Cited by 247Parkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsNeurotransmitter Receptor Influence on Behavior

Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease

Fisher, Beth E., Li, Quanzheng, Nacca, Angelo, Salem, George J., Song, Jooeun, Yip, Jeanine, Hui, Jennifer S., Jakowec, Michael W. +1 more·2013·Neuroreport

Abstract

We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease (PD), including an increase in the dopamine D2 receptor (DA-D2R), using noninvasive PET imaging with the radioligand [18F]fallypride. The purpose of this feasibility and translational study was to examine whether intensive exercise leads to similar alterations in DA-D2R expression using PET imaging with [18F]fallypride in individuals with early-stage PD. In this pilot study, four patients with early-stage PD were randomized to receive intensive exercise (treadmill training sessions three times/week for 8 weeks) or no exercise. Two healthy age-matched individuals participated in treadmill training. Alterations in the DA-D2R binding potential (BP) as a marker for receptor expression were determined using PET imaging with [18F]fallypride. Turning performance in the patients with PD as a measure of postural control and the Unified Parkinson's Disease Rating Scale scores pre-exercise and postexercise were determined. Our data showed an exercise-induced increase in [18F]fallypride BP as well as improved postural control in patients with PD who exercised. Changes in DA-D2R BP were not observed in patients with PD who did not exercise. These results suggest that exercise can lead to neuroplasticity in dopaminergic signaling and contribute to improved function that may be task specific (postural control) in early-stage PD.

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Crossref · 10.1097/wnr.0b013e328361dc13

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  • Studies in animals have shown that brain changes seen in exercise are distinct from those observed in learning.

    “Consistent with this notion, studies in animals have shown that brain changes seen in exercise are distinct from those observed in learning 52.”
  • Rats that have undergone aerobic exercise have an increase in density of capillaries in cerebral motor regions, without an increase in number of synapses, but display improved cortical related behaviors.

    “Interestingly, rats that have undergone aerobic exercise have an increase in the density of capillaries in the cerebral motor regions, without an increase in the number of synapses, but display improved cortical related behaviors52.”

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Authors
Fisher, B. E., Li, Q., Nacca, A., Salem, G. J., Song, J., Yip, J., Hui, J. S., Jakowec, M. W., & Petzinger, G. M.
Affiliations
University of Southern California (US)
Corresponding author
Petzinger, Giselle M.
Venue
Neuroreport
Published
2013-07-10
Volume
24
Issue
10
Pages
509-514
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2037477382
Cited by
247
References
28
Citations by year
2026: 9 · 2025: 23 · 2024: 24 · 2023: 18 · 2022: 24 · 2021: 10 · 2020: 25 · 2019: 16 · 2018: 25 · 2017: 18 · 2016: 19 · 2015: 21 · 2014: 11 · 2013: 3
FWCI
11.42
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
  • OPUS - Open Publications of UTS Scholars (University of Technology Sydney) (submittedVersion)
Funders
Siemens Medical Solutions USA
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
Parkinson's disease, treadmill exercise, dopamine D2 receptor, [18F]fallypride, receptor binding potential, dopamine signaling, postural control, turning performance, neuroplasticity, early-stage Parkinson's disease, exercise therapy
MeSH terms
Benzamides, Biomechanical Phenomena, Brain, Exercise Therapy, Female, Gait, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuronal Plasticity, Parkinson Disease, Pilot Projects, Posture, Psychomotor Performance, Pyrrolidines, Neostriatum, Receptors, Dopamine D2, Radiopharmaceuticals, Positron-Emission Tomography

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