Inflammation, the complement system and the diseases of aging

Inflammation, Atherosclerosis, and Coronary Artery Disease

Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990

Complement factor H polymorphism and age-related macular degeneration

Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449

Complement factor H variant increases the risk of age-related macular degeneration

Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424

A common haplotype in the complement regulatory gene factor H ( HF1/CFH ) predisposes individuals to age-related macular degeneration

Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961

The many faces of macrophage activation

Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902

A role for local inflammation in the formation of drusen in the aging eye

Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817

Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease

Chen, H., Zhang, S. M., Hernán, M. Á., Schwarzschild, M. A., Willett, W. C., Colditz, G. A., Speizer, F. E., & Ascherio, A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1059 · Cited by 641

Inflammation and neurodegeneration in Parkinson's disease

McGeer, P. L., & McGeer, E. G. (2004) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.01.005 · Cited by 632

Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

Henkel-Tigges, J., Engelhardt, J., Siklós, L., Simpson, E. P., Kim, S. H., Pan, T., Goodman, J. C., Siddique, T., Beers, D. R., & Appel, S. H. (2003) · Annals of Neurology · doi:10.1002/ana.10805 · Cited by 576

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

Kawamata, T., Akiyama, H., Yamada, T., & McGeer, P. L. (1992) · PubMed Central · Cited by 546

Inflammation and the Degenerative Diseases of Aging

McGeer, P. L., & McGeer, E. G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.007 · Cited by 530

C-Reactive Protein: A Simple Test to Help Predict Risk of Heart Attack and Stroke

Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000093381.57779.67 · Cited by 448

Brain microglia constitutively express β-2 integrins

Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90055-r · Cited by 430

Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

Butterfield, D. A., & Kański, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00249-4 · Cited by 420

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

McGeer, P. L., Schwab, C., Parent, A., & Doudet, D. (2003) · Annals of Neurology · doi:10.1002/ana.10728 · Cited by 400

Association Between C-Reactive Protein and Age-Related Macular Degeneration

Keenan, T. D. L., & Chew, E. Y. (2017) · International Journal of Research in Medical Sciences · doi:10.1001/jamaophthalmol.2017.2210 · Cited by 378

Association between C-reactive protein and age-related macular degeneration

Seddon, J. M. (2004) · JAMA · doi:10.1001/jama.291.6.704 · Cited by 376

Activated microglia in the human glaucomatous optic nerve head

Yuan, L., & Neufeld, A. H. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1104 · Cited by 348

Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons

Gao, H., Liu, B., & Hong, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06181.2003 · Cited by 338

High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

ZHANG, X., Dong, F., Ren, J. T., Driscoll, M., & Culver, B. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.10.011 · Cited by 290

IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

Szczepanik, A. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00404-5 · Cited by 250

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C. J., Chew, E. Y., Tsai, J. –., Sackler, R. S., Haynes, C. M., Henning, A. K., SanGiovanni, J. P., Manne, S., Mayne, S. T., et al. (2005) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2005.06.004 · Cited by 213

Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure

Barcia, C., Sánchez-Bahíllo, A., Fernández‐Villalba, E., Bautista‐Hernández, V., Poza, M., Fernández-Barreiro, A., Hirsch, É. C., & Herrero, M. T. (2004) · Glia · doi:10.1002/glia.20015 · Cited by 206

Immunological aspects of microglia: relevance to Alzheimer's disease

Benveniste, E. N., Nguyen, V. T., & O'Keefe, G. M. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00045-6 · Cited by 189

Human Heart Generates Complement Proteins That Are Upregulated and Activated After Myocardial Infarction

Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (1998) · Circulation Research · doi:10.1161/01.res.83.8.860 · Cited by 161

Major histocompatibility complex antigen expression on rat microglia following epidural kainic acid lesions

Akiyama, H., Itagaki, S., & McGeer, P. L. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490200202 · Cited by 160

Microglia and the Process of Phagocytosis in Gliomas.

Penfield, W. G. (1925) · Europe PMC (PubMed Central) · Cited by 153

Inflammation and degeneration in multiple sclerosis

Brück, W., & Stadelmann, C. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0170-7 · Cited by 130

Detection of complement alternative pathway mRNA and proteins in the Alzheimer’s disease brain

Strohmeyer, R., Shen, Y., & Rogers, J. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00149-2 · Cited by 114

Atypical Antiinflammatory Activation of Microglia Induced by Apoptotic Neurons: Possible Role of Phosphatidylserine–Phosphatidylserine Receptor Interaction

Simone, R. D., Ajmone‐Cat, M. A., & Minghetti, L. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:2:197 · Cited by 89

Pharmacologic Approaches to the Treatment of Amyotrophic Lateral Sclerosis

McGeer, E. G., & McGeer, P. L. (2005) · BioDrugs · doi:10.2165/00063030-200519010-00004 · Cited by 75

Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system

Klegeris, A., Bissonnette, C. J., & McGeer, P. L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.012 · Cited by 54

Interleukin‐4, interleukin‐10, and interleukin‐1‐receptor antagonist but not transforming growth factor‐β induce ramification and reduce adhesion molecule expression of rat microglial cells

Wirjatijasa, F., Dehghani, F., Blaheta, R. A., Korf, H., & Hailer, N. P. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10254 · Cited by 52

Sparing of age-related macular degeneration in rheumatoid arthritis

McGeer, P. L., & Sibley, J. T. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.02.003 · Cited by 51

Neuroprotection from Complement‐Mediated Inflammatory Damage

Kulkarni, A. P., Kellaway, L. A., Lahiri, D. K., & Kotwal, G. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.010 · Cited by 50

Tumour necrosis factor-α blockade: a new era for effective management of rheumatoid arthritis

Hamilton, K., & Clair, E. W. S. T. (2000) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.1.5.1041 · Cited by 39

Chymotrypsin‐like proteases contribute to human monocytic THP‐1 cell as well as human microglial neurotoxicity

Klegeris, A., & McGeer, P. L. (2005) · Glia · doi:10.1002/glia.20186 · Cited by 22

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

Langston, J. W., Forno, L. S., Tetrud, J., Reeves, A. G., Kaplan, J. A., & Karluk, D. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199910)46:4 · Cited by 1

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045

Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

Persidsky, Y., Ramirez, S. H., Haorah, J., & Kanmogne, G. D. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9025-3 · Cited by 922

Para-Inflammation in the Aging Retina

Xu, H., Chen, M., & Forrester, J. V. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.001 · Cited by 659

Complement, neuroinflammation and neuronal degeneration in Alzheimer disease

McGeer, P. L., McGeer, E. G., & Yasojima, K. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8225-5_2 · Cited by 1

Inflammation and the Degenerative Diseases of Aging

McGeer, P. L., & McGeer, E. G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.007 · Cited by 530

Role of complement in neurodegeneration and neuroinflammation

Bonifati, D. M., & Kishore, U. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.007 · Cited by 314

Microglial Cell Dysregulation in the Aged Brain and Neurodegeneration

Triolo-Mieses, M., Fadić, R., & Rommy von Bernhardi, M. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_180 · Cited by 1

Innate Immunity, Local Inflammation, and Degenerative Disease

McGeer, P. L., & McGeer, E. G. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.29.re3 · Cited by 75