BDNF genotype potentially modifying the association between incident stroke and depression
Abstract
Objective To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression. Method Five hundred community residents aged >65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline. Results The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function. Conclusion The BDNF val66met polymorphism may modify the association between stroke and depression.
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rs6265 has been associated with occurrence of major depressive disorder, anxiety disorders, suicidal tendencies, and depressive episodes in bipolar disorder and in patients with Alzheimer's disease.
“This SNP has also been associated with the occurrence of major depressive disorder, anxiety disorders, suicidal tendencies, and depressive episodes in bipolar disorder and in patients with Alzheimer's disease (Kim et al., 2008; Terracciano et al., 2010).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Kim et al., 2008
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- Authors
- Kim, J.-M., Stewart, R., Kim, S.-W., Yang, S.-J., Shin, I.-S., Kim, Y.-H., & Yoon, J.-S.
- Affiliations
- Chonnam National University (KR)
- King's College London (GB)
- Inje University (KR)
- Corresponding author
- Stewart, Robert
- Yoon, Jin-Sang
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 29
- Issue
- 5
- Pages
- 789-792
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2087118256
- Cited by
- 64
- References
- 2
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 8 · 2013: 6 · 2012: 9
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Ministry of Health and Welfare (A050113)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, stroke, depression, genetic susceptibility, gene-environment interaction, older adults, disability, cognitive function
- MeSH terms
- Aged, Depression, Female, Genotype, Humans, Korea, Male, Risk Factors, Comorbidity, Incidence, Risk Assessment, Brain-Derived Neurotrophic Factor, Genetic Predisposition to Disease, Stroke, Polymorphism, Single Nucleotide
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