Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats

Yang, J.; Sadler, T.R.; Givrad, T.K.; Maarek, J.-M.I.; Holschneider, D.P.

doi:10.1016/j.neuroimage.2007.03.010

Cited by 41Neurological disorders and treatmentsParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats

Open access

Yang, J., Sadler, T.R., Givrad, T.K., Maarek, J.-M.I., Holschneider, D.P.·2007·NeuroImage

DOI 10.1016/j.neuroimage.2007.03.010PMC PMC2039721

Open this paper in CoChat — free account

Abstract

To evaluate functional neuronal compensation after partial damage to the nigrostriatal system, we lesioned rats unilaterally in the striatum with 6-hydroxydopamine. Five weeks later, cerebral perfusion was mapped at rest or during treadmill walking using [(14)C]-iodoantipyrine. Regional CBF-related tissue radioactivity (CBF-TR) was quantified by autoradiography and analyzed by statistical parametric mapping and region-of- interest analysis. Lesions were confirmed by tyrosine hydroxylase immunohistochemistry and changes in rotational locomotor activity. Functional compensations were bilateral and differed at rest and during treadmill walking. Consistent with the classic view of striatopallidal connections, CBF-TR of lesioned compared to sham-lesioned rats increased in the ipsilateral subthalamic nucleus (STN) and internal globus pallidus, and decreased in the striatum and external globus pallidus. Contrary to the classic view, CBF-TR increased in the ipsilateral ventral lateral, ventral anterior thalamus and motor cortex, as well as in the central medial thalamus, midline cerebellum, and contralateral STN. During walking, perfusion decreased in lesioned compared to sham-lesioned rats across the ipsilateral striato-pallidal-thalamic-cortical motor circuit. Compensatory increases were seen bilaterally in the ventromedial thalamus and red nucleus, in the contralateral STN, anterior substantia nigra, subiculum, motor cortex, and in midline cerebellum. Enhanced recruitment of associative sensory areas was noted cortically and subcortically. Future models of compensatory changes after nigrostriatal damage need to address the effects of increased neural activity by residual dopaminergic neurons, interhemispheric interactions and differences between resting and locomotor states. Identification of sites at which functional compensation occurs may define useful future targets for neurorehabilitative or neurorestorative interventions in Parkinson's disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2007.03.010

Cites

109 of 109 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Studies support an exercise-induced beneficial effect on the immune system in the CNS.
“In general, studies support an exercise-induced beneficial effect of the immune system in the CNS.106–109”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [106]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353 · see citing works
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131 · see citing works
Primate models of movement disorders of basal ganglia origin
DeLong, M. R. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90110-v · Cited by 3,824 · see citing works
The rat nervous system
Paxinos, G. (1985) · Cited by 3,715 · see citing works
A pyramid approach to subpixel registration based on intensity
Thévenaz, P., Ruttimann, U. E., & Unser, M. A. (1998) · IEEE Transactions on Image Processing · doi:10.1109/83.650848 · Cited by 3,097 · see citing works
Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990) · PubMed · Cited by 2,422 · see citing works
Statistics for the social sciences
Hays, W. L. (1973) · Medical Entomology and Zoology · Cited by 2,100 · see citing works
Reversal of experimental parkinsonism by lesions of the subthalamic nucleus.
Bergman, H., Wichmann, T., & Delong, M. (1990) · Science · doi:10.1126/science.2402638 · Cited by 2,003 · see citing works
Chapter 6 Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62678-3 · Cited by 1,961 · see citing works
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
Schallert, T. J., Fleming, S. M., Leasure, J. L., Tillerson, J. L., & Bland, S. T. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00005-8 · Cited by 1,357 · see citing works
Circuits and Circuit Disorders of the Basal Ganglia
DeLong, M. R., & Wichmann, T. (2007) · Archives of Neurology · doi:10.1001/archneur.64.1.20 · Cited by 1,074 · see citing works
Self-initiated versus externally triggered movements
Jahanshahi, M., Jenkins, I. H., Brown, R. G., MARSDEN, C. D., Passingham, R. E., & Brooks, D. J. (1995) · Brain · doi:10.1093/brain/118.4.913 · Cited by 999 · see citing works
Measurement of local cerebral blood flow with iodo [14C] antipyrine
Sakurada, O., Kennedy, C., Jehle, J. W., Brown, J. D., Carbin, G. L., & Sokoloff, L. (1978) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1978.234.1.h59 · Cited by 926 · see citing works
The Relationship between Global and Local Changes in PET Scans
Friston, K. J., Frith, C., Liddle, P. F., Dolan, R. J., Lammertsma, A. A., & Frackowiak, R. S. J. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.88 · Cited by 858 · see citing works
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
Sauer, H., & Oertel, W. H. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90605-x · Cited by 807 · see citing works
The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments
Schwarting, R. K. W., & Huston, J. P. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00040-8 · Cited by 741 · see citing works
Impaired mesial frontal and putamen activation in Parkinson's disease: A positron emission tomography study
Playford, E. D., Jenkins, I. H., Passingham, R. E., Nutt, J. G., Frackowiak, R. S. J., & Brooks, D. J. (1992) · Annals of Neurology · doi:10.1002/ana.410320206 · Cited by 611 · see citing works
Cortical motor reorganization in akinetic patients with Parkinson's disease
Sabatini, U., Boulanouar, K., Fabre, N., Martin, F., Carel, C., Colonnese, C., Bozzao, L., Berry, I., Montastruc, J., Chollet, F., et al. (2000) · Brain · doi:10.1093/brain/123.2.394 · Cited by 592 · see citing works
A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats.
Kolb, B. E., Sutherland, R. J., & Whishaw, I. Q. (1983) · Behavioral Neuroscience · doi:10.1037//0735-7044.97.1.13 · Cited by 432 · see citing works
Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine
Jenkins, I. H., Fernandez, W., Playford, E. D., Lees, A. J., Frackowiak, R. S. J., Passingham, R. E., & Brooks, D. J. (1992) · Annals of Neurology · doi:10.1002/ana.410320608 · Cited by 419 · see citing works
Evidence for lateral premotor and parietal overactivity in Parkinson's disease during sequential and bimanual movements. A PET study
Samuel, M. (1997) · Brain · doi:10.1093/brain/120.6.963 · Cited by 400 · see citing works
Brain functional activity during gait in normal subjects: a SPECT study
Fukuyama, H., Ouchi, Y., Matsuzaki, S., et al. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00381-9 · Cited by 363 · see citing works
Presymptomatic compensation in Parkinson's disease is not dopamine-mediated
Bézard, E., Gross, C. E., & Brotchie, J. M. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00038-9 · Cited by 351 · see citing works
UNILATERAL 6-HYDROXYDOPAMINE LESIONS OF MESO-STRIATAL DOPAMINE NEURONS AND THEIR PHYSIOLOGICAL SEQUELAE
Schwarting, R. K. W., & Huston, J. P. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00015-9 · Cited by 345 · see citing works
A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats.
Kolb, B. E., Sutherland, R. J., & Whishaw, I. Q. (1983) · Behavioral Neuroscience · doi:10.1037/0735-7044.97.1.13 · Cited by 333 · see citing works
Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease
Goldberg, J. A., Boraud, T., Maraton, S., Haber, S. N., Vaadia, E., & Bergman, H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04639.2002 · Cited by 304 · see citing works
Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position
Voges, J., Volkmann, J., Allert, N., Lehrke, R., Koulousakis, A., Freund, H., & Sturm, V. (2002) · Journal of neurosurgery · doi:10.3171/jns.2002.96.2.0269 · Cited by 301 · see citing works
Comparison of the basal ganglia in rats, marmosets, macaques, baboons, and humans: Volume and neuronal number for the output, internal relay, and striatal modulating nuclei
Hardman, C. D., Henderson, J. M., Finkelstein, D. I., Horne, M. K., Paxinos, G., & Halliday, G. M. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10165 · Cited by 282 · see citing works
Commentary and Opinion: II. Statistical Parametric Mapping: Ontology and Current Issues
Friston, K. J. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.45 · Cited by 268 · see citing works
Chemoarchitecture of the rat lateral septal nucleus 1Published on the World Wide Web on 2 June 1997. 1
Risold, P. Y., & Swanson, L. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00008-8 · Cited by 263 · see citing works
The role of the locus coeruleus in the development of Parkinson's disease
Gesi, M., Soldani, P., Giorgi, F. S., Santinami, A., Bonaccorsi, I., & Fornai, F. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00028-2 · Cited by 254 · see citing works
Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF
Cohen, A. D., Tillerson, J. L., Smith, A. D., Schallert, T., & Zigmond, M. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01657.x · Cited by 243 · see citing works
Striatal dopamine turnover during treadmill running in the rat: Relation to the speed of running
Hattori, S., Naoi, M., & Nishino, H. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90214-3 · Cited by 234 · see citing works
The supramammillary area: its organization, functions and relationship to the hippocampus
Pan, W.-X., & McNaughton, N. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.003 · Cited by 223 · see citing works
Supplementary and Primary Sensory Motor Area Activity in Parkinson's Disease
Rascol, O. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530260044017 · Cited by 223 · see citing works
A PET study of sequential finger movements of varying length in patients with Parkinson's disease
Catalán, M. J., Ishii, K., Honda, M., Samii, A., & Hallett, M. (1999) · Brain · doi:10.1093/brain/122.3.483 · Cited by 215 · see citing works
Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's disease
Yuan, H., Sarre, S., Ebinger, G., & Michotte, Y. M. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.004 · Cited by 210 · see citing works
Sensory processing in Parkinson's and Huntington's disease
Boecker, H., Ceballos-Baumann, A., Bartenstein, P., Weindl, A., Siebner, H. R., Fassbender, T., Munz, F., Schwaiger, M., & Conrad, B. (1999) · Brain · doi:10.1093/brain/122.9.1651 · Cited by 207 · see citing works
The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients
Rascol, O. (1997) · Brain · doi:10.1093/brain/120.1.103 · Cited by 207 · see citing works
Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implications for limbic--striatal interactions.
Burns, L. H., Annett, L. E., Kelly, A. E., Everitt, B. J., & Robbins, T. W. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.1.60 · Cited by 196 · see citing works
Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implication for limbic—striatal interactions.
Burns, L. H., Annett, L. E., Kelley, A. E., Everitt, B. J., & Robbins, T. W. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.1.60 · Cited by 177 · see citing works
Cortical motor overactivation in parkinsonian patients with L-dopa- induced peak-dose dyskinesia
Rascol, O. (1998) · Brain · doi:10.1093/brain/121.3.527 · Cited by 164 · see citing works
Some Fiber Pathways Related to the Posterior Thalamic Region in the Cat; pp. 363–378
Graybiel, A. M. (2008) · Brain Behavior and Evolution · doi:10.1159/000123723 · Cited by 159 · see citing works
Evolution of the basal ganglia: new perspectives through a comparative approach
Smeets, W. J. A. J., Marín, Ó., & González, A. (2000) · Journal of Anatomy · doi:10.1046/j.1469-7580.2000.19640501.x · Cited by 158 · see citing works
Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracelullar striatal dopamine
Meissner, W. G., Ravenscroft, P., Reese, R., Harnack, D., Morgenstern, R., Kupsch, A. R., Klitgaard, H., Bioulac, B. H., Gross, C. E., Bézard, E., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.009 · Cited by 150 · see citing works
Neurotransmitter Organization and Connectivity of the Basal Ganglia in Vertebrates: Implications for the Evolution of Basal Ganglia (Part 1 of 2)
Medina, L. M., & Reiner, A. J. (2008) · Brain Behavior and Evolution · doi:10.1159/000113277 · Cited by 145 · see citing works
Experience-Associated Structural Events, Subependymal Cellular Proliferative Activity, and Functional Recovery After Injury to the Central Nervous System
Schallert, T. J., Leasure, J. L., & Kolb, B. E. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200011000-00001 · Cited by 144 · see citing works
Normal activation of the supplementary motor area in patients with Parkinson's disease undergoing long-term treatment with levodopa.
Rascol, O., Sabatini, U., Chollet, F., Fabre, N., Sénard, J., Montastruc, J., Celsis, P., Marc-Vergnes, J. P., & Rascol, A. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.5.567 · Cited by 143 · see citing works
Brain blood flow in the conscious and anesthetized rat
Goldman, H., & Sapirstein, L. A. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.1.122 · Cited by 143 · see citing works
5‐hydroxytryptamine (5‐HT, serotonin) and Parkinson's disease – opportunities for novel therapeutics to reduce the problems of levodopa therapy
Nicholson, S. L., & Brotchie, J. M. (2002) · European Journal of Neurology · doi:10.1046/j.1468-1331.9.s3.1.x · Cited by 142 · see citing works
Regional brain blood flow in the conscious gerbil.
Uitert, R. L. V., & Levy, D. E. (1978) · Stroke · doi:10.1161/01.str.9.1.67 · Cited by 133 · see citing works
Precerebellar Nuclei and Red Nucleus
Ruigrok, T. J. H. (2004) · Elsevier eBooks · doi:10.1016/b978-012547638-6/50009-2 · Cited by 133 · see citing works
Pathophysiologic basis of surgery for Parkinson's disease.
Obeso, J. A., Rodríguez-Oroz, M. C., Rodriguez, M., Macıás, R., Álvarez, L., Guridi, J., Vitek, J. L., & DeLong, M. R. (2000) · PubMed · Cited by 126 · see citing works
Hyperlocomotion and increased dopamine efflux in the rat nucleus accumbens evoked by electrical stimulation of the ventral subiculum: role of ionotropic glutamate and dopamine D 1 receptors
Taepavarapruk, P., Floresco, S., & Phillips, A. G. (2000) · Psychopharmacology · doi:10.1007/s002130000376 · Cited by 121 · see citing works
Walking evokes a distinctive pattern of Fos-like immunoreactivity in the caudal brainstem and spinal cord of the rat
Jasmin, L., Gogas, K. R., Ahlgren, S. C., Levine, J. D., & Basbaum, A. I. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90034-5 · Cited by 120 · see citing works
Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells*
Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 108 · see citing works
Discharge Characteristics of Neurons in the Red Nucleus During Voluntary Gait Modifications: A Comparison with the Motor Cortex
Lavoie, S., & Drew, T. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.4.1791 · Cited by 107 · see citing works
Modifications of precentral cortex discharge and EMG activity in monkeys with MPTP-induced lesions of DA nigral neurons
Doudet, D. J., Gross, C. E., Arluison, M., & Bioulac, B. H. (1990) · Experimental Brain Research · doi:10.1007/bf00228859 · Cited by 102 · see citing works
When did Ray Kennedy's Parkinson's disease begin?
Lees, A. J. (1992) · Movement Disorders · doi:10.1002/mds.870070203 · Cited by 102 · see citing works
Postmortem analysis of bilateral subthalamic electrode implants in Parkinson's disease
Henderson, J. M., Pell, M. F., O'Sullivan, D. J., McCusker, E. A., Fung, V. S. C., Hedges, P., & Halliday, G. M. (2002) · Movement Disorders · doi:10.1002/mds.1261 · Cited by 98 · see citing works
Comparison of unilateral and bilateral intrastriatal 6‐hydroxydopamine‐induced axon terminal lesions: Evidence for interhemispheric functional coupling of the two nigrostriatal pathways
Rödter, A., Winkler, C., Samii, M., Walter, G. F., Brandis, A., & Nikkhah, G. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1098 · Cited by 90 · see citing works
Role of the posterior parietal association cortex in the processing of spatial event information.
DiMattia, B. V., & Kesner, R. P. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.3.397 · Cited by 81 · see citing works
An Evaluation of Errors in the Determination of Blood Flow by the Indicator Fractionation and Tissue Equilibration (Kety) Methods
Patlak, C. S., Blasberg, R. G., & Fenstermacher, J. D. (1984) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1984.7 · Cited by 79 · see citing works
The use of cerebral blood flow as an index of neuronal activity in functional neuroimaging: experimental and pathophysiological considerations
Gsell, W., de Sadeleer, C., Marchalant, Y., MacKenzie, E. T., Schumann‐Bard, P., & Dauphin, F. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00095-8 · Cited by 77 · see citing works
Evidence for a glutamatergic projection from the zona incerta to the basal ganglia of rats
Heise, C. E., & Mitrofanis, J. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10971 · Cited by 76 · see citing works
Projection systems and terminal localization of dorsal column afferents: An autoradiographic and horseradish peroxidase study in the rat
Massopust, L. C., Hauge, D. H., Ferneding, J. C., et al. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902370409 · Cited by 75 · see citing works
How does Parkinson's disease begin? The role of compensatory mechanisms
Obeso, J. A., Rodríguez‐Oroz, M., Lanciego, J. L., et al. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.12.006 · Cited by 74 · see citing works
Frontal-striatal disconnection disrupts cognitive performance of the frontal-type in the rat
Dunnett, S. B., Meldrum, A., & Muir, J. L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.033 · Cited by 70 · see citing works
Overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients
Thobois, S., Dominey, P. F., Decety, J., et al. (2000) · Neuroreport · doi:10.1097/00001756-200003200-00026 · Cited by 69 · see citing works
Functional Activity of Zona Incerta Neurons Is Altered after Nigrostriatal Denervation in Hemiparkinsonian Rats
Perier, C., Vila, M., Féger, J., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7331 · Cited by 65 · see citing works
The effect of 6-ohda lesions of the lateral septum on schedule-induced polydipsia
Taghzouti, K., Simon, H., Tazi, A., Dantzer, R., & Moal, M. L. (1985) · Behavioural Brain Research · doi:10.1016/0166-4328(85)90012-9 · Cited by 64 · see citing works
Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle.
Caine, S. B., Humby, T., Robbins, T. W., & Everitt, B. J. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.880 · Cited by 64 · see citing works
Long-term behavioral and biochemical effects of 6-hydroxydopamine injections in rat caudate-putamen
Cadet, J. L., Last, R., Kostić, V., et al. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90164-f · Cited by 63 · see citing works
Statistical parametric mapping applied to an autoradiographic study of cerebral activation during treadmill walking in rats
Nguyen, P. T., Holschneider, D. P., Maarek, J. I., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.05.014 · Cited by 62 · see citing works
Self-citation
Biochemical and Immunocytochemical Changes Induced by Intrastriatal 6-Hydroxydopamine Injection in the Rat Nigrostriatal Dopamine Neuron System: Evidence for Cell Death in the Substantia Nigra
Ichitani, Y., Okamura, H., Nakahara, D., et al. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1205 · Cited by 61 · see citing works
Recent Advances in Heart Rate Variability Signal Processing and Interpretation
Cerutti, S., Goldberger, A. L., & Yamamoto, Y. (2005) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2005.859777 · Cited by 59 · see citing works
Role of the posterior parietal association cortex in the processing of spatial event information.
DiMattia, B. V., & Kesner, R. P. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.3.397 · Cited by 58 · see citing works
Bilateral overactivation of the sensorimotor cortex in the unilateral rodent model of Parkinson's disease – a functional magnetic resonance imaging study
Pelled, G., Bergman, H., & Goelman, G. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01866.x · Cited by 56 · see citing works
Functional Brain Mapping in Freely Moving Rats during Treadmill Walking
Holschneider, D. P., Maarek, J.-M. I., Yang, J., Harimoto, J., & Scremin, O. U. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000072797.66873.6a · Cited by 51 · see citing works
Self-citation
Pathogenesis and preclinical course of Parkinson’s disease
Foley, P., & Riederer, P. F. (1999) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6360-3_2 · Cited by 50 · see citing works
Distinct temporal activity patterns in the rat M1 and red nucleus during skilled versus unskilled limb movement
Hermer-Vazquez, L., Hermer-Vazquez, R., Moxon, K. A., Kuo, K.-H., Viau, V., Zhan, Y., & Chapin, J. K. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00226-2 · Cited by 47 · see citing works
In vivo dialysis measurements of dopamine and DOPAC in rats trained to turn on a circular treadmill
Sabol, K. E., Richards, J. B., & Freed, C. R. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90119-3 · Cited by 46 · see citing works
Ipsilateral and contralateral subthalamic activity after unilateral dopaminergic lesion
Perier, C., Agid, Y., Hirsch, É. C., et al. (2000) · Neuroreport · doi:10.1097/00001756-200009280-00045 · Cited by 42 · see citing works
An implantable bolus infusion pump for use in freely moving, nontethered rats
Holschneider, D. P., Maarek, J. M. I., Harimoto, J., et al. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00362.2002 · Cited by 38 · see citing works
Self-citation
Nigrostriatal dopaminergic cell activity is under control by substantia nigra of the contralateral brain side: Electrophysiological evidence
Castellano, M. A., & Rodrı́guez, M. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90070-z · Cited by 36 · see citing works
Functional metabolic mapping during forelimb movement in rat. II. Stimulation of forelimb muscles
Santori, E., Der, T. C., & Collins, R. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-02-00463.1986 · Cited by 34 · see citing works
Voxel-based statistical analysis of cerebral glucose metabolism in the rat cortical deafness model by 3D reconstruction of brain from autoradiographic images
Lee, J. S., Ahn, S., Lee, D. S., Oh, S. H., Kim, C. S., Jeong, J. M., Park, K. S., Chung, J., & Lee, M. C. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1739-y · Cited by 31 · see citing works
Apomorphine-induced changes in local cerebral blood flow in normal rats and after lesions of the dopaminergic nigrostriatal bundle
Ingvar, M., Lindvall, O., & Stenevi, U. (1983) · Brain Research · doi:10.1016/0006-8993(83)91016-8 · Cited by 31 · see citing works
Striatal input from the ventrobasal complex of the rat thalamus
Erro, M. E., Lanciego, J. L., Arribas, J., & Giménez‐Amaya, J. M. (2001) · Histochemistry and Cell Biology · doi:10.1007/s004180100273 · Cited by 30 · see citing works
Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's disease
Metz, G. A. S., Piecharka, D. M., Kleim, J. A., et al. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.025 · Cited by 28 · see citing works
Presymptomatic revelation of experimental Parkinsonism
Bézard, E., Boraud, T., Bioulac, B., et al. (1997) · Neuroreport · doi:10.1097/00001756-199701200-00012 · Cited by 28 · see citing works
Selective immunotoxin-induced cholinergic deafferentation alters blood flow distribution in the cerebral cortex
Waite, J. J., Holschneider, D. P., & Scremin, O. U. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01174-3 · Cited by 27 · see citing works
Self-citation
Locomotion coincides with c-Fos expression in related areas of inferior olive and cerebellar nuclei in the rat
Ruigrok, T. J. H., van der Burg, H., & Sabel-Goedknegt, E. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12898-6 · Cited by 26 · see citing works
A Topographic analysis of limbic and somatic inputs to the cerebellar cortex in the rat
Saint‐Cyr, J. A., & Woodward, D. J. (1980) · Experimental Brain Research · doi:10.1007/bf00236658 · Cited by 26 · see citing works
Cerebral circulatory response to hypercapnia: Effects of lesions of central dopaminergic and serotoninergic neuron systems
Dahlgren, N., Lindvall, O., Nobin, A., et al. (1981) · Brain Research · doi:10.1016/0006-8993(81)90403-0 · Cited by 25 · see citing works
Cerebral Blood Flow with the Indicator Fractionation of [ 14 C]Iodoantipyrine: Effect of P a co 2 on Cerebral Venous Appearance Time
Jones, S. C., Korfalı, E., & Marshall, S. A. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.55 · Cited by 25 · see citing works
Effects of Ovariectomy on Cerebral Blood Flow of Rats
Holschneider, D. P., & Scremin, O. U. (1998) · Neuroendocrinology · doi:10.1159/000054321 · Cited by 24 · see citing works
Self-citation
Species-dependence and relationshipof morphological andelectrophysiological propertiesin nigral compacta neurons
KÃ¶tter, R. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00088-9 · Cited by 24 · see citing works
Effects of metamphetamine on blood flow in the caudate-putamen after lesions of the nigrostriatal dopaminergic bundle in the rat
Lindvall, O., Ingvar, M., & Stenevi, U. (1981) · Brain Research · doi:10.1016/0006-8993(81)90086-x · Cited by 23 · see citing works
Transcutaneous RF-Powered Implantable Minipump Driven by a Class-E Transmitter
Moore, W. H., Holschneider, D. P., Givrad, T. K., et al. (2006) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2006.873698 · Cited by 23 · see citing works
Self-citation
Four facets of a single brain: behaviour, cerebral blood flow/metabolism, neuronal activity and neurotransmitter dynamics
Kéri, S., & Gulyás, B. Z. (2003) · Neuroreport · doi:10.1097/00001756-200306110-00001 · Cited by 23 · see citing works
The interhemispheric projection from the substantia nigra to the caudate-putamen as depicted by the anterograde transport of [3H]leucine
Morgan, S. L., & Huston, J. P. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90013-5 · Cited by 20 · see citing works
Abnormalities of cerebral oxidative metabolism in animal models of Parkinson disease
Harik, S. I., LaManna, J. C., Snyder, S. E., et al. (1982) · Neurology · doi:10.1212/wnl.32.4.382 · Cited by 18 · see citing works
A role of subicular and hippocampal afterdischarges in initiation of locomotor activity in rats
Ma, J., Brudzyński, S. M., & Leung, L.-W. S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00165-6 · Cited by 15 · see citing works
The role of language areas in motor control dysfunction in Parkinson's disease
Albani, G., K�nig, G., Martin-Söelch, C., et al. (2001) · Neurological Sciences · doi:10.1007/s100720170038 · Cited by 10 · see citing works
Cerebrovascular and metabolic uncoupling in the caudate-putamen following unilateral lesion of the mesencephalic dopaminergic neurons in the rat
Mraovitch, S., Calando, Y., Onteniente, B., et al. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90722-w · Cited by 7 · see citing works
Untitled work
Price (1999) · doi:10.1002/1531-8249(199903)45:3

Flagged first, then by citations

Sorted by citations

Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works
Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease
Fisher, B. E., Li, Q., Nacca, A., Salem, G. J., Song, J., Yip, J., Hui, J. S., Jakowec, M. W., & Petzinger, G. M. (2013) · Neuroreport · doi:10.1097/wnr.0b013e328361dc13 · Cited by 247 · see citing works
Lesion of the Cerebellar Noradrenergic Innervation Enhances the Harmaline-Induced Tremor in Rats
Kolasiewicz, W., Kuter, K., Nowak, P., Pastuszka, A., & Ossowska, K. (2011) · The Cerebellum · doi:10.1007/s12311-011-0250-9 · Cited by 14 · see citing works

[Recent advances in research on basal ganglia. Introduction].
Takada, M. (2009) · PubMed
Two Pathways Between the Cortex and the Basal Ganglia Output Nuclei and the Globus Pallidus
Kita, H. (1996) · Advances in behavioral biology · doi:10.1007/978-1-4899-0194-1_9 · Cited by 11 · see citing works
Nitric oxide synthase mRNA expression in human subthalamic nucleus, striatum and globus pallidus: implications for basal ganglia function
Nisbet, A. P., Foster, O. J. F., Kingsbury, A. E., et al. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90062-0 · Cited by 35 · see citing works
Lesion of the subthalamic nucleus or globus pallidus does not cause chaotic firing patterns in basal ganglia neurons in rats
Ryan, L. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02542-7 · Cited by 3 · see citing works
Basal Ganglia Circuitry and Synaptic Connectivity
Charara, A., Sidibé, M., & Smith, Y. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-312-5_2 · Cited by 12 · see citing works

Authors: Yang, J., Sadler, T. R., Givrad, T. K., Maarek, J.-M. I., & Holschneider, D. P.
Affiliations: University of Southern California (US)
Corresponding author: Holschneider, D.P.
ORCID: Yang, J.
Maarek, J.-M.I.
Holschneider, D.P.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2007-07
Volume: 36
Issue: 3
Pages: 755-773
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2007.03.010
PMC: PMC2039721
OpenAlex: W1967838925
Cited by: 41
References: 109
Citations by year: 2025: 1 · 2024: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 10 · 2012: 3
FWCI: 2.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS050171)
Topics: Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: 6-hydroxydopamine lesion, functional compensation, cerebral blood flow, resting state, treadmill locomotion, subthalamic nucleus, globus pallidus, thalamus, motor cortex, cerebellum, red nucleus, Parkinson's disease, neurorehabilitation, neurorestoration
MeSH terms: Amphetamine, Central Nervous System Stimulants, Animals, Autoradiography, Brain, Brain Damage, Chronic, Brain Mapping, Cerebellum, Globus Pallidus, Image Processing, Computer-Assisted, Functional Laterality, Locomotion, Male, Models, Neurological, Rest, Tyrosine 3-Monooxygenase, Walking, Oxidopamine, Neostriatum, Rats, Sprague-Dawley, Subthalamic Nucleus, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks