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Cited by 135Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder

Rosa-Neto, Pedro, Lou, Hans C., Cumming, Paul, Pryds, Ole, Karrebaek, Hanne, Lunding, Jytte, Gjedde, Albert·2005·NeuroImage
DOI 10.1016/j.neuroimage.2004.11.031
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Abstract

Abnormal central dopamine (DA) neurotransmission has been implicated in the impulsivity, inattention, and hyperactivity of attention deficit hyperactivity disorder (ADHD). We hypothesized that a pharmacological challenge with methylphenidate (MP) at a therapeutic dose increases extracellular DA concentrations in proportion to the severity of these specific ADHD symptoms. To test this hypothesis, we measured by PET the effect of acute challenge with MP on the availability of striatal binding sites for [11C]raclopride (pB), an index of altered interstitial DA concentration, in nine unmedicated adolescents (1 female, 8 males; age 13.7 +/- 1.8 years) with a current diagnosis of ADHD. We estimated the pB of [11C]raclopride for brain dopamine D2/3 receptors first in a baseline resting condition, and again after an acute challenge with MP (0.3 mg/kg, p.o.), and calculated the percentage change in (%DeltapB) in left and right striatum. On another day, measurements of impulsivity and inattention were performed using a computerized continuous performance test. There was a significant correlation between the magnitude of %DeltapB in the right striatum and the severity of inattention and impulsivity. MP-evoked %DeltapB correlated with standard scores for impulse control (r = 0.68; P = 0.02), attention (r = 0.81; P = 0.005), information processing (r = 0.66; P = 0.02), and consistency of attention, or variability (r = 0.60; P = 0.04). In conclusion, the results link inattention and impulsivity with sensitivity of brain DA receptor availability to an MP challenge, corroborating the hypothesis that MP serves to potentiate decreased DA neurotransmission in ADHD.

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Metadata

Authors
Rosa-Neto, P., Lou, H. C., Cumming, P., Pryds, O., Karrebaek, H., Lunding, J., & Gjedde, A.
Affiliations
  • Aarhus University (DK)
  • Kennedy Center (DK)
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2005-04
Volume
25
Issue
3
Pages
868-876
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2004.11.031
OpenAlex
W1974649221
Cited by
135
References
67
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 11 · 2012: 12
FWCI
6.02
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
Lundbeckfonden
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
attention deficit hyperactivity disorder, methylphenidate, striatal dopamine, dopamine D2/D3 receptors, [11C]raclopride, inattention, impulsivity, adolescents, continuous performance test, impulse control
MeSH terms
Adolescent, Central Nervous System Stimulants, Attention, Attention Deficit Disorder with Hyperactivity, Child, Corpus Striatum, Dominance, Cerebral, Dopamine, Dose-Response Relationship, Drug, Drug Synergism, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Male, Methylphenidate, Neuropsychological Tests, Pattern Recognition, Visual, Psychomotor Performance, Radioligand Assay, Reaction Time, Statistics as Topic, Treatment Outcome, Receptors, Dopamine D2, Raclopride, Positron-Emission Tomography, Receptors, Dopamine D3

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