The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Visual contrast sensitivity in Alzheimer’s disease, mild cognitive impairment, and older adults with cognitive complaints
Open accessAbstract
Deficits in contrast sensitivity (CS) have been reported in Alzheimer’s disease (AD). However, the extent of these deficits in prodromal AD stages, including mild cognitive impairment (MCI) or even earlier, has not been investigated. In this study, CS was assessed using frequency doubling technology (FDT) in older adults with AD (n=10), amnestic MCI (n=28), cognitive complaints without performance deficits (CC, n=20), and healthy controls (HC, n=29). The association between CS and cognition was also evaluated. Finally, the accuracy of CS measures for classifying MCI versus HC was evaluated. CS deficits were found in AD and MCI, while CC showed intermediate performance between MCI and HC. Upper right visual field CS showed the most significant difference among groups. CS was also associated with cognitive performance. Finally, CS measures accurately classified MCI versus HC. The CS deficits in AD and MCI, and intermediate performance in CC, indicate that these measures are sensitive to early AD-associated changes. Therefore, FDT-based measures of CS may have promise as a novel AD biomarker.
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Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Mild Cognitive Impairment: Clinical Characterization and Outcome
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Visual dysfunction, neurodegenerative diseases, and aging
Jackson, G. R., & Owsley, C. (2003) · Neurologic Clinics · doi:10.1016/s0733-8619(02)00107-x · Cited by 226
Cited by
Jessen, F., Amariglio, R. E., van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., Dubois, B., Dufouil, C., Ellis, K. A., van der Flier, W. M., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.01.001 · Cited by 3,014
Self-citationOlfactory and other sensory impairments in Alzheimer disease
Murphy, C. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0097-5 · Cited by 425
Aging-associated sensory decline and Alzheimer’s disease
Hong, S., Baek, S.-H., Lai, M. K. P., Arumugam, T. V., & Jo, D.-G. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00776-y · Cited by 76
Sensory processing deficits and related cortical pathological changes in Alzheimer’s disease
Zhang, N. K., Zhang, S. K., Zhang, L. I., Tao, H. W., & Zhang, G.-W. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1213379 · Cited by 49
Xie, L., He, B., Varathan, P., Nho, K., Risacher, S. L., Saykin, A. J., Salama, P., & Yan, J. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab121 · Cited by 16
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Metadata
- Authors
- Risacher, S. L., WuDunn, D., Pepin, S. M., MaGee, T. R., McDonald, B. C., Flashman, L. A., Wishart, H. A., Pixley, H. S., Rabin, L. A., Paré, N., Englert, J. J., Schwartz, E., Curtain, J. R., West, J. D., O’Neill, D. P., Santulli, R. B., Newman, R. W., & Saykin, A. J.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 34
- Issue
- 4
- Pages
- 1133-1144
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2076436215
- Cited by
- 158
- References
- 5
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- green
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