulation of angiogenesis by omega-3 polyunsaturated fatty acids is mediated by cyclooxygenases.

Szymczak, M., Murray, M., & Petrovic, N. (2008) · Blood · doi:10.1182/blood-2007-08-109934 · Cited by 121 · see citing works

RENEWAL OF FATTY ACIDS IN THE MEMBRANES OF VISUAL CELL OUTER SEGMENTS

Bibb, C. A., & Young, R. W. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.61.2.327 · Cited by 120 · see citing works

Omega-3 Essential Fatty Acids Modulate Initiation and Progression of Neurodegenerative Disease

Peláez, R. P., Lukiw, W. J., & Bazan, N. G. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8139-z · Cited by 120 · see citing works

Molecular species of phosphatidylcholine, -ethanolamine, -serine, and -inositol in microsomal and photoreceptor membranes of bovine retina.

Aveldaño, M. I., & Bazan, N. G. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37967-0 · Cited by 119 · see citing works

Homeostatic Regulation of Photoreceptor Cell Integrity: Significance of the Potent Mediator Neuroprotectin D1 Biosynthesized from Docosahexaenoic Acid The Proctor Lecture

Bazan, N. G. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0918 · Cited by 116 · see citing works

Omega-3 Fatty Acid Docosahexaenoic Acid Increases SorLA/LR11, a Sorting Protein with Reduced Expression in Sporadic Alzheimer's Disease (AD): Relevance to AD Prevention

Ma, Q., Teter, B., Ubeda, O. J., Morihara, T., Dhoot, D. S., Nyby, M. D., Tuck, M. L., Frautschy, S. A., & Cole, G. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3593-07.2007 · Cited by 115 · see citing works

Filling the Gaps in the Aβ Cascade Hypothesis of Alzheimers Disease

Golde, T. E., Dickson, D. W., & Hutton, M. L. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025189 · Cited by 115 · see citing works

Acute Changes in Dietary ω-3 and ω-6 Polyunsaturated Fatty Acids Have a Pronounced Impact on Survival following Ischemic Renal Injury and Formation of Renoprotective Docosahexaenoic Acid-Derived Protectin D1

Hassan, I., & Gronert, K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802064 · Cited by 114 · see citing works

Comparison of cytokine modulation by natural peroxisome proliferator–activated receptor γ ligands with synthetic ligands in intestinal-like Caco-2 cells and human dendritic cells—potential for dietary modulation of peroxisome proliferator–activated receptor γ in intestinal inflammation

Marion‐Letellier, R., Butler, M., Déchelotte, P., Playford, R. J., & Ghosh, S. K. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.939 · Cited by 113 · see citing works

Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: Relationship with central serotonin turnover

McNamara, R. K., Jandacek, R. J., Rider, T., Tso, P., Cole-Strauss, A., & Lipton, J. W. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.08.004 · Cited by 113 · see citing works

Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis

Mukherjee, P. K., Marcheselli, V. L., Vaccari, J. C. D. R., Gordon, W. C., Jackson, F. R., & Bazan, N. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705963104 · Cited by 110 · see citing works

Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex☆☆Grant support: United States Public Health Service Grant NS23002 from the National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD.

Tu, B., & Bazan, N. G. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(02)00019-5 · Cited by 108 · see citing works

Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina

Bazan, N. G., Birkle, D. L., & Reddy, T. S. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)90601-6 · Cited by 107 · see citing works

Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid

Kim, H., Akbar, M. D., & Kim, Y. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.02.025 · Cited by 107 · see citing works

Fyn-Tau-Amyloid: A Toxic Triad

Haass, C., & Mandelkow�, E. (2010) · Cell · doi:10.1016/j.cell.2010.07.032 · Cited by 106 · see citing works

Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein

Bettler, J., Zimmer, J. P., Neuringer, M. D., & DeRusso, P. A. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0047-5 · Cited by 106 · see citing works

An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n‐6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance

Lim, S., Hoshiba, J., & Salem, N. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03427.x · Cited by 106 · see citing works

Docosahexaenoic acid reduces levodopa‐induced dyskinesias in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine monkeys

Samadi, P., Grégoire, L., Rouillard, C., Bédard, P. J., Paolo, T. D., & Lévesque, D. (2006) · Annals of Neurology · doi:10.1002/ana.20738 · Cited by 105 · see citing works

Selective survival rescue in 15-Lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1

Calandria, J. M., Marcheselli, V. L., Mukherjee, P. K., Uddin, J., Winkler, J. W., Petasis, N. A., & Bazan, N. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003988 · Cited by 104 · see citing works

Docosahexaenoic acid utilization during rod photoreceptor cell renewal

Gordon, W., & Bazan, N. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-07-02190.1990 · Cited by 101 · see citing works

Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils

Marcheselli, V. L., Mukherjee, P. K., Arita, M., Hong, S., Antony, R., Sheets, K. G., Winkler, J. W., Petasis, N. A., Serhan, C. N., & Bazan, N. G. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.10.010 · Cited by 101 · see citing works

Mobilization of arachidonate and docosahexaenoate by stimulation of the 5-HT2A receptor in rat C6 glioma cells

Garcia, M. C., & Kim, H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00583-0 · Cited by 101 · see citing works

Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension

SINGER, P. A., Berger, I., Lück, K., Taube, C., Naumann, E., & Gödicke, W. (1986) · Atherosclerosis · doi:10.1016/0021-9150(86)90100-0 · Cited by 99 · see citing works

β-Amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase–NF-κB signaling pathway

Jang, J.-H., & Surh, Y. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.023 · Cited by 99 · see citing works

PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis

Faghiri, Z., & Bazan, N. G. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.03.002 · Cited by 98 · see citing works

Docosahexaenoic Acid Uptake and Metabolism in Photoreceptors: Retinal Conservation By an Efficient Retinal Pigment Epithelial Cell-Mediated Recycling Process

Bazan, N. G., Gordon, W. C., & Turco, E. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-3426-6_26 · Cited by 97 · see citing works

Trans‐4‐hydroxy‐2‐hexenal is a neurotoxic product of docosahexaenoic (22:6; n‐3) acid oxidation

Long, E. K., Murphy, T. C., Leiphon, L. J., Watt, J. A., Morrow, J. D., Milne, G. L., Howard, J. R. H., & Picklo, M. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05175.x · Cited by 97 · see citing works

Effect of Dietary n-3 Polyunsaturated Fatty Acids on Brain Lipid Fatty Acid Composition, Learning Ability, and Memory of Senescence-Accelerated Mouse

Pétursdóttir, A., Farr, S. A., Morley, J. E., Banks, W. A., & Skúladóttir, G. V. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.11.1153 · Cited by 93 · see citing works

Role of Long‐chain Polyunsaturated Fatty Acids in the First Year of Life

Agostoni, C. V. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000338811.52062.b2 · Cited by 92 · see citing works

N-3 Fatty Acid Deficiency Induced by a Modified Artificial Rearing Method Leads to Poorer Performance in Spatial Learning Tasks

Lim, S., Hoshiba, J., Moriguchi, T., & Salem, N. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000180547.46725.cc · Cited by 92 · see citing works

α-Synuclein Adopts an α-Helical Conformation in the Presence of Polyunsaturated Fatty Acids To Hinder Micelle Formation

Broersen, K., van den Brink, D. M., Fraser, G. M., Goedert, M., & Davletov, B. A. (2006) · Biochemistry · doi:10.1021/bi061743l · Cited by 92 · see citing works

Towards an understanding of age-related macular disease

Bird, A. C. (2003) · Eye · doi:10.1038/sj.eye.6700562 · Cited by 92 · see citing works

Topical Combination of NGF and DHA Increases Rabbit Corneal Nerve Regeneration after Photorefractive Keratectomy

Esquenazi, S., Bazán, H. E. P., Bui, V., He, J., Kim, D. B., & Bazan, N. G. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0241 · Cited by 91 · see citing works

Minireview on pancreatic lipase and colipase

Chapus, C., ROVERY, M., Sarda, L., et al. (1988) · Biochimie · doi:10.1016/0300-9084(88)90188-5 · Cited by 90 · see citing works

Retinal pigment epithelial cells play a central role in the conservation of docosahexaenoic acid by photoreceptor cells after shedding and phagocytosis

Gordon, W. C., de Turco, E. B. R., & Bazan, N. G. (1992) · Current Eye Research · doi:10.3109/02713689209069169 · Cited by 89 · see citing works

Identification of putative metabolites of docosahexaenoic acid as potent PPARγ agonists and antidiabetic agents

Yamamoto, K., Itoh, T., Abe, D., Shimizu, M., Kanda, T., Koyama, T., Nishikawa, M., Tamai, T., Ooizumi, H., & Yamada, S. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.11.053 · Cited by 87 · see citing works

Differential lipid deacylation during brain ischemia in a homeotherm and a poikilotherm. Content and composition of free fatty acids and triacylglycerols

̃o, M. I. A., & ́n, N. ́. G. B. (1975) · Brain Research · doi:10.1016/0006-8993(75)90244-9 · Cited by 85 · see citing works

Effect of GDNF on neuroblast proliferation and photoreceptor survival: additive protection with docosahexaenoic acid.

Politi, L. E., Rotstein, N. P., & Carri, N. G. (2001) · Americanae (AECID Library) · Cited by 83 · see citing works

Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate.

Organisciak, D. T., Darrow, R. M., Jiang, Y.-L., & Blanks, J. C. (1996) · PubMed · Cited by 83 · see citing works

Growth factors and their receptors in the retina and pigment epithelium

Tanihara, H., Inatani, M., & Honda, Y. (1997) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(96)00028-6 · Cited by 82 · see citing works

Non-steroidal Anti-inflammatory Drugs Stimulate Secretion of Non-amyloidogenic Precursor Protein

Avramovich‐Tirosh, Y., Amit, T., & Youdim, M. B. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201308200 · Cited by 81 · see citing works

Role of peroxisome proliferator-activated receptor γ in amyloid precursor protein processing and amyloid β-mediated cell death

d’Abramo, C., Massone, S., Zingg, J.-M., Pizzuti, A., Marambaud, P., Piccola, B. D., Azzi, A., Marinari, U. M., Pronzato, M. A., & Ricciarelli, R. (2005) · Biochemical Journal · doi:10.1042/bj20050560 · Cited by 81 · see citing works

Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

Cansev, M., Ulus, I. H., Wang, L., Maher, T. J., & Wurtman, R. J. (2008) · Neuroscience Research · doi:10.1016/j.neures.2008.07.005 · Cited by 81 · see citing works

Inhibition of Neuronal Apoptosis by Polyunsaturated Fatty Acids

Kim, H., Akbar, M. D., & Kim, K.-Y. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:223 · Cited by 79 · see citing works

Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in usher's syndrome

Bazan, N. G., Scott, B. L., Reddy, T. S., et al. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(86)80215-7 · Cited by 78 · see citing works

n-3 Fatty acids and the inflammatory response ? biological background

DeCaterina, R. (2001) · European Heart Journal Supplements · doi:10.1016/s1520-765x(01)90118-x · Cited by 76 · see citing works

Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems - an observational cohort study

Huß, M., Völp, A., & Stauss‐Grabo, M. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-105 · Cited by 76 · see citing works

Nutritional Manipulation of Primate Retinas, II: Effects of Age, n–3 Fatty Acids, Lutein, and Zeaxanthin on Retinal Pigment Epithelium

Leung, I. Y.-F., Sandstrom, M. M., Zucker, C. L., Neuringer, M., & Snodderly, D. M. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1233 · Cited by 75 · see citing works

Plasma docosahexaenoic acid levels in various genetic forms of retinitis pigmentosa.

Gong, J., ROSNER, B. A., Rees, D., Berson, E. L., Weigel-DiFranco, C., & Schaefer, E. J. (1992) · PubMed · Cited by 74 · see citing works

Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis

Rapoport, S. I., Igarashi, M., & Gao, F. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.02.015 · Cited by 74 · see citing works

Protection from oxidative stress by methionine sulfoxide reductases in RPE cells

Sreekumar, P. G., Kannan, R., Yaung, J., Spee, C. K., Ryan, S. J., & Hinton, D. R. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.081 · Cited by 72 · see citing works

Docosahexaenoic acid in red blood cells of patients with X-linked retinitis pigmentosa.

Hoffman, D. R., & Birch, D. G. (1995) · PubMed · Cited by 70 · see citing works

Brain Incorporation of [ 11 C]Arachidonic Acid in Young Healthy Humans Measured with Positron Emission Tomography

Giovacchini, G., Chang, M., Channing, M. A., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000033209.60867.7a · Cited by 70 · see citing works

Neuroprotectin D1 Induces Dephosphorylation of Bcl-xL in a PP2A-dependent Manner during Oxidative Stress and Promotes Retinal Pigment Epithelial Cell Survival

Antony, R., Lukiw, W. J., & Bazan, N. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095232 · Cited by 69 · see citing works

Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations.

Anderson, R. E., Maude, M. B., McClellan, M. E., Matthes, M. T., Yasumura, D., & LaVail, M. M. (2002) · PubMed · Cited by 67 · see citing works

Effects of an n-3-deficient diet on brain, retina, and liver fatty acyl composition in artificially reared rats

Moriguchi, T., Lim, S., Greiner, R. S., Lefkowitz, W., Loewke, J., Hoshiba, J., & Salem, N. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400087-jlr200 · Cited by 64 · see citing works

Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA?

Rapoport, S. I., & Igarashi, M. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.021 · Cited by 63 · see citing works

Protection of Photoreceptor Cells in Adult Rats from Light-induced Degeneration by Adaptation to Bright Cyclic Light

Li, F., Cao, W., & Anderson, R. E. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.1068 · Cited by 61 · see citing works

Impaired synthesis of DHA in patients with X-linked retinitis pigmentosa

Hoffman, D. R., DeMar, J. C., Heird, W. C., et al. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30271-6 · Cited by 61 · see citing works

The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease.

Tanrιöver, G., Seval, Y., Özsoy, Ö., Akkoyunlu, G., Savcıoğlu, F., Hacıoğlu, G., Demır, N., & Ağar, A. (2010) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-010-0047-6 · Cited by 60 · see citing works

Docosahexaenoic acid stimulates non‐amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer's disease

Sahlin, C., Pettersson, F. E., Nilsson, L. N. G., Lannfelt, L., & Johansson, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05719.x · Cited by 59 · see citing works

Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses.

Bazan, N. G., & Scott, B. L. (1990) · PubMed · Cited by 58 · see citing works

The birth and death of photoreceptors: the Friedenwald Lecture.

Papermaster, D. S. (2002) · PubMed · Cited by 56 · see citing works

Fatty acid composition and level of diacylglycerols and phosphoglycerides in brain and retina

Aveldaño, M. I., & Bazan, N. G. (1973) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(73)90038-6 · Cited by 55 · see citing works

Inflammation in the pathogenesis of age-related macular degeneration

Kanda, A., Abecasis, G. R., & Swaroop, A. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.131581 · Cited by 55 · see citing works

Defective desaturation and elongation of N-6 and N-3 fatty acids in hypertensive patients

SINGER, P. A., Jaeger, W., Voigt, S., et al. (1984) · Prostaglandins Leukotrienes and Medicine · doi:10.1016/0262-1746(84)90173-2 · Cited by 54 · see citing works

Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract

Masson, C. J., Plat, J., Mensink, R. P., Namiot, A., Kisielewski, W., Namiot, Z., Füllekrug, J., Ehehalt, R., Glatz, J. F. C., & Pelsers, M. M. A. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010380 · Cited by 54 · see citing works

DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-κB Activity in LPS-treated Human Umbilical Vein Endothelial Cells

Lee, S. A., Kim, H. J., Chang, K. C., Baek, J. C., Park, J. K., Shin, J. K., Choi, W. J., Lee, J. H., & Paik, W. Y. (2009) · The Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2009.13.4.301 · Cited by 53 · see citing works

Red blood cell membrane phosphatidylethanolamine fatty acid content in various forms of retinitis pigmentosa

Schaefer, E. J., Robins, S. J., Patton, G. M., Sandberg, M., Weigel-DiFranco, C., ROSNER, B. A., & Berson, E. L. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39729-7 · Cited by 53 · see citing works

Keratocyte Density and Recovery of Subbasal Nerves After Penetrating Keratoplasty and in Late Endothelial Failure

Patel, S. V. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.12.1693 · Cited by 50 · see citing works

High content of 22:6 (docosahexaenoate) and active [2-3h]glycerol metabolism of phosphatidic acid from photoreceptor membranes

Bazan, N. G., de Escalante, M. S. D. F., Careaga, M. M., et al. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90301-0 · Cited by 50 · see citing works

Multiple mechanisms for polyunsaturated fatty acid regulation of hepatic gene transcription

Jump, D. Β., Thelen, A. P., Ren, B., et al. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(99)80010-6 · Cited by 47 · see citing works

Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695

Peng, Y., Lee, D. Y. W., Jiang, L., Ma, Z., Schachter, S. C., & Lemere, C. A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.022 · Cited by 47 · see citing works

TNF-α and IL-1β Increase Pericyte/Endothelial Cell Co-Culture Permeability

Kerkar, S. P., Williams, M., Blocksom, J. M., Wilson, R. F., Tyburski, J. G., & Steffes, C. P. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.06.033 · Cited by 47 · see citing works

The Release of Polyunsaturated Fatty Acids and Their Lipoxygenation in the Brain

Kim, H., Edsall, L. C., Garcia, M. C., et al. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4861-4_7 · Cited by 45 · see citing works

Composition and biosynthesis of molecular species of retina phosphoglycerides

de Caldironi, M. I. A., & Bazan, N. G. (1980) · Neurochemistry International · doi:10.1016/0197-0186(80)90074-1 · Cited by 45 · see citing works

Polyunsaturated fatty acids of the retina

de Caldironi, M. I. A., Giusto, N. M., & Bazan, N. G. (1981) · Progress in Lipid Research · doi:10.1016/0163-7827(81)90013-8 · Cited by 45 · see citing works

Surface keratopathy after penetrating keratoplasty.

Feiz, V., Mannis, M. J., Kandavel, G. R., et al. (2001) · PubMed · Cited by 43 · see citing works

Initiation and propagation of neurodegeneration

Haass, C. (2010) · Nature Medicine · doi:10.1038/nm.2223 · Cited by 42 · see citing works

Displacement into incubation medium by albumin of highly unsaturated retina free fatty acids arising from membrane lipids

Aveldaño, M. I., & Bazan, N. G. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80892-6 · Cited by 42 · see citing works

Effects of docosapentaenoic acid on neuronal apoptosis

Kim, H., Akbar, M. D., & Lau, A. O. T. (2003) · Lipids · doi:10.1007/s11745-003-1083-z · Cited by 41 · see citing works

New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing α‐secretase activity

Yang, H., Pan, J., Ba, M., Sun, Z., Ma, G., Lü, G., Xiao, Q., & Chen, S. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05648.x · Cited by 40 · see citing works

Acyl Groups, Molecular Species, and Labeling by 14C-Glycerol and 3H-Arachidonic Acid of Vertebrate Retina Glycerolipids

de Caldironi, M. I. A., & Bazan, N. G. (1977) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3276-3_37 · Cited by 37 · see citing works

Red Blood Cell Fatty Acid Levels in Patients with Autosomal Dominant Retinitis Pigmentosa

Hoffman, D. R., Uauy, R. D., & Birch, D. G. (1993) · Experimental Eye Research · doi:10.1006/exer.1993.1135 · Cited by 36 · see citing works

Regulation of fatty acid transport

Kalant, D., & Cianflone, K. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200406000-00011 · Cited by 36 · see citing works

Synthesis of arachidonoyl coenzyme A and docosahexaenoyl coenzyme A in retina

Reddy, T. S., & Bazan, N. G. (1984) · Current Eye Research · doi:10.3109/02713688409000826 · Cited by 34 · see citing works

Pathways for the uptake and conservation of docosahexaenoic acid in photoreceptors and synapses: biochemical and autoradiographic studies

Bazan, N. G., Turco, E., & Gordon, W. C. (1993) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y93-103 · Cited by 33 · see citing works

De novo biosynthesis of docosahexaenoyl-phosphatidic acid in bovine retinal microsomes

Bazán, H. E. P., Sprecher, H. W., & Bazan, N. G. (1984) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(84)90232-7 · Cited by 33 · see citing works

Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cells

Zhao, Y., Cui, J.-G., & Lukiw, W. J. (2007) · Neuroreport · doi:10.1097/wnr.0b013e32821c56c4 · Cited by 31 · see citing works

Biosynthesis of molecular species of inositol, choline, serine, and ethanolamine glycerophospholipids in the bovine retina.

Aveldaño, M. I., de Garcia, S. J. P., & Bazan, N. G. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37968-2 · Cited by 31 · see citing works

Brain Incorporation of [11C]Arachidonic Acid in Young Healthy Humans Measured With Positron Emission Tomography

Giovacchini, G., Chang, M., Channing, M. A., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200212000-00006 · Cited by 31 · see citing works

Congeners of Nα-acetyl-L-cysteine but not aminoguanidine act as neuroprotectants from the lipid peroxidation product 4-hydroxy-2-nonenal

Neely, M. D., Zimmerman, L. J., Picklo, M. J., et al. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00411-1 · Cited by 28 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA

Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943 · see citing works

Alzheimer's Disease: Treatment Strategies and Their Limitations.

Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 592 · see citing works

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420 · see citing works

Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson’s Disease

Caputi, V., & Giron, M. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061689 · Cited by 338 · see citing works

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Zhang, Y., Chen, J., Qiu, J., Li, Y., Wang, J., & Jiao, J. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.124081 · Cited by 330 · see citing works

Fish-oil supplementation enhances the effects of strength training in elderly women

Rodacki, C. L., Rodacki, A. L., Pereira, G., Naliwaiko, K., Coelho, I., Pequito, D., & Fernandes, L. C. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.021915 · Cited by 274 · see citing works

Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice

Sugasini, D., Thomas, R., Yalagala, P. C. R., Tai, L. M., & Subbaiah, P. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-11766-0 · Cited by 201 · see citing works

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148 · see citing works

Inadequate supply of vitamins and DHA in the elderly: Implications for brain aging and Alzheimer-type dementia

Mohajeri, M. H., Troesch, B., & Weber, P. (2015) · Nutrition · doi:10.1016/j.nut.2014.06.016 · Cited by 141 · see citing works

Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity

Bazan, N. G., Musto, A. E., & Knott, E. J. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8200-6 · Cited by 125 · see citing works

Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

Rice, D. S., Calandria, J. M., Gordon, W. C., Jun, B., Zhou, Y., Gelfman, C. M., Li, S., Jin, M., Knott, E. J., Chang, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms7228 · Cited by 124 · see citing works

The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina

Chen, D., Chao, D. L., Rocha, L., Kolar, M., Nguyen Huu, V. A., Krawczyk, M., Dasyani, M., Wang, T., Jafari, M., Jabari, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13100 · Cited by 109 · see citing works

Docosanoids promote neurogenesis and angiogenesis, blood-brain barrier integrity, penumbra protection, and neurobehavioral recovery after experimental ischemic stroke

Belayev, L., Hong, S.-H., Menghani, H., Marcell, S. J., Obenaus, A., Freitas, R. S., Khoutorova, L., Balaszczuk, V., Jun, B., Oriá, R. B., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1136-3 · Cited by 103 · see citing works

Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity

Jun, B., Mukherjee, P. K., Asatryan, A., Kautzmann, M.-A., Heap, J., Gordon, W. C., Bhattacharjee, S., Yang, R., Petasis, N. A., & Bazan, N. G. (2017) · Scientific Reports · doi:10.1038/s41598-017-05433-7 · Cited by 80 · see citing works

Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation

Shi, Z., Ren, H., Huang, Z., Peng, Y., He, B., Yao, X., Yuan, T.-F., & Su, H. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0212-9 · Cited by 62 · see citing works

Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury

Bhattacharjee, S., Jun, B., Belayev, L., Heap, J., Kautzmann, M.-A., Obenaus, A., Menghani, H., Marcell, S. J., Khoutorova, L., Yang, R., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700735 · Cited by 57 · see citing works

A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa

Zhang, J., Wang, C., Shen, Y., Chen, N., Wang, L., Liang, L., Guo, T., Yin, X., Ma, Z., Zhang, B., et al. (2016) · Human Genetics · doi:10.1007/s00439-016-1730-2 · Cited by 57 · see citing works

NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival

Calandria, J. M., Asatryan, A., Balaszczuk, V, Knott, E. J., Jun, B. K., Mukherjee, P. K., Belayev, L., & Bazan, N. G. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.233 · Cited by 47 · see citing works

Stereocontrolled total synthesis of neuroprotectin D1/protectin D1 and its aspirin-triggered stereoisomer

Petasis, N. A., Yang, R., Winkler, J. W., Zhu, M., Uddin, J., Bazan, N. G., & Serhan, C. N. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.01.032 · Cited by 45 · see citing works

Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy

Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41 · see citing works

Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1

Musto, A. E., Walker, C. P., Petasis, N. A., & Bazan, N. G. (2015) · PLOS ONE · doi:10.1371/journal.pone.0116543 · Cited by 39 · see citing works

Different effects of omega-3 fatty acids on the cell cycle in c2c12 myoblast proliferation

Peng, Y., Zheng, Y., Zhang, Y., Zhao, J., Chang, F., Lu, T., Zhang, R., Li, Q., Hu, X., & Li, N. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1329-4 · Cited by 34 · see citing works

Retinal pigment epithelium and photoreceptor preconditioning protection requires docosanoid signaling

Knott, E. J., Gordon, W. C., Jun, B., Do, K., & Bazan, N. G. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0565-2 · Cited by 18 · see citing works

Is there a molecular logic that sustains neuronal functional integrity and survival? Lipid signaling is necessary for neuroprotective neuronal transcriptional programs

Bazan, N. G. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8897-0 · Cited by 15 · see citing works

Rod-specific downregulation of omega-3 very-long-chain polyunsaturated fatty acid pathway in age-related macular degeneration

Gordon, W. C., Kautzmann, M.-A. I., Jun, B., Cothern, M. L., Fang, Z., & Bazan, N. G. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109639 · Cited by 14 · see citing works

Deciphering the contributions of neuroinflammation to neurodegeneration: lessons from antibody-mediated encephalitis and coronavirus disease 2019

Shir, D., & Day, G. S. (2022) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001033 · Cited by 13 · see citing works

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

Niranjan, R. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.003 · Cited by 112 · see citing works

Mitochondria and the Link Between Neuroinflammation and Neurodegeneration

Filippo, M. D., Chiasserini, D., Tozzi, A., Picconi, B., & Calabresi, P. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100543 · Cited by 155 · see citing works

Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration

Batista, C. R. A., Gomes, G. F., Candelario-Jalil, E., Fiebich, B. L., & de Oliveira, A. C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092293 · Cited by 529 · see citing works

Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation

Nakano-Kobayashi, A., Fukumoto, A., Morizane, A., Nguyen, D. T., Le, T. M., Hashida, K., Hosoya, T., Takahashi, R., Takahashi, J. B., Hori, O., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc1428 · Cited by 50 · see citing works