Effects of ApoE4 and maternal history of dementia on hippocampal atrophy
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We applied an automated hippocampal segmentation technique based on adaptive boosting (AdaBoost) to the 1.5 T magnetic resonance imaging (MRI) baseline and 1-year follow-up data of 243 subjects with mild cognitive impairment (MCI), 96 with Alzheimer's disease (AD), and 145 normal controls (NC) scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). MCI subjects with positive maternal history of dementia had smaller hippocampal volumes at baseline and at follow-up, and greater 12-month atrophy rates than subjects with negative maternal history. Three-dimensional maps and volumetric multiple regression analyses demonstrated a significant effect of positive maternal history of dementia on hippocampal atrophy in MCI and AD after controlling for age, ApoE4 genotype, and paternal history of dementia, respectively. ApoE4 showed an independent effect on hippocampal atrophy in MCI and AD and in the pooled sample.
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Maternal inheritance appears to determine several AD endophenotypes.
“Maternal inheritance appears to determine several AD endophenotypes.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [138]
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- Authors
- Andrawis, J. P., Hwang, K. S., Green, A. E., Kotlerman, J., Elashoff, D., Morra, J. H., Cummings, J. L., Toga, A. W., Thompson, P. M., & Apostolova, L. G.
- Affiliations
- University of Chicago (US)
- University of California, Los Angeles (US)
- Monash University (AU)
- Corresponding author
- Apostolova, Liana G.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 33
- Issue
- 5
- Pages
- 856-866
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC3010297
- OpenAlex
- W2087182902
- Cited by
- 54
- References
- 67
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 2 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 12 · 2012: 4
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (U01 AG024904, U54 RR021813)
- NIA (K23 AG026803, P50 AG16570)
- NIBIB (EB01651)
- NLM (LM05639)
- NCRR (RR019771, P41 RR013642)
- NIMH (R01 MH071940)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- APOE ε4, hippocampal atrophy, hippocampal volume, mild cognitive impairment, Alzheimer's disease, genetic risk factors, family history of dementia, hippocampus segmentation, atrophy rate
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Dementia, Female, Genetic Markers, Hippocampus, Humans, Male, Middle Aged, Mothers, Apolipoprotein E4, Neuroimaging
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