Cited by 135Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

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Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder

Rosa-Neto, Pedro, Lou, Hans C., Cumming, Paul, Pryds, Ole, Karrebaek, Hanne, Lunding, Jytte, Gjedde, Albert·2005·NeuroImage

DOI 10.1016/j.neuroimage.2004.11.031

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Abstract

Abnormal central dopamine (DA) neurotransmission has been implicated in the impulsivity, inattention, and hyperactivity of attention deficit hyperactivity disorder (ADHD). We hypothesized that a pharmacological challenge with methylphenidate (MP) at a therapeutic dose increases extracellular DA concentrations in proportion to the severity of these specific ADHD symptoms. To test this hypothesis, we measured by PET the effect of acute challenge with MP on the availability of striatal binding sites for [11C]raclopride (pB), an index of altered interstitial DA concentration, in nine unmedicated adolescents (1 female, 8 males; age 13.7 +/- 1.8 years) with a current diagnosis of ADHD. We estimated the pB of [11C]raclopride for brain dopamine D2/3 receptors first in a baseline resting condition, and again after an acute challenge with MP (0.3 mg/kg, p.o.), and calculated the percentage change in (%DeltapB) in left and right striatum. On another day, measurements of impulsivity and inattention were performed using a computerized continuous performance test. There was a significant correlation between the magnitude of %DeltapB in the right striatum and the severity of inattention and impulsivity. MP-evoked %DeltapB correlated with standard scores for impulse control (r = 0.68; P = 0.02), attention (r = 0.81; P = 0.005), information processing (r = 0.66; P = 0.02), and consistency of attention, or variability (r = 0.60; P = 0.04). In conclusion, the results link inattention and impulsivity with sensitivity of brain DA receptor availability to an MP challenge, corroborating the hypothesis that MP serves to potentiate decreased DA neurotransmission in ADHD.

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Authors: Rosa-Neto, P., Lou, H. C., Cumming, P., Pryds, O., Karrebaek, H., Lunding, J., & Gjedde, A.
Affiliations: Aarhus University (DK)
Kennedy Center (DK)
ORCID: Cumming, Paul
Pryds, Ole
Gjedde, Albert
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2005-04
Volume: 25
Issue: 3
Pages: 868-876
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2004.11.031
OpenAlex: W1974649221
Cited by: 135
References: 67
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 11 · 2012: 12
FWCI: 6.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
Funders: Lundbeckfonden
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: attention deficit hyperactivity disorder, methylphenidate, striatal dopamine, dopamine D2/D3 receptors, [11C]raclopride, inattention, impulsivity, adolescents, continuous performance test, impulse control
MeSH terms: Adolescent, Central Nervous System Stimulants, Attention, Attention Deficit Disorder with Hyperactivity, Child, Corpus Striatum, Dominance, Cerebral, Dopamine, Dose-Response Relationship, Drug, Drug Synergism, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Male, Methylphenidate, Neuropsychological Tests, Pattern Recognition, Visual, Psychomotor Performance, Radioligand Assay, Reaction Time, Statistics as Topic, Treatment Outcome, Receptors, Dopamine D2, Raclopride, Positron-Emission Tomography, Receptors, Dopamine D3

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Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder

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