Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-α Treatment
Open accessAbstract
Depression has been associated with inflammation, and inflammation may both influence and interact with growth factors such as brain-derived neurotrophic factor (BDNF). Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. It is thus plausible that decreased BDNF could mediate and/or moderate cytokine-induced depression. We therefore prospectively employed the Beck Depression Inventory-II (BDI-II), the Hospital Anxiety and Depression Scale (HADS), and the Montgomery-Asberg Depression Rating Scale (MADRS) in 124 initially euthymic patients during treatment with interferon-alpha (IFN-α), assessing serum BDNF and rs6265. Using mixed-effect repeated measures, lower pretreatment BDNF was associated with higher depression symptoms during IFN-α treatment (F144,17.2=6.8; P<0.0001). However, although the Met allele was associated with lower BDNF levels (F1,83.0=5.0; P=0.03), it was only associated with increased MADRS scores (F4,8.9=20.3; P<0.001), and not the BDI-II or HADS. An exploratory comparison of individual BDI-II items indicated that the Met allele was associated with suicidal ideation, sadness, and worthlessness, but not neurovegetative symptoms. Conversely, the serotonin transporter promoter polymorphism (5-HTTLPR) short allele was associated with neurovegetative symptoms such as insomnia, poor appetite and fatigue, but not sadness, worthlessness, or suicidal ideation. IFN-α therapy further lowered BDNF serum levels (F4,37.7=5.0; P=0.003), but this decrease occurred regardless of depression development. The findings thus do not support the hypothesis that decreasing BDNF is the primary pathway by which IFN-α worsens depression. Nonetheless, the results support the hypothesis that BDNF levels influence resiliency against developing inflammatory cytokine-associated depression, and specifically to a subset of symptoms distinct from those influenced by 5-HTTLPR.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The met allele of BDNF, associated with decreased BDNF release, is associated with symptoms of depression during IFN-alpha treatment.
“However, as described in section 2.6, the met allele (which is associated with decreased BDNF release) has been associated with symptoms of depression during IFN-alpha treatment (Lotrich et al., 2013).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Lotrich et al., 2013
IFN-alpha administration decreases systemic BDNF levels in humans, as do other inflammatory cytokines and LPS injections.
“IFN-alpha administration has also been found to decrease systemic BDNF levels in humans (Kenis et al., 2010, Lotrich et al., 2013) (see Figure 1), as can other inflammatory cytokines and LPS injections (Tong et al., 2008, Cortese et al., 2011) (Guan and Fang, 2006).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Lotrich et al., 2013
A direct comparison found the 5-HTTLPR Short allele specifically associated with risk for neurovegetative symptoms of depression, while the BDNF Met allele was primarily associated with cognitive symptoms.
“It is noteworthy that a direct comparison of the 5-HTTLPR and the met/val allele of BDNF found that the 5-HTTLPR Short allele was specifically associated with risk for neurovegetative symptoms of depression, while the BDNF Met allele was primarily associated with the cognitive symptoms (Lotrich et al., 2013).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Lotrich et al., 2013
Patients treated with IFN-α were shown to have decreased serum BDNF levels in combination with increased protein levels of the cytokines IL-1 and IL-2.
“Patients treated with IFN-α were shown to have decreased serum BDNF levels in combination with increased protein levels of the cytokines IL-1 and IL-2 [81, 82].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [81]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
Beck, A. T., Steer, R. A., & Carbin, M. G. (1988) · Clinical Psychology Review · doi:10.1016/0272-7358(88)90050-5 · Cited by 11,696 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070 · see citing works
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Miller, M. D., Paradis, C. F., Houck, P. R., Mazumdar, S., Stack, J. A., Rifai, A. H., Mulsant, B., & Reynolds, C. F. (1992) · Psychiatry Research · doi:10.1016/0165-1781(92)90005-n · Cited by 1,990 · see citing works
Binder (2004) · doi:10.1080/08977190410001723308 · Cited by 1,481 · see citing works
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354 · see citing works
Lasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273 · see citing works
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151 · see citing works
Mood disorders in the medically ill: scientific review and recommendations
Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.001 · Cited by 1,071 · see citing works
Kerschensteiner, M., Gallmeier, E., Behrens, L., Vargas-Leal, V., Misgeld, T., Klinkert, W. E. F., Kolbeck, R., Hoppe, E., Oropeza-Wekerle, R. L., Bartke, I., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.865 · Cited by 1,019 · see citing works
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works
Castrén, E., & Rantamäki, T. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20758 · Cited by 864 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works
Capuron, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00407-9 · Cited by 797 · see citing works
Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630 · see citing works
Brain-immune communication pathways
Quan, N., & Banks, W. A. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.05.005 · Cited by 626 · see citing works
Poduslo, J. F., & Curran, G. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00250-v · Cited by 614 · see citing works
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607 · see citing works
BDNF function and intracellular signaling in neurons.
Numakawa, T., Suzuki, S., Kumamaru, E., Adachi, N., Richards, M., & Kunugi, H. (2010) · PubMed · doi:10.14670/hh-25.237 · Cited by 598 · see citing works
Zhu, C.-B., Blakely, R. D., & Hewlett, W. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301029 · Cited by 549 · see citing works
Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works
Neuropsychiatric Adverse Effects of Interferon-??: Recognition and Management
Raison, C. L., Demetrashvili, M., Capuron, L., & Miller, A. H. (2005) · CNS Drugs · doi:10.2165/00023210-200519020-00002 · Cited by 483 · see citing works
Verhagen, M., van der Meij, A., van Deurzen, P. A. M., Janzing, J. G. E., Arias-Vásquez, A., Buitelaar, J. K., & Franke, B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.109 · Cited by 470 · see citing works
Nierenberg, A. A., Husain, M. M., Trivedi, M. H., Fava, M., Warden, D., Wisniewski, S. R., Miyahara, S., & Rush, A. J. (2010) · Psychological Medicine · doi:10.1017/s0033291709006011 · Cited by 458 · see citing works
Vascular endothelial cells synthesize and secrete brain‐derived neurotrophic factor
Nakahashi, T., Fujimura, H., Altar, C. A., Li, J., Kambayashi, J.-I., Tandon, N. N., & Sun, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01302-8 · Cited by 430 · see citing works
Hashimoto, K. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02113.x · Cited by 388 · see citing works
Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367 · see citing works
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works
Porcelli, S., Fabbri, C., & Serretti, A. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.10.003 · Cited by 331 · see citing works
Morrow, G. R., Hickok, J. T., Roscoe, J. A., Raubertas, R. F., Andrews, P. L. R., Flynn, P. J., Hynes, H. E., Banerjee, T. K., Kirshner, J. J., & King, D. K. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.04.070 · Cited by 324 · see citing works
Zhu, C.-B., Lindler, K. M., Owens, A. W., Daws, L. C., Blakely, R. D., & Hewlett, W. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.116 · Cited by 317 · see citing works
Neuronal plasticity: A link between stress and mood disorders
Calabrese, F., Molteni, R., Racagni, G., & Riva, M. A. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.014 · Cited by 299 · see citing works
Anisman, H. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0902 · Cited by 292 · see citing works
Sartorius, A., Hellweg, R., Litzke, J., Vogt, M., Dormann, C., Vollmayr, B., Danker-Hopfe, H., & Gass, P. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1224162 · Cited by 276 · see citing works
Ziemssen, T. (2002) · Brain · doi:10.1093/brain/awf252 · Cited by 268 · see citing works
Aguilera, M., Arias, B., Wichers, M., Barrantes-Vidal, N., Moya, J., Villa, H., van Os, J., Ibáñez, M. I., Ruipérez, M. A., Ortet, G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291709005248 · Cited by 265 · see citing works
Barrientos, R. M., Sprunger, D. B., Campeau, S., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00564-5 · Cited by 251 · see citing works
Guan, Z., & Fang, J. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.04.005 · Cited by 247 · see citing works
Jiang, X., Xu, K., Hoberman, J., Tian, F., Marko, A. J., Waheed, J. F., Harris, C. R., Marini, A. M., Enoch, M.-A., & Lipsky, R. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300703 · Cited by 244 · see citing works
McClintock, S. M., Husain, M. M., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Trivedi, M. H., Cook, I., Morris, D., Warden, D., & Rush, A. J. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31820ebd2c · Cited by 234 · see citing works
Bull, S. J., Huezo-Diaz, P., Binder, E. B., Cubells, J. F., Ranjith, G., Maddock, C., Miyazaki, C., Alexander, N., Hotopf, M., Cleare, A. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.48 · Cited by 228 · see citing works
Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction
Tong, L., Balazs, R., Soiampornkul, R., Thangnipon, W., & Cotman, C. W. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.027 · Cited by 222 · see citing works
Besser, M. J., & Wank, R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6303 · Cited by 214 · see citing works
Felger, J. C., Alagbe, O., Hu, F., Mook, D., Freeman, A. A., Sanchez, M. M., Kalin, N. H., Ratti, E., Nemeroff, C. B., & Miller, A. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.026 · Cited by 214 · see citing works
Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women
Aydemir, Ç., Yalcın, E., Aksaray, S., Kısa, C., Yildirim, S. G., Uzbay, T. I., & Göka, E. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.025 · Cited by 210 · see citing works
Gervasoni, N., Aubry, J., Bondolfi, G., Osiek, C., Schwald, M., Bertschy, G., & Karege, F. (2005) · Neuropsychobiology · doi:10.1159/000085725 · Cited by 204 · see citing works
Measurements of brain-derived neurotrophic factor. Methodological aspects and demographical data.
Trajkovska, V., Marcussen, A. B., Vinberg, M., Hartvig, P., Aznar, S., & Knudsen, G. M. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.03.009 · Cited by 203 · see citing works
Kunugi, H., Hori, H., Adachi, N., & Numakawa, T. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02135.x · Cited by 200 · see citing works
QTL Analysis of Multiple Behavioral Measures of Anxiety in Mice
Henderson, N. D., Turri, M. G., DeFries, J. C., & Jonathan Flint, C. (2004) · Behavior Genetics · doi:10.1023/b:bege.0000017872.25069.44 · Cited by 192 · see citing works
Raison, C. L., Borisov, A. S., Woolwine, B. J., Massung, B., Vogt, G., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.58 · Cited by 183 · see citing works
Bocchio‐Chiavetto, L., Zanardini, R., Bortolomasi, M., Abate, M., Segala, M., Giacopuzzi, M., Riva, M. A., Marchina, E., Pasqualetti, P., Pérez, J., et al. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.04.010 · Cited by 180 · see citing works
Mößner, R., Daniel, S., Albert, D., Heils, A., Okladnova, O., Schmitt, A. G., & Lesch, K. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(99)00122-9 · Cited by 172 · see citing works
Montag, C., Weber, B., Fliessbach, K., Elger, C., & Reuter, M. (2009) · Psychological Medicine · doi:10.1017/s0033291709005509 · Cited by 165 · see citing works
Su, K., Huang, S., Peng, C., Lai, H., Huang, C., Chen, Y.-C., Aitchison, K. J., & Pariante, C. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.005 · Cited by 165 · see citing works
Kaneko, N., Kudo, K., Mabuchi, T., Takemoto, K., Fujimaki, K., Wati, H., Iguchi, H., Tezuka, H., & Kanba, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301137 · Cited by 152 · see citing works
Peng, C., Chiou, S., Chen, S., Chou, Y., Ku, H., Cheng, C., Yen, C.-J., Tsai, T., Chang, Y., & Kao, C.-L. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.05.002 · Cited by 145 · see citing works
Menachem-Zidon, O. B., Goshen, I., Kreisel, T., Menahem, Y. B., Reinhartz, E., Hur, T. B., & Yirmiya, R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301606 · Cited by 141 · see citing works
Lavebratt, C., Åberg, E., Sjöholm, L. K., & Forsell, Y. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.02.113 · Cited by 140 · see citing works
Cytokine-induced depression during IFN-α treatment: The role of IL-6 and sleep quality
Prather, A. A., Rabinovitz, M., Pollock, B. G., & Lotrich, F. E. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.07.001 · Cited by 139 · see citing works
Self-citationLotrich, F. E., Ferrell, R. E., Rabinovitz, M., & Pollock, B. G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.009 · Cited by 136 · see citing works
Self-citationThe effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels
Ozan, E., Okur, H., Eker, M. C., Eker, Ö. D., Gönül, A. S., & Akarsu, N. A. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.022 · Cited by 130 · see citing works
Mößner, R. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(98)00026-6 · Cited by 130 · see citing works
Lau, J. Y. F., Goldman, D. A., Búzás, B., Hodgkinson, C. A., Leibenluft, E., Nelson, E. E., Sankin, L. S., Pine, D. S., & Monique Ernst, D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.026 · Cited by 121 · see citing works
Cortese, G. P., Barrientos, R. M., Maier, S. F., & Patterson, S. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5818-10.2011 · Cited by 119 · see citing works
Montag, C., Basten, U., Stelzel, C., Fiebach, C. J., & Reuter, M. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2008.08.005 · Cited by 117 · see citing works
Montag, C., Reuter, M., Newport, B., Elger, C. E., & Weber, B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.008 · Cited by 116 · see citing works
Sarchiapone, M., Carli, V., Roy, A., Iacoviello, L., Cuomo, C., Latella, M. C., di Giannantonio, M., Janiri, L., de Gaetano, M., & Janal, M. N. (2008) · Neuropsychobiology · doi:10.1159/000142361 · Cited by 115 · see citing works
Cattaneo, A., Bocchio‐Chiavetto, L., Zanardini, R., Milanesi, E., Placentino, A., & Gennarelli, M. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990812 · Cited by 106 · see citing works
Kraus, M. R., Al‐Taie, O., Schäfer, A., Pfersdorff, M., Lesch, K., & Scheurlen, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.053 · Cited by 104 · see citing works
Ribeiro, L., Busnello, J. V., Cantor, R. M., Whelan, F., Whittaker, P., Deloukas, P., Wong, M., & Licinio, J. (2007) · Neuroreport · doi:10.1097/wnr.0b013e328273bcb0 · Cited by 101 · see citing works
Depression following pegylated interferon-alpha: Characteristics and vulnerability
Lotrich, F. E., Rabinovitz, M., Gironda, P., & Pollock, B. G. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.05.013 · Cited by 100 · see citing works
Self-citationGoldstein, B. I., Collinger, K. A., Lotrich, F. E., Marsland, A. L., Gill, M., Axelson, D., & Birmaher, B. B. (2011) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0009 · Cited by 97 · see citing works
Self-citationSchüle, C., Zill, P., Baghai, T. C., Eser, D., Zwanzger, P., Wenig, N., Rupprecht, R., & Bondy, B. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.06.002 · Cited by 94 · see citing works
Interaction between genetic polymorphisms and stressful life events in first episode depression
Bukh, J. D., Bock, C., Vinberg, M., Werge, T. M., Gether, U., & Kessing, L. V. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.023 · Cited by 92 · see citing works
Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker for affective disorders?
Gass, P., & Hellweg, R. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991039 · Cited by 90 · see citing works
Genetic association study of BDNF in depression: Finding from two cohort studies and a meta‐analysis
Chen, L., Lawlor, D. A., Lewis, S. J., Yuan, W., Abdollahi, M. R., Timpson, N. J., Day, I. N. M., Ebrahim, S. B. J., Smith, G. D., & Shugart, Y. Y. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30686 · Cited by 90 · see citing works
The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide
Pregelj, P., Nedic, G., Paska, A. V., Zupanc, T., Nikolac, M., Balažic, J., Tomori, M., Komel, R., Seler, D. M., & Pivac, N. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.07.001 · Cited by 88 · see citing works
Gatt, J. M., Nemeroff, C. B., Schofield, P. R., Paul, R. H., Clark, C. R., Gordon, E., & Williams, L. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.025 · Cited by 88 · see citing works
Lotrich, F. E., Sears, B., & McNamara, R. K. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.007 · Cited by 86 · see citing works
Self-citationZhou, Z., Lu, T., Xu, G., Yue, X., Zhu, W., Ma, M., Liu, W., Zhu, S., & Liu, X. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.039 · Cited by 83 · see citing works
Kanellopoulos, D., Gunning, F. M., Morimoto, S. S., Hoptman, M. J., Murphy, C. F., Kelly, R. E., Glatt, C. E., Lim, K. O., & Alexopoulos, G. S. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181f61d62 · Cited by 81 · see citing works
Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression
Duncan, L. E., Hutchison, K. E., Carey, G., & Craighead, W. E. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.08.016 · Cited by 81 · see citing works
Heritability of individual depressive symptoms
Jang, K. L., Livesley, W. J., Taylor, S. J., Stein, M. B., & Moon, E. C. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00108-3 · Cited by 80 · see citing works
Fatigue as a residual symptom of depression.
Targum, S. D., & D, M. F. M. (2011) · PubMed Central · Cited by 76 · see citing works
The BDNF Val66Met polymorphism is associated with rumination in healthy adults.
Beevers, C. G., Wells, T. T., & McGeary, J. E. (2009) · Emotion · doi:10.1037/a0016189 · Cited by 74 · see citing works
Gatt, J. M., Kuan, S. A., Dobson‐Stone, C., Paul, R. H., Joffe, R. T., Kemp, A. H., Gordon, E., Schofield, P. R., & Williams, L. M. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.07.004 · Cited by 72 · see citing works
Major depression during interferon-α treatment: vulnerability and prevention
Lotrich, F. E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.4/felotrich · Cited by 71 · see citing works
Self-citationBDNF Genetic Variations Increase the Risk of Alzheimer's Disease-Related Depression
Borroni, B., Grassi, M., Archetti, S., Costanzi, C., Bianchi, M., Caimi, L., Caltagirone, C., Luca, M. D., & Padovani, A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1191 · Cited by 68 · see citing works
Choi, S., Bhang, S., & Ahn, J. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.07.028 · Cited by 67 · see citing works
Kairisalo, M., Korhonen, L., Sepp, M., Pruunsild, P., Kukkonen, J. P., Kivinen, J., Timmusk, T., Blomgren, K., & Lindholm, D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06898.x · Cited by 65 · see citing works
BDNF genotype potentially modifying the association between incident stroke and depression
Kim, J.-M., Stewart, R., Kim, S.-W., Yang, S.-J., Shin, I.-S., Kim, Y.-H., & Yoon, J.-S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.021 · Cited by 64 · see citing works
Plasma BDNF concentration, Val66Met genetic variant and depression- related personality traits
Terracciano, A., Martin, B., Ansari, D., Tanaka, T., Ferrucci, L., Maudsley, S., Mattson, M. P., & Costa, P. T. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00579.x · Cited by 63 · see citing works
Franzen, P. L., Buysse, D. J., Rabinovitz, M., Pollock, B. G., & Lotrich, F. E. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.02.011 · Cited by 62 · see citing works
Self-citationKenis, G., Prickaerts, J., van Os, J., Koek, G. H., Robaeys, G., Steinbusch, H. W. M., & Wichers, M. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000830 · Cited by 58 · see citing works
An association study between the Val66Met polymorphism of the BDNF gene and postpartum depression
Figueira, P. G., Malloy‐Diniz, L. F., Campos, S. B., de Miranda, D. M., Romano‐Silva, M. A., Marco, L. A. D., Neves, F. S., & Corrêa, H. (2010) · Archives of Women s Mental Health · doi:10.1007/s00737-010-0146-6 · Cited by 58 · see citing works
Brain-Derived Neurotrophic Factor in TNF-α Modulation of Ca2+ in Human Airway Smooth Muscle
Prakash, Y. S., Thompson, M. A., & Pabelick, C. M. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0151oc · Cited by 58 · see citing works
Inflammatory Cytokines, Growth Factors, and Depression
Lotrich, F. E. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523680 · Cited by 55 · see citing works
Self-citationNeurotrophins Regulate Bone Marrow Stromal Cell IL-6 Expression through the MAPK Pathway
Rezaee, F., Rellick, S. L., Piedimonte, G., Akers, S. M., O’Leary, H. A., Martin, K. H., Craig, M., & Gibson, L. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009690 · Cited by 54 · see citing works
BDNF Val66Met genotype and 6-month remission rates in late-life depression
Taylor, W. D., McQuoid, D. R., Ashley‐Koch, A. E., MacFall, J. R., Bridgers, J., Krishnan, R. R., & Steffens, D. C. (2010) · The Pharmacogenomics Journal · doi:10.1038/tpj.2010.12 · Cited by 50 · see citing works
Tsao, C. ‐., Lin, Y.-S., Cheng, J.-T., Lin, C.-F., Wu, H., Wu, S. ‐., & Tsai, W.-H. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107082951 · Cited by 49 · see citing works
Zhang, L., Fang, Y., Zeng, Z., Lian, Y., Wei, J., Zhu, H., Jia, Y., Zhao, X., & Xu, Y. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110113 · Cited by 47 · see citing works
Su, N., Zhang, L., Fei, F., Hu, H., Wang, K., Hui, H., Jiang, X., Li, X., Zhen, H., Li, J., et al. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.005 · Cited by 47 · see citing works
Jen, J. F., Glue, P., Ezzet, F., Chung, C., Gupta, S. K., Jacobs, S., & Hajian, G. (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.115872 · Cited by 47 · see citing works
Fahey, B., Hickey, B., Kelleher, D., O’Dwyer, A.-M., & O’Mara, S. M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.05.005 · Cited by 43 · cited 1× · see citing works
“Neuropsychopharmacology depression and those who did not—consistent with IFN-a having behavioral effects in rodents without affecting cortical BDNF levels (Fahey et al, 2007).”
ResultAnxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?
Middeldorp, C. M., Landt, M., Medland, S. E., van Beijsterveldt, C. E. M., Bartels, M., Willemsen, G. A. H. M., Hottenga, J., de Geus, E. J. C., Suchiman, H. E. D., Dolan, C. V., et al. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00619.x · Cited by 43 · see citing works
Lotrich, F. E., Pollock, B. G., Kirshner, M. A., Ferrell, R. F., & Reynolds, C. F. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0814 · Cited by 42 · see citing works
Self-citationHayden, E. P., Klein, D. N., Dougherty, L. R., Olino, T. M., Dyson, M. W., Durbin, C. E., Sheikh, H. I., & Singh, S. M. (2010) · Psychological Science · doi:10.1177/0956797610385357 · Cited by 42 · see citing works
Felger, J. C., Alagbe, O., Pace, T. W. W., Woolwine, B. J., Hu, F., Raison, C. L., & Miller, A. H. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.02.015 · Cited by 41 · see citing works
Lotrich, F. E., Ferrell, R. E., Rabinovitz, M., & Pollock, B. G. (2010) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181de8966 · Cited by 41 · see citing works
Self-citationLisak, R. P., Benjamins, J. A., Bealmear, B., Nedelkoska, L., Yao, B. W., Land, S. J., & Studzinski, D. M. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-30 · Cited by 36 · see citing works
Lotrich, F. E., Loftis, J. M., Ferrell, R. E., Rabinovitz, M., & Hauser, P. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0074 · Cited by 35 · see citing works
Self-citationFoley, D. L., Neale, M. C., Gardner, C. O., Pickles, A. R., & Kendler, K. S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2128 · Cited by 35 · see citing works
Liguori, M., Fera, F. S., Patitucci, A., Manna, I., Condino, F., Valentino, P., Telarico, P., Cerasa, A., Gioia, M. C., Palma, G. D., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.047 · Cited by 32 · see citing works
Kunz, D., Walker, G., Bedoucha, M., Certa, U., März, P., Dimitriades‐Schmutz, B., & Otten, U. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-90 · Cited by 22 · see citing works
Furuno, T., & Nakanishi, M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.031 · Cited by 22 · see citing works
Gene-Environment Interactions in Geriatric Depression
Lotrich, F. E. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.02.003 · Cited by 21 · see citing works
Self-citationSuchanek-Raif, R., Owczarek, A. J., Kowalczyk, M., Kucia, K. A., & Kowalski, J. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9478-y · Cited by 20 · see citing works
Cirulli, F., Reif, A., Herterich, S., Lesch, K., Berry, A., Francia, N., Aloe, L., Barr, C. S., Suomi, S. J., & Alleva, E. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.10.019 · Cited by 20 · see citing works
Wray, N. R., James, M. R., Handoko, H. Y., Dumenil, T. D., Lind, P. A., Montgomery, G. W., & Martin, N. G. (2008) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283050aee · Cited by 18 · see citing works
Brain-derived neurotrophic factor selectively enhances allergen-specific IgE production
Kimata, H. (2005) · Neuropeptides · doi:10.1016/j.npep.2005.06.001 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Self-citationBrain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Kim, Y.-K., Na, K.-S., Myint, A.-M., & Leonard, B. E. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.008 · Cited by 620 · see citing works
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Wu, A., & Zhang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02964-x · Cited by 327 · see citing works
Polacchini, A., Metelli, G., Francavilla, R., Baj, G., Florean, M., Mascaretti, L. G., & Tongiorgi, E. (2015) · Scientific Reports · doi:10.1038/srep17989 · Cited by 263 · see citing works
The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders
Jin, Y., Sun, L., Yang, W., Cui, R., & Xu, S. B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00515 · Cited by 199 · see citing works
Low-grade inflammation predicts persistence of depressive symptoms
Zalli, A., Jovanova, O., Hoogendijk, W. J. G., Tiemeier, H. W., & Carvalho, L. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3919-9 · Cited by 193 · see citing works
Inflammatory cytokine-associated depression
Lotrich, F. E. (2015) · Brain Research · doi:10.1016/j.brainres.2014.06.032 · Cited by 183 · see citing works
Self-citationBrain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
Porter, G., & O'Connor, J. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i1.77 · Cited by 167 · see citing works
Haase, J. K., & Brown, E. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.10.002 · Cited by 173 · see citing works
Major Depression: One Brain, One Disease, One Set of Intertwined Processes
Filatova, E. V., Shadrina, M. I., & Slominsky, P. A. (2021) · Cells · doi:10.3390/cells10061283 · Cited by 167 · see citing works
Therapeutic Strategies for Treatment of Inflammation-related Depression
Adžić, M., Brkic, Z., Mitić, M., Francija, E., Jovicic, M. J., Radulović, J., & Marić, N. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170828163048 · Cited by 156 · see citing works
Yin, Y., Ju, T., Zeng, D., Duan, F., Zhu, Y., Liu, J., Li, Y., & Lu, W. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107322 · Cited by 152 · see citing works
Depression and chronic liver diseases: are there shared underlying mechanisms?
Huang, X., Liu, X., & Yu, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00134 · Cited by 121 · see citing works
Hoyo-Becerra, C., Schlaak, J., & Hermann, D. M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.200 · Cited by 117 · see citing works
Golub, V. M., & Reddy, D. S. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000375 · Cited by 112 · see citing works
Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses
Audet, M., & Anisman, H. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00068 · Cited by 106 · see citing works
Udina, M., Navinés, R., Egmond, E., Oriolo, G., Langohr, K., Giménez, D., Valdés, M., Gómez‐Gil, E., Grande, I., Gratacòs, M., et al. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv135 · Cited by 88 · see citing works
Lotrich, F. E., Butters, M. A., Aizenstein, H. J., Marron, M. M., Reynolds, C. F., & Gildengers, A. G. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4048 · Cited by 83 · see citing works
Self-citationUdina, M., Moreno-España, J., Navinés, R., Giménez, M. D., Langohr, K., Gratacòs, M., Capuron, L., de la Torre, R., Sola, R. L., & Martín‐Santos, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.007 · Cited by 63 · see citing works
The Neurobiology of Motivational Deficits in Depression—An Update on Candidate Pathomechanisms
Treadway, M. T. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_400 · Cited by 63 · see citing works
Hepgul, N., Cattaneo, A., Agarwal, K., Baraldi, S., Borsini, A., Bufalino, C., Forton, D. M., Mondelli, V., Nikkheslat, N., Lopizzo, N., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.50 · Cited by 62 · see citing works
Association between the dietary inflammatory index and common mental health disorders profile scores
Haghighatdoost, F., Feizi, A., Esmaillzadeh, A., Feinle‐Bisset, C., Keshteli, A. H., Afshar, H., & Adibi, P. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.016 · Cited by 56 · see citing works
Dooley, L. N., Ganz, P. A., Cole, S. W., Crespi, C. M., & Bower, J. E. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.059 · Cited by 50 · see citing works
Eshragh, J. L., Dhruva, A., Paul, S. M., Cooper, B. A., Mastick, J., Hamolsky, D., Levine, J. D., Miaskowski, C. A., & Kober, K. M. (2016) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2016.08.004 · Cited by 48 · see citing works
González‐Castro, T. B., Nicolini, H., Lanzagorta, N., López‐Narváez, M. L., Genis, A. D., García, S. P., & Tovilla‐Zárate, C. A. (2014) · Bipolar Disorders · doi:10.1111/bdi.12227 · Cited by 47 · see citing works
Moretti, M., Neis, V. B., MATHEUS, F. C., Cunha, M. P., da Rosa, P. B., Ribeiro, C. M., Rodrigues, A. L. S., & Prediger, R. D. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9540-1 · Cited by 46 · see citing works
Grygiel‐Górniak, B., Limphaibool, N., & Puszczewicz, M. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12826 · Cited by 45 · see citing works
Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging
Michel, J. J., Griffin, P. C., & Vallejo, A. N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00530 · Cited by 41 · see citing works
Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression
Caldieraro, M. A., McKee, M., Leistner-Segal, S., Vares, E. A., Kubaski, F., Spanemberg, L., Brusius-Facchin, A. C., Fleck, M. P., & Mischoulon, D. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1347713 · Cited by 39 · see citing works
Increased levels of plasma IL-1b and BDNF can predict resistant depression patients
Uint, L., Bastos, G. M., Thurow, H. S., Borges, J. B., Hirata, T. D. C., França, J. Í. D., Hirata, M. H., & Sousa, A. (2019) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.65.3.361 · Cited by 40 · see citing works
Chan, S. Y., Probert, F., Radford‐Smith, D. E., Hebert, J. C., Claridge, T. D. W., Anthony, D. C., & Burnet, P. W. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-74008-w · Cited by 38 · see citing works
Huckans, M. S., Fuller, B. E., Olavarria, H., Sasaki, A. W., Chang, M., Flora, K. D., Kolessar, M., Kříž, D., Anderson, J. R., Vandenbark, A. A., et al. (2013) · Brain and Behavior · doi:10.1002/brb3.200 · Cited by 38 · see citing works
Differential Neuroinflammatory Response in Male and Female Mice: A Role for BDNF
Rossetti, A. C., Paladini, M. S., Trepci, A., Mallien, A. S., Riva, M. A., Gass, P., & Molteni, R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00166 · Cited by 38 · see citing works
Colle, R., Trabado, S., David, D. J. P., Brailly‐Tabard, S., Hardy, P., Falissard, B., Fève, B., Becquemont, L., Verstuyft, C., & Corruble, E. (2017) · Neuropsychobiology · doi:10.1159/000478862 · Cited by 33 · see citing works
Francis, K., Dougali, A., Sideri, K., Κroupis, C., Vasdekis, V., Dima, K., & Douzenis, A. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12872 · Cited by 33 · see citing works
Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids
Lotrich, F. E., Sears, B., & McNamara, R. K. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.07.012 · Cited by 31 · see citing works
Self-citationZhao, Y., Zhang, Y., & Pan, F. (2015) · Central European Journal of Immunology · doi:10.5114/ceji.2015.49427 · Cited by 31 · see citing works
Réus, G. Z., Nacif, M., Abelaira, H. M., Tomaz, D. B., Santos, M. A. D. J. C., Carlessi, A. S., Matias, B. I., da Luz, J. R., Steckert, A. V., Jeremias, G. C., et al. (2015) · Current Neurovascular Research · doi:10.2174/1567202612666150122122924 · Cited by 27 · see citing works
State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders
Mucci, F., Marazziti, D., Vecchia, A. D., Baroni, S., Morana, P., Carpita, B., Mangiapane, P., Morana, F., Morana, B., & Dell’Osso, L. (2020) · Life · doi:10.3390/life10060082 · Cited by 26 · see citing works
Brain derived neurotrophic factor deficiency exacerbates inflammation-induced anhedonia in mice
Parrott, J. M., Porter, G. A., Redus, L., & O’Connor, J. C. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105404 · Cited by 24 · see citing works
Depression in Late-Life: A Focus on Prevention
Okereke, O. I., Lyness, J. M., Lotrich, F. E., & Reynolds, C. F. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.22 · Cited by 25 · see citing works
Self-citationCallaghan, C. K., Rouine, J., & O’Mara, S. M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.07.018 · Cited by 24 · see citing works
Karthik, S., Saraswathi, I., Alarifi, A., Al-Atram, A. A., Mickeymaray, S., Paramasivam, A., Shaikh, S., Jeraud, M., & Alothaim, A. S. (2022) · PeerJ · doi:10.7717/peerj.14227 · Cited by 23 · see citing works
Neurobiological and psychological factors to depression
Turner, M. (2024) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2024.2382091 · Cited by 22 · see citing works
Nicholson, W., Kempf, M., Moneyham, L. D., & Vance, D. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s136065 · Cited by 19 · see citing works
Porcelli, S., Crisafulli, C., Donato, L., Calabrò, M., Politis, A. M., Liappas, I., Albani, D., Rita, A. A., Salfi, R., Raimondi, I., et al. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.09.053 · Cited by 19 · see citing works
Mood disturbance after infection
Gunaratne, P., Lloyd, A. R., & Vollmer-Conna, U. S. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413503718 · Cited by 18 · see citing works
Cozzolongo, R., Porcelli, P., Cariola, F., Giannuzzi, V., Lanzilotta, E., Gentile, M., Sonnante, G., & Leandro, G. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.056 · Cited by 18 · see citing works
Fighting Insomnia and Battling Lethargy: The Yin and Yang of Palliative Care
Davis, M. P., & Goforth, H. W. (2014) · Current Oncology Reports · doi:10.1007/s11912-014-0377-1 · Cited by 17 · see citing works
Zheng, Q., Xu, M., Cheng, J. Y., Chen, J., Zheng, L., & Li, Z. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.12.001 · Cited by 18 · see citing works
Blood and tissue levels of lncRNAs in periodontitis
Sayad, A., Ghafouri‐Fard, S., Shams, B., Arsang‐Jang, S., Gholami, L., & Taheri, M. N. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29764 · Cited by 17 · see citing works
Sick and Tired: Mood, Fatigue, and Inflammation in Cancer
Kruse, J. L., & Strouse, T. B. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0555-3 · Cited by 16 · see citing works
Translational Functional Neuroimaging in the Explanation of Depression
Stoyanov, D., Kandilarova, S., & Borgwardt, S. (2017) · Balkan Medical Journal · doi:10.4274/balkanmedj.2017.1160 · Cited by 16 · see citing works
Lotrich, F. E., & Germain, A. (2014) · Acta Neuropsychiatrica · doi:10.1017/neu.2014.30 · Cited by 15 · see citing works
Self-citationPeng, J.-H., Liu, C., Pan, S., Wu, H., Liang, Q., Gan, R., Huang, L., Ding, Y., Bian, Z., Huang, H., et al. (2017) · BMC Geriatrics · doi:10.1186/s12877-016-0393-0 · Cited by 15 · see citing works
Cheng, M. T., Jiang, Z., Yang, J., Sun, X., Song, N., Du, C., Luo, Z.-L., & Zhang, Z. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1561848 · Cited by 18 · see citing works
Depressive Disorders And Pain: A Joint Model Of Diagnosis And Treatment
Torta, R. (2013) · Journal of Pain & Relief · doi:10.4172/2167-0846.1000s2-003 · Cited by 13 · see citing works
Baer, M., Klemetson, B. A., Scott, D., Murtishaw, A. S., Navalta, J. W., Kinney, J. W., & Landers, M. R. (2018) · Neurology Report · doi:10.1097/npt.0000000000000213 · Cited by 13 · see citing works
Neurotrophins in Neurodevelopmental Disorders: A Narrative Review of the Literature
Panvino, F., Paparella, R., Tarani, F., Lombardi, C., Ferraguti, G., Pisani, F., Fiore, M., Pancheva, R., Ardizzone, I., & Tarani, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178335 · Cited by 13 · see citing works
Felice, G. D., Luciano, M., Boiano, A., Colangelo, G., Catapano, P., Rocca, B. D., Lapadula, M. V., Piegari, E., Toni, C., & Fiorillo, A. (2023) · Brain Sciences · doi:10.3390/brainsci13081221 · Cited by 12 · see citing works
Psychiatric Clearance for Patients Started on Interferon-Alpha-Based Therapies
Lotrich, F. E. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12121572 · Cited by 12 · see citing works
Self-citationMałyszczak, K., Inglot, M., Frydecka, D., Hadryś, T., & Pawłowski, T. (2019) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/104617 · Cited by 12 · see citing works
Sun, C.-F., Chiu, W., Chen, P., Chang, H.-C., Guu, T., Shityakov, S., Miller, A. H., Felger, J. C., Chang, J. P., & Su, K. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.044 · Cited by 10 · see citing works
Vinberg, M., Miskowiak, K. W., & Kessing, L. V. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.007 · Cited by 9 · see citing works
Polyunsaturated fatty acids moderate the effect of poor sleep on depression risk
Lotrich, F. E., Sears, B., & McNamara, R. K. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.10.004 · Cited by 9 · see citing works
Self-citationMarıno, A., Scuderi, D., Locatelli, M. E., Gentile, A., Pampaloni, A., Cosentino, F., Ceccarelli, M., Celesia, B. M., Benanti, F., Nunnari, G., et al. (2020) · Hepatitis Monthly · doi:10.5812/hepatmon.95101 · Cited by 8 · see citing works
Ramawat, R. B., Quraishi, R., Deep, R., Kumar, R., Mishra, A. K., & Jain, R. (2024) · Indian Journal of Psychological Medicine · doi:10.1177/02537176241280050 · Cited by 7 · see citing works
Evaluation of the effect of soybean diet on interferon-α-induced depression in male mice.
Fashi, Y. A., Mesripour, A., & Hajhashemi, V. (2017) · Europe PMC (PubMed Central) · doi:10.22038/ajp.2017.20914.1793 · Cited by 7 · see citing works
Obolenskaya, M. Y., Dotsenko, V., Martsenyuk, O. P., Ralchenko, S., Krupko, O., Pastukhov, A. O., Filimonova, N. B., Starosila, D., Chernykh, S. I., & Borisova, Т. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110317 · Cited by 7 · see citing works
Zai, C. C., George, J., Cheema, S. Y., Zai, G. C., Fonseka, T. M., Danesi, M., Shaikh, S. A., Irwin, D., Tampakeras, M., Freeman, N., et al. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.02.034 · Cited by 6 · see citing works
Fábregas, B. C., Vieira, É. L. M., Moura, A. S., Carmo, R. A., de Ávila, R. E., Abreu, M. N. S., Prossin, A. R., & Teixeira, A. L. (2016) · NeuroImmunoModulation · doi:10.1159/000444531 · Cited by 6 · see citing works
Research of related factors of depression in COPD patients
Zhai, Q., Xu, K., & Xiu, L. (2024) · Medicine · doi:10.1097/md.0000000000040046 · Cited by 3 · see citing works
Nylocks, K. M., Gilman, T. L., Latsko, M. S., Jasnow, A. M., & Coifman, K. G. (2018) · Motivation and Emotion · doi:10.1007/s11031-018-9679-1 · Cited by 3 · see citing works
Rodent Modeling of Aggression, Elucidating the Role of Cytokines in the Brain
Лазаревна, А. Е., Idova, G. V., & Zhanaeva, S. Y. (2023) · Springer eBooks · doi:10.1007/978-3-030-98711-4_150-1 · Cited by 3 · see citing works
Udina, M., Navinés, R., Capuron, L., & Martín‐Santos, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.019 · Cited by 3 · see citing works
BDNF–TrkB signaling as a therapeutic target in neuropsychiatric disorders
Hill, R., Du, X., & Wu, Y. C. (2014) · Journal of Receptor Ligand and Channel Research · doi:10.2147/jrlcr.s50404 · Cited by 2 · see citing works
Diversity of CD28null T Cells in the Elderly: A Glimpse in a Biological Adaptation of Aging
Griffin, P. C., Michel, J. J., & Vallejo, A. N. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_87-1 · Cited by 2 · see citing works
Malaguarnera, G., Bertino, G., Greco, C., Gagliano, C., Motta, M., Chisari, G., Rapisarda, V., Nunnari, G., Vecchio, M. M., Drago, F., et al. (2017) · Translational Medicine Communications · doi:10.1186/s41231-016-0010-4 · Cited by 1 · see citing works
Fakih, N., & Fakhoury, M. (2024) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000779 · Cited by 1 · see citing works
de Araújo, C. M., Swardfager, W., Zugman, A., Cogo‐Moreira, H., Belangero, S. I., Ota, V., Spíndola, L., Hakonarson, H. H., Pellegrino, R., Gadelha, A., et al. (2019) · CNS Spectrums · doi:10.1017/s1092852919001688 · Cited by 1 · see citing works
Diversity of CD28null T Cells in the Elderly: A Glimpse in a Biological Adaptation of Aging
Griffin, P. C., Michel, J. J., & Vallejo, A. N. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_87 · Cited by 1 · see citing works
Aboul‐Fotouh, S., Hassan, D. M., Habib, M. Z., Amin, A. I., Kassim, S. K., & Mohamed, A. S. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2017.v11i1.21593
Yamagata, H., Tsunedomi, R., Kamishikiryo, T., Kobayashi, A., Seki, T., Kobayashi, M., Hagiwara, K., Yamada, N., Chen, C., Uchida, S., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13059 · Cited by 2 · see citing works
Rodent Modeling of Aggression: Elucidating the Role of Cytokines in the Brain
Лазаревна, А. Е., Idova, G. V., & Zhanaeva, S. Y. (2023) · Springer eBooks · doi:10.1007/978-3-031-31547-3_150
Mithaiwala, M. N., Dugan, A. M., de la Flor, M. A., Subramanian, S. K., Acheson, A., & O’Connor, J. C. (2025) · Psychiatry International · doi:10.3390/psychiatryint6030087
Neuroimmune Disturbances in Animal Models of Aggressive Behavior
Лазаревна, А. Е., Zhanaeva, S. Y., & Idova, G. V. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700370
Kliuchnykova, A., & Bielska, L. (2026) · Immunology and Allergy Science and Practice · doi:10.37321/immunology.2025.4-02
Elevated C-reactive protein is associated with suicide attempts in youth with bipolar disorder
Desai, D., Dimick, M. K., Kennedy, K. G., Sultan, A. A., Mio, M., & Goldstein, B. I. (2026) · Psychological Medicine · doi:10.1017/s0033291726103948
Boukhatem, I., Blais, J., Welman, M., Tardif, J., Dubé, M., Jourdi, G., & Lordkipanidzé, M. (2026) · Genes and Immunity · doi:10.1038/s41435-026-00405-2
- Authors
- Lotrich, F. E., Albusaysi, S., & Ferrell, R. E.
- Affiliations
- University of Pittsburgh Medical Center (US)
- University of Pittsburgh (US)
- Corresponding author
- Lotrich, Francis E
- ORCID
- Albusaysi, Salwa
- Venue
- Neuropsychopharmacology
- Published
- 2012-12-18
- Volume
- 38
- Issue
- 6
- Pages
- 985-995
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3629388
- OpenAlex
- W1997351479
- Cited by
- 92
- References
- 129
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 7 · 2015: 11 · 2014: 7 · 2013: 12
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Institute of Mental Health (R01MH090250, P30MH090333)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, interferon-alpha, interferon-induced depression, inflammatory cytokines, depressive symptoms, suicidal ideation, 5-HTTLPR, serotonin transporter polymorphism, neurovegetative symptoms, depression resilience
- MeSH terms
- Adolescent, Adult, Aged, Depression, Female, Genotype, Humans, Male, Middle Aged, Neural Pathways, Polymorphism, Genetic, Cohort Studies, Biomarkers, Treatment Outcome, Interferon-alpha, Brain-Derived Neurotrophic Factor, Hepatitis C, Chronic, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
