Cerebral perfusion abnormality in narcolepsy with cataplexy
Open accessAbstract
To investigate abnormal cerebral perfusion in narcoleptics with cataplexy, 25 narcoleptics with cataplexy and 25 normal controls were enrolled in this study. Cerebral perfusion was measured by brain single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer. Patients and normal controls had not received any medication prior to the SPECT scan. Differences in cerebral perfusion between narcoleptics and normal controls were subjected to statistical parametric mapping (SPM) analysis. Overnight polysomnography and multiple sleep latency test (MSLT) were performed in all patients. Brain SPECT was carried out on all patients and normal controls during the waking state. Clinical symptoms and MSLT results of all patients are in accord with the International Classification of Sleep Disorders criteria for narcolepsy. MSLT showed a short mean sleep latency (1.69 +/- 1.0 min) and 2-5 sleep onset REM periods in individual patient. SPM analysis of brain SPECT showed hypoperfusion of the bilateral anterior hypothalami, caudate nuclei, and pulvinar nuclei of thalami, parts of the dorsolateral/ventromedial prefrontal cortices, parahippocampal gyri, and cingulate gyri in narcoleptics [P < 0.05 by Student's t test with false discovery rate (FDR) correction]. Significant hypoperfusion in the white matter of frontal and parietal lobes was also noted in narcoleptics. This study shows reduced cerebral perfusion in subcortical structures and cortical areas in narcoleptics. The distribution of abnormal cerebral perfusion is concordant with the pathway of the cerebral hypocretin system and may explain the characteristic features of narcolepsy, i.e., cataplexy, emotional lability, and attention deficit.
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“, 2014); b) The impairment of the limbic system has been repeatedly found in narcoleptic patients (e.g., Mignot et al., 2002; Joo et al., 2005; Hong et al., 2006; Schwartz et al., 2008; Meletti et al., 2015).”
Background
- Authors
- Yeon Joo, E., Hong, S. B., Tae, W. S., Kim, J. H., Han, S. J., Cho, Y. W., Yoon, C. H., Lee, S. I., Lee, M. H., Lee, K. H., Kim, M.-H., Kim, B. T., & Kim, L.
- Affiliations
- Samsung Medical Center (KR)
- Keimyung University Dongsan Medical Center (KR)
- Inha University (KR)
- Wonkwang University (KR)
- Daegu Catholic University (KR)
- Ewha Womans University (KR)
- Korea University (KR)
- Corresponding author
- Hong, Seung Bong
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 28
- Issue
- 2
- Pages
- 410-416
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1969696137
- Cited by
- 90
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 9 · 2012: 5
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- KUMeL Repository (Keimyung University) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- narcolepsy type 1, cerebral perfusion, cerebral hypoperfusion, hypothalamus, caudate nucleus, prefrontal cortex, sleep onset REM periods, multiple sleep latency test
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Cataplexy, Caudate Nucleus, Cerebrovascular Disorders, Cysteine, Data Interpretation, Statistical, Female, Humans, Hypothalamus, Image Processing, Computer-Assisted, Male, Middle Aged, Narcolepsy, Sleep, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Polysomnography, Radiopharmaceuticals
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