Inflammation, the complement system and the diseases of aging

Inflammation, Atherosclerosis, and Coronary Artery Disease

Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990

Complement factor H polymorphism and age-related macular degeneration

Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449

Complement factor H variant increases the risk of age-related macular degeneration

Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424

A common haplotype in the complement regulatory gene factor H ( HF1/CFH ) predisposes individuals to age-related macular degeneration

Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961

The many faces of macrophage activation

Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902

A role for local inflammation in the formation of drusen in the aging eye

Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817

Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease

Chen, H., Zhang, S. M., Hernán, M. Á., Schwarzschild, M. A., Willett, W. C., Colditz, G. A., Speizer, F. E., & Ascherio, A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1059 · Cited by 641

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045

Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

Persidsky, Y., Ramirez, S. H., Haorah, J., & Kanmogne, G. D. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9025-3 · Cited by 922

Para-Inflammation in the Aging Retina

Xu, H., Chen, M., & Forrester, J. V. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.001 · Cited by 659

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Gralinski, L. E., Sheahan, T. P., Morrison, T. E., Menachery, V. D., Jensen, K., Leist, S. R., Whitmore, A. C., Heise, M. T., & Baric, R. S. (2018) · mBio · doi:10.1128/mbio.01753-18 · Cited by 656

Synuclein activates microglia in a model of Parkinson's disease

Su, X., Maguire-Zeiss, K. A., Giuliano, R., Prifti, L., Venkatesh, K., & Federoff, H. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.006 · Cited by 474

Parkinson’s Disease

Mhyre, T. R., Boyd, J. T., Hamill, R. W., & Maguire‐Zeiss, K. A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5416-4_16 · Cited by 463

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

Bureau, G., Longpré, F., & Martinoli, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21503 · Cited by 344

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

Daniele, S. G., Béraud, D., Davenport, C., Cheng, K., Yin, H., & Maguire-Zeiss, K. A. (2015) · Science Signaling · doi:10.1126/scisignal.2005965 · Cited by 303

Genetic Analysis of Pathways to Parkinson Disease

Hardy, J. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.014 · Cited by 276

Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa

Yoshida, N., Ikeda, Y., Notomi, S., Ishikawa, K., Murakami, Y., Hisatomi, T., Enaida, H., & Ishibashi, T. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2012.07.006 · Cited by 262

Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: a review

Ranneh, Y., Ali, F., Akim, A. M., Hamid, H. A., Khaza’ai, H., & Fadel, A. (2017) · Applied Biological Chemistry · doi:10.1007/s13765-017-0285-9 · Cited by 266

Complement activation in experimental and human temporal lobe epilepsy

Aronica, E., Boer, K., van Vliet, E. A., Redeker, S., Baayen, J. C., Spliet, W. G. M., van Rijen, P. C., Troost, D., Lopes, F. H. D. S., Wadman, W. J., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.01.015 · Cited by 235

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

Brouwers, N., Van Cauwenberghe, C., Engelborghs, S., Lambert, J.-C., Bettens, K., Le Bastard, N., Pasquier, F., Montoya, A. G., Peeters, K., Mattheijssens, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.24 · Cited by 227

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

Janelsins, M. C., Mastrangelo, M. A., Park, K. M., Sudol, K. L., Narrow, W. C., Oddo, S., LaFerla, F. M., Callahan, L. M., Federoff, H. J., & Bowers, W. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.080528 · Cited by 220

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6‐hydroxydopamine model of Parkinson’s disease

Marinova‐Mutafchieva, L., Sadeghian, M., Broom, L., Davis, J. B., Medhurst, A. D., & Dexter, D. T. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06189.x · Cited by 217

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer’s disease

Liu, Y., Yoo, M.-J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E., & Lee, M. K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4218-08.2008 · Cited by 206

Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

Singhal, G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00097 · Cited by 186

REVIEW: Pin1 in Alzheimer's disease

Butterfield, D. A., Abdul, H. M., Opii, W. O., Newman, S. F., Gururaj Joshi, A., Ansari, M. A., & Rukhsana Sultana, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03995.x · Cited by 182

The Effects of Age on Pain Sensitivity: Preclinical Studies

Yezierski, R. P. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01311.x · Cited by 177

Targeted delivery of siRNA to macrophages for anti-inflammatory treatment.

Kim, S.-S., Ye, C., Kumar, P., Chiu, I., Subramanya, S., Wu, H., Shankar, P., & Manjunath, N. (2010) · Molecular Therapy · doi:10.1038/mt.2010.27 · Cited by 176

Laboratory Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

Yoshida, N., Ikeda, Y., Notomi, S., Ishikawa, K., Murakami, Y., Hisatomi, T., Enaida, H., & Ishibashi, T. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2012.07.008 · Cited by 175

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

Huang, Q., & Figueiredo‐Pereira, M. E. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0466-z · Cited by 177

IFN‐γ enhances neurogenesis in wild‐type mice and in a mouse model of Alzheimer's disease

Baron, R., Nemirovsky, A., Harpaz, I., Cohen, H., Owens, T., & Monsonego, A. (2008) · The FASEB Journal · doi:10.1096/fj.08-105866 · Cited by 173

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)

Ramkumar, H. L., Zhang, J., & Chan, C.-C. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.02.002 · Cited by 163

Alzheimers Disease and Retinal Neurodegeneration

Guo, L., Duggan, J., & Cordeiro, M. F. (2010) · Current Alzheimer Research · doi:10.2174/156720510790274491 · Cited by 164

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

Su, X., Federoff, H. J., & Maguire-Zeiss, K. A. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9053-x · Cited by 145

Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents

Jan, M. S., Ahmad, S., Hussain, F., Ahmad, A., Mahmood, F., Rashid, U., Abid, O., Ullah, F., Ayaz, M., & Sadiq, A. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111863 · Cited by 138

Age-related macular degeneration and the immune response: implications for therapy

Nussenblatt, R. B., & Ferris, F. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.06.025 · Cited by 130

Vitamin B-6 Intake Is Inversely Related to, and the Requirement Is Affected by, Inflammation Status

Morris, M. S., Sakakeeny, L., Jacques, P. F., Picciano, M. F., & Selhub, J. (2009) · Journal of Nutrition · doi:10.3945/jn.109.114397 · Cited by 130

Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126

Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy

Wang, Y., Hancock, A. M., Bradner, J. M., Chung, K. A., Quinn, J. F., Peskind, E. R., Galasko, D. R., Jankovic, J. J., Zabetian, C. P., Kim, H. M., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.006 · Cited by 121

Pathogenic Upregulation of Glial Lipocalin-2 in the Parkinsonian Dopaminergic System

Kim, B.-W., Jeong, K. H., Kim, J., Jin, M., Kim, J., Lee, M., Choi, D., Won, S.-Y., McLean, C., Jeon, M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4261-15.2016 · Cited by 118

The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration

Hadziahmetovic, M., Song, Y., Wolkow, N., Iacovelli, J., Grieco, S. F., Lee, J., Lyubarsky, A., Praticò, D., Connelly, J., Spino, M., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6207 · Cited by 119

Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation

Helbling, P. M., Piñeiro-Yáñez, E., Gerosa, R., Boettcher, S., Al-Shahrour, F., Manz, M. G., & Nombela-Arrieta, C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.004 · Cited by 116

Regulator of G-Protein Signaling 10 Promotes Dopaminergic Neuron Survival via Regulation of the Microglial Inflammatory Response

Lee, J., McCoy, M. K., Harms, A. S., Ruhn, K. A., Gold, S. J., & Tansey, M. G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1806-08.2008 · Cited by 114

Notch signaling modulates the activation of microglial cells

Grandbarbe, L., Michelucci, A., Heurtaux, T., Hemmer, K., Morga, E., & Heuschling, P. (2007) · Glia · doi:10.1002/glia.20553 · Cited by 112

The Ubiquitin–Proteasome System in Retinal Health and Disease

Campello, L., Esteve-Rudd, J., Cuenca, N., & Martín‐Nieto, J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-012-8391-5 · Cited by 110

Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits

Beach, T. G., Sue, L. I., Walker, D. G., Lue, L. F., Connor, D. J., Caviness, J. N., Sabbagh, M. N., & Adler, C. H. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0250-5 · Cited by 104

Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease

Doorn, K. J., Lucassen, P. J., Boddeke, H. W. G. M., Prins, M., Berendse, H. W., Drukarch, B., & van Dam, A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.005 · Cited by 98

Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina

Song, D., Song, Y., Hadziahmetovic, M., Zhong, Y., & Dunaief, J. L. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.020 · Cited by 96

Age-Dependent Retinal Iron Accumulation and Degeneration in Hepcidin Knockout Mice

Hadziahmetovic, M., Song, Y., Ponnuru, P., Iacovelli, J., Hunter, A. A., Haddad, N., Beard, J., Connor, J. R., Vaulont, S., & Dunaief, J. L. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6113 · Cited by 99

Effect of Complement CR1 on Brain Amyloid Burden During Aging and Its Modification by APOE Genotype

Thambisetty, M., An, Y., Nalls, M., Sojkova, J., Swaminathan, S., Zhou, Y., Singleton, A. B., Wong, D. F., Ferrucci, L., Saykin, A. J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.015 · Cited by 90

Interferon γ–Inducible Protein-10 (IP-10) and Eotaxin as Biomarkers in Age-Related Macular Degeneration

Mo, F. M., Proia, A. D., Johnson, W. H., Cyr, D., & Lashkari, K. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3910 · Cited by 97

Inflammation in transgenic mouse models of neurodegenerative disorders

Schwab, C., Klegeris, A., & McGeer, P. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.013 · Cited by 97

The Complement System, Aging, and Aging-Related Diseases

Zheng, R., Zhang, Y., Zhang, K., Yuan, Y., Jia, S., & Liu, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158689 · Cited by 98

Immunological outcomes of exercise in older adults

Senchina, D. S., & Kohut, M. L. (2007) · Clinical Interventions in Aging · doi:10.2147/ciia.2007.2.1.3 · Cited by 91

Curcumin Protects Dopaminergic Neuron Against LPS Induced Neurotoxicity in Primary Rat Neuron/Glia Culture

Yang, S., Zhang, D., Yang, Z., Hu, X., Qian, S. Y., Liu, J., Wilson, B. C., Block, M. L., & Hong, J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9675-z · Cited by 93

Regulator of G-Protein Signaling-10 Negatively Regulates NF-κB in Microglia and Neuroprotects Dopaminergic Neurons in Hemiparkinsonian Rats

Lee, J., Chung, J., McAlpine, F. E., & Tansey, M. G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1002-11.2011 · Cited by 89

Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice

Okuyama, S., Minami, S., Shimada, N., Makihata, N., Nakajima, M., & Furukawa, Y. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.043 · Cited by 88

Metabolism, mood and cognition in aging: the importance of lifestyle and dietary intervention

Hendrickx, H., McEwen, B. S., & Ouderaa, F. V. D. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.005 · Cited by 83

Inflammation and the pathogenesis of age-related macular degeneration

Augustin, A. J., & Kirchhof, J. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902942322 · Cited by 85

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

Chavarría, C., Rodríguez-Bottero, S., Quijano, C., Cassina, P., & Souza, J. M. (2018) · Biochemical Journal · doi:10.1042/bcj20180297 · Cited by 83

Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration

Lueck, K., Wasmuth, S., Williams, J., Hughes, T. R., Morgan, B. P., Lommatzsch, A., Greenwood, J., Moss, S. E., & Pauleikhoff, D. (2011) · Eye · doi:10.1038/eye.2011.109 · Cited by 80

Mendelian disorders and multifactorial traits: the big divide or one for all?

Antonarakis, S. E., Chakravarti, A., Cohen, J. C., & Hardy, J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2793 · Cited by 85

Inflammation in Dry Age-Related Macular Degeneration

Rodrigues, E. B. (2007) · Ophthalmologica · doi:10.1159/000099293 · Cited by 73

Brain progranulin expression in GRN-associated frontotemporal lobar degeneration

Chen‐Plotkin, A. S., Xiao, J., Geser, F., Martinez‐Lage, M., Grossman, M., Unger, T. L., Wood, E. M., Deerlin, V. M. V., Trojanowski, J. Q., & Lee, V. M. ‐. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0576-2 · Cited by 72

CD 4 T cells in immunity and immunotherapy of A lzheimer's disease

Monsonego, A., Nemirovsky, A., & Harpaz, I. (2013) · Immunology · doi:10.1111/imm.12103 · Cited by 72

Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells

Fernandes, A. F., Zhou, J., Zhang, X., Bian, Q., Sparrow, J. R., Taylor, A., Pereira, P., & Shang, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800268200 · Cited by 69

Modulation by Astrocytes of Microglial Cell-Mediated Neuroinflammation: Effect on the Activation of Microglial Signaling Pathways

Tichauer, J. E., Saud, K., & Rommy von Bernhardi, M. (2007) · NeuroImmunoModulation · doi:10.1159/000110642 · Cited by 68

Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease

Shin, W.-H., Jeon, M., Leem, E., Won, S.-Y., Jeong, K. H., Park, S., McLean, C., Lee, S. J., Jin, B. K., Jung, U. J., et al. (2015) · Scientific Reports · doi:10.1038/srep14764 · Cited by 65

Role of Complement Cascade in Abdominal Aortic Aneurysms

Hinterseher, I., Erdman, R., Donoso, L. A., Vrabec, T. R., Schworer, C. M., Lillvis, J. H., Boddy, A. M., Derr, K., Golden, A. M., Bowen, W. D., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.227652 · Cited by 62

Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis

Iannaccone, A., Giorgianni, F., New, D. D., Hollingsworth, T., Umfress, A. C., Alhatem, A., Neeli, I., Lenchik, N. I., Jennings, B., Calzada, J. I., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145323 · Cited by 62

Loss of P2Y2 Nucleotide Receptors Enhances Early Pathology in the TgCRND8 Mouse Model of Alzheimer's Disease

Ajit, D., Woods, L. T., Camden, J. M., Thebeau, C. N., El-Sayed, F. G., Greeson, G. W., Erb, L., Petris, M. J., Miller, D. C., Sun, G. Y., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8577-5 · Cited by 60

Bioprospecting of brown seaweeds for biotechnological applications: Phlorotannin actions in inflammation and allergy network

Barbosa, M., Lopes, G., Andrade, P. B., & Valentão, P. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.02.037 · Cited by 58

Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response

Mendes-Pinheiro, B., Soares‐Cunha, C., Marote, A., Loureiro‐Campos, E., Campos, J., Barata‐Antunes, S., Monteiro‐Fernandes, D., Santos, D. J., Duarte‐Silva, S., Pinto, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111530 · Cited by 60

Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models

López‐González, I., Viana, R., Sanz, P., & Ferrer, I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9884-4 · Cited by 54

C4b-binding protein in Alzheimer's disease: Binding to Aβ1–42 and to dead cells

Trouw, L. A., Nielsen, H. M., Minthon, L., Londos, E., Landberg, G., Veerhuis, R., Janciauskiene, S. M., & Blom, A. M. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.04.025 · Cited by 54

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Banerjee, K., Madhyastha, R., Nakajima, Y., Maruyama, M., & Madhyastha, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094748 · Cited by 53

Paeonol Suppresses Neuroinflammatory Responses in LPS-Activated Microglia Cells

He, L. X., Tong, X., Zeng, J., Tu, Y., Wu, S., Li, M., Deng, H., Zhu, M., Li, X., Nie, H., et al. (2016) · Inflammation · doi:10.1007/s10753-016-0426-z · Cited by 51

Developmental roles of microglia: A window into mechanisms of disease

Anderson, S., & Vetter, M. L. (2018) · Developmental Dynamics · doi:10.1002/dvdy.1 · Cited by 53

Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease

Tang, Y.-W., Shi, C., Yang, H., Cai, P., Liu, Q., Yang, X., Kong, L., & Wang, X. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.11.040 · Cited by 51

Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis

Swarup, V., Ghosh, J., Das, S., & Basu, A. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.01.014 · Cited by 48

Differential expression of interferon-γ receptor on human glial cells in vivo and in vitro

Hashioka, S., Klegeris, A., Schwab, C., Yu, S. Y., & McGeer, P. L. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.04.023 · Cited by 48

Proteomics of Alzheimer’s disease: understanding mechanisms and seeking biomarkers

Lovestone, S., Güntert, A., Hye, A., Lynham, S., Thambisetty, M., & Ward, M. A. (2007) · Expert Review of Proteomics · doi:10.1586/14789450.4.2.227 · Cited by 46

Targeting complement in neurodegeneration: challenges, risks, and strategies

Zelek, W. M., & Morgan, B. P. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.02.006 · Cited by 43

Complement in Neurologic Disease

Propson, N. E., Gedam, M., & Zheng, H. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-031620-113409 · Cited by 45

Tumor Necrosis Factor-α Potentiates Intraneuronal Ca2+ Signaling via Regulation of the Inositol 1,4,5-Trisphosphate Receptor

Park, K. M., Yule, D. I., & Bowers, W. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802209200 · Cited by 44

P2Y receptors in Alzheimer's disease

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The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms

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Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide‐Induced Inflammation in the Mouse Brain

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The Senescence Hypothesis of Disease Progression in Alzheimer Disease: an Integrated Matrix of Disease Pathways for FAD and SAD

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Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity

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Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity

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Opposite Effects of Bone Marrow-Derived Cells Transplantation in MPTP-rat Model of Parkinson's Disease: A Comparison Study of Mononuclear and Mesenchymal Stem Cells

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Culture and Characterization of Microglia from the Adult Murine Retina

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Complement activation by islet amyloid polypeptide (IAPP) and α-synuclein 112

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Dihydropyrimidinase-like 3 regulates the inflammatory response of activated microglia

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Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large

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Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells

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The effects of anti‐VEGF and kinin B1 receptor blockade on retinal inflammation in laser‐induced choroidal neovascularization

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Lack of association between IL-1β, TNF-α, and IL-10 gene polymorphisms and sporadic Parkinson’s disease in an Italian cohort

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Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function

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IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model

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In vitro scavenging activity for reactive oxygen species by N‐substituted indole‐2‐carboxylic acid esters

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Complement, neuroinflammation and neuronal degeneration in Alzheimer disease

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Role of complement in neurodegeneration and neuroinflammation

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Microglial Cell Dysregulation in the Aged Brain and Neurodegeneration

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