Cited by 525Regulation of Appetite and ObesityNeural and Behavioral Psychology StudiesAdvanced Neuroimaging Techniques and Applications

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Brain abnormalities in human obesity: A voxel-based morphometric study

Pannacciulli, Nicola, Del Parigi, Angelo, Chen, Kewei, Le, Duc Son N.T., Reiman, Eric M., Tataranni, Pietro A.·2006·NeuroImage

DOI 10.1016/j.neuroimage.2006.01.047

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Abstract

Obesity is accompanied by damage to several tissues. Overweight is a risk factor for Alzheimer's disease and other neurodegenerative disorders. Whether structural abnormalities associated with excess body fat may also occur in the brain is unknown. We sought to determine to what extent excess body fat is associated with regional alterations in brain structure using voxel-based morphometry (VBM), a whole-brain unbiased technique based upon high-definition 3D magnetic resonance imaging (MRI) scans normalized into a common standard space and allowing for an objective assessment of neuroanatomical differences throughout the brain. We studied 24 obese (11 male, 13 female; age: 32 +/- 8 years; body mass index [BMI]: 39.4 +/- 4.7 kg/m2) and 36 lean (25 male, 11 female; mean age: 33 +/- 9 years; BMI: 22.7 +/- 2.2 kg/m2) non-diabetic Caucasians. In comparison with the group of lean subjects, the group of obese individuals had significantly lower gray matter density in the post-central gyrus, frontal operculum, putamen, and middle frontal gyrus (P < 0.01 after adjustment for sex, age, handedness, global tissue density, and multiple comparisons). BMI was negatively associated with GM density of the left post-central gyrus in obese but not lean subjects. This study identified structural brain differences in human obesity in several brain areas previously involved in the regulation of taste, reward, and behavioral control. These alterations may either precede obesity, representing a neural marker of increased propensity to gaining weight, or occur as a consequence of obesity, indicating that also the brain is affected by increased adiposity.

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Authors: Pannacciulli, N., Del Parigi, A., Chen, K., Le, D. S. N. T., Reiman, E. M., & Tataranni, P. A.
Affiliations: National Institutes of Health (US)
Banner - University Medical Center Phoenix (US)
Corresponding author: Pannacciulli, Nicola
ORCID: Chen, Kewei
Reiman, Eric M.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2006-07
Volume: 31
Issue: 4
Pages: 1419-1425
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2006.01.047
OpenAlex: W2077965626
Cited by: 523
References: 45
Citations by year: 2026: 9 · 2025: 13 · 2024: 23 · 2023: 22 · 2022: 22 · 2021: 28 · 2020: 23 · 2019: 34 · 2018: 34 · 2017: 36 · 2016: 41 · 2015: 37 · 2014: 41 · 2013: 31 · 2012: 27
FWCI: 5.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords: obesity, brain structure, gray matter density, body mass index, postcentral gyrus, frontal operculum, putamen, middle frontal gyrus, adiposity
MeSH terms: Adult, Anthropometry, Blood Glucose, Brain, Brain Chemistry, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Insulin, Magnetic Resonance Imaging, Male, Obesity, Body Mass Index

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Brain abnormalities in human obesity: A voxel-based morphometric study

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