Cited by 232Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

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High-fat diet-induced memory impairment in triple-transgenic Alzheimer’s disease (3xTgAD) mice is independent of changes in amyloid and tau pathology.

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Knight, Elysse M., Martins, Isaura V.A., Gümüsgöz, Sarah, Allan, Stuart M., Lawrence, Catherine B.·2014·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2014.02.010PMC PMC4024197

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Abstract

Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive deficits in AD mouse models. However, the effect of a high-fat diet on both the neuropathology and memory impairments in the triple-transgenic mouse model of AD (3xTgAD) is unknown. Therefore, groups of 2-month-old male 3xTgAD and control (non-Tg) mice were maintained on a high-fat or control diet and memory was assessed at the age of 3-4, 7-8, 11-12, and 15-16 months using a series of behavioral tests. A comparable increase in body weight was observed in non-Tg and 3xTgAD mice after high-fat feeding at all ages tested but a significantly greater increase in epididymal adipose tissue was observed in 3xTgAD mice at the age of 7-8, 11-12, and 15-16 months. A high-fat diet caused memory impairments in non-Tg control mice as early as the age of 3-4 months. In 3xTgAD mice, high-fat consumption led to a reduction in the age of onset and an increase in the extent of memory impairments. Some of these effects of high-fat diet on cognition in non-Tg and 3xTgAD mice were transient, and the age at which cognitive impairment was detected depended on the behavioral test. The effect of high-fat diet on memory in the 3xTgAD mice was independent of changes in AD neuropathology as no significant differences in (plaques, oligomers) or tau neuropathology were observed. An acute increase in microglial activation was seen in high-fat fed 3xTgAD mice at the age of 3-4 months but in non-Tg control mice microglial activation was not observed until the age of 15-16 months. These data indicate therefore that a high-fat diet has rapid and long-lasting negative effects on memory in both control and AD mice that are associated with neuroinflammation, but independent of changes in beta amyloid and tau neuropathology in the AD mice.

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RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769 · cited 1×
“Ab oligomers are currently thought to be the key species involved in Ab toxicity (Lesne et al., 2006; Shankar et al., 2008; Walsh et al., 2002) but in the present study no change in expression of soluble oligomers was detected in the hippocampus of 3xTgAD mice on a high-fat diet at any time point.”
Retracted
Morris water maze: procedures for assessing spatial and related forms of learning and memory
Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629 · cited 1×
“During the MWM test, mice were given 2 days of visual platform training followed by 8 days of hidden platform training and a 1 day probe trial (based on protocol by Vorhees and Williams (2006)).”
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
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“Ab oligomers are currently thought to be the key species involved in Ab toxicity (Lesne et al., 2006; Shankar et al., 2008; Walsh et al., 2002) but in the present study no change in expression of soluble oligomers was detected in the hippocampus of 3xTgAD mice on a high-fat diet at any time point.”
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · cited 1×
“Ab oligomers are currently thought to be the key species involved in Ab toxicity (Lesne et al., 2006; Shankar et al., 2008; Walsh et al., 2002) but in the present study no change in expression of soluble oligomers was detected in the hippocampus of 3xTgAD mice on a high-fat diet at any time point.”
Neuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · cited 1×
“In humans, the severity of AD-related neuropathology especially Ab plaque burden, does not always correlate with, or is predictive of, cognitive deficits, and memory impairments can occur in mouse AD models in advance of overt Ab plaque (and tangle) pathology (Billings et al., 2005; Oddo et al., 2003b; Serrano-Pozo et…”
Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice
Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · cited 3×
“The 3xTgAD mouse does not present with an aggressive pathology, as we do not observe Ab plaques and tangle-like pathology until approximately at the age of 12 months, which is after cognitive deficits are detected (Billings et al., 2005; Knight et al., 2012, 2013).”
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291 · cited 2×
“However, obesity atmidlife can also increase the risk of dementia and AD later in life (Beydoun et al., 2008; Fitzpatrick et al., 2009; Gustafson et al., 2003; Hassing et al., 2009; Kivipelto et al., 2005; Profenno et al., 2009; Rosengren et al., 2005; Whitmer et al., 2005, 2007, 2008), an effect that is independent o…”
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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
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Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques
Natunen, T., Martiskainen, H., Marttinen, M., Gabbouj, S., Koivisto, H., Kemppainen, S., Kaipainen, S., Takalo, M., Svobodová, H., Leppänen, L., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00415-2 · Cited by 36
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Background
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BackgroundResult
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“Based on previous reports [29, 30], mice with triple gene mutations such as the human A (cid:2) PP Swe , PS1 M126V , and Tau P301L exhibit cognitive impairment, which progresses with aging.”
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“However, other studies found that HFD have no effect on Aβ or tau (Studzinski et al., 2009; Herculano et al., 2013; Knight et al., 2014) or cognitive performance (Elhaik Goldman et al., 2018).”
BackgroundInfluential
Low-Dose Radiation Therapy Reduces Amyloid Load in Young 3xTg-AD Mice
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MethodSelf-citation
Neuroprotective role of alendronate against APP processing and neuroinflammation in mice fed a high fat diet
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Influential
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BackgroundResultInfluential
Animal Models of Alzheimer’s Disease
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“(52) demonstrated that a HFD increased the onset and severity of memory deficits in transgenic mice, but the effects of a HFD on cognition were independent of the effect on AD neuropathology as no difference was observed in the deposition of Aβ and tau protein.”
Background
High fat diet worsens pathology and impairment in an Alzheimer’s mouse model, but not by synergistically decreasing cerebral blood flowPreprint
Bracko, O., Vinarcsik, L., Hernández, J. C. C., Ruiz‐Uribe, N. E., Haft‐Javaherian, M., Falkenhain, K., Ramanauskaitė, E. M., Ali, M. A., Mohapatra, A., Swallow, M. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.16.878397 · Cited by 23
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BackgroundResultInfluential
Myelin Lipid Alterations in Neurodegenerative Diseases: Landscape and Pathogenic Implications
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“Notably, diet-induced obesity induces memory decline in 3xTg AD mouse model (Knight et al., 2014).”
A long-term high-fat diet influences brain damage and is linked to the activation of HIF-1α/AMPK/mTOR/p70S6K signalling
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Group 2 innate lymphoid cells are numerically and functionally deficient in the triple transgenic mouse model of Alzheimer’s disease
Fung, I. T. H., Zhang, Y., Shin, D. S.-H., Sankar, P., Sun, X., D’Souza, S. S., Song, R., Kuentzel, M. L., Chittur, S. V., Zuloaga, K. L., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02202-2 · Cited by 22
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“, 2010), cognitive impairment (Kanoski et al., 2010; Knight et al., 2014; Stranahan et al., 2008), and increased AD-related pathology (Barron et al.”
Background
Dietary composition affects the development of cognitive deficits in WT and Tg AD model mice
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Result
Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice
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“Furthermore, using another transgenic model of AD inmice (tg2576), Kohjima et al. (2010) explored the effects of feeding a HFD and high-calorie diet to suchmice on brain Aβ and brain-derived neurotrophic factor (BDNF) levels.”
BackgroundMethodInfluential
Chronic Mild Unpredictable Stress and High-Fat Diet Given during Adolescence Impact Both Cognitive and Noncognitive Behaviors in Young Adult Mice
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“Highfat diary foods have been found to contribute to the risk of Alzheimer’s disease (Knight et al., 2014).”
Background
Time-course study of high fat diet induced alterations in spatial memory, hippocampal JNK, P38, ERK and Akt activity
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High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
Ibeh, S., Bakkar, N. Z., Ahmad, F. A., Nwaiwu, J. I., Barsa, C., Mekhjian, S., Reslan, M. A., Eid, A. H., Harati, H., Nabha, S. M., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121316 · Cited by 15
The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model
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Enterogenic dementia: defining the gut–brain axis and the role of inflammatory bowel disease in cognitive impairment
Alshammari, F. F., Al-Kuraishy, H. M., Shokr, M. M., Papadakis, M., Alexiou, A. T., & Batiha, G. E. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01940-6 · Cited by 15
“More-over, SCFAs inhibit neuroinflammation in the AD model (Knight et al. 2014).”
Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease
Sonsalla, M. M., & Lamming, D. W. (2023) · GeroScience · doi:10.1007/s11357-023-00782-w · Cited by 17
The Effect of Gut Microbe Dysbiosis on the Pathogenesis of Alzheimer's Disease (AD) and Related Conditions
Nafady, M. H., Sayed, Z. S., Abdelkawy, D. A., Shebl, M. E., Elsayed, R. A., Ashraf, G. M., Perveen, A., Attia, M. S., & Bahbah, E. I. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220419101205 · Cited by 13
Effect of Obesity and High-Density Lipoprotein Concentration on the Pathological Characteristics of Alzheimer’s Disease in High-Fat Diet-Fed Mice
Choi, M., Kim, D., Youn, Y.-J., Ryu, J., & Jeong, Y. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012296 · Cited by 13
“HFD feeding before 3 months of age had protective effects on amyloid plaque deposition and cognitive decline [13,14].”
Reexamining the Causes and Effects of Cholesterol Deposition in the Brains of Patients with Alzheimer’s Disease
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Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress
Liu, L., Yang, J., Qian, F., & Lu, C. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4498 · Cited by 13
“HFD was shown to have rapid and long-lasting negative effects on memory in model mice with and without Alzheimer's disease (34).”
9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model
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“Boomerang Neuropathology” of Late-Onset Alzheimer’s Disease is Shrouded in Harmful “BDDS”: Breathing, Diet, Drinking, and Sleep During Aging
Daulatzai, M. A. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9528-x · Cited by 12
“HF consumption by (3xTgAD) mice led to a reduction in the age of onset and an increase in the extent of memory impairments (Knight et al. 2014).”
Background
Electroacupuncture Attenuates High‐Fat Diet‐Exacerbated Alzheimer's Pathology by Enhancing TFEB / TFE3 ‐Mediated Autophagic Clearance of Tau and NLRP3 Inflammasome in 3xTg Mice
Zheng, X., Luo, Z., Zheng, J., Deng, C., Liu, D., Chen, Y., Zhou, R., Zou, J., Huang, G., Zeng, Q., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70497 · Cited by 12
AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
Mao, Y.-Z., Cui, M., Jiang, Y., Yu, H., Wang, M., Li, G., Zhang, H., Zhao, C., Shen, Y., An, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.09.004 · Cited by 13
Neuroinflammatory mechanisms linking high‐fat diets to Alzheimer's disease vulnerability: Beyond the amyloid hypothesis
Mackey-Alfonso, S. E., & Barrientos, R. M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70911 · Cited by 13
“185,186 Other studies have found 3 to 8 week regimens impaired mitochondrial function and oxidative stress, 187 increased A β pathology, 185,188 and increased astrogliosis and microgliosis.”
Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond
Perdaens, O., & Pesch, V. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312637 · Cited by 12
High-Fat Diet-Induced Excessive Accumulation of Cerebral Cholesterol Esters and Microglial Dysfunction Exacerbate Alzheimer's Disease Pathology in APPNL−G−F mice
Yang, S., Miyazaki, H., Wannakul, T., Amo, E., Saido, T. C., Saito, T., Sasaguri, H., Maekawa, M., & Owada, Y. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05052-8 · Cited by 11
“Some studies found that although HFD impaired cognition and memory in AD mouse models, it had no significant effect on the histopathological progression [9–11].”
Downregulation of miR-33 Has Protective Effect Against Aβ25–35-Induced Injury in SH-SH-SY5Y Cells
Wang, X.-P., Li, X.-J., Huang, B., Yang, L., Chen, K., Zhao, D., Luo, X., & Wang, Y. (2020) · Medical Science Monitor · doi:10.12659/msm.921026 · Cited by 15
“Background Alzheimer disease (AD), characterized by memory loss and progressive cognitive dysfunction, is a common chronic neurodegenerative disease [1].”
Background
Liver-X receptor β-selective agonist CE9A215 regulates Alzheimer’s disease-associated pathology in a 3xTg-AD mouse model
Ban, S. Y., Nam, Y., Do, T. T., Kim, B., Shin, S. J., Nguyen, M. T. T., Kim, J., Moon, M., & Park, J. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117895 · Cited by 11
Relationship between Alzheimer’s Disease and the Human Microbiome
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Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function
Park, S. K., Lee, H. L., Kang, J. Y., Kim, J. M., & Heo, H. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-10520-5 · Cited by 10
Sex Differences in Hypothalamic Changes and the Metabolic Response of TgAPP Mice to a High Fat Diet
Freire‐Regatillo, A., Díaz-Pacheco, S., Frago, L. M., Arévalo, M., Argente, J., García‐Segura, L. M., CEBALLOS, M. L. D., & Chowen, J. A. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.910477 · Cited by 10
Cognitive improvements and reduction in amyloid plaque deposition by saikosaponin D treatment in a murine model of Alzheimer's disease
Zhou, L., Huang, J., Zhang, D., & Zhao, Y. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8760 · Cited by 9
“In recent years, 3xTg mice have been used to study AD, since they share similar clinicopathological characteristics with patients with AD, including memory impairments, early-onset brain amyloidosis, neuronal apoptosis and permanent loss of neurons (18,19).”
Background
Retracted
Blockage of Fc Gamma Receptors Alleviates Neuronal and Microglial Toxicity Induced by Palmitic Acid
Phitthayaphong, P., Kumfu, S., Chattipakorn, N., & Chattipakorn, S. C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210417 · Cited by 10
Interaction Between a High-Fat Diet and Tau Pathology in Mice: Implications for Alzheimer’s Disease
Jang, Y. J., Choi, M. G., Yoo, B. J., Lee, K. J., Jung, W. B., Kim, S., & Park, S. A. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230927 · Cited by 8
“5. chronicHFDfeedingisconsistentwithpreviousstud-iesonmiceoverexpressinghumanWT[43]and mutanttau:Tau22( MAPT G272 V & P301S) and 3 × TG-AD ( APP swe, PSEN1 M146 V, and MAPT P301L) [25–27] (Table 2).”
Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type
Carús-Cadavieco, M., Berenguer, I., Canelo, A. M., Serrano-Lope, M. A., la Fuente, S. G., Aguado, B., Fernández‐Rodrigo, A., Saido, T. C., Frank, A., Venero, C., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202201789 · Cited by 9
“…AD (e.g., the triple transgenic mouse), concluding that diabetes produce significant changes in the brain to produce AD (Pedersen & Flynn, 2004; Knight et al, 2014; Vandal et al, 2015; 1Molecular Neuropathology Unit, Physiological and Pathological Processes Program, Centro de Biologı́a…”
Background
The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD
Low, Z. S., Chua, D., Cheng, H. S., Tee, R., Tan, W., Ball, C., Sahib, N. B. E., Ng, S. S., Qu, J. T., Liu, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202404326 · Cited by 8
Categorizing Food Related Illness: Have We Got It Right?
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Metabolic and Transcriptomic Changes in the Mouse Brain in Response to Short-Term High-Fat Metabolic Stress
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Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1
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“However, in rodents it appears that the effects of HFD on cognition depends on the treatment design (e.g. duration of diet exposure) and the cognitive domains analysed (Kanoski & Davidson 2010; Knight et al. 2014; Morrison et al. 2010).”
Background
Tau, Diabetes and Insulin
Gratuze, M., Joly‐Amado, A., Buée, L., Vieau, D., & Blum, D. L. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9358-8_21 · Cited by 8
Iron Chelation Remits Memory Deficits Caused by the High-Fat Diet in a Mouse Model of Alzheimer’s Disease
Xiao, Y., Gong, X., Deng, R., Liu, W., Yang, Y., Wang, X., Wang, J., Bao, J., & Shu, X. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215705 · Cited by 8
“Using the triple-transgenic AD mouse model, Knight et al. demonstrated that high-fat consumption resulted in memory impairment and more severe cognitive impairment, which is independent of alterations in tau neuropathology [37].”
A PDK-1 Allosteric Agonist Improves Spatial Learning and Memory in a ΒAPP/PS-1 Transgenic Mouse-High Fat Diet Intervention Model of Alzheimer's DiseasePreprint
Querfurth, H. W., Slitt, A. L., DiCamillo, A., Surles, N. O., DeBoef, B., & Lee, H. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4105279 · Cited by 8
Lasting metabolic effect of a high-fructose diet on global cerebral ischemia
Ojo, O. P., Perez-Corredor, P. A., Vargas, J. A. G., Akinola, O. B., & Cardona‐Gómez, G. P. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1841482 · Cited by 7
A multi-network comparative analysis of whole-transcriptome and translatome reveals the effect of high-fat diet on APP/PS1 mice and the intervention with Chinese medicine
Gao, W., Zhou, J., Gu, X., Zhou, Y., Wang, L., Si, N., Fan, X., Bian, B., Wang, H., & Zhao, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.974333 · Cited by 7
Receptor-based approaches and therapeutic targets in Alzheimer’s disease along with role of AI in drug designing: Unraveling pathologies and advancing treatment strategies
Patwekar, M., Patwekar, F., Shaikh, D., Fatema, S. R., Aher, S. J., & Sharma, R. (2023) · Applied Chemical Engineering · doi:10.24294/ace.v6i3.2338 · Cited by 8
“Disruptions in cholesterol receptor function can have detrimental effects on neuronal health, synaptic function, and cognitive processes [31] . b) Serotonin receptors: Hypercholesterolemia has been associated with alterations in serotonin receptors.”
Background
Effects of high‐fat diet on nutrient metabolism and cognitive functions in young APPKI NL‐G‐F/NL‐G‐F mice
Wang, W., Tanokashira, D., Shibayama, Y., Tsuji, R., Maruyama, M., Kuroiwa, C., Saito, T., Saido, T. C., & Taguchi, A. (2022) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12257 · Cited by 5
Prodromal Glutamatergic Modulation with Riluzole Impacts Glucose Homeostasis and Spatial Cognition in Alzheimer’s Disease Mice
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High-fat diet negatively affects brain markers, cognitive behaviors, and noncognitive behaviors in the rTg4510 tau mouse model
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High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice – partial prevention by Fenretinide
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Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice
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Filbertone-Induced Nrf2 Activation Ameliorates Neuronal Damage via Increasing BDNF Expression
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High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies
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Maternal High-Energy Diet during Pregnancy and Lactation Impairs Neurogenesis and Alters the Behavior of Adult Offspring in a Phenotype-Dependent Manner
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Avenanthramide-C Mitigates High-Fat Diet-Accelerated Alzheimer’s Pathologies via NOD1-Driven Neuroinflammation in 5×FAD Mice
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“While previous studies reported that HFD did not significantly affect the A β burden in the hippocampus [65], our data show increased A β deposition in both the hippocampus and cortex in HFD-fed 5 × FAD mice.”
Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer’s DiseasePreprint
Lai, A. Y., Almanza, D. L., Ribeiro, J. A., Hill, M. E., Mandrozos, M., Koletar, M. M., Stefanovic, B., & McLaurin, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.11.575200 · Cited by 4
Gene Transfer Induced Hypercholesterolemia in Amyloid Mice
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Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury
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Evaluating the efficacy of neurotensin receptor-1 antagonist SR48692 in high-fat diet-induced neurotoxicity in mice: An in vivo study
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Advances in the Use of Traditional Chinese Medicine Prescriptions for Alzheimer's Disease
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阿尔茨海默病与肠道微生物
胡, 旭., 金, 锋., & 王, 涛. (2016) · Scientia Sinica Vitae · doi:10.1360/n052016-0080 · Cited by 1

Authors: Knight, E. M., Martins, I. V. A., Gümüsgöz, S., Allan, S. M., & Lawrence, C. B.
Affiliations: University of Manchester (GB)
Corresponding author: Lawrence, Catherine B.
ORCID: Knight, Elysse M.
Allan, Stuart M.
Lawrence, Catherine B.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2014-08
Volume: 35
Issue: 8
Pages: 1821-1832
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2014.02.010
PMC: PMC4024197
OpenAlex: W1994083528
Cited by: 232
References: 56
Citations by year: 2026: 11 · 2025: 14 · 2024: 14 · 2023: 19 · 2022: 23 · 2021: 20 · 2020: 21 · 2019: 26 · 2018: 24 · 2017: 18 · 2016: 30 · 2015: 7 · 2014: 5
FWCI: 13.33
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Neurobiology of Aging (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: high-fat diet, Alzheimer's disease, 3xTg-AD mice, memory impairment, obesity, amyloid plaques, tau pathology, microglial activation, neuroinflammation, adipose tissue, cognitive aging
MeSH terms: Adipose Tissue, Alzheimer Disease, Animals, Brain, Cognition, Disease Models, Animal, Epididymis, Male, Memory, Mice, Transgenic, Risk, Amyloid beta-Peptides, tau Proteins, Mice, Diet, High-Fat

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High-fat diet-induced memory impairment in triple-transgenic Alzheimer’s disease (3xTgAD) mice is independent of changes in amyloid and tau pathology.

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