The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Alteration of brain default network in subacute phase of injury in concussed individuals: Resting-state fMRI study
Open accessAbstract
There are a number of symptoms, both neurological and behavioral, associated with a single episode of r mild traumatic brain injury (mTBI). Neuropsychological testing and conventional neuroimaging techniques are not sufficiently sensitive to detect these changes, which adds to the complexity and difficulty in relating symptoms from mTBI to their underlying structural or functional deficits. With the inability of traditional brain imaging techniques to properly assess the severity of brain damage induced by mTBI, there is hope that more advanced neuroimaging applications will be more sensitive, as well as specific, in accurately assessing mTBI. In this study, we used resting state functional magnetic resonance imaging to evaluate the default mode network (DMN) in the subacute phase of mTBI. Fourteen concussed student-athletes who were asymptomatic based upon clinical symptoms resolution and clearance for aerobic exercise by medical professionals were scanned using resting state functional magnetic resonance imaging. Nine additional asymptomatic yet not medically cleared athletes were recruited to investigate the effect of a single episode of mTBI versus multiple mTBIs on the resting state DMN. In concussed individuals the resting state DMN showed a reduced number of connections and strength of connections in the posterior cingulate and lateral parietal cortices. An increased number of connections and strength of connections was seen in the medial prefrontal cortex. Connections between the left dorso-lateral prefrontal cortex and left lateral parietal cortex showed a significant reduction in magnitude as the number of concussions increased. Regression analysis also indicated an overall loss of connectivity as the number of mTBI episodes increased. Our findings indicate that alterations in the brain resting state default mode network in the subacute phase of injury may be of use clinically in assessing the severity of mTBI and offering some insight into the pathophysiology of the disorder.
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Traumatic brain injury as a disorder of brain connectivity
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Chronic traumatic encephalopathy: Where are we and where are we going?
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Psychological and Physiological Markers of Stress in Concussed Athletes Across Recovery Milestones
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Sex differences in orbitofrontal connectivity in male and female veterans with TBI
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Morelli, N., Johnson, N. F., Kaiser, K., Andreatta, R. D., Heebner, N. R., & Hoch, M. C. (2021) · Brain Injury · doi:10.1080/02699052.2021.1972339 · Cited by 38
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Neural mechanisms of emotional health in traumatic brain injury patients undergoing rTMS treatment
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Understanding individual variability in symptoms and recovery following mTBI: a role for TMS-EEG
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Metadata
- Authors
- Johnson, B., Zhang, K., Gay, M., Horovitz, S., Hallett, M., Sebastianelli, W., & Slobounov, S.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 59
- Issue
- 1
- Pages
- 511-518
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2111066106
- Cited by
- 309
- References
- 16
- FWCI
- 14.70
- Type
- journal article
- Language
- en
- Open access
- green
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