Ecphory of autobiographical memories: an fMRI study of recent and remote memory retrieval.
Open accessAbstract
Ecphory occurs when one recollects a past event cued by a trigger, such as a picture, odor, or name. It is a central component of autobiographical memory, which allows us to "travel mentally back in time" and re-experience specific events from our personal past. Using fMRI and focusing on the role of medial temporal lobe (MTL) structures, we investigated the brain bases of autobiographical memory and whether they change with the age of memories. Importantly, we used an ecphory task in which the remote character of the memories was ensured. The results showed that a large bilateral network supports autobiographical memory: temporal lobe, temporo-parieto-occipital junction, dorsal prefrontal cortex, medial frontal cortex, retrosplenial cortex and surrounding areas, and MTL structures. This network, including MTL structures, changed little with the age of the memories.
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The dorsal attentional network and the default-mode network work in tandem to facilitate further activation of the central executive network necessary to carry out higher-order cognitive tasks, including emotional regulatory processes, which are typically altered among individuals with PTSD.
“The dorsal attentional network and the default-mode network are thought to work in tandem to facilitate further activation of the central executive network necessary to carry out higher-order cognitive tasks, including emotional regulatory processes (Picó-Pérez et al., 2017; Zilverstand et al., 2017) typically altered among individuals with PTSD (Steinvorth et al., 2006; Andrews-Hanna et al., 2014”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Steinvorth et al., 2006
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“It is unclear, however, to what degree this approach accesses detailed truly episodic memories because deficits in remote autobiographical memories in amnesic patients have been well documented (Moscovitch et al., 1999; Spiers et al., 2001; Steinvorth et al., 2005).”
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- Authors
- Steinvorth, S., Corkin, S., & Halgren, E.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Steinvorth, Sarah
- ORCID
- Halgren, Eric
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 30
- Issue
- 1
- Pages
- 285-298
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC1513614
- OpenAlex
- W2031599878
- Cited by
- 148
- References
- 7
- Citations by year
- 2025: 7 · 2024: 9 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 12 · 2012: 9
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Research Resources (P41RR14075)
- Mind and Life Institute
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Developmental and Educational Psychology › Identity, Memory, and Therapy
- Keywords
- autobiographical memory, memory retrieval, remote memory, recent memory, medial temporal lobe, artificial neural networks, retrosplenial cortex, dorsal prefrontal cortex, memory age
- MeSH terms
- Adult, Age Factors, Association Learning, Autobiographies as Topic, Brain Mapping, Cerebral Cortex, Cues, Dominance, Cerebral, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Psychomotor Performance, Reaction Time, Mental Recall, Retention, Psychology, Semantics, Parahippocampal Gyrus
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