The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
High-fat diet-induced memory impairment in triple-transgenic Alzheimer’s disease (3xTgAD) mice is independent of changes in amyloid and tau pathology.
Open accessAbstract
Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive deficits in AD mouse models. However, the effect of a high-fat diet on both the neuropathology and memory impairments in the triple-transgenic mouse model of AD (3xTgAD) is unknown. Therefore, groups of 2-month-old male 3xTgAD and control (non-Tg) mice were maintained on a high-fat or control diet and memory was assessed at the age of 3-4, 7-8, 11-12, and 15-16 months using a series of behavioral tests. A comparable increase in body weight was observed in non-Tg and 3xTgAD mice after high-fat feeding at all ages tested but a significantly greater increase in epididymal adipose tissue was observed in 3xTgAD mice at the age of 7-8, 11-12, and 15-16 months. A high-fat diet caused memory impairments in non-Tg control mice as early as the age of 3-4 months. In 3xTgAD mice, high-fat consumption led to a reduction in the age of onset and an increase in the extent of memory impairments. Some of these effects of high-fat diet on cognition in non-Tg and 3xTgAD mice were transient, and the age at which cognitive impairment was detected depended on the behavioral test. The effect of high-fat diet on memory in the 3xTgAD mice was independent of changes in AD neuropathology as no significant differences in (plaques, oligomers) or tau neuropathology were observed. An acute increase in microglial activation was seen in high-fat fed 3xTgAD mice at the age of 3-4 months but in non-Tg control mice microglial activation was not observed until the age of 15-16 months. These data indicate therefore that a high-fat diet has rapid and long-lasting negative effects on memory in both control and AD mice that are associated with neuroinflammation, but independent of changes in beta amyloid and tau neuropathology in the AD mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Also, the addition of an HFD exacerbated AD phenotypes in mouse models relevant to early-onset AD (Knight et al., 2014; Jones et al., 2019; Bracko et al., 2020; Robison et al., 2020; Jones et al., 2021).”
From Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice (2022) · cites this paper as Knight et al., 2014
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769 · cited 1×
“Ab oligomers are currently thought to be the key species involved in Ab toxicity (Lesne et al., 2006; Shankar et al., 2008; Walsh et al., 2002) but in the present study no change in expression of soluble oligomers was detected in the hippocampus of 3xTgAD mice on a high-fat diet at any time point.”
RetractedMorris water maze: procedures for assessing spatial and related forms of learning and memory
Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629 · cited 1×
“During the MWM test, mice were given 2 days of visual platform training followed by 8 days of hidden platform training and a 1 day probe trial (based on protocol by Vorhees and Williams (2006)).”
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · cited 1×
“Ab oligomers are currently thought to be the key species involved in Ab toxicity (Lesne et al., 2006; Shankar et al., 2008; Walsh et al., 2002) but in the present study no change in expression of soluble oligomers was detected in the hippocampus of 3xTgAD mice on a high-fat diet at any time point.”
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · cited 1×
“Ab oligomers are currently thought to be the key species involved in Ab toxicity (Lesne et al., 2006; Shankar et al., 2008; Walsh et al., 2002) but in the present study no change in expression of soluble oligomers was detected in the hippocampus of 3xTgAD mice on a high-fat diet at any time point.”
Neuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · cited 1×
“In humans, the severity of AD-related neuropathology especially Ab plaque burden, does not always correlate with, or is predictive of, cognitive deficits, and memory impairments can occur in mouse AD models in advance of overt Ab plaque (and tangle) pathology (Billings et al., 2005; Oddo et al., 2003b; Serrano-Pozo et…”
Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · cited 3×
“The 3xTgAD mouse does not present with an aggressive pathology, as we do not observe Ab plaques and tangle-like pathology until approximately at the age of 12 months, which is after cognitive deficits are detected (Billings et al., 2005; Knight et al., 2012, 2013).”
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291 · cited 2×
“However, obesity atmidlife can also increase the risk of dementia and AD later in life (Beydoun et al., 2008; Fitzpatrick et al., 2009; Gustafson et al., 2003; Hassing et al., 2009; Kivipelto et al., 2005; Profenno et al., 2009; Rosengren et al., 2005; Whitmer et al., 2005, 2007, 2008), an effect that is independent o…”
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study
Whitmer, R. A., Gunderson, E. P., Barrett-Connor, E., Quesenberry, C. P., & Yaffe, K. (2005) · BMJ · doi:10.1136/bmj.38446.466238.e0 · Cited by 1,090
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
Oddo, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.012 · Cited by 980
Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975 · cited 2×
“Microglia are the brain-resident “immune” cells and are proposed to play a key role in many neurodegenerative conditions and particularly in AD (Wyss-Coray and Rogers, 2012).”
Dietary fat intake and the risk of incident dementia in the Rotterdam study
Kalmijn, S., Launer, L. J., Ott, A., Witteman, J. C. M., Hofman, A., & Breteler, M. M. B. (1997) · Annals of Neurology · doi:10.1002/ana.410420514 · Cited by 895 · cited 2×
“saturated fats (especially in midlife) are a major risk factor for the development of AD (Eskelinen et al., 2008; Grant, 1999; Kalmijn et al., 1997; Laitinen et al., 2006; Luchsinger et al., 2002), and this risk is higher in individuals with the APOE ε4 allele (Laitinen et al.”
An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease
Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., & Skoog, I. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.13.1524 · Cited by 811 · cited 2×
“However, obesity atmidlife can also increase the risk of dementia and AD later in life (Beydoun et al., 2008; Fitzpatrick et al., 2009; Gustafson et al., 2003; Hassing et al., 2009; Kivipelto et al., 2005; Profenno et al., 2009; Rosengren et al., 2005; Whitmer et al., 2005, 2007, 2008), an effect that is independent o…”
Central obesity and increased risk of dementia more than three decades later
Whitmer, R. A., Gustafson, D. R., Barrett-Connor, E., Haan, M. N., Gunderson, E. P., & Yaffe, K. (2008) · Neurology · doi:10.1212/01.wnl.0000306313.89165.ef · Cited by 803
Midlife and Late-Life Obesity and the Risk of Dementia: Cardiovascular Health Study
Fitzpatrick, A. L., Kuller, L. H., Lopez, O. L., Diehr, P., O’Meara, E. S., Longstreth, W. T., & Luchsinger, J. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.582 · Cited by 796 · cited 3×
“However, obesity atmidlife can also increase the risk of dementia and AD later in life (Beydoun et al., 2008; Fitzpatrick et al., 2009; Gustafson et al., 2003; Hassing et al., 2009; Kivipelto et al., 2005; Profenno et al., 2009; Rosengren et al., 2005; Whitmer et al., 2005, 2007, 2008), an effect that is independent o…”
Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders
Profenno, L. A., Porsteinsson, A. P., & Faraone, S. V. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.013 · Cited by 718
Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Kanoski, S. E., & Davidson, T. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.003 · Cited by 710 · cited 1×
“A difference in the timing of the detrimental effect of a high-fat diet on cognition has been reported previously and is dependent on the use of spatial versus nonspatial memory tests (Kanoski and Davidson, 2011).”
Ho, L., Qin, W., Pompl, P. N., Xiang, Z., Wang, J., Zhao, Z., Peng, Y., Cambareri, G. M., Rocher, A. B., Mobbs, C. V., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0978fje · Cited by 640 · cited 3×
“Furthermore, most of these studies identifying an effect of a high-fat diet in AD on neuropathology and behavior have modified diet in AD mice only and have not studied the effect of diet in control animals (Ho et al., 2004; Maesako et al., 2012a).”
Cognitive impairment following high fat diet consumption is associated with brain inflammation
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 623 · cited 1×
“As high-fat diets have been shown to affect memory in cognitively-normal rodents (McNeilly et al., 2011; Pistell et al., 2010; Winocur and Greenwood, 2005), it is not clear whether the cognitive deficits observed in AD mice fed a high-fat diet are related to or independent of AD pathology.”
Halagappa, V. K. M., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R. G., LaFerla, F. M., & Mattson, M. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.019 · Cited by 580
Beydoun, M. A., Beydoun, H. A., & Wang, Y. (2008) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00473.x · Cited by 563
Takeda, S., Sato, N., Uchio‐Yamada, K., Sawada, K., Kunieda, T., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., & Morishita, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000645107 · Cited by 515 · cited 1×
“crossed with an obese mouse model (ob/ob) the resulting offspring (APPþ-ob/ob) showworse cognitive deficits and vascular inflammation that appear before significant Ab deposition (Takeda et al., 2010).”
Stewart, R., Masaki, K., Xue, Q.-L., Peila, R., Petrovitch, H., White, L. R., & Launer, L. J. (2005) · Archives of Neurology · doi:10.1001/archneur.62.1.55 · Cited by 478 · cited 1×
“, 2009) andweight loss actually precedes disease onset (Buchman et al., 2005; Stewart et al., 2005).”
Caloric Intake and the Risk of Alzheimer Disease
Luchsinger, J. A., Tang, M., Shea, S. A., & Mayeux, R. P. (2002) · Archives of Neurology · doi:10.1001/archneur.59.8.1258 · Cited by 470 · cited 3×
“, 2002), and this risk is higher in individuals with the APOE ε4 allele (Laitinen et al., 2006; Luchsinger et al., 2002).”
Body Mass Index in Midlife and Risk of Alzheimer Disease and Vascular Dementia
Whitmer, R., Gunderson, E., Quesenberry, C., Zhou, J., & Yaffe, K. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362047 · Cited by 430
Change in body mass index and risk of incident Alzheimer disease
Buchman, A. S., Wilson, R. S., Bienias, J. L., Shah, R. C., Evans, D. A., & Bennett, D. A. (2005) · Neurology · doi:10.1212/01.wnl.0000176061.33817.90 · Cited by 407 · cited 1×
“, 2009) andweight loss actually precedes disease onset (Buchman et al., 2005; Stewart et al., 2005).”
The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study
Ward, M. A., Carlsson, C. M., Trivedi, M. A., Sager, M. A., & Johnson, S. C. (2005) · BMC Neurology · doi:10.1186/1471-2377-5-23 · Cited by 361 · cited 1×
“, temporal lobe), and white matter lesions (Gazdzinski et al., 2008; Gustafson et al., 2004a, 2004b; Jagust et al., 2005; Ward et al., 2005).”
A 24-year follow-up of body mass index and cerebral atrophy
Gustafson, D., Lissner, L., Bengtsson, C., Björkelund, C., & Skoog, I. G. (2004) · Neurology · doi:10.1212/01.wnl.0000141850.47773.5f · Cited by 342
Central Obesity and the Aging Brain
Jagust, W. J., Harvey, D. J., Mungas, D., & Haan, M. N. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1545 · Cited by 326 · cited 1×
“, temporal lobe), and white matter lesions (Gazdzinski et al., 2008; Gustafson et al., 2004a, 2004b; Jagust et al., 2005; Ward et al., 2005).”
Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study
Eskelinen, M. H., Ngandu, T., Helkala, E., Tuomilehto, J., Nissinen, A., Soininen, H., & Kivipelto, M. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1969 · Cited by 321 · cited 2×
“saturated fats (especially in midlife) are a major risk factor for the development of AD (Eskelinen et al., 2008; Grant, 1999; Kalmijn et al., 1997; Laitinen et al., 2006; Luchsinger et al., 2002), and this risk is higher in individuals with the APOE ε4 allele (Laitinen et al.”
Fat Intake at Midlife and Risk of Dementia and Alzheimer’s Disease: A Population-Based Study
Laitinen, M. H., Ngandu, T., Rovio, S., Helkala, E.-L., Uusitalo, U. M., Viitanen, M. H., Nissinen, A. M., Tuomilehto, J., Soininen, H. S., & Kivipelto, M. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000093478 · Cited by 298 · cited 3×
“, 2002), and this risk is higher in individuals with the APOE ε4 allele (Laitinen et al., 2006; Luchsinger et al., 2002).”
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
Julien, C., Tremblay, C., Phivilay, A., Berthiaume, L., Émond, V., Julien, P., & Calon, F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.022 · Cited by 288 · cited 3×
“Most studies to date examining the role of high-fat diets in AD mouse models have assessed neuropathology only (Julien et al., 2010; Pedrini et al., 2009; Phivilay et al., 2009) and few have monitored both neuropathology and memory (Herculano et al.”
Studies of the effects of high fat diets on cognitive function in a rat model
Winocur, G., & Greenwood, C. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.003 · Cited by 250 · cited 1×
“As high-fat diets have been shown to affect memory in cognitively-normal rodents (McNeilly et al., 2011; Pistell et al., 2010; Winocur and Greenwood, 2005), it is not clear whether the cognitive deficits observed in AD mice fed a high-fat diet are related to or independent of AD pathology.”
Brain inflammation is induced by co-morbidities and risk factors for stroke
Drake, C., Boutin, H., Jones, M. S., Dénes, Á., McColl, B. W., Selvarajah, J. R., Hulme, S., Georgiou, R. F., Hinz, R., Gerhard, A., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.008 · Cited by 214
Self-citationMediterranean diet and cognitive decline
Panza, F., Solfrizzi, V., Colacicco, A., D’Introno, A., Capurso, C. A., Torres, F., Parigi, A., Capurso, S. A., & Capurso, C. A. (2004) · Public Health Nutrition · doi:10.1079/phn2004561 · Cited by 211 · cited 2×
“88 mm relative to bregma according to the atlas of Paxinos and Franklin (2001)), on a freezing sliding microtome (Bright 8000-001, Bright Instrument Co Ltd, UK).”
Body Mass Index, Other Cardiovascular Risk Factors, and Hospitalization for Dementia
Rosengren, A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.3.321 · Cited by 207 · cited 2×
“However, obesity atmidlife can also increase the risk of dementia and AD later in life (Beydoun et al., 2008; Fitzpatrick et al., 2009; Gustafson et al., 2003; Hassing et al., 2009; Kivipelto et al., 2005; Profenno et al., 2009; Rosengren et al., 2005; Whitmer et al., 2005, 2007, 2008), an effect that is independent o…”
Overweight in midlife and risk of dementia: a 40-year follow-up study
Hassing, L. B., Dahl, A. K., Thorvaldsson, V, Berg, S., Gatz, M., Pedersen, N. L., & Johansson, B. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.104 · Cited by 197 · cited 3×
“However, obesity atmidlife can also increase the risk of dementia and AD later in life (Beydoun et al., 2008; Fitzpatrick et al., 2009; Gustafson et al., 2003; Hassing et al., 2009; Kivipelto et al., 2005; Profenno et al., 2009; Rosengren et al., 2005; Whitmer et al., 2005, 2007, 2008), an effect that is independent o…”
Body mass index and magnetic resonance markers of brain integrity in adults
Gazdzinski, S., Kornak, J., Weiner, M. W., & Meyerhoff, D. J. (2008) · Annals of Neurology · doi:10.1002/ana.21377 · Cited by 191 · cited 1×
“, temporal lobe), and white matter lesions (Gazdzinski et al., 2008; Gustafson et al., 2004a, 2004b; Jagust et al., 2005; Ward et al., 2005).”
Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease
Verri, M., Pastoris, O., Dossena, M., Aquilani, R., Guerriero, F., Cuzzoni, G., Venturini, L., Ricevuti, G., & Bongiorno, A. I. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500204 · Cited by 145
Maesako, M., Uemura, K., Kubota, M., Kuzuya, A., Sasaki, K., Hayashida, N., Asada-Utsugi, M., Watanabe, K., Uemura, M., Kihara, T., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.367011 · Cited by 141
Dietary Links to Alzheimer's Disease: 1999 Update
Grant, W. B. (1999) · Journal of Alzheimer s Disease · doi:10.3233/jad-1999-14-501 · Cited by 138 · cited 2×
“Midlife obesity and consumption of diets high in fat are linked to a greater risk of AD in humans (Beydoun et al., 2008; Eskelinen et al., 2008; Fitzpatrick et al., 2009; Grant, 1999; Gustafson et al., 2003; Hassing et al., 2009; Kalmijn et al., 1997; Kivipelto et al., 2005; Laitinen et al., 2006; Luchsinger et al., 2…”
Herculano, B., Tamura, M., Ohba, A., Shimatani, M., Kutsuna, N., & Hisatsune, T. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121324 · Cited by 130
Body mass index and white matter lesions in elderly women. An 18-year longitudinal study
Gustafson, D., Steen, B., & Skoog, I. G. (2004) · International Psychogeriatrics · doi:10.1017/s1041610204000353 · Cited by 117
Wall, P. M., & Messier, C. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0979-9 · Cited by 116
Assessing the contribution of inflammation in models of Alzheimer's disease
Johnston, H. R., Boutin, H., & Allan, S. M. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390886 · Cited by 114 · cited 1×
“Neuroinflammation and oxidative stress are pathologic features of AD that are proposed to play a key role in the disease pathogenesis (Johnston et al., 2011; Verri et al., 2012; Wyss-Coray and Rogers, 2012).”
Self-citationMaesako, M., Uemura, K., Kubota, M., Kuzuya, A., Sasaki, K., Asada, M., Watanabe, K., Hayashida, N., Ihara, M., Ito, H., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.10.028 · Cited by 114
Interactive Effect of Obesity Indexes on Cognition
Jeong, S., Nam, H., Son, M.-H., Son, E.-J., & Cho, K.-H. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000082659 · Cited by 113 · cited 1×
“Furthermore, central obesity has been linked with poorer cognition in elderly nondemented individuals (Jeong et al., 2005).”
Dietary links to Alzheimer’s disease
Grant, W. B. (1997) · Cited by 104
McNeilly, A. D., Williamson, R., Sutherland, C. D., Balfour, D. J. K., & Stewart, C. A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.017 · Cited by 101
Hypermetabolism in a triple-transgenic mouse model of Alzheimer's disease
Knight, E. M., Verkhratsky, A., Luckman, S. M., Allan, S. M., & Lawrence, C. B. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.003 · Cited by 62 · cited 2×
“The present data also confirms a previous study showing that early in life 3xTgAD mice on a control diet weigh more and have higher food consumption than non-Tg controls (Knight et al., 2012), although food intake was not assessed here.”
Self-citationKnight, E. M., Brown, T. M., Gümüsgöz, S., Smith, J., Waters, E. J., Allan, S. M., & Lawrence, C. B. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010173 · Cited by 59
Self-citationPhivilay, A., Julien, C., Tremblay, C., Berthiaume, L., Julien, P., Giguère, Y., & Calon, F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.006 · Cited by 55
Effects of Dynorphin A (1-13) on Carbon Monoxide-Induced Delayed Amnesia in Mice
Hiramatsu, M., Sasaki, M., NABESHIMA, T., & Kameyama, T. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00159-1 · Cited by 54 · cited 2×
“Spontaneous alternation was defined as a successive entry into 3 different arms, on overlapping triplet sets (Hiramatsu et al., 1997;Wall andMessier, 2002).”
Pedrini, S., Thomas, C., Brautigam, H., Schmeidler, J., Ho, L., Fraser, P., Westaway, D. A., George‐Hyslop, P. S., Martins, R. N., Buxbaum, J. D., et al. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-40 · Cited by 50 · cited 3×
“However, several studies have shown that high-fat feeding can increase solubleAb and/orAbplaques in thebrainof ADmice (Hoet al., 2004; Julien et al., 2010; Maesako et al., 2012a; Pedrini et al., 2009).”
Adebakin, A., Bradley, J., Gümüsgöz, S., Waters, E. J., & Lawrence, C. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045179 · Cited by 36
Self-citation
Flagged first, then by citations
1 of the 56 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases
Giorgi, C., Marchi, S., Simões, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas‐Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., et al. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 484
Daniels, M. J. D., Rivers‐Auty, J., Schilling, T., Spencer, N. G., Watremez, W., Fasolino, V., Booth, S., White, C., Baldwin, A. G., Freeman, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12504 · Cited by 453
Self-citationYin, F. (2023) · The FEBS Journal · doi:10.1111/febs.16344 · Cited by 441
Daulatzai, M. A. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23777 · Cited by 440
Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy
Zheng, Q., & Wang, X. (2024) · Protein & Cell · doi:10.1093/procel/pwae026 · Cited by 483
Metadata
- Authors
- Knight, E. M., Martins, I. V. A., Gümüsgöz, S., Allan, S. M., & Lawrence, C. B.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Lawrence, Catherine B.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 35
- Issue
- 8
- Pages
- 1821-1832
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC4024197
- OpenAlex
- W1994083528
- Cited by
- 232
- References
- 56
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 14 · 2023: 19 · 2022: 23 · 2021: 20 · 2020: 21 · 2019: 26 · 2018: 24 · 2017: 18 · 2016: 30 · 2015: 7 · 2014: 5
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neurobiology of Aging (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- high-fat diet, Alzheimer's disease, 3xTg-AD mice, memory impairment, obesity, amyloid plaques, tau pathology, microglial activation, neuroinflammation, adipose tissue, cognitive aging
- MeSH terms
- Adipose Tissue, Alzheimer Disease, Animals, Brain, Cognition, Disease Models, Animal, Epididymis, Male, Memory, Mice, Transgenic, Risk, Amyloid beta-Peptides, tau Proteins, Mice, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
