The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Brain abnormalities in human obesity: A voxel-based morphometric study
Abstract
Obesity is accompanied by damage to several tissues. Overweight is a risk factor for Alzheimer's disease and other neurodegenerative disorders. Whether structural abnormalities associated with excess body fat may also occur in the brain is unknown. We sought to determine to what extent excess body fat is associated with regional alterations in brain structure using voxel-based morphometry (VBM), a whole-brain unbiased technique based upon high-definition 3D magnetic resonance imaging (MRI) scans normalized into a common standard space and allowing for an objective assessment of neuroanatomical differences throughout the brain. We studied 24 obese (11 male, 13 female; age: 32 +/- 8 years; body mass index [BMI]: 39.4 +/- 4.7 kg/m2) and 36 lean (25 male, 11 female; mean age: 33 +/- 9 years; BMI: 22.7 +/- 2.2 kg/m2) non-diabetic Caucasians. In comparison with the group of lean subjects, the group of obese individuals had significantly lower gray matter density in the post-central gyrus, frontal operculum, putamen, and middle frontal gyrus (P < 0.01 after adjustment for sex, age, handedness, global tissue density, and multiple comparisons). BMI was negatively associated with GM density of the left post-central gyrus in obese but not lean subjects. This study identified structural brain differences in human obesity in several brain areas previously involved in the regulation of taste, reward, and behavioral control. These alterations may either precede obesity, representing a neural marker of increased propensity to gaining weight, or occur as a consequence of obesity, indicating that also the brain is affected by increased adiposity.
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“Brain imaging studies comparing obese and lean individuals have also reported lower grey matter density in frontal regions (frontal operculum and middle frontal gyrus) and in post-central gyrus and putamen (128).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [128]
In the citing paper
“Brain imaging studies comparing obese and lean individuals have also reported lower gray matter density in frontal regions (frontal operculum and middle frontal gyrus) and in postcentral gyrus and putamen (Pannacciulli et al 2006).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Pannacciulli et al 2006
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Cites
Diagnostic and Statistical Manual of Mental Disorders
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Positional cloning of the mouse obese gene and its human homologue
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Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
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Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258
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Changes in brain activity related to eating chocolate: From pleasure to aversion
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An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease
Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., & Skoog, I. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.13.1524 · Cited by 811
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Reward, dopamine and the control of food intake: implications for obesity
Volkow, N. D., Wang, G.-J., & Baler, R. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.001 · Cited by 1,400
Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry
Robbins, T. W., Gillan, C. M., Smith, D. G., de Wit, S., & Ersche, K. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.009 · Cited by 1,003
Obesity and addiction: Neurobiological overlaps
Volkow, N. D., Wang, G. ‐., Tomasi, D., & Baler, R. D. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01031.x · Cited by 800
Obesity and neuroinflammation: A pathway to cognitive impairment
Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 834
Smith, E., Hay, P., Campbell, L. V., & Trollor, J. N. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00920.x · Cited by 706
Metadata
- Authors
- Pannacciulli, N., Del Parigi, A., Chen, K., Le, D. S. N. T., Reiman, E. M., & Tataranni, P. A.
- Affiliations
- National Institutes of Health (US)
- Banner - University Medical Center Phoenix (US)
- Corresponding author
- Pannacciulli, Nicola
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 31
- Issue
- 4
- Pages
- 1419-1425
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2077965626
- Cited by
- 523
- References
- 45
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 23 · 2023: 22 · 2022: 22 · 2021: 28 · 2020: 23 · 2019: 34 · 2018: 34 · 2017: 36 · 2016: 41 · 2015: 37 · 2014: 41 · 2013: 31 · 2012: 27
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- obesity, brain structure, gray matter density, body mass index, postcentral gyrus, frontal operculum, putamen, middle frontal gyrus, adiposity
- MeSH terms
- Adult, Anthropometry, Blood Glucose, Brain, Brain Chemistry, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Insulin, Magnetic Resonance Imaging, Male, Obesity, Body Mass Index
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