The decrease of CD8-positive lymphocytes in Alzheimer's disease
Abstract
The aim of this study was to analyze the possible association of the changes in systemic immunity in the neurodegenerative diseases and in brain atrophy per se. Therefore we enumerated the numbers and proportions of the CD3-, CD4- and CD8-positive cells and B-lymphocytes in peripheral blood of 136 patients with various neurodegenerative disorders of the brain and 58 healthy age-matched controls. The selective decrease of the CD8-positive lymphocytes was demonstrated in the patients with Alzheimer's disease. In contrast, in the patients with brain atrophy of unknown origin and in the patients with vascular dementia the number of the CD8-positive cells tended to increase. The results suggest that brain degenerative changes are associated with changes in the systemic immunity and the changes are linked with the underlying disorder more than brain degeneration per se.
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Investigations on proportions and phenotypes of circulating B cells in AD patients compared to age-matched healthy controls have concluded in a significant reduction of both absolute numbers and percentages of blood B cells in AD patients.
“Investigations performed on the proportions and phenotypes of circulating B cells in AD patients compared to age-matched healthy controls have concluded in a significant reduction of both the absolute numbers and percentages of blood B cells in AD patients [84 -87].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [87]
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- Authors
- Pirttilä, T., Mattinen, S., & Frey, H.
- Affiliations
- Tampere University Hospital (FI)
- Tampere University (FI)
- Corresponding author
- Pirttilä, Tuula
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1992-02
- Volume
- 107
- Issue
- 2
- Pages
- 160-165
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2088474532
- Cited by
- 72
- References
- 37
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 3 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 1 · 2013: 5
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Emil Aaltosen Säätiö
- Turun Yliopisto
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, CD8-positive lymphocytes, systemic immunity, neurodegenerative diseases, brain atrophy, vascular dementia, CD4-positive lymphocytes, B cells, peripheral blood lymphocyte subsets
- MeSH terms
- Adult, Aged, Alzheimer Disease, Atrophy, B-Lymphocytes, Brain Diseases, Cerebrovascular Disorders, Female, Humans, Male, Middle Aged, Parkinson Disease, Reference Values, T-Lymphocyte Subsets, CD4-CD8 Ratio, CD8 Antigens
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