Cited by 526Advanced Glycation End Products researchAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 131 of the 132 references it cites were found in a registry or an index.

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

Srikanth, Velandai, Maczurek, Annette, Phan, Thanh, Steele, Megan, Westcott, Bernadette, Juskiw, Damian, Münch, Gerald·2011·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2009.04.016

Open this paper in CoChat — free account

Abstract

Alzheimer's disease (AD) is the most common dementing disorder of late life. Although there might be various different triggering events in the early stages of the disease, they seem to converge on a few characteristic final pathways in the late stages, characterized by inflammation and neurodegeneration. In this review, we revisit the hypothesis that advanced glycation endproducts (AGEs) and their receptor RAGE may play an important role in disease pathogenesis. Accumulation of AGEs in cells and tissues is a normal feature of aging, but is accelerated in AD. In AD, AGEs can be detected in pathological deposits such as amyloid plaques and neurofibrillary tangles. AGEs explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking, glial induction of oxidative stress and neuronal cell death. Oxidative stress and AGEs initiate a positive feedback loop, where normal age-related changes develop into a pathophysiological cascade. RAGE and its decoy receptor soluble RAGE, may contribute to or protect against AD pathogenesis by influencing transport of β-amyloid into the brain or by manipulating inflammatory mechanisms. Targeted pharmacological interventions using AGE-inhibitors, RAGE-antagonists, RAGE-antibodies, soluble RAGE or RAGE signalling inhibitors such as membrane-permeable antioxidants may be promising therapeutic strategies to slow down the progression of AD.

Integrity signals

Registry

Crossref · 10.1016/j.neurobiolaging.2009.04.016

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175
Copper, iron and zinc in Alzheimer's disease senile plaques
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012
S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles
Donato, R. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00046-2 · Cited by 1,580
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,545
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329
Advanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312

Show all 132 references

Research works printed but not linked: 2

Dukic-Stefanovic, 2003, Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs), J. Neurochem., 87, 44, 10.1046/j.1471-4159.2003.01988.x · DOI
Yan, 1996, RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease, Nature, 382, 685, 10.1038/382685a0 · DOI · Paper page

Sorted by citations

Items 301–400 of 526

The association between diabetes mellitus and postoperative cognitive dysfunction: a systematic review and meta-analysis
Liu, H., Chen, J., Ling, J., Wu, Y., Yang, P., Liu, X., Liu, J., Zhang, D., Yin, X., Yu, P., et al. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000002156 · Cited by 19
Contribution of hyperglycemia-induced changes in microglia to Alzheimer’s disease pathology
Rodríguez, M. H., Flores‐Clemente, C., Macías-Pérez, M. E., Rodríguez-Fonseca, R. A., Nicolás‐Vázquez, M. I., Martínez, J. O., Miranda, R., Rosas, M., & Jiménez, E. M. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00405-9 · Cited by 17
“AGEs induce the expression of RAGE in several brain cells [135].”
Background
The neuroprotective role of rosiglitazone in advanced glycation end product treated human neural stem cells is PPARgamma-dependent
Chiang, M., Cheng, Y., Nicol, C. J. B., & Lin, C. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.09.020 · Cited by 17
Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice
Gyengési, E., Liang, H., Millington, C., Sonego, S., Sirijovski, D., Gunawardena, D., Dhananjayan, K., Venigalla, M., Niedermayer, G., & Münch, G. W. (2018) · Pharmaceutical Research · doi:10.1007/s11095-017-2326-9 · Cited by 16
“A decrease in AGE formation might lower total AGE levels, and thereby decreasing proinflammatory activation of the AGE receptor RAGE (31,32).”
BackgroundSelf-citation
Effect of atorvastatin on AGEs-induced injury of cerebral cortex via inhibiting NADPH oxidase -NF-κB pathway in ApoE−/− mice
Li, Z., Yang, P., & Feng, B. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05998-z · Cited by 16
Potential new therapeutic target for Alzheimer's disease: Glucagon‐like peptide‐1
Liu, X., Zhang, N., Zhang, S., & Xu, P. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15502 · Cited by 16
Dihydroxanthyletin-type coumarins from Angelica decursiva that inhibits the formation of advanced glycation end products and human recombinant aldose reductase
Ali, M. Y., Jung, H. A., Jannat, S., & Choi, J. S. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0999-6 · Cited by 16
Antioxidants as Potential Therapeutics in Neurodegeneration
Sharma, S. K., & Ebadi, M. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_85 · Cited by 15
Model studies of advanced glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen structure and mechanical properties
Rock, C. A., Keeney, S. J., Zakharchenko, A., Takano, H., Spiegel, D. A., Krieger, A. Μ., Ferrari, G. M., & Levy, R. J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.12.053 · Cited by 15
A comprehensive review on RAGE-facilitated pathological pathways connecting Alzheimer’s disease, diabetes mellitus, and cardiovascular diseases
Chakraborty, A., Sami, S. A., & Marma, K. K. S. (2021) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-021-00081-w · Cited by 18
“RAGE and its role in oxidative stress Oxidative stress is induced due to an imbalance of free radical production and detoxification [8].”
Background
Understanding the relationship between type-2 diabetes, MRI markers of neurodegeneration and small vessel disease, and dementia risk: a mediation analysis
Grasset, L., Frison, É., Helmer, C., Catheline, G., Chêne, G., & Dufouil, C. (2024) · European Journal of Epidemiology · doi:10.1007/s10654-023-01080-7 · Cited by 15
Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis
Gasparotto, J., Senger, M. R., Kunzler, A., Degrossoli, A., De-Simone, S. G., Bortolin, R. C., Somensi, N., Girardi, C. S., de Souza, C. D. S. F., Calabrese, K. D. S., et al. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.204 · Cited by 16
“The receptor for advanced glycation endproducts (RAGE) is a multiligand membrane receptor that exerts crucial roles in the development of chronic inflammatory processes (Srikanth et al., 2011).”
Skin Autofluorescence Examination as a Diagnostic Tool for Mild Cognitive Impairment in Healthy People
Igase, M., Ohara, M., Igase, K., Kato, T., Okada, Y., Ochi, M., Tabara, Y., Kohara, K., & Ohyagi, Y. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160917 · Cited by 16
“Accumulation of AGEs in cells and tissues is a normal feature of aging but is accelerated in AD [4], suggesting a contribution of AGEs to the pathogenesis of dementia.”
Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort
Chambers, A., Bury, J. J., Minett, T., Richardson, C. D., Brayne, C., Ince, P. G., Shaw, P. J., Garwood, C. J., Heath, P. R., Simpson, J. E., et al. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa064 · Cited by 15
Perspectives on signaling for biological- and processed food-related advanced glycation end-products and its role in cancer progression
Eva, T. A., Barua, N., Chowdhury, M. M., Yeasmin, S., Rakib, A., Islam, M. R., Emran, T. B., & Simal‐Gándara, J. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1856771 · Cited by 15
Understanding the Aging Process Using Epidemiologic Approaches
Sanders, J. L., Boudreau, R. M., Newman, A. B., Newman, A. B., & Newman, A. B. (2012) · Springer eBooks · doi:10.1007/978-94-007-5061-6_12 · Cited by 15
Advanced Glycation Endproducts Interfere with Adhesion and Neurite Outgrowth
Bennmann, D., Horstkorte, R., Hofmann, B., Jacobs, K. E., Santos, A. N., Simm, A., Bork, K., & Gnanapragassam, V. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112115 · Cited by 15
“This is of special interest since AGE-modified proteins had been already detected in ß-amyloid plaques of Alzheimer patients [29].”
Background
Inhibitory Effects of Hydroxysafflor Yellow A on the Formation of Advanced Glycation End Products in Vitro
Ni, Z., Zhuge, Z., Li, W., Xu, H., Zhang, Z., & Dai, H. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00249 · Cited by 15
Reprint of “Accumulation of modified proteins and aggregate formation in aging”
Nowotny, K., Jung, T., Grune, T., & Höhn, A. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.001 · Cited by 15
“For example, AGEs are involved in the genesis of neurodegenerative diseases including AD and PD (Li J. et al., 2012; Srikanth et al., 2011).”
Background
Targeting AGEs-RAGE pathway inhibits inflammation and presents neuroprotective effect against hepatic ischemia-reperfusion induced hippocampus damage
Ren, L., & Yan, H. (2021) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2021.101792 · Cited by 14
Identification of ribosomal protein L9 as a novel regulator of proinflammatory damage-associated molecular pattern molecules
Watanabe, M., Toyomura, T., Wake, H., Nishinaka, T., Hatipoğlu, Ö. F., Takahashi, H. K., Nishibori, M., & Mori, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07096-0 · Cited by 14
d-ribose-mediated glycation of fibrinogen: Role in the induction of adaptive immune response
Alouffi, S., Khanam, A., Husain, A., Akasha, R., Rabbani, G., & Ahmad, S. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110147 · Cited by 16
Unveiling new secrets in Parkinson’s disease: The glycatome
Chegão, A., & Miranda, H. V. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114309 · Cited by 15
“RAGE has been linked to several pathological conditions, such as diabetes complications, chronic inflammation, cancer, and neurodegenerative diseases such as PD [57, 63-66].”
Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization
Putranto, E. W., Murata, H., Yamamoto, K., Kataoka, K., Yamada, H., Futami, J., Sakaguchi, M., & Huh, N. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1467 · Cited by 14
“…the increased expression of RAGE potentially lead to inflam-mation-associated pathological conditions, such as those found in neurodegenerative diseases (8,15,16), cardiovascular and renal diseases (17,18), pulmonary diseases (19), diabetes and metabolic disorders (20,21), as well as cancer (22).”
Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease
Cahlíková, L., Macáková, K., Benešová, N., Chlebek, J., Hošťálková, A., & Opletal, L. (2014) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63281-4.00006-9 · Cited by 14
From Fork to Brain: The Role of AGE–RAGE Signaling and the Western Diet in Neurodegenerative Disease
Pomroy, H. J., Mote, A., Mathew, S., Chanasseril, S., Lu, V., & Cheema, A. K. (2025) · NeuroSci · doi:10.3390/neurosci6030089 · Cited by 13
“…AGEs did not cross the gastrointestinal barrier and enter our bloodstream, meaning AGEs had no or little impact [21], compelling evidence now shows that reducing dietary AGEs can improve blood sugar regulation and reduce inflammation, particularly in patients with diabetes or renal disease [22,23].”
Amyloid-beta glycation induces neuronal mitochondrial dysfunction and Alzheimer’s pathogenesis via VDAC1-dependent mtDNA efflux
Akhter, F., Akhter, A., Zhu, X., Schiff, H. C., Maffei, A., Douglas, J. T., Zhou, Q., Zhao, Z., & Zhu, D. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2505046122 · Cited by 16
“…of gA β to substrates or its binding to surface receptors, such as receptor for AGE (RAGE), leads to neuroinflammation and synaptic toxicity ( 7 ). gA β with the altered secondary structure is a more suitable ligand than authentic A β for RAGE, resulting in the subsequent activation of…”
Inhibition of Amyloid-β (Aβ)-Induced Cognitive Impairment and Neuroinflammation in CHI3L1 Knockout Mice through Downregulation of ERK-PTX3 Pathway
Ham, H. J., Lee, Y. S., Koo, J. K., Yun, J., Son, D. J., Han, S., & Hong, J. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105550 · Cited by 13
Advanced glycation end products (AGEs) synergistically potentiated the proinflammatory action of lipopolysaccharide (LPS) and high mobility group box-1 (HMGB1) through their direct interactions
Watanabe, M., Toyomura, T., Tomiyama, M., Wake, H., Liu, K., Teshigawara, K., Takahashi, H. K., Nishibori, M., & Mori, S. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05783-y · Cited by 13
An insight into the potential of berberine in animal nutrition: Current knowledge and future perspectives
Ghavipanje, N., Nasri, M. H. F., & Vargas‐Bello‐Pérez, E. (2022) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13769 · Cited by 13
Dietary Patterns Are Not Associated with Brain Atrophy or Cerebral Small Vessel Disease in Older Adults with and without Type 2 Diabetes
Zabetian‐Targhi, F., Srikanth, V. K., Smith, K. J., Oddy, W. H., Beare, R. J., Moran, C., Wang, W., & Callisaya, M. L. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz139 · Cited by 13
Self-citation
Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase
Abidar, S., Yıldız, O., Değirmenci, A., Amakran, A., Maadoudi, M. E., & Nhiri, M. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.13009 · Cited by 13
Age, sex, and regional differences in scavenger receptor CD36 in the mouse brain: Potential relevance to cerebral amyloid angiopathy and Alzheimer's disease
Edler, M. K., Johnson, C. T., Ahmed, H. S., & Richardson, J. R. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25089 · Cited by 14
“Elevated in AD patients, AGE products act as a mediator of inflammation and vascular dysfunction, by depositing in the vessel wall and forming crosslinks with collagen that lead to vascular stiffness (Hughes et al., 2015; Srikanth et al., 2011).”
Background
Detecting beta-amyloid glycation by intrinsic fluorescence - Understanding the link between diabetes and Alzheimer's disease
Alghamdi, A., Forbes, S., Birch, D. J. S., Vyshemirsky, V., & Rolinski, O. J. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108886 · Cited by 13
Tissue expression of glycated apolipoprotein B in colorectal adenoma and cancer.
Reddavide, R., Misciagna, G., Caruso, M. G., Notarnicola, M., Armentano, R., Caruso, M. L., Pirrelli, M., & Valentini, A. M. (2011) · PubMed · Cited by 12
Lower expression level of two RAGE alternative splicing isoforms in Alzheimer’s disease
Zhu, H., & Ding, Q. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.04.032 · Cited by 12
Blood–Brain Barrier Transport of Alzheimer’s Amyloid β-Peptide
Nelson, A. R., Sagare, A. P., & Zloković, B. V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00009-5 · Cited by 12
Advanced glycation end products attenuate the function of tumor necrosis factor-like weak inducer of apoptosis to regulate the inflammatory response
Watanabe, M., Toyomura, T., Wake, H., Liu, K., Teshigawara, K., Takahashi, H. K., Nishibori, M., & Mori, S. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3045-6 · Cited by 12
Ethyl Pyruvate Prevents Renal Damage Induced by Methylglyoxal-Derived Advanced Glycation End Products
Jung, E., Kang, W. S., Jo, K., & Kim, J. (2019) · Journal of Diabetes Research · doi:10.1155/2019/4058280 · Cited by 12
Cerebrospinal fluid oxidative stress markers in Alzheimer's disease
Sakakibara, R., & Kawai, T. (2020) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.12413 · Cited by 12
Inhibition of the Receptor for Advanced Glycation End Products Enhances the Cytotoxic Effect of Gemcitabine in Murine Pancreatic Tumors
Swami, P., O’Connell, K. A., Thiyagarajan, S., Crawford, A. J., Patil, P. P., Radhakrishnan, P., Shin, S. C., Caffrey, T. C., Grunkemeyer, J. A., Neville, T. L. L., et al. (2021) · Biomolecules · doi:10.3390/biom11040526 · Cited by 12
Protective Effects of Troxerutin on β-Amyloid (1-42)-Induced Impairments of Spatial Learning and Memory in Rats
Babri, S., Amani, M., Mohaddes, G., Alihemmati, A., & Ebrahimi, H. (2012) · Neurophysiology · doi:10.1007/s11062-012-9309-6 · Cited by 12
Innovative insights into the roasting‐driven transformation of volatile compounds and quality markers in flaxseed ( Linum usitatissimum L.) oil
Chen, Z., Yang, J., Fu, Y., Wan, Y., Liu, W., Wang, T., Fu, X., Liu, W., & Wei, C. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17295 · Cited by 11
Influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats
Köse, O., Altın, A., Bayrakdar, S. K., Bostan, S. A., Mercantepe, T., Akyıldız, K., Tümkaya, L., Yılmaz, A., Köse, S., Yemenoğlu, H., et al. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12929 · Cited by 11
Polymorphisms in the receptor for advanced glycation end products gene are associated with susceptibility to drug-resistant epilepsy
Guo, M., Wang, J., Qi, H., Liu, F., Yao, L., Zhang, S., & Li, K. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.01.043 · Cited by 11
Enhanced carbonyl stress and disrupted white matter integrity in schizophrenia
Son, S., Arai, M., Miyata, J., Toriumi, K., Mizuta, H., Hayashi, T., Aso, T., Itokawa, M., & Murai, T. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.08.007 · Cited by 11
New 2,3-diaminopropionic acidinhibitors of AGE and ALE formation
Audic, N., Potier, G., & Sasaki, N. A. (2012) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob27084f · Cited by 11
The Effect of Added Peanut Butter on the Glycemic Response to a High–Glycemic Index Meal: A Pilot Study
Lilly, L., Heiss, C. J., Maragoudakis, S. F., Braden, K. L., & Smith, S. E. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1519404 · Cited by 11
Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats
Coirini, H., Rey, M., Deniselle, M. C. G., & Kruse, M. S. (2022) · Biomedicines · doi:10.3390/biomedicines10112723 · Cited by 10
“The activation of the AGE-RAGE pathway has been strongly associated with diabetes-related complications [26] and cognitive impairments in Alzheimer’s disease [27].”
Background
Development of p-Tau Differentiated Cell Model of Alzheimer’s Disease to Screen Novel Acetylcholinesterase Inhibitors
Uras, G., Li, X., Manca, A., Pantaleo, A., Bo, M., Xu, J., Allen, S., & Zhu, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314794 · Cited by 10
Inhibitory potential of N-acetylaspartate against protein glycation, AGEs formation and aggregation: Implication of brain osmolyte in glycation-related complications
Waseem, R., Khan, T., Shamsi, A., Shahid, M., Kazim, S. N., Hassan, M. I., & Islam, A. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125405 · Cited by 10
Neurochemical changes underlying cognitive impairment in olfactory bulbectomized rats and the impact of the mGlu5-positive allosteric modulator CDPPB
Płoska, A., Cieślik, P., Siekierzycka, A., Kalinowski, L., & Wierońska, J. M. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147577 · Cited by 10
Novel pathways and therapies in experimental diabetic atherosclerosis
Koulis, C., de Haan, J. B., & Allen, T. J. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.13 · Cited by 10
Psychology and Pathophysiological Outcomes of Eating
Takada, A., & Himmerich, H. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.92917 · Cited by 10
RETRACTED: On the early toxic effect of quinolinic acid: Involvement of RAGE
Cuevas, E., Lantz, S. M., Newport, G. D., Divine, B., Wu, Q., Paule, M. G., Tobón-Velasco, J. C., Ali, S. F., & Santamarı́a, A. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.007 · Cited by 10
Retracted
The protective effects of sciadopitysin against methylglyoxal‐induced cytotoxicity in cultured pancreatic β‐cells
Suh, K. S., Chon, S., & Choi, E. M. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3620 · Cited by 10
“In the presence of transition metals and oxygen, glucose and Amadori products undergo autoxidation to form free radicals (Ahmed, 2005; Srikanth et al., 2011), which cause damage to biomolecules in the body (Styskal, Van Remmen, Richardson, & Salmon, 2012).”
Background
Studies on mechanism of free Nε‐(carboxymethyl)lysine‐induced toxic injury in mice
Wang, Y., Xu, H., Liu, X., Liu, L., Wu, Y., & Gong, Z. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22322 · Cited by 10
The causal effect of HbA1c on white matter brain aging by two-sample Mendelian randomization analysis
Tian, C., Ye, Z., McCoy, R. G., Pan, Y., Bi, C., Gao, S., Ma, Y., Mo, C., Yu, J., Lu, T., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1335500 · Cited by 10
“Some study have confirmed that AGEs formed during prolonged hyperglycemia can accumulate in brain tissues and contribute to the pathogenesis of neurodegenerative diseases (Dei et al., 2002; Srikanth et al., 2011).”
Background
A pathophysiological intersection between metabolic biomarkers and memory: a longitudinal study in the STZ-induced diabetic mouse model
Venuti, M. T., Roda, E., Brandalise, F., Sarkar, M., Cappelletti, M., Speciani, A. F., Soffientini, I., Priori, E. C., Giammello, F., Ratto, D., et al. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1455434 · Cited by 11
The network pharmacology study and molecular docking to investigate the potential mechanism of Acoritataninowii Rhizoma against Alzheimer's Disease
Qiu, Z.-K., Zhou, B.-X., Pang, J., Zeng, W.-Q., Wu, H.-B., & Yang, F. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01179-6 · Cited by 13
Glucocorticoids decrease the numbers and activation of mast cells by inducing the transactivation receptors of AGEs
Santoro, T., de Azevedo, C. T., Silva, P., Martins, M. A., & Carvalho, V. F. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0917-364rr · Cited by 9
Identification and quantification of glucose degradation products in heat-sterilized glucose solutions for parenteral use by thin-layer chromatography
Leitzen, S., Vogel, M., Engels, A., Zapf, T., & Brandl, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253811 · Cited by 9
“Furthermore, reactive amino acid side chains of proteins may react with GDPs and form so-called AGEs (advanced glycation end products) [1, 7], which are being investigated in the context of Alzheimer’s disease [14], cardiovascular disease, and stroke [15, 16].”
Background
The whole‐brain voxel‐based morphometry study in early stage of T2DM patients
He, Y., Li, L., & Liu, J. (2022) · Brain and Behavior · doi:10.1002/brb3.2497 · Cited by 9
Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model
Jang, M., Lee, H., Seo, E. U., & Kim, H. N. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123504 · Cited by 8
Targeting the awry Aβ pathway in Alzheimer’s disease: hype and hurdles
Al-Kuraishy, H. M., Sulaiman, G. M., Al-Gareeb, A. I., Mohammed, H. A., Albuhadily, A. K., & Abomughaid, M. M. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01983-9 · Cited by 8
“Furthermore, RAGE can increase the neurotoxicity of Aβ through activation of microglia and the release of pro-inflammatory cytokines (Srikanth et al. 2011).”
Design, current states, and challenges of nanomaterials in anti-neuroinflammation: A perspective on Alzheimer’s disease
Hong, X., Chen, T., Liu, Y., Li, J., Huang, D., Ye, K., Liao, W., Wang, Y., Liu, M., & Luan, P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102669 · Cited by 9
Effect of Italian Sour Cherry (Prunus cerasus L.) on the Formation of Advanced Glycation End Products and Lipid Peroxidation
Ferretti, G., Neri, D., & Bacchetti, T. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.516170 · Cited by 8
“Recent studies have also shown that some fruit phenolics inhibit the formation of advanced glycation end products (AGEs) [5]-[10], whose formation and accumulation exert a pathophysiological role in patients with diabetes, renal and neurodegenerative disease as well as some types of cancer [11] [12].”
Background
The Effect of Glycation Stress on Skeletal Muscle
Egawa, T., Kido, K., Yokokawa, T., Fujibayashi, M., Goto, K., & Hayashi, T. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97769 · Cited by 8
Prevention of Protein Glycation by Nanoparticles: Potential Applications in T2DM and Associated Neurodegenerative Diseases
Patil, N. A., Kelkar, A., & Sivaram, A. (2022) · BioNanoScience · doi:10.1007/s12668-022-00954-6 · Cited by 8
“Thus AGE-driven extracellular amyloid plaques and intracellular tau neurofibrillary tangles build up in the neurons disrupting the structure of the neurons and widening the synaptic cleft, finally leading to loss of communication and function of the neurons [26].”
Background
Characterization of dehydroascorbate‐mediated modification of glutaredoxin by mass spectrometry
Flandrin, A., Allouche, S., Rolland, Y., McDuff, F., Wagner, J. R., & Klarskov, K. (2015) · Journal of Mass Spectrometry · doi:10.1002/jms.3706 · Cited by 8
Amyloid-beta transporter expression at the choroid plexus in normal aging: the possibility of reduced resistance to oxidative stress insults.
Liu, C., Wang, R., Dong, M., Gao, X.-R., & Feng, Y. (2014) · PubMed · Cited by 8
The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals
Tasca, K. I., Caleffi, J. T., Corrêa, C. R., Gatto, M., de Camargo, C. C., Mendes, M. B., Golim, M. D. A., Biasin, M., & de Souza, L. D. R. (2016) · Mediators of Inflammation · doi:10.1155/2016/2909576 · Cited by 8
“Because of the current ever-earlier recommendations to start cART and its prolonged use, these and other markers should be investigated in order to monitor and postpone the appearance of non-AIDS comorbidities in PLWHA.”
Background
Advanced Glycation End Products in Chinese Medicine Mediated Aging Diseases: A Review
Zhang, W., Zhao, T., Zhao, Y., Gui, D., & Xu, Y. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190507112157 · Cited by 8
Erratum to: Protective Effects of Troxerutin on β-Amyloid (1-42)-Induced Impairments of Spatial Learning and Memory in Rats
Babri, S., Amani, M., Mohaddes, G., Alihemmati, A., & Ebrahimi, H. (2012) · Neurophysiology · doi:10.1007/s11062-012-9328-3 · Cited by 8
Correction to: Dihydroxanthyletin-type coumarins from Angelica decursiva that inhibits the formation of advanced glycation end products and human recombinant aldose reductase
Ali, M. Y., Jung, H. A., Jannat, S., & Choi, J. S. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01113-4 · Cited by 8
An Overview of the Latest Developments in the Electrochemical Aptasensing of Neurodegenerative Diseases
Mikuła, E., & Malecka, K. (2023) · Coatings · doi:10.3390/coatings13020235 · Cited by 7
Neuropathological links between T2DM and LOAD: systematic review and meta-analysis
Lemche, E., Hortobágyi, T., Kiecker, C. M., & Turkheimer, F. (2025) · Physiological Reviews · doi:10.1152/physrev.00040.2024 · Cited by 9
The Association of -429T>C and -374T>A Polymorphisms in the RAGE Gene with Polycystic Ovary Syndrome
Park, J., Li, L., Choi, J.-W., & Baek, K. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.15389 · Cited by 7
RAGE Exacerbate Amyloid Beta (Aβ) Induced Alzheimer Pathology: A Systemic Overview
Akhter, F., Akhter, A., Kesari, K. K., Javed, R., Ruokolainen, J., & Vuorinen, T. (2019) · Environmental science and engineering · doi:10.1007/978-3-319-96511-6_9 · Cited by 7
Development of Disposable Single-Use Biosensor for Fructosyl Valine and Glycated Hemoglobin A1c
Liu, S. T. H., Leng, J., & Aquino, T. C. (2019) · Journal of Sensor Technology · doi:10.4236/jst.2019.94005 · Cited by 7
“In addition to diabetes, AGEs have been implicated in Alzheimer’s Disease [3], cardiovascular disease [4], and stroke [5].”
Background
Lycopene can modulate the LRP1 and RAGE transporters expression at the choroid plexus in Alzheimer’s disease rat
Wang, R., Xu, Z., Li, Y., Li, W., Gao, X.-R., Liu, C., & Liu, C. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104644 · Cited by 7
Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation
Wang, G., Wang, X., Zheng, X., Sun, S., Zhao, J., Ying, L., & Mao, Y. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.08.005 · Cited by 7
Plasma Concentrations of High Mobility Group Box 1 Proteins and Soluble Receptors for Advanced Glycation End-Products Are Relevant Biomarkers of Cognitive Impairment in Alcohol Use Disorder: A Pilot Study
de Fonseca, F. R., Medina-Paz, F., Sapozhnikov, M., Hurtado-Guerrero, I., Rubio, L., Martín‐de‐las‐Heras, S., Requena-Ocaña, N., Flores-López, M., Fernández‐Arjona, M. D. M., Rivera, P., et al. (2024) · Toxics · doi:10.3390/toxics12030190 · Cited by 7
“RAGE is a member of the immunoglobulin superfamily and a type I transmembrane protein that binds to AGEs, HMGB1, lipopolysaccharides, S100, and amyloid beta, among others [17,18].”
Background
Nitrilotriacetic Acid–Copper(II) Monolayer Deposited on a Gold Electrode for the Immobilization of Histidine Tagged V Domain of Receptor for Advanced Glycation End Products–The Basis of Amyloid–Beta Peptide Sensing
Zborowska, M., Sulima, M., Marszałek, I., Wysłouch‐Cieszyńska, A., Radecka, H., & Radecki, J. (2014) · Analytical Letters · doi:10.1080/00032719.2013.867501 · Cited by 7
“Amyloid-beta peptide is the main component of senile plaques typical of Alzheimer’s diseased brains (Finder et al. 2010; Srikanth et al. 2011).”
Background
Synergistic and inhibitory effects of propolis and aspirin on structural changes of human hemoglobin resulting from glycation: an in vitro study
Sahebi, U., & Divsalar, A. (2016) · Journal of the Iranian Chemical Society · doi:10.1007/s13738-016-0917-8 · Cited by 7
Inflammation in Alzheimer's Disease, and Prevention with Antioxidants and Phenolic Compounds – What Are the Most Promising Candidates?
Sharman, M. J., Verdile, G., Kirubakaran, S., & Münch, G. W. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch8 · Cited by 8
Self-citation
RAGE Is Essential for Subretinal Fibrosis in Laser-Induced Choroidal Neovascularization: Therapeutic Implications
Sreekumar, P. G., Nam, M., Hong, E., Kannan, R., & Nagaraj, R. H. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.6.30 · Cited by 6
“15,18 19–24 Polymorphisms in the RAGE gene (rs1800624 and rs1800625) have been linked to an increased susceptibility to early and exudative age-related macular degeneration (AMD).”
Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders
Singh, K., Gupta, J. K., Sethi, P., Mathew, S., Bhatt, A., Sharma, M. C., Saha, S., Khan, S., & Kumar, S. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266305736240725052825 · Cited by 6
Characterization and cytological effects of a novel glycated gelatine substrate
Boonkaew, B., Tompkins, K. A., Manokawinchoke, J., Pavasant, P., & Supaphol, P. (2014) · Biomedical Materials · doi:10.1088/1748-6041/9/2/025001 · Cited by 6
Modification of Fibronectin by Non-Enzymatic Glycation Impairs K+ Channel Function in Rat Cerebral Artery Smooth Muscle Cells
Yang, Y., Nourian, Z., Li, M., Sun, Z., Zhang, L., Davis, M. J., Meininger, G. A., Wu, J., Braun, A. P., & Hill, M. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.871968 · Cited by 6
“Rat lung total RNA was also purified as a positive control for RAGE mRNA expression (Srikanth et al., 2011).”
Method
Advanced Glycation End Products’ Receptor DNA Methylation Associated with Immune Infiltration and Prognosis of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma
Yang, J., Lin, M., Zhang, M., Wang, Z., Lin, H., Yu, Y., Zheng, Q., Chen, X., Wu, Y., Yao, Q., et al. (2023) · Genetics Research · doi:10.1155/2023/7129325 · Cited by 5
Recent advances in nanotechnology for combating Alzheimer's disease
Hu, C., Wu, B., Wu, Y., Shi, M., Ma, J., Gao, H., & Zhang, J. (2023) · Materials Chemistry Frontiers · doi:10.1039/d3qm00493g · Cited by 7
Cytotoxic role of advanced glycation end-products in PC12 cells treated with β-amyloid peptide
Yan, F., HAN, G.-L., & WU, G.-J. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1545 · Cited by 6
Not only a bad guy: potential proneurogenic role of the RAGE/NF-κB axis in Alzheimer's disease brain
Grilli, M., & Bortolotto, V. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.197130 · Cited by 6
“This concept is in agreement with previous work showing that infusion of picomolar concentrations of Aβ oligomers can indeed enhance long term potentiation in hippocampal slices and significantly improve spatial long-term hippocampal memory (Srikanth et al., 2011).”
The Chemistry of Advanced Glycation End-products
Torres, N. M. P. O., Xavier, J. A., Goulart, M. O. F., Alves, R. B., & de Freitas, R. P. (2018) · Revista Virtual de Química · doi:10.21577/1984-6835.20180029 · Cited by 6
Overexpression of the receptor for advanced glycation end-products in the auditory cortex of rats with noise-induced hearing loss
Lee, C. H., Kim, K. W., Lee, D.-H., Lee, S. M., & Kim, S. Y. (2021) · BMC Neuroscience · doi:10.1186/s12868-021-00642-3 · Cited by 6
“Background The receptor for advanced glycation end-products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily and can bind to multiple ligands, including advanced glycation end-products (AGEs) and β-amyloid peptide [3, 27].”
Background
Diabetes and cognitive dysfunction
Kim, B., Sims‐Robinson, C., Sakowski, S. A., & Feldman, E. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00027-7 · Cited by 8
Sex Differences in Obesity-Induced Inflammation
Terrazas, S., Brashear, L., Escoto, A.-K., Lynch, S. E., Slaughter, D., Xavier, N., Estes, N. R., & Giordano‐Mooga, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84941 · Cited by 6
“Advanced glycation end products, or AGEs, are markers of carbonyl stress due to oxidative stress, and their formation is irreversible and leads to protein deposits and amyloidosis [92].”
BackgroundInfluential
Receptor for advanced glycation end products (RAGE)-mediated cytotoxicity of 3-hydroxypyridinium derivatives
Murakami, Y., Fujino, T., Hasegawa, T., Kurachi, R., Miura, A., Daikoh, T., Usui, T., Hayase, F., & Watanabe, H. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1422971 · Cited by 6
“There is accumulating evidence that the AGEsRAGE interaction is implicated in neurodegenerative diseases as well as diabetic complications [6].”
Background
Existence of global attractor in reaction–diffusion model of obesity-induced Alzheimer’s disease and its control strategies
Upadhyay, R. K., Pradhan, D., Parshad, R. D., & Roy, P. (2024) · Communications in Nonlinear Science and Numerical Simulation · doi:10.1016/j.cnsns.2024.108396 · Cited by 5

Authors: Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D., & Münch, G.
Affiliations: Monash University (AU)
Western Sydney University (AU)
James Cook University (AU)
ORCID: Srikanth, Velandai
Phan, Thanh
Steele, Megan
Münch, Gerald
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2011-05
Volume: 32
Issue: 5
Pages: 763-777
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2009.04.016
OpenAlex: W2027183895
Cited by: 524
References: 132
Citations by year: 2026: 20 · 2025: 25 · 2024: 31 · 2023: 25 · 2022: 34 · 2021: 46 · 2020: 32 · 2019: 43 · 2018: 26 · 2017: 46 · 2016: 33 · 2015: 39 · 2014: 38 · 2013: 26 · 2012: 32
FWCI: 2.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
ResearchOnline at James Cook University (James Cook University) (submittedVersion)
Funders: National Health and Medical Research Council (436797, 491109)
Alzheimer's Australia
Deutsche Forschungsgemeinschaft (Mu 1011/14-1, Mu1011/15-1)
Alzheimer Forschung Initiative
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: advanced glycation end products, RAGE, Alzheimer's disease, soluble RAGE, amyloid plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, neurodegeneration, protein cross-linking, RAGE antagonists, AGE inhibitors, pathogenesis
MeSH terms: Receptor for Advanced Glycation End Products, Aging, Alzheimer Disease, Diabetes Mellitus, Type 2, Humans, Macrophages, Receptors, Immunologic, Neurofibrillary Tangles, Glycation End Products, Advanced, Microglia, Oxidative Stress, Disease Progression, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks