The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Inflammation, the complement system and the diseases of aging
Abstract
Inflammation is characteristic of neurodegenerative diseases of aging. Neuropathological evidence of activated microglia and activated astrocytes in lesioned areas, combined with epidemiological evidence of sparing of Alzheimer's disease (AD), Parkinson's disease (PD) and age-related macular degeneration (AMD) in long-term users of anti-inflammatory agents, indicates that inflammation is autodestructive of neurons. Locally produced autodestructive molecules include the membrane attack complex (MAC) of complement and oxygen-free radicals. Stimulation is provided by a variety of inflammatory cytokines. Agents which reduce the intensity of inflammation should have broad spectrum application in degenerative diseases of aging.
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“These studies suggest a role of microglial cells in aging and AMD pathogenesis (Xu et al., 2009; McGeer et al., 2005).”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as McGeer et al., 2005
Citations
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Metadata
- Authors
- McGeer, E. G., Klegeris, A., & McGeer, P. L.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- McGeer, Patrick L.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 26
- Issue
- 1
- Pages
- 94-97
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1974854661
- Cited by
- 170
- References
- 41
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 9 · 2012: 12
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- inflammation, complement system, neurodegenerative diseases, aging, Alzheimer's disease, Parkinson's disease, age-related macular degeneration, microglial activation, astrocytes, membrane attack complex, oxygen free radicals, inflammatory cytokines, anti-inflammatory agents, neurodegeneration
- MeSH terms
- Aging, Animals, Complement System Proteins, Humans, Inflammation, Neuroglia, Neurodegenerative Diseases
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