The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Protective effect of the green tea component, l-theanine on environmental toxins-induced neuronal cell death
Abstract
Several environmental neurotoxins and oxidative stress inducers are known to damage the nervous system and are considered major factors associated with the selective vulnerability of nigral dopaminergic neurons in Parkinson's disease (PD). Gamma-glutamylethylamide (L-theanine), a natural glutamate analog in green tea, has been shown to exert strong anti-ischemic effect. In this study, we investigated the protective effects of L-theanine on neurotoxicity induced by PD-related neurotoxicants, rotenone and dieldrin in cultured human dopaminergic cell line, SH-SY5Y. Our initial experiments revealed that L-theanine (500 microM) attenuated both rotenone- and dieldrin-induced DNA fragmentation and apoptotic death in SH-SY5Y cells. In addition, L-theanine partially prevented both rotenone- and dieldrin-induced heme oxygenase-1 (HO-1) up-regulation. Both rotenone- and dieldrin-induced down-regulation of extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation was significantly blocked by pretreatment with L-theanine. Furthermore, pretreatment with L-theanine significantly attenuated the down-regulation of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) production in SH-SY5Y cells. These results suggest that L-theanine directly provide neuroprotection against PD-related neurotoxicants and may be clinically useful for preventing PD symptoms.
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“Functionally L-theanine especially crossing the blood brain barrier, is measurable in a range from 30 min and up to 5 h after ingestion [10,11,33]”
From l -theanine: A potential multifaceted natural bioactive amide as health supplement (2017) · cites this paper as [10]
Citations
Cites
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,770
ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE
Olanow, C. W., & Tatton, W. G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.123 · Cited by 1,409
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.
Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M. T., Michel, P. P., Marquez, J., Prigent, A., Ruberg, M., Hirsch, É. C., & Agid, Y. (1997) · PubMed · Cited by 1,045
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
Schapira, A. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70327-7 · Cited by 883
Keeney, P. M., Xie, J., Capaldi, R., & Bennett, J. P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0984-06.2006 · Cited by 765
Hartmann, A., Hunot, S., Michel, P. P., Muriel, M., Vyas, S., Faucheux, B. A., Prigent, A., Turmel, H., Srinivasan, A. N., Ruberg, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040556597 · Cited by 717
Understanding cell death in parkinson's disease
Jenner, P., & Olanow, C. W. (1998) · Annals of Neurology · doi:10.1002/ana.410440712 · Cited by 686
Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra
Howells, D. W., Porritt, M. J., Wong, J. Y. F., Batchelor, P. E., Kalnins, R., Hughes, A. J., & Donnan, G. A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7483 · Cited by 513
Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain
Siegel, G. J., & Chauhan, N. B. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00030-8 · Cited by 492
l-theanine reduces psychological and physiological stress responses
Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.06.006 · Cited by 349
Cited by
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Lopez-Suarez, L., Awabdh, S. A., Coumoul, X., & Chauvet, C. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.07.008 · Cited by 265
Wang, L., Xu, R., Hu, B., Li, W., Sun, Y., Tu, Y., & Zeng, X. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.05.063 · Cited by 198
“Moreover, it has been reported to have physiological activities including neuroprotection and anti-obesity (Cho et al., 2008; Egashira et al., 2004; Zheng et al., 2005).”
BackgroundLee, Y., Choi, D., Yun, Y., Han, S., Oh, K., & Hong, J. T. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.011 · Cited by 196
“Green tea extract or EGCG has been reported to attenuate Aβ-induced neurotoxicity in cultured human neuronal cell lines and to modulate both tau pathology and Aβmediated cognitive impairment in transgenic mice models of AD [22– 26].”
BackgroundKim, T. I., Lee, Y. K., Park, S. G., Choi, I. S., Ban, J. O., Park, H. K., Nam, S.-Y., Yun, Y. W., Han, S., Oh, K. W., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.008 · Cited by 194
Lee, Y. K., Yuk, D. Y., Lee, J. W., Lee, S. Y., Ha, T. Y., Oh, K. W., Yun, Y. P., & Hong, J. T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.012 · Cited by 186
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Metadata
- Authors
- Cho, H.-S., Kim, S., Lee, S.-Y., Park, J. A., Kim, S.-J., & Chun, H. S.
- Affiliations
- Chosun University (KR)
- Corresponding author
- Chun, Hong Sung
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 29
- Issue
- 4
- Pages
- 656-662
- ISSN
- 0161-813X (ISSN-L)
- OpenAlex
- W1974965926
- Cited by
- 138
- References
- 40
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 3 · 2016: 10 · 2015: 8 · 2014: 5 · 2013: 12 · 2012: 13
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chosun University
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- theanine, green tea, Parkinson's disease, neuroprotection, rotenone, dieldrin, dopaminergic neurons, SH-SY5Y cells, apoptosis, DNA fragmentation, heme oxygenase-1, ERK1/2 phosphorylation, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, neurotoxicity, oxidative stress
- MeSH terms
- Analysis of Variance, Cell Line, Transformed, Dieldrin, Dose-Response Relationship, Drug, Drug Interactions, Glutamates, Humans, Indoles, Insecticides, Nerve Growth Factors, Neurons, Rotenone, Apoptosis, Neuroprotective Agents, Heme Oxygenase-1
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