Cited by 526Advanced Glycation End Products researchAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 131 of the 132 references it cites were found in a registry or an index.

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

Srikanth, Velandai, Maczurek, Annette, Phan, Thanh, Steele, Megan, Westcott, Bernadette, Juskiw, Damian, Münch, Gerald·2011·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2009.04.016

Open this paper in CoChat — free account

Abstract

Alzheimer's disease (AD) is the most common dementing disorder of late life. Although there might be various different triggering events in the early stages of the disease, they seem to converge on a few characteristic final pathways in the late stages, characterized by inflammation and neurodegeneration. In this review, we revisit the hypothesis that advanced glycation endproducts (AGEs) and their receptor RAGE may play an important role in disease pathogenesis. Accumulation of AGEs in cells and tissues is a normal feature of aging, but is accelerated in AD. In AD, AGEs can be detected in pathological deposits such as amyloid plaques and neurofibrillary tangles. AGEs explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking, glial induction of oxidative stress and neuronal cell death. Oxidative stress and AGEs initiate a positive feedback loop, where normal age-related changes develop into a pathophysiological cascade. RAGE and its decoy receptor soluble RAGE, may contribute to or protect against AD pathogenesis by influencing transport of β-amyloid into the brain or by manipulating inflammatory mechanisms. Targeted pharmacological interventions using AGE-inhibitors, RAGE-antagonists, RAGE-antibodies, soluble RAGE or RAGE signalling inhibitors such as membrane-permeable antioxidants may be promising therapeutic strategies to slow down the progression of AD.

Integrity signals

Registry

Crossref · 10.1016/j.neurobiolaging.2009.04.016

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175
Copper, iron and zinc in Alzheimer's disease senile plaques
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012
S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles
Donato, R. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00046-2 · Cited by 1,580
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,545
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329
Advanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312

Show all 132 references

Research works printed but not linked: 2

Dukic-Stefanovic, 2003, Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs), J. Neurochem., 87, 44, 10.1046/j.1471-4159.2003.01988.x · DOI
Yan, 1996, RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease, Nature, 382, 685, 10.1038/382685a0 · DOI · Paper page

Sorted by citations

Items 401–500 of 526

Metabolic status and brain health: the relationship between the metabolic score for insulin resistance and cognitive function in older adults
Gu, B., Bu, Y., Hao, Z., Song, M., & Chen, J. (2025) · European journal of medical research · doi:10.1186/s40001-025-03522-2 · Cited by 5
“These processes simultaneously activate microglia, triggering neuroinflammatory responses [34–36].”
An anti-RAGE chimeric antibody alleviates CCl4-induced liver fibrosis via RAGE/NF-kB pathway in mice
Liu, J., Li, H., Chen, H., Xiao, X., Jin, Z., Paerhati, P., Bao, W., Cui, C., Zhu, J., & Yuan, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117737 · Cited by 5
Identification of pyridinoline, a collagen crosslink, as a novel intrinsic ligand for the receptor for advanced glycation end-products (RAGE)
Murakami, Y., Fujino, T., Kurachi, R., Hasegawa, T., Usui, T., Hayase, F., & Watanabe, H. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1475213 · Cited by 5
“The AGEs-RAGE axis is associated with the pathogenesis and development of multiple chronic diseases such as diabetic complications and neurodegenerative diseases [5].”
Background
Mori Cortex radicis extract protected against diet-induced neuronal damage by suppressing the AGE-RAGE/MAPK signaling pathway in C. elegans and mouse model
You, S., Jang, M., & Kim, G. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104996 · Cited by 5
Postprandial Light Exercise Attenuates the Glycemic Effect of a Candy Bar
Heiss, C. J., & Tollefson, M. (2014) · Topics in Clinical Nutrition · doi:10.1097/01.tin.0000445897.59899.48 · Cited by 5
Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity
Pearce, K. L., Hatzinikolas, A., Moran, L., de Courten, M., Forbes, J. M., Scheijen, J. L. J. M., Schalkwijk, C. G., Walker, K. Z., & de Courten, B. V. (2017) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2017.1319468 · Cited by 5
“…body of evidence suggests that AGEs, both formed within the body and those ingested, are significant pathogenic mediators contributing to a number of chronic diseases including diabetes (Tan et al. 2011), cardiovascular disease (Hegab et al. 2012) and Alzheimer’s dementia (Srikanth et al. 2011).”
Background
Fraction n‐Butanol of Radix Notoginseng Protects PC12 Cells from Aβ25–35‐Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and Aβ Accumulation
Huang, J.-L., Feng, Y.-Q., Bai, L., Qin, M.-C., Xu, Z., Liu, Z., Chen, W., Wu, D., & Zhong, Z.-G. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/8469754 · Cited by 5
“There are reports showing that oxidative stress contributes to Aβ generation either by downregulating the lowdensity lipoprotein receptor-related protein 1 (LRP-1) and upregulating the receptor for advanced glycation end products (RAGE) or by increasing the activity of β- and γsecretases [30].”
Background
Interventional effect of Codonopsis pilosula oligosaccharides against d -galactose-induced aging in SD rats via suppression of oxidative stress, inflammation, and apoptosis
Zhou, J., Li, X., Wang, Y., Zhang, Y., Jia, X., Fan, J., Zhang, Q., Hu, F., & Li, W. (2021) · Journal of Carbohydrate Chemistry · doi:10.1080/07328303.2021.1921786 · Cited by 5
“It is accompanied by many diseases, such as atherosclerosis, kidney disease, diabetes, and Alzheimer’s disease.([2,3]) It is widely accepted that oxidative”
Background
Electrochemical Aptasensors for Parkinson’s Disease Biomarkers Detection
Mikuła, E., Katrlı́k, J., & Rodrigues, L. R. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220520123337 · Cited by 5
Combined in vivo confocal Raman spectroscopy and density functional theory to detect carboxymethyl(lysine) in the human stratum corneum
S., C. A. T., Mendes, T. D. O., dos Santos, L., Silva, M. G. P., Pereira, L., Fávero, P. P., Singh, P., & Martin, A. A. (2018) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2018.10.005 · Cited by 6
Berberine mitigates methotrexate-induced oxidative stress and inflammation in the cerebrum of rats
Hozayen, W. G., Ramadan, S. M., Fadel, A., & Mahmoud, A. M. (2017) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2017.71106 · Cited by 5
Shared pathophysiology and therapeutic repurposing in Alzheimer's disease and type 2 diabetes: a critical review of convergent mechanisms and clinical challenges
Fu, W., Lu, R., Wang, D., & Sang, Z. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110044 · Cited by 4
Association between enhanced carbonyl stress and decreased apparent axonal density in schizophrenia by multimodal white matter imaging
Son, S., Arai, M., Toriumi, K., Andica, C., Matsuyoshi, D., Kamagata, K., Aoki, S., Kawashima, T., Kochiyama, T., Okada, T., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-39379-w · Cited by 4
Comparison of intestinal absorption of soybean protein isolate-, glutenin- and peanut protein isolate-bound Nε-(carboxymethyl) lysine after in vitro gastrointestinal digestion
Hao, S., Ye, M., Li, N., Lu, Z., Quan, W., Xu, H., & Li, M. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114811 · Cited by 5
Gut–Brain Axis in Alzheimer’s Disease: Interplay Between Cholecystokinin, Dysbiosis, and Brain-Derived Neurotrophic Factor
Ouerdane, Y., El-Nahas, Z. S., Ouerdane, F., Hamam, K. M., & Ebada, M. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_12 · Cited by 4
Recent Treatment Strategies in Alzheimer's Disease and Chronic Traumatic Encephalopathy
Lucke-Wold, B. P. (2022) · Biomedical Research and Clinical Reviews · doi:10.31579/2692-9406/128 · Cited by 4
“This provides another clue as to why aging is a risk factor for AD [88,89,92].”
Background
Cationic ribosomal proteins can inhibit pro‐inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products
Watanabe, M., Toyomura, T., Wake, H., Nishinaka, T., Hatipoğlu, Ö. F., Takahashi, H. K., Nishibori, M., & Mori, S. (2023) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2538 · Cited by 4
A Soluble Receptor for Advanced Glycation End Product Levels in Patients with Systemic Lupus Erythematosus
Bayoumy, N. M. K., EL-SHABRAWI, M., & NADA3, H. (2013) · Archives of Rheumatology · doi:10.5606/tjr.2013.2845 · Cited by 4
“Since RAGE induction is under the effect of AGEs, the RAGE-AGEs pathway is thought to be incriminated in the pathogenesis of these diseases.[20,21]”
Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats.
Wang, Y.-F., Xu, Y., Pan, Y., Li, W., Zhang, W., Liu, Y., Jia, J., & Li, P. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.18.002 · Cited by 4
“Our experimental findings are consistent with the results of Srikanth et al [66].”
Result
Polyphenolic Compounds with Anti-Ages Activity from Three Clusiaceae Plants
Magadula, J. J., Mbwambo, Z. H., Gatto, J., Derbré, S., Guilet, D., & Richomme, P. (2014) · European Journal of Medicinal Plants · doi:10.9734/ejmp/2014/10812 · Cited by 4
“In various types of cells, the transcription of NF-kB regulated genes induces an inflammation process [7] and pathological changes [8].”
Background
The Biology of Aging: Implications for Diseases of Aging and Health Care in the Twenty‐First Century
Watt, D. F. (2014) · Wiley eBooks · doi:10.1002/9781118730676.ch1 · Cited by 4
The association of RAGE gene polymorphisms with inflammatory and oxidative stress markers in diabetic kidney disease patients
Kamel, W. A., Haghi, M., Khosroshahi, H. T., & Dehghan, G. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10846-z · Cited by 3
Exploring the toxicological impact of di(2-ethylhexyl) phthalate exposure on Alzheimer's disease via network toxicology and integrative bioinformatics analysis
Yang, W., Yong, S., Zhang, W., Zhou, Q., Tan, X., & Xu, Y. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111635 · Cited by 3
Frailty and aging are associated with cognitive decline and dermal advanced glycation end-product accumulation in older Japanese men
Takei, S., Ochi, M., Shiraoka, A., Matsumoto, S., Fujishita, S., Okada, Y., Miura, S., Ochi, H., Igase, M., & Ohyagi, Y. (2024) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2024.100071 · Cited by 3
Hyperglycemia- and Hyperlipidemia-Induced Inflammation and Oxidative Stress through Human T Lymphocytes and Human Aortic Endothelial Cells (HAEC)
Stentz, F. B. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.94427 · Cited by 3
Pericytes and the Neurovascular Unit: The Critical Nexus of Alzheimer Disease Pathogenesis?
Cercy, S. P. (2021) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2020.00062 · Cited by 4
Improving mouse models for the study of Alzheimer's disease
Reagan, A. M., Onos, K. D., Heuer, S. E., Sasner, M., & Howell, G. R. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2021.12.005 · Cited by 5
Ursolic Acid: Historical Aspects to Promising Pharmacological Actions for the Treatment of Central Nervous System Diseases
Singh, A., Ansari, V. A., Mahmood, T., Ahsan, F., & Wasim, R. (2023) · Current Cosmetic Science · doi:10.2174/2666779702666230220111250 · Cited by 3
Effect of Cerebralcare Granule® combined with memantine on Alzheimer's disease
Yang, M., Zhang, X., Qiao, O., Zhang, J., Li, X., Ma, X., Zhou, S., & Gao, W. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117609 · Cited by 3
Plant-derived peptides and bioactive compounds: Mechanisms of AGEs formation, detection, and innovative approaches for prevention in food processing
Phyo, S. H., Siddique, M. S., Mushtaq, A., Yiasmin, M. N., Alahmad, K., Khan, I., Ghamry, M., & Zhao, W. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106818 · Cited by 3
The plasma level of soluble receptor for advanced glycation end products in systemic lupus erythematosus patients and its relation to disease activity
Abou‐Raya, A., Kamel, M. A. E.-N., Sayed, E. A. G., & El-Sharkawy, A. A. H. (2015) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2015.06.005 · Cited by 3
“Since RAGE induction is under the effect of AGEs, the RAGE-AGEs pathway is thought to be incriminated in the pathogenesis of these diseases.(20,21) Receptor for advanced glycation end products is a receptor for a family of about 20 related calcium binding proteins that are only expressed in vertebrates.”
Background
Diabetes Associated Memory Impairment: Perspective on Management Strategies
Sharma, G., Sonu, & Harikumar, S. (2015) · International journal of pharma research and review · Cited by 3
Catalytic antibody (catabody) platform for age-associated amyloid disease: From Heisenberg’s uncertainty principle to the verge of medical interventions
Planque, S. A., Massey, R. J., & Paul, S. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111188 · Cited by 3
“The misfolding process is accelerated by age-associated metabolic disturbances, for example, increased generation of advanced glycation and lipid peroxidation end products (Butterfield et al., 2010; Srikanth et al., 2011).”
Background
Hyperglycation of extra and intracellular proteins; marker or active element of diabetic pathomechanisms
Szutowicz, A. (2015) · Diagnostyka Laboratoryjna · doi:10.5604/01.3001.0008.2261 · Cited by 3
The C‐terminal region of tumor necrosis factor like weak inducer of apoptosis is required for interaction with advanced glycation end products
Watanabe, M., Toyomura, T., Wake, H., Liu, K., Teshigawara, K., Takahashi, H. K., Nishibori, M., & Mori, S. (2018) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1706 · Cited by 3
Epigenetic contributions to cancer: Exploring the role of glycation reactions
Khan, H., Rafi, Z., Khan, M. Y., Maarfi, F., Rehman, S., Kaur, K., Ahmad, M. K., Shahab, U., Ahmad, S., & Ahmad, S. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2024.04.001 · Cited by 2
Capsaicin attenuates methylglyoxal-induced neurotoxicity via the ATF4–Sestrin2 signaling and direct scavenging of methylglyoxal
Koike, S., Kajiki, H., Kamegai, M., Kayama, T., & Ogasawara, Y. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103444 · Cited by 2
Deconstructing the RAGE signaling maze: the molecular key to opening a new dimension of ovarian anti-aging
Bai, X., Zhang, G., Xiao, X., Zeng, Q., Zhao, Y., Wang, P., Long, F., & Liu, W. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01678-3 · Cited by 3
Alzheimer Disease and Dementia
AYDIN, A. C. (2020) · Journal of Literature Pharmacy Sciences · doi:10.5336/pharmsci.2019-71813 · Cited by 3
Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice
Hiramoto, K., Imai, M., Tanaka, S., & Ooi, K. (2023) · Life · doi:10.3390/life13071540 · Cited by 2
“Microglia and astrocytes in the brain contain RAGE, a receptor for AGEs, and the number of patients with AD is increasing compared to healthy elderly people [9,17].”
Background
Stem Cells Vs Exosomes: Promising Therapeutic Approach and Biomarkers Agent against Neurodegenerative Disorders
Khan, J., & Tatlı, I. İ. (2023) · Springer eBooks · doi:10.1007/978-981-99-3848-3_8 · Cited by 2
Diabetes mellitus in older persons with neurocognitive disorder: overtreatment prevalence and associated structural brain MRI findings
Putallaz, P., Seematter‐Bagnoud, L., Draganski, B., Rouaud, O., Krief, H., & Büla, C. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05025-x · Cited by 2
“Indeed, some of these mechanisms have also been reported in Alzheimer’s disease [8, 9].”
Background
Effects of glycaemic control on memory performance, hippocampal volumes and depressive symptomology
Sevim, G. Y., Alkan, E., Taporoski, T. P., Krieger, J. E., Pereira, A. C., & Evans, S. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01429-2 · Cited by 2
“Elevated cortisol has been associated with poor glycaemic control, and the hippocampus is highly sensitive to the neurotoxic effects of cortisol [23]; glucotoxic-ity due to hyperglycaemia may also contribute, through the build-up of AGEs [19, 20].”
Background
Differences Between Tg2576 and Wild Type Mice in the NMDA Receptor–Nitric Oxide Pathway After Prolonged Application of a Diet High in Advanced Glycation End Products
Krištofíková, Z., Říčný, J., Šírová, J., Řı́pová, D., Lubitz, I., & Beeri, M. S. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1654-6 · Cited by 2
“In the brain tissue of AD patients, colocalization of AGE products and nNOS [24] or AGE products and iNOS [25] have been found.”
Background
Post-Meal Exercise may Attenuate the Glycemic Response to a Carbohydrate Load: Important Implications for Adults who are Obese, with Pre-Diabetes or Diabetes, and/or At-Risk for Dementia
Heiss, C. J., & Goldberg, L. R. (2015) · Obesity Research - Open Journal · doi:10.17140/oroj-2-113 · Cited by 2
A synthetic fragment 60–70 of the receptor for advanced glycation end products exhibits a therapeutic effect in an animal model of Alzheimer’s disease
Koroev, D. O., Volpina, O. M., Volkova, T. D., Kamynina, A. V., Филатова, М. П., Balasanyants, S. M., Samokhin, A. N., & Бобкова, Н. В. (2017) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162017020066 · Cited by 2
The role of d-galactose in the aging heart and brain
Bo‐Htay, C., Shwe, T., Chattipakorn, S. C., & Chattipakorn, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-849886-6.00022-7 · Cited by 2
Carbohydrate and Protein Metabolism: Influences on Cognition and Alzheimer's Disease
Fernando, W. M. A. D. B., Gupta, V. B., Jayasena, V., Brennan, C. S., & Martins, R. N. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch6 · Cited by 2
Investigation of the potential connections between NAFLD-associated Alzheimer's disease: bioinformatics analysis of shared genesPreprint
Bhattacharya, I., Bhattacharya, T., Sahu, A., Das, P., Sarkar, S., Prasanna, V. S., Sreed, R., Ravichandiran, V., & Arumugam, S. (2024) · Research Square · doi:10.21203/rs.3.rs-4667019/v1 · Cited by 2
Glycogen synthase kinase-3 activation and dysregulation of amyloid transport receptors expression and shedding in HIV-induced Alzheimer’s disease-like pathology: modulatory effects of CCR5 antagonists
Bhargavan, B., Annadurai, N., & Kanmogne, G. D. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02197-4 · Cited by 1
“This increase in RAGE correlated with RAGE-Aβ colocalization, increased CNS Aβ 42 , and severe AD pathology [74, 119, 130], and was associated with increased Aβ 42 CNS influx, pTau, neuroinflammation, and neurodegeneration [36, 116].”
Enterococcus faecalis : A Key Metabolic Strain of Myofibrillar Protein-Bound N ε -(Carboxymethyl)lysine In Vitro Simulated Colon after Gastrointestinal Digestion
Lu, Z., Hao, S., Yan, H., Li, N. N., Hu, J., Quan, W., Cheng, J., Xu, H. R., & Li, M. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c11716 · Cited by 1
A Lecithin-Based Delivery Form of Quercetin Promotes Stress Resistance and Longevity in Caenorhabditis elegans
Romeo, M., Barzago, M. M., Fracasso, C., Nettis, M., Riva, A., Gobbi, M., Tongiani, S., & Diomede, L. (2026) · Pharmaceuticals · doi:10.3390/ph19040525 · Cited by 1
“We also assessed QF’s ability to reduce the accumulation of advanced glycation end products (AGEs), which are considered markers of senescence [25–27], and to modify the expression of genes encoding components of the IIS pathway.”
An elusive link between blood measures of advanced glycation end products and their receptors and cognitive impairment syndromes in people with diabetes: A scoping review
Shapiro, A. L. B., Thangthaeng, N., DeSanto, K., Bettcher, B. M., & Killeen, A. A. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10061-6 · Cited by 1
“Glycated proteins, lipids, and amino acids are shown to directly damage neural tissue, with extensive in vivo evidence of their role in cortical neuron apoptosis and broad neurotoxicity via neuroinflammation [ 50, 51], which contribute to neurodegenerative disease [12, 13, 51, 52].”
Effect of Added Mango vs. Sucrose on the Glycemic and Satiety Response to a High Glycemic Load Breakfast
Ramos, N., Heiss, C. J., Sikalidis, A. K., Avila, J. T., & Rompicharla, R. (2026) · Journal of the American Nutrition Association · doi:10.1080/27697061.2026.2678431 · Cited by 1
Grape seed polyphenols improve cognition and remodel the hippocampal transcriptome in aged high-fat diet-fed mice
Lee, H., Buongiorno, P. A., Tam, C. C., Shukitt‐Hale, B., & Yokoyama, W. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107454 · Cited by 1
RAGE and Its Ligands in Melanoma
Leclerc, E. (2015) · InTech eBooks · doi:10.5772/59172 · Cited by 1
“[92] Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, et al.”
Background
Multifaceted Role of Matrix Metalloproteases on Human Diseases
Roy, S., Pramanik, A., Chakraborti, T., & Chakraborti, S. (2017) · Springer eBooks · doi:10.1007/978-981-10-3162-5_2 · Cited by 2
“Activation of the receptor for AGE (RAGE) causes release of proinflammatory cytokines and free radicals which contributes to inflammatory processes [16].”
Background
Biomarkers of Oxidative Stress in Parkinson’s Disease
Fernández‐Espejo, E. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622888-00423 · Cited by 1
Immunopathogenesis of Alzheimer’s disease, Parkinson’s Disease, and other Neurodegenerative Diseases
Kumar, S., Shukla, A. K., Yadav, V. K., Srivastava, A., Dwivedi, D., & Singh, S. P. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815238754124010006 · Cited by 1
Role of oxidative stress in Alzheimer's disease and related consequences
Chmátalová, Z., & Skoumalová, A. (2014) · Klinická biochemie a metabolismus · doi:10.61568/kbm.2014.031 · Cited by 1
Point of View about Erythropoietin in Treatment of Central Nervous System Diseases
Yang, L. Z., Li, R. L., Wu, B., Luo, J., Chen, Z., Ping, X., Yan, & Tan, W. (2017) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000320 · Cited by 1
Neurocognitive and Neuropsychological Effects of OSA
Spector, A. R., & Farrer, T. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-54146-0_4 · Cited by 1
The analysis of advanced glycation endproducts
Scheijen (2017) · Research Publications (Maastricht University) · doi:10.26481/dis.20170621js · Cited by 1
Deterioration of Glutaraldehyde Crosslinked Heterograft Biomaterials due to Advanced Glycation End Product Formation and Serum Albumin InfiltrationPreprint
Rock, C. A., Keeney, S. J., Zakharchenko, A., Takano, H., Spiegel, D. A., Krieger, A. Μ., Ferrari, G. M., & Levy, R. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.28.117739 · Cited by 1
Veldwerk in het onderwijs
Doppen, P. (2007) · Utrecht University Repository (Utrecht University) · Cited by 1
p -Coumaric acid protects against D-galactose induced neurotoxicity by attenuating neuroinflammation and apoptosis in mice brainPreprint
Juvekar, A. R., Daroi, P. A., & Dhage, S. N. (2022) · Research Square · doi:10.21203/rs.3.rs-1406225/v1 · Cited by 1
Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer’s Dementia to Living HumansPreprint
Iturria‐Medina, Y., Poole, V. N., Zammit, A. R., Yu, L., Tasaki, S., Hong, J. H., Lopes, K. D. P., Batalha, C. M. P. F., Ridwan, A. R., Vialle, R. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.20.644323 · Cited by 1
“…noteworthy, as they—such as advanced glycation end products (AGEs)—can accumulate in neural tissues and are associated with neurodegeneration. amyloid-β For instance, the presence of AGEs in amyloid-β plaques and neurofibrillary tangles can exacerbate oxidative stress and neuronal death (27, 28) .”
Influence of genetic variability and external regulating factors on amyloid-beta peptide aggregation
Hubin, E. (2014) · doi:10.3990/1.9789036537643
Effect of glycated proteins and inhibitory compounds intervening with the AGE-RAGE pathway on macrophages
Younessi, P. (2010)
Evaluation of the activity of the immune system and age-related tissue markers in Turquoise killifish (Nothobranchius furzeri, Jubb 1971) and their role in cell ageing
Cicco, E. D. (2010) · Unicam Scientific Publications (University of Camerino)
A Soluble Receptor for Advanced Glycation End Product Levels in Patients with Systemic Lupus Erythematosus Sistemik Lupus Eritematöz Olan Hastalarda İlerlemiş Glikasyon Son Ürün Düzeylerinin Çözünür Reseptörü
Bayoumy, N. M. K., El-Shabrawi, M., & Nada, H. (2013)
Antidiabetic effect of potential Indian medicinal plants: A target specific in-vitro study
Kaur, G., Ali, Z., & Yagnambhatla, R. (2014)
Editorial: Molecular Mechanism of Neuronal Dysfunction in the Diabetic Brain
Goalstone, M. L., & Pugazhenthi, S. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00045
“Chronic hyperglycemia-induced accumulation of advanced glycation end products (AGEs) (4) and their receptor RAGE are among the mechanistic links between diabetes and AD (5).”
Background
Polymorphism in the ligand binding domain of rage alters its binding affinity towards Aβ42 peptides: an in-silico study
Krishnan, S., & Rani, P. (2016) · International Journal of Bioinformatics Research and Applications · doi:10.1504/ijbra.2016.078226
Interactions of the receptor for advanced glycation end products (RAGE) with advanced glycation end products and S100B
Indurthi, V. S. K. (2016)
Morbus Alzheimer – Ansätze für die Prävention und Therapie
Friedrichsen, H.-P. (2017) · Erfahrungsheilkunde · doi:10.1055/s-0043-104514
“Der Anteil von Neuronen und Gliazellen mit AGEEinlagerung bei Alzheimer-Patienten steigt mit dem Fortschreiten der Erkrankung und ist mit dem Anstieg oxidativer und inflammatorischer Prozesse verbunden [13].”
Background
Effect and Disease Indicative Role of Inflammation in Neurodegenerative Pathology: A Mechanistic Crosstalk of Promise and Dilemma
Choudhury, A., Chakraborty, I., Banerjee, T. S., Vana, D. R., Adapa, D., & Arun Kumar, R. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000360
“Microglial activation triggers the receptor for advanced glycoxidation end-products (RAGE), which is responsible for sensing Aβ [51].”
Background
DIETARY POLYPHENOLS AND THEIR GUT MICROBIOTA METABOLITES AS POTENTIAL TREATMENTS FOR ALZHEIMER'S DISEASE
Rose, K. N. (2019) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/diss-rose-kenneth-2019
Investigation into the molecular complexity of Alzheimer's disease : an amyloid-β centered approach
Cioffi, F. (2019) · doi:10.3990/1.9789036548410
Summery and perspective for future research on insulin resistance and insulin resistance–linked visceral and neurological disorders
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819603-8.00010-9
Insulin resistance, dementia, and depression
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819603-8.00008-0
Receptor for advanced glycation endproducts (RAGE) modulates glyoxalase-1 enzyme activity in mouse models.
Gore, S. S. (2019) · KU ScholarWorks (The University of Kansas)
Inhibition of neuroinflammatory nitric oxide signalling supresses protein glycation and recovers neuronal dysfunction in prion diseasePreprint
Bourgognon, J.-M., Spiers, J. G., Robinson, S., Scheiblich, H., Ortori, C. A., Bradley, S. J., Tobin, A. B., & Steinert, J. R. (2020) · doi:10.21203/rs.3.rs-20075/v1
“The production of AGE following TPI nitrotyrosination is directly linked to the activation of the receptor for AGE (RAGE) and the expression of RAGE reflects a positive confirmation for AGE signaling [47].”
Background
The ketogenic diet revisited - evaluation of the ketogenic diet in neurological disorders
Yıldız, D., & Scheurink, A. J. W. (2016)
Revisión bibliográfica de los avances más recientes en la comprensión etiológica de la enfermedad de Alzheimer
Ramírez, U. A. T., Medina, M. E., Ruiz, A. P. R., Borja, M. D. L. Á. S., & Ricoy, O. U. D. (2021) · Lux Médica · doi:10.33064/48lm20212964 · Cited by 1
Estudo fitoquímico das folhas e galhos de Endlicheria paniculata e avaliação das atividades biológicas dos extratos e neolignanas
Souza, R. A. C. (2021) · doi:10.14393/ufu.te.2021.5539
PYRAZOLINE CONTAINING MOLECULES AS MULTIFUNCTIONAL AGENTS IN ALZHEIMER’S DISEASE
Khambete, M., Murumkar, P. R., Kumar, A., Darreh‐Shori, T., De, S., Yadav, M. R., & Degani, M. S. (2019) · INDIAN DRUGS · doi:10.53879/id.56.10.12104
Perspective Chapter: Alzheimer - A Complex Genetic Background
Calabrò, M., & Crisafulli, C. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.101455
Mecanismos de dano celular e envelhecimento humano
Sgarbieri, V. C., Pacheco, M. T. B., Gibrim, N. F., de Oliveira, D. A. G., & Caetano‐Silva, M. E. (2021) · Editora da Unicamp eBooks · doi:10.7476/9788526815353.0003
The Multifaceted Roles of Ketogenic Diets in Neurology-Brain Cancers and Other Neurologic Diseases
Binsaeedu, A. S., Khalifa, M., & Tan-Shalaby, J. L. (2023) · Recent Progress in Nutrition · doi:10.21926/rpn.2302007
Inhibition of AGEs-RAGE-PP2A axis alleviates cognitive impairment after chronic heart failure
Li, S., Wang, L., Wang, J., 梁碧荣, Gao, W., Huang, Y., Deng, B., Liu, Q., Zhou, Z., Zhang, L., et al. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.5.28
“Some neurological research revealed that AGE-RAGE axis stimulation can lead to tau hyperphosphorylation and Aβ deposition (9), which induce neurofibrillary tangles (NFTs) and senile plaques (SP), two characteristic pathologic changes of cognitive impairment.”
Background
Aging—the most important collagen neoepitope?
LAURSEN, C. F. G., Genovese, F., & Karsdal, M. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15617-5.00041-x
Nutrition in the pathogenesis of metabolic syndrome: Roles of sugar, salt and fat
Banik, S. P., Downs, B. W., Kushner, S. W., Ghosh, R. B., Chakraborty, S., Bagchi, M., & Bagchi, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85732-1.00009-8 · Cited by 1
Neurotoxicity induced by glycotoxins
Lidia de, B. A. R. I., Sukach, V. A., & Kalapos, M. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00077-4
Additional file 1 of Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro
Ding, B., Lin, C., Liu, Q., He, Y., Ruganzu, J. B., Jin, H. Z., Peng, X., Ji, S., Ma, Y., & Yang, W. (2020) · Figshare · doi:10.6084/m9.figshare.13093892
Soluble Receptor Level of Advanced Glycation (sRAGE) Products in Serum in Patients with Systemic Lupus Erythematosus:
Gök, S., Okyar, B., Tuncel, D. A., Tolun, F. İ., Baylan, F. A., Acıpayam, C., Doğaner, A., & Çetin, G. Y. (2024) · Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi · doi:10.17517/ksutfd.1287352
Manual de Medicina Interna Vol. 6
Verduga, M. D. F. N., Vélez, K. E. C., Guaman, J. D. R., Mendoza, H. N. G., Sánchez, L. M. C., Guajala, R. G. Y., & Vera, A. G. M. (2024) · doi:10.56470/978-9942-660-78-7
Association of Cognitive Function, Hand Grip Strength, Dexterity and Functional Abilities in Type 2 Diabetes Mellitus – A Cross Sectional Study
Paul, G., Remya, N., Unnikrishnanan, M., Baby, R. E., & Baby, P. (2025) · doi:10.38124/ijisrt/25jul1968
Diet and Dementia Worldwide: The Role of Meat Fat, Meat Protein, and Development Indicators
You, W., & Feng, S. (2025) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad2040043 · Cited by 1
“These compounds disrupt vascular and neuronal integrity, amplify oxidative stress, and accelerate amyloid and tau pathology, reinforcing the plausibility of fat-related risk [16,63].”
Introduction to confluence of diabetes and Alzheimer's disease
Anju, T. R., Sunny, S., & Malat, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-40559-4.00011-8

Authors: Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D., & Münch, G.
Affiliations: Monash University (AU)
Western Sydney University (AU)
James Cook University (AU)
ORCID: Srikanth, Velandai
Phan, Thanh
Steele, Megan
Münch, Gerald
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2011-05
Volume: 32
Issue: 5
Pages: 763-777
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2009.04.016
OpenAlex: W2027183895
Cited by: 524
References: 132
Citations by year: 2026: 20 · 2025: 25 · 2024: 31 · 2023: 25 · 2022: 34 · 2021: 46 · 2020: 32 · 2019: 43 · 2018: 26 · 2017: 46 · 2016: 33 · 2015: 39 · 2014: 38 · 2013: 26 · 2012: 32
FWCI: 2.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
ResearchOnline at James Cook University (James Cook University) (submittedVersion)
Funders: National Health and Medical Research Council (436797, 491109)
Alzheimer's Australia
Deutsche Forschungsgemeinschaft (Mu 1011/14-1, Mu1011/15-1)
Alzheimer Forschung Initiative
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: advanced glycation end products, RAGE, Alzheimer's disease, soluble RAGE, amyloid plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, neurodegeneration, protein cross-linking, RAGE antagonists, AGE inhibitors, pathogenesis
MeSH terms: Receptor for Advanced Glycation End Products, Aging, Alzheimer Disease, Diabetes Mellitus, Type 2, Humans, Macrophages, Receptors, Immunologic, Neurofibrillary Tangles, Glycation End Products, Advanced, Microglia, Oxidative Stress, Disease Progression, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks