The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Neural response to reward anticipation is modulated by Gray's impulsivity
Abstract
According to the Reinforcement Sensitivity Theory (RST), Gray's dimension of impulsivity, reflecting human trait reward sensitivity, determines the extent to which stimuli activate the Behavioural Approach System (BAS). The potential neural underpinnings of the BAS, however, remain poorly understood. In the present study, we examined the association between Gray's impulsivity as defined by the RST and event-related fMRI BOLD-response to anticipation of reward in twenty healthy human subjects in brain regions previously associated with reward processing. Anticipation of reward during a Monetary Incentive Delay Task elicited activation in key components of the human reward circuitry such as the ventral striatum, the amygdala and the orbitofrontal cortex. Interindividual differences in Gray's impulsivity accounted for a significant amount of variance of the reward-related BOLD-response in the ventral striatum and the orbitofrontal cortex. Specifically, higher trait reward sensitivity was associated with increased activation in response to cues indicating potential reward. Extending previous evidence, here we show that variance in functional brain activation during anticipation of reward is attributed to interindividual differences regarding Gray's dimension of impulsivity. Thus, trait reward sensitivity contributes to the modulation of responsiveness in major components of the human reward system which thereby display a core property of the BAS. Generally, fostering our understanding of the neural underpinnings of the association of reward-related interindividual differences in affective traits might aid researchers in quest for custom-tailored treatments of psychiatric disorders, further disentangling the complex relationship between personality traits, emotion, and health.
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“Additionally, experimental data suggest an association between risky and impulsive behavior, which is characteristic of ADHD,14–16 and dopamine release or dopamine-dependent BOLD response to rewards in the striatum.11,17–20”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [19]
In the citing paper
“First, there is a positive association between trait impulsivity or reward-related impulsivity and neural activation in the striatum following reward-predicting cues19,20,22 in healthy adult samples”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [19]
Citations
Cites
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Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
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Torrubia, R., Ávila, C., Moltó, J., & Caseras, X. (2001) · Personality and Individual Differences · doi:10.1016/s0191-8869(00)00183-5 · Cited by 1,348
CORRELATION CALCULATED FROM FAULTY DATA
Spearman, C. (1910) · British Journal of Psychology 1904-1920 · doi:10.1111/j.2044-8295.1910.tb00206.x · Cited by 1,215
Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex
Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003) · Science · doi:10.1126/science.1087919 · Cited by 1,165
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076
Dissociated neural representations of intensity and valence in human olfaction
Anderson, A. K., Christoff, K., Stappen, I., Panitz, D., Ghahremani, D. G., Glover, G., Gabrieli, J. D. E., & Sobel, N. (2003) · Nature Neuroscience · doi:10.1038/nn1001 · Cited by 1,054
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Plichta, M. M., & Scheres, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.012 · Cited by 424
“, 2011) and linked to impulsivity in clinical and non-clinical populations (Kirsch et al., 2006; Scheres et al., 2007; Hahn et al., 2009; Plichta et al., 2009; Forbes et al., 2009; Juckel et al., 2012).”
BackgroundReward processing and mood-related symptoms: An RDoC and translational neuroscience perspective
Nusslock, R., & Alloy, L. B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.001 · Cited by 342
Test-retest reliability of evoked BOLD signals from a cognitive-emotive fMRI test battery.
Plichta, M. M., Schwarz, A. J., Grimm, O., Morgen, K., Mier, D., Haddad, L., Gerdes, A. B. M., Sauer, C., Tost, H., Esslinger, C., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.129 · Cited by 287
“, 2006) and is linked to impulsivity and (an-)hedonic states in clinical and non-clinical populations (Forbes et al., 2010; Hahn et al., 2009; Kirsch et al., 2006; Plichta et al., 2009; Scheres et al., 2007) and (3) an n-back working memory paradigm (Callicott et al.”
BackgroundPrefrontal cortex mediation of cognitive enhancement in rewarding motivational contexts
Jimura, K., Locke, H., & Braver, T. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002007107 · Cited by 301
“An important question raised by our findings is why individual differences in reward-related personality traits, which have been shown tomodulate activity in brain reward circuitry (37), can also be specifically linked to contextual changes in cognitive control.”
BackgroundLinking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience
Michelini, G., Palumbo, I. M., DeYoung, C. G., Latzman, R. D., & Kotov, R. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102025 · Cited by 304
Metadata
- Authors
- Hahn, T., Dresler, T., Ehlis, A.-C., Plichta, M. M., Heinzel, S., Polak, T., Lesch, K.-P., Breuer, F., Jakob, P. M., & Fallgatter, A. J.
- Affiliations
- University of Würzburg (DE)
- MRB Research Center for Magnetic Resonance Bavaria (DE)
- Corresponding author
- Hahn, Tim
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 46
- Issue
- 4
- Pages
- 1148-1153
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1973808229
- Cited by
- 136
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 15 · 2013: 14 · 2012: 10
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- reward anticipation, Reinforcement Sensitivity Theory, Behavioural Approach System, ventral striatum, orbitofrontal cortex, amygdala, monetary incentive delay task, individual differences, personality traits, reward processing
- MeSH terms
- Brain, Brain Mapping, Emotions, Female, Humans, Image Interpretation, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Reward, Sex Factors
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