The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease
Open accessAbstract
This longitudinal study sought to determine whether the 18 kDa translocator protein (TSPO), a marker of neuroinflammation, increases over time in Alzheimer’s disease. Positron emission tomography (PET) imaging with the TSPO radioligand 11C-PBR28 imaging was performed at baseline and after a median follow-up of 2.7 years in 14 amyloid-positive patients and eight amyloid-negative controls. Patients had a greater increase in TSPO binding than controls in inferior parietal lobule, precuneus, occipital cortex, hippocampus, entorhinal cortex, and combined middle and inferior temporal cortex. TSPO binding in temporo-parietal regions increased 3.9 – 6.3% per annum in patients, but ranged from −0.5 – 1% per annum in controls. The change in TSPO binding correlated with cognitive worsening on Clinical Dementia Rating scale – Sum of Boxes and with reduced cortical volume. The annual rate of increased TSPO binding in temporo-parietal regions was about five-fold higher in patients with clinical progression (n = 9) compared to those who did not progress (n = 5). TSPO may serve as a biomarker of Alzheimer’s progression and response to anti-inflammatory therapies.
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Brain β-amyloid load approaches a plateau
Jack, C. R., Wiste, H. J., Lesnick, T. G., Weigand, S. D., Knopman, D. S., Vemuri, P., Pankratz, V. S., Senjem, M. L., Gunter, J. L., Mielke, M. M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182840bbe · Cited by 406
Microglial activation and amyloid deposition in mild cognitive impairment: A PET study
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In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease
Kreisl, W. C., Lyoo, C. H., McGwier, M., Snow, J., Jenko, K. J., Kimura, N., Corona, W., Morse, C. L., Zoghbi, S. S., Pike, V. W., et al. (2013) · Brain · doi:10.1093/brain/awt145 · Cited by 350
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Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179
Fricker, M., Tolkovsky, A. M., Borutaite, V., Coleman, M., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,108
Microglial activation and tau propagate jointly across Braak stages
Pascoal, T. A., Benedet, A. L., Ashton, N. J., Kang, M. S., Therriault, J., Chamoun, M., Savard, M., Lussier, F. Z., Tissot, C., Karikari, T. K., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01456-w · Cited by 490
Neuroinflammation in Neurodegenerative Disorders-a Review
Schain, M., & Kreisl, W. C. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0733-2 · Cited by 301
Self-citationMicroglial activation correlates in vivo with both tau and amyloid in Alzheimer’s disease
Dani, M., Wood, M., Mizoguchi, R., Fan, Z., Walker, Z., Morgan, R., Hinz, R., Biju, M., Kuruvilla, T., Brooks, D. J., et al. (2018) · Brain · doi:10.1093/brain/awy188 · Cited by 270
Metadata
- Authors
- Kreisl, W. C., Lyoo, C. H., Liow, J.-S., Wei, M., Snow, J., Page, E., Jenko, K. J., Morse, C. L., Zoghbi, S. S., Pike, V. W., Turner, R. S., & Innis, R. B.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 44
- Pages
- 53-61
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2343157050
- Cited by
- 174
- References
- 14
- FWCI
- 14.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Kreisl, W. C., Lyoo, C. H., Liow, J.-S., Wei, M., Snow, J., Page, E., Jenko, K. J., Morse, C. L., Zoghbi, S. S., Pike, V. W., Turner, R. S., & Innis, R. B. (2016). 11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2016.04.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
