Aβ1–42 stimulated T cells express P-PKC-δ and P-PKC-ζ in Alzheimer disease
Abstract
The protein kinase C (PKC) family of enzymes is a regulator of transmembrane signal transduction, and involvement of some PKC isoforms in T-cell activation has been demonstrated. Nevertheless, very little is known about their involvement in the Amyloid beta (Abeta)-dependent molecular signals in the T lymphocytes of Alzheimer disease (AD) patients. Therefore, the aim of this study was to investigate the involvement of PKC-alpha, PKC-delta and PKC-zeta expression and activity in the signaling machinery activated in Abeta-reactive T cells, in adult healthy individuals, elderly healthy subjects, and from patients with AD. The results show that in peripheral T-cells from early AD patients, Abeta(1-42) produced a distinct subpopulation highly expressing P-PKC-delta, while in severe AD patients the same treatment induced two distinct P-PKC-delta and P-PKC-zeta T-cell subpopulations. Such subpopulations were not noticeable following CD3/CD28 treatment of the same samples or after treatment of peripheral T cells from healthy adult or elderly subjects with Abeta(1-42) or with CD3/CD28. We believe that these findings may be of help in possible attempts to develop further diagnostic strategies useful for the characterization of AD.
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Systemic immune response, including T-cell immune response, may be involved in the inflammation process of AD.
“increased studies suggest that systemic immune response, including T-cell immune response, may be involved in the inflammation process of AD [152, 153].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [152]
Cites
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Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works
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PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
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- Authors
- Miscia, S., Ciccocioppo, F., Lanuti, P., Velluto, L., Bascelli, A., Pierdomenico, L., Genovesi, D., Di Siena, A., Santavenere, E., Gambi, F., Ausili-Cèfaro, G., Grimley, P. M., Marchisio, M., & Gambi, D.
- Affiliations
- University of Chieti-Pescara (IT)
- Uniformed Services University of the Health Sciences (US)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 30
- Issue
- 3
- Pages
- 394-406
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2135428009
- Cited by
- 40
- References
- 4
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 7
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid-beta 42, T cells, protein kinase C delta, protein kinase C zeta, protein kinase C alpha, phosphorylation, T cell activation, anti-CD3/CD28 stimulation, T cell subsets, diagnostic biomarkers
- MeSH terms
- Protein Kinase C zeta, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Male, Middle Aged, Peptide Fragments, Protein Kinase C, Signal Transduction, Gene Expression Regulation, Enzymologic, T-Lymphocyte Subsets, Amyloid beta-Peptides, Protein Kinase C-alpha, Protein Kinase C-delta
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