Cited by 138Parkinson's Disease Mechanisms and TreatmentsTea Polyphenols and EffectsNuclear Receptors and Signaling

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Protective effect of the green tea component, l-theanine on environmental toxins-induced neuronal cell death

Cho, Hong-Suk, Kim, Seung, Lee, Sook-Young, Park, Jeong Ae, Kim, Sung-Jun, Chun, Hong Sung·2008·NeuroToxicology

DOI 10.1016/j.neuro.2008.03.004

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Abstract

Several environmental neurotoxins and oxidative stress inducers are known to damage the nervous system and are considered major factors associated with the selective vulnerability of nigral dopaminergic neurons in Parkinson's disease (PD). Gamma-glutamylethylamide (L-theanine), a natural glutamate analog in green tea, has been shown to exert strong anti-ischemic effect. In this study, we investigated the protective effects of L-theanine on neurotoxicity induced by PD-related neurotoxicants, rotenone and dieldrin in cultured human dopaminergic cell line, SH-SY5Y. Our initial experiments revealed that L-theanine (500 microM) attenuated both rotenone- and dieldrin-induced DNA fragmentation and apoptotic death in SH-SY5Y cells. In addition, L-theanine partially prevented both rotenone- and dieldrin-induced heme oxygenase-1 (HO-1) up-regulation. Both rotenone- and dieldrin-induced down-regulation of extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation was significantly blocked by pretreatment with L-theanine. Furthermore, pretreatment with L-theanine significantly attenuated the down-regulation of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) production in SH-SY5Y cells. These results suggest that L-theanine directly provide neuroprotection against PD-related neurotoxicants and may be clinically useful for preventing PD symptoms.

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Authors: Cho, H.-S., Kim, S., Lee, S.-Y., Park, J. A., Kim, S.-J., & Chun, H. S.
Affiliations: Chosun University (KR)
Corresponding author: Chun, Hong Sung
ORCID: Kim, Seung
Lee, Sook-Young
Kim, Sung-Jun
Chun, Hong Sung
Venue: NeuroToxicology
Publisher: Elsevier BV
Published: 2008-07
Volume: 29
Issue: 4
Pages: 656-662
ISSN: 0161-813X (ISSN-L)
DOI: 10.1016/j.neuro.2008.03.004
OpenAlex: W1974965926
Cited by: 138
References: 40
Citations by year: 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 3 · 2016: 10 · 2015: 8 · 2014: 5 · 2013: 12 · 2012: 13
FWCI: 7.44
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroToxicology (publishedVersion)
PubMed (publishedVersion)
Funders: Chosun University
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: theanine, green tea, Parkinson's disease, neuroprotection, rotenone, dieldrin, dopaminergic neurons, SH-SY5Y cells, apoptosis, DNA fragmentation, heme oxygenase-1, ERK1/2 phosphorylation, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, neurotoxicity, oxidative stress
MeSH terms: Analysis of Variance, Cell Line, Transformed, Dieldrin, Dose-Response Relationship, Drug, Drug Interactions, Glutamates, Humans, Indoles, Insecticides, Nerve Growth Factors, Neurons, Rotenone, Apoptosis, Neuroprotective Agents, Heme Oxygenase-1

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Protective effect of the green tea component, l-theanine on environmental toxins-induced neuronal cell death

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