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Cited by 163Dementia and Cognitive Impairment ResearchTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function—data from the Berlin Aging Study II

Tegeler, Christina, O'Sullivan, Julie Lorraine, Bucholtz, Nina, Goldeck, David, Pawelec, Graham, Steinhagen-Thiessen, Elisabeth, Demuth, Ilja·2016·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2015.10.039
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Abstract

Inflammation may be an underlying mechanism in cognitive decline. The present study investigated the relationship between cognitive function and the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and IL-10 in a nonclinical sample of elderly adults. Serum levels of CRP, IL-6, and IL-10 were measured in n = 1312 elderly adults (60-85 years, 50.5% females) who underwent comprehensive neuropsychological testing. Multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. Levels of IL-6, IL-10, and CRP were negatively associated with a composite score of executive function and processing speed, whereas the IL-6 to IL-10 ratio was not predictive for executive function and processing speed. No associations were found between inflammatory markers and verbal episodic memory. These findings suggest a relationship between higher proinflammatory and anti-inflammatory activation of the innate immune system and executive function within the normal range. Further research is needed to examine the relevance of an inflammatory pathway as a potential therapeutic target.

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Crossref · 10.1016/j.neurobiolaging.2015.10.039

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Metadata

Authors
Tegeler, C., O'Sullivan, J. L., Bucholtz, N., Goldeck, D., Pawelec, G., Steinhagen-Thiessen, E., & Demuth, I.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • University of Tübingen (DE)
Corresponding author
  • Tegeler, Christina
  • Demuth, Ilja
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2016-02
Volume
38
Pages
112-117
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2015.10.039
OpenAlex
W2167109574
Cited by
163
References
42
Citations by year
2026: 14 · 2025: 19 · 2024: 23 · 2023: 20 · 2022: 14 · 2021: 19 · 2020: 18 · 2019: 13 · 2018: 10 · 2017: 7 · 2016: 6
FWCI
6.23
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung (16SV5536K)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
C-reactive protein, interleukin-6, IL-10, inflammation, cognitive function, executive function, processing speed, verbal episodic memory, cognitive decline, older adults, innate immune system
MeSH terms
Aged, Aged, 80 and over, C-Reactive Protein, Cognition, Female, Humans, Immunity, Innate, Male, Middle Aged, Interleukin-6, Linear Models, Interleukin-10, Inflammation Mediators, Executive Function

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