Cited by 152Stress Responses and CortisolEstrogen and related hormone effectsNeuroendocrine regulation and behavior

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Age-related differences in glucocorticoid receptor mRNA levels in the human brain

Perlman, William R., Webster, Maree J., Herman, Mary M., Kleinman, Joel E., Weickert, Cynthia Shannon·2007·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2006.01.010

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Abstract

Glucocorticoids and their receptors (GRs) are implicated in dynamic cognitive and neuroendocrine processes mediated by the prefrontal cortex and hippocampus. Additionally, a primary defect in forebrain GR levels can mimic symptoms of depression. We hypothesized that changes in GR mRNA levels may occur in the human brain across the life span thus positioning GR to differentially influence behavior and disease susceptibility. Following in situ hybridization with a riboprobe for human GR mRNA, we employed quantitative film autoradiography to measure expression levels in the prefrontal cortex and hippocampus in five age groups (infants, adolescents, young adults, adults, and aged) and in primary visual and visual association cortices for comparison. We detected a main effect of age group on cortical, but not hippocampal GR mRNA, with greater cortical expression in adolescents and adults than in infants or the aged. Increased GR mRNA in prefrontal cortex during adolescence and adulthood suggests that human GR-mediated forebrain regulation of cognition and the neuroendocrine stress response may be more salient during late maturation and at maturity.

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Authors: Perlman, W. R., Webster, M. J., Herman, M. M., Kleinman, J. E., & Weickert, C. S.
Affiliations: National Institutes of Health (US)
Uniformed Services University of the Health Sciences (US)
Corresponding author: Weickert, Cynthia Shannon
ORCID: Webster, Maree J.
Kleinman, Joel E.
Weickert, Cynthia Shannon
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2007-03
Volume: 28
Issue: 3
Pages: 447-458
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2006.01.010
OpenAlex: W2049840063
Cited by: 152
References: 87
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 11 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 11 · 2013: 13 · 2012: 6
FWCI: 2.18
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: glucocorticoid receptor, age differences, prefrontal cortex, hippocampus, visual cortex, visual association cortex, brain development, neuroendocrine stress response, depression, cognitive function, human brain
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Analysis of Variance, Autoradiography, Brain, Female, Humans, Infant, Male, Receptors, Glucocorticoid, In Situ Hybridization, Gene Expression Regulation, Developmental

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Age-related differences in glucocorticoid receptor mRNA levels in the human brain

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