The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Hemodynamic correlates of EEG: A heuristic
Abstract
In this note we describe a heuristic, starting with a dimensional analysis, which relates hemodynamic changes to the spectral profile of ongoing EEG activity. In brief, this analysis suggests that 'activation', as indexed by increases in hemodynamic signals, should be associated with a loss of power in lower EEG frequencies, relative to higher frequencies. The fact that activation is expressed in terms of frequency (i.e., per second) is consistent with a dimensional analysis in the sense that activations reflect the rate of energy dissipation (per second). In this heuristic, activation causes an acceleration of temporal dynamics leading to (i) increased energy dissipation; (ii) decreased effective membrane time constants; (iii) increased effective coupling among neuronal ensembles; and (iv) a shift in the EEG spectral profile to higher frequencies. These predictions are consistent with empirical observations of how changes in the EEG spectrum are expressed hemodynamically. Furthermore, the heuristic provides a simple measure of neuronal activation based on spectral analyses of EEG.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This is because it is generally assumed that fMRI signals scale with the predominant frequency of neuronal activity (Kilner et al., 2005; Laufs & Duncan 2007; Rosa et al., 2010).”
From Network discovery with DCM (2011) · cites this paper as Kilner et al., 2005
Citations
Cites
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564
The Theory of Stochastic Processes
Cox, D. R., Miller, H. D., Weiss, G., & Shuler, K. (1966) · Physics Today · doi:10.1063/1.3047872 · Cited by 3,324
Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems
Dayan, P., & Abbott, L. F. (2001) · Cited by 3,153
Dynamic Statistical Parametric Mapping
Dale, A. M., Liu, A. K., Fischl, B. R., Buckner, R. L., Belliveau, J. W., Lewine, J. D., & Halgren, E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81138-1 · Cited by 1,787
Synaptic depression and cortical gain control
Abbott, L. F., Varela, J. A., Sen, K., & Nelson, S. B. (1997) · Science · doi:10.1126/science.275.5297.221 · Cited by 1,690
The Theory of Stochastic Processes.
Bartholomew, D. J., Cox, D., & Miller, H. D. (1966) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2343509 · Cited by 1,201
Magistretti, P. J., Pellerin, L., Rothman, D. L., & Shulman, R. G. (1999) · Science · doi:10.1126/science.283.5401.496 · Cited by 1,170
Simultaneous EEG and fMRI of the alpha rhythm
Goldman, R. I., Stern, J. M., Engel, J., & Cohen, M. S. (2002) · Neuroreport · doi:10.1097/00001756-200212200-00022 · Cited by 1,131
Laufs, H., Krakow, K., Sterzer, P., Eger, E., Beyerle, A., Salek-Haddadi, A., & Kleinschmidt, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831638100 · Cited by 1,028
EEG-correlated fMRI of human alpha activity
Laufs, H., Kleinschmidt, A., Beyerle, A., Eger, E., Salek-Haddadi, A., Preibisch, C., & Krakow, K. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00286-6 · Cited by 1,025
The neural basis of functional brain imaging signals
Attwell, D., & Iadecola, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02264-6 · Cited by 957
Simultaneous EEG and fMRI of the alpha rhythm
Stern (2002) · Neuroreport · doi:10.1097/01.wnr.0000047685.08940.d0 · Cited by 945
Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging
Magistretti, P. J., & Pellerin, L. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0471 · Cited by 750
A mechanism for generation of long-range synchronous fast oscillations in the cortex
Traub, R. D., Whittington, M. A., Stanford, I. M., & Jefferys, J. G. R. (1996) · Nature · doi:10.1038/383621a0 · Cited by 714
Very Slow Activity Fluctuations in Monkey Visual Cortex: Implications for Functional Brain Imaging
Leopold, D. A. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.4.422 · Cited by 675
Correlates of alpha rhythm in functional magnetic resonance imaging and near infrared spectroscopy
Moosmann, M., Ritter, P., Krastel, I., den Brink, A. M.-V., Thees, S., Blankenburg, F., Taskin, B., Obrig, H., & Villringer, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00344-6 · Cited by 595
Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex
Hoge, R. D., Atkinson, J., Gill, B., Crelier, G. R., Marrett, S., & Pike, G. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9403 · Cited by 564
Jueptner, M., & Weiller, C. (1995) · NeuroImage · doi:10.1006/nimg.1995.1017 · Cited by 522
Interneuron Diversity series: Inhibitory interneurons and network oscillations in vitro
Whittington, M. A., & Traub, R. D. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.016 · Cited by 506
Constraints on cortical and thalamic projections: the no-strong-loops hypothesis
Crick, F., & Koch, C. (1998) · Nature · doi:10.1038/34584 · Cited by 353 · cited 1×
“For example, it ensures that activation does not violate the Fnostrong-loops hypothesis_ (Crick and Koch, 1998).”
BackgroundConcurrent EEG/fMRI analysis by multiway Partial Least Squares
Martínez‐Montes, E., Valdes-Sosa, P. A., Miwakeichi, F., Goldman, R. I., & Cohen, M. S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.038 · Cited by 327
The labile brain. I. Neuronal transients and nonlinear coupling
Friston, K. J. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0560 · Cited by 299
Relationship of spikes, synaptic activity, and local changes of cerebral blood flow
Lauritzen, M. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200112000-00001 · Cited by 253
fMRI “deactivation” of the posterior cingulate during generalized spike and wave
Archer, J. S. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00294-5 · Cited by 227
Studying spontaneous EEG activity with fMRI
Salek‐Haddadi, A., Friston, K. J., Lemieux, L., & Fish, D. R. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00193-0 · Cited by 205
Phillips, C. L. M., Rugg, M. D., & Friston, K. J. (2002) · NeuroImage · doi:10.1006/nimg.2002.1143 · Cited by 191
Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates
Czisch, M., Wehrle, R., Kaufmann, C., Wetter, T. C., Holsboer, F., Pollmächer, T., & Auer, D. P. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03518.x · Cited by 188
A long-range cortical network emerging with theta oscillation in a mental task
Mizuhara, H., Wang, L., KOBAYASHI, K., & Yamaguchi, Y. (2004) · Neuroreport · doi:10.1097/01.wnr.0000126755.09715.b3 · Cited by 152
Interpreting functional imaging studies in terms of neurotransmitter cycling
Shulman, R. G., & Rothman, D. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11993 · Cited by 149
Comparison of Spike-Triggered Functional MRI BOLD Activation and EEG Dipole Model Localization
Lemieux, L., Krakow, K., & Fish, D. R. (2001) · NeuroImage · doi:10.1006/nimg.2001.0896 · Cited by 112
Spatio‐temporal imaging of focal interictal epileptiform activity using EEG‐triggered functional MRI
Krakow, K., Lemieux, L., Messina, D., Scott, C. A., Symms, M. R., Duncan, J. S., & Fish, D. R. (2001) · Epileptic Disorders · doi:10.1684/j.1950-6945.2001.tb00473.x · Cited by 95
Lövblad, K., THOMAS, R. J., Jakob, P. M., Scammell, T. E., Bassetti, C. L., Griswold, M. A., Ives, J. R., Matheson, J. K., Edelman, R. R., & Warach, S. J. (1999) · Neurology · doi:10.1212/wnl.53.9.2193 · Cited by 91
EEG/Functional MRI in Epilepsy: The Queen Square Experience
Hamandi, K., Salek‐Haddadi, A., Fish, D. R., & Lemieux, L. (2004) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200407000-00002 · Cited by 88
Reduced BOLD response to periodic visual stimulation
Parkes, L. M., Fries, P., Kerskens, C., & Norris, D. G. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.08.025 · Cited by 52
Relating Macroscopic Measures of Brain Activity to Fast, Dynamic Neuronal Interactions
Chawla, D., Lumer, E. D., & Friston, K. J. (2000) · Neural Computation · doi:10.1162/089976600300014737 · Cited by 50
Neurophysiologic Basis of Functional Neuroimaging: Animal Studies
Shin, C. (2000) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200001000-00002 · Cited by 13
Flagged first, then by citations
Cited by
Sorted by citations
High-Frequency Brain Activity and Muscle Artifacts in MEG/EEG: A Review and Recommendations
Muthukumaraswamy, S. D. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00138 · Cited by 697
Role of local network oscillations in resting-state functional connectivity
Cabral, J., Hugues, E., Sporns, O., & Deco, G. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.04.010 · Cited by 531
Hsieh, L.-T., & Ranganath, C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.003 · Cited by 525
Jokisch, D., & Jensen, O. B. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5399-06.2007 · Cited by 508
Oscillatory power decreases and long-term memory: the information via desynchronization hypothesis
Hanslmayr, S., Staudigl, T., & Fellner, M.-C. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00074 · Cited by 543
Metadata
- Authors
- Kilner, J. M., Mattout, J., Henson, R., & Friston, K. J.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- Corresponding author
- Kilner, J.M.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 28
- Issue
- 1
- Pages
- 280-286
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2153427235
- Cited by
- 206
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 12 · 2014: 11 · 2013: 16 · 2012: 16
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- neuronal activation, dimensional analysis, energy dissipation, membrane time constant, neuronal ensembles, hemodynamic response
- MeSH terms
- Algorithms, Cerebrovascular Circulation, Electroencephalography, Energy Metabolism, Hemodynamics, Humans, Magnetic Resonance Imaging, Models, Neurological, Oxygen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
